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Results in Journal Endocrine Practice: 8,332

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, Muhammed Erkam Sencar, Murat Calapkulu, Ilknur Ozturk Unsal, Levent Aktas, Bekir Ucan, Mustafa Ozbek, Erman Cakal
Published: 1 December 2021
Endocrine Practice, Volume 27, pp 1199-1204; https://doi.org/10.1016/j.eprac.2021.07.011

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Parisa Hashemi Moghanjoughi, Sina Neshat, Abbas Rezaei,
Published: 23 November 2021
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Published: 21 November 2021
Abstract:
Adiposity-Based Chronic Disease (ABCD) is a chronic disease and requires life-long treatment and follow-up. Obesity protects obesity through altered regulation of caloric intake and set point mechanisms that maintains a high equilibrium body weight. Lifestyle interventions and obesity medications do not permanently alter the set point which often makes weight loss achieved by lifestyle short-lived and operates to drive weight regain once medications are discontinued. Bariatric surgery procedures can alter appetite and lower the "set point" for equilibrium body weight via unknown mechanisms. However, few patients attain ideal body weight following surgery, many regain weight, and all require long-term follow-up for the disease. The excess adiposity of ABCD gives rise to complications that impair health and confer morbidity and mortality; however, the genetic risks and potential interactions between genes and environment that give rise to complications also cannot be eliminated. The equilibrium body weight around which set point mechanisms operate can be modified by environment, which underscores the importance of a less obesogenic environment for prevention and treatment of ABCD on a population basis. If ABCD will eventually be curable, this will depend on a clear understanding of the molecular mechanisms that determine the set point regulation of body weight, and an ability to permanently modulate the set point to oscillate around and a lean body mass. The conceptualization of ABCD as a chronic disease, however, does present us with opportunities for primary, secondary, and tertiary prevention to avert disease progression. For tertiary care, the advent of new, more effective, second-generation obesity medications will allow clinicians to treat-to-target via active management of body weight into a target range that will ameliorate specific complications.
Elizabeth Doll, Ian Gunsolus, Abigail Thorgerson, Vin Tangpricha, Nathan Lamberton,
Published: 12 November 2021
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Vishal K. Patel, , Sherwin D’Souza, Rajib K. Bhattacharya, Megan Francis-Sedlak, Robert J. Holt
Published: 11 November 2021
Abstract:
Objective Thyroid eye disease (TED) is a debilitating autoimmune disease characterized by ocular/periorbital tissue inflammation, proptosis, and visual impairment. Known risk factors for TED include radioactive iodine therapy, female sex, and smoking. Risk factors for severe TED include hyperthyroidism, male sex, smoking, and diabetes, but little is known on how diabetes mellitus (DM) influences TED. This claims-based analysis examined TED characteristics in patients with and without diabetes. Methods The Symphony database (2010-2015 US claims) was mined for patients with ≥1 Graves' disease diagnosis code and ≥1 TED-associated eye code, including proptosis, strabismus, diplopia, lid retraction, exposure keratoconjunctivitis, and optic neuropathy (ON). DM status was determined by type 1/type 2 diabetes coding. Sight-threatening TED was defined as ≥1 optic neuropathy or exposure keratoconjunctivitis code. Results A total of 51,220 patients were identified. Of these, 2618 (5.1%) and 12,846 (25.1%) had type 1 and type 2 DM, respectively. Patients with and without DM were similar, but patients with DM were more often male (type 1: 30.3%, type 2: 28.7% vs. no DM: 20.5%; both p<0.001) and older at first TED code. DM patients had more strabismus (25.4%, 22.6% vs. 19.9%) and diplopia (38.6%, 37.9% vs. 29.9%), but less proptosis (42.3%, 46.3% vs. 58.5%; all p<0.001). Sight-threatening TED occurred more often in DM patients because of higher ON rates. Conclusion TED patients with DM may have more extraocular muscle involvement. Further, higher prevalence of severe TED stemmed from higher optic neuropathy rates, possibly associated with diabetes-related vasculopathies. These hypothesis-generating data justify further exploration.
, Coral Shefler, Eytan Roitman, Sigal Levy, Zamir Dovrish, Martin Ellis, Orit Twito
Published: 2 November 2021
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Zhila Maghbooli, Mohammad Ali Sahraian, SaeidReza Jamalimoghadamsiahkali, Asma Asadi, M.D. Azadeh Zarei, Abolfazl Zendehdel, Tarlan Varzandi, Sara Mohammadnabi, Neda Alijani, Mehrdad Karimi, et al.
Published: 12 October 2021
Endocrine Practice, Volume 27, pp 1242-1251; https://doi.org/10.1016/j.eprac.2021.09.016

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, Snow Yunni Lin, Yip Han Chin, Ming Hui Lee, Nicholas Syn, Xin Lei Goh, Jin Hean Koh, Jingxuan Quek, Darren Jun Hao Tan, Shao Feng Mok, et al.
Published: 30 September 2021
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Poonam Kumari, Ashutosh Kumar Arya, Rimesh Pal, Ashwani Sood, Divya Dahiya, Soham Mukherjee, Ashu Rastogi,
Published: 30 September 2021
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Lauren A. Buehler, Vignesh Balasubramanian, Scott Baskerville, Ryan Bailey, Keira McCarthy, Marc Rippen, James F. Bena,
Published: 29 September 2021
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, Sandra Park, Tina W. Yen, William Rilling, Lisa Rein, Kara Doffek, James W. Findling, Steven B. Magill, Srividya Kidambi, Douglas B. Evans, et al.
Published: 24 September 2021
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Narriane Chaves Pereira de Holanda, Ingrid De Lima Carlos, Caio Chaves De Holanda Limeira, David Cesarino de Sousa, Fábio Antônio Serra De Lima Junior, André Telis De Vilela Araújo, Ana Carla Peres Montenegro, Francisco Bandeira
Published: 23 September 2021
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Hajime Kato, Nobuaki Ito, Noriko Makita, Masaomi Nangaku, Angela M. Leung,
Published: 23 September 2021
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Published: 21 September 2021
Endocrine Practice, Volume 27, pp 1260-1263; https://doi.org/10.1016/j.eprac.2021.09.006

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, Kristen Gonzales, Neil Kaminsky, Allen Adolphe, Lynda Shey, Robert Philip Eaton
Published: 18 September 2021
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Grace E. Cromwell, Margo S. Hudson, Donald C. Simonson,
Published: 14 September 2021
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, Guido Di Dalmazi, Paola Altieri, Carla Pelusi, Rita Golfieri, Cristina Mosconi, Caterina Balacchi, Claudio Borghi, Eugenio Roberto Cosentino, Ilaria Di Cintio, et al.
Published: 8 September 2021
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, Virginia Dines, , Todd Nippoldt, Andrea Kattah, Caroline Davidge-Pitts
Published: 30 August 2021
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, Michal Baum, Michal Horovitz, Moshe Phillip, Galia Barash, Orit Pinhas-Hamiel, Liora Lazar
Published: 23 August 2021
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