Journal Information
ISSN / EISSN : 00987484 / 15383598
Current Publisher: American Medical Association (AMA) (10.1001)
Total articles ≅ 248,726
Google Scholar h5-index: 209
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Latest articles in this journal

Ali Rowhani-Rahbar, Morgan A. Bellenger, Frederick P. Rivara
Published: 11 October 2019
JAMA; doi:10.1001/jama.2019.16286

Irsk Anderson, Geoffrey D. Wool, William Madden
Published: 11 October 2019
JAMA; doi:10.1001/jama.2019.15720

Evan Wood, David L. Simel, Jan Klimas
Published: 10 October 2019
JAMA pp 1-3; doi:10.1001/jama.2019.15802

Deborah Dowell, Wilson M. Compton, Brett P. Giroir
Published: 10 October 2019
JAMA pp 1-3; doi:10.1001/jama.2019.16409

David H. Howard, Mylin A. Torres
Published: 9 October 2019
JAMA; doi:10.1001/jama.2019.15888

Jose F. Figueroa, Kathryn E. Horneffer, Ashish K. Jha
Published: 9 October 2019
JAMA; doi:10.1001/jama.2019.15918

Rebecca Voelker
Published: 8 October 2019
JAMA, Volume 322; doi:10.1001/jama.2019.14732

Rita Rubin
Published: 8 October 2019
JAMA, Volume 322; doi:10.1001/jama.2019.14684

Matthew J. O’Brien, David B. Sacks
Published: 8 October 2019
JAMA, Volume 322; doi:10.1001/jama.2019.14063

Brian A. Ference, Deepak L. Bhatt, Alberico L. Catapano, Chris J. Packard, Ian Graham, Stephen Kaptoge, Thatcher B. Ference, Qi Guo, Ulrich Laufs, Christian T. Ruff, et al.
Published: 8 October 2019
JAMA, Volume 322; doi:10.1001/jama.2019.14120

Abstract:Numerous randomized trials have demonstrated that treatment for up to 5 years with therapies that reduce low-density lipoprotein cholesterol (LDL-C) and systolic blood pressure (SBP) reduce the risk of cardiovascular events.1-3 In addition, mendelian randomization studies suggest that the benefit of exposure to lower LDL-C levels and lower SBP may accumulate over time.4-8 Because the biological effects of LDL-C and SBP may be cumulative, long-term exposure to the combination of both could potentially substantially reduce the lifetime risk of cardiovascular disease.9-11 However, the association of combined lifetime exposure to both lower LDL-C and lower SBP with the risk of cardiovascular disease has not been reliably quantified.