Journal of Neurology

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ISSN / EISSN : 0367-004X / 1432-1459
Published by: Springer Nature (10.1007)
Total articles ≅ 18,514
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Latest articles in this journal

James J. Sun, Bhathika Perera, William Henley, Heather Angus-Leppan, Indermeet Sawhney, Lance Watkins, Kiran N. Purandare, Mogbeyiteren Eyeoyibo, Mark Scheepers, Geraldine Lines, et al.
Published: 24 January 2022
Journal of Neurology pp 1-11; https://doi.org/10.1007/s00415-021-10938-3

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Alexandre Jentzer, Clarisse Carra-Dallière, Claire Lozano, Sophie Riviere, Olivier Darmon, Xavier Ayrignac, Pierre Labauge,
Published: 22 January 2022
Journal of Neurology pp 1-4; https://doi.org/10.1007/s00415-022-10972-9

Andrea Horta-Barba, Saül Martínez-Horta, Jesus Pérez-Pérez, Frederic Sampedro, Arnau Puig-Davi, Javier Pagonabarraga,
Published: 21 January 2022
Journal of Neurology pp 1-9; https://doi.org/10.1007/s00415-021-10955-2

Abstract:
Background: Patients with Huntington’s disease (HD) exhibit a variable predominance of cognitive, behavioral and motor symptoms. A specific instrument focusing on the impact of cognitive impairment in HD over functional capacity is lacking. Objective: To address the need for a brief and specifically developed HD questionnaire able to capture functional aspects suspected to be sensitive to cognitive impairment. Methods: We developed and validated the “Huntington’s Disease-Cognitive Functional Rating Scale” (HD-CFRS) in 78 symptomatic carriers of the Huntington’s disease mutation. We also administered the HD-CFRS to a knowledgeable informant to measure the level of agreement. To explore the association between HD-CFRS scores and participants’ cognitive status, we administered objective measures of cognition. Participants were classified as cognitively preserved (HD-NC), as having mild cognitive impairment (HD-MCI), or as having dementia (HD-Dem). Results: The HD-CFRS showed concurrent validity and internal consistency in the three groups. HD carriers and informants in the HD-NC group obtained similar HD-CFRS scores. However, in patients with mild cognitive impairment and dementia, informers reported greater functional impairment than HD participants. The HD-CFRS total score showed strong correlations with measures assessing cognition. Conclusions: These findings support the utility of the HD-CFRS as a brief and reliable instrument to measure functional defects associated with cognitive impairment in HD. We believe this questionnaire could be a useful tool both for clinical practice and research.
, Lisa Marie Tako, Johann Philipp Zöllner, Rejane Golbach, Waltraud Pfeilschifter, Helmuth Steinmetz, Felix Rosenow, Adam Strzelczyk
Published: 19 January 2022
Journal of Neurology pp 1-9; https://doi.org/10.1007/s00415-022-10968-5

Abstract:
Background: Mechanical thrombectomy and systemic thrombolysis are important therapies for stroke patients. However, there is disagreement about the accompanying risk of acute symptomatic seizures. Methods: A retrospective analysis of patients with an acute ischaemic stroke caused by large vessel occlusion was performed. The patients were divided into four groups based on whether they received either mechanical thrombectomy (MT) or systemic thrombolysis (ST; group 1: MT+/ST−; group 2: MT+/ST+; group 3: MT−/ST+; group 4: MT−/ST−). Propensity score matching was conducted for each group combination (1:3, 1:4, 2:3, 2:4, 1:2, 3:4) using the covariates “NIHSS at admission”, “mRS prior to event” and “age”. The primary endpoint was defined as the occurrence of acute symptomatic seizures. Results: A total of 987 patients met the inclusion criteria, of whom 208, 264, 169 and 346 belonged to groups 1, 2, 3 and 4, respectively. Propensity score matched groups consisted of 160:160, 143:143, 156:156, 144:144, 204:204 and 165:165 patients for the comparisons 1:3, 1:4, 2:3, 2:4, 1:2 and 3:4, respectively. Based on chi-squared tests, there was no significant difference in the frequency of acute symptomatic seizures between the groups. Subgroups varied in their frequency of acute symptomatic seizures, ranging from 2.8 to 3.8%, 2.8–4.4%, 3.6–3.8% and 4.9–6.3% in groups 1, 2, 3 and 4, respectively. Conclusion: There was no association between MT or ST and an increased risk of acute symptomatic seizures in patients with an acute ischaemic stroke caused by large vessel occlusion who were treated at a primary stroke centre.
Yevgenia Rosenblum, Tamara Shiner, Noa Bregman, Firas Fahoum, Nir Giladi, Inbal Maidan,
Published: 18 January 2022
Journal of Neurology pp 1-12; https://doi.org/10.1007/s00415-021-10953-4

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