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Results in Journal Journal of Alternative, Complementary & Integrative Medicine: 146

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, Dutch Osteopathic Association
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-9; https://doi.org/10.24966/acim-7562/100197

Abstract:
A proposition is made for scientific substantiation of “Primary respiration” and related concepts, including suggestions for future research. For research and support, the field of mathematics, artificial intelligence, chaos theory and complex systems thinking can be of fundamental and essential value.
, David Geffen School Of Medicine At UCLA
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-3; https://doi.org/10.24966/acim-7562/100199

Abstract:
Emerging data have suggested lack of sleep as being a possible contributor to the development of Alzheimer’s disease pathology, placing insomnia as a prospective target to positively impact underlying disease progression. Diagnosis and treatment of insomnia can be a challenge in general, with even more complexities occurring in the population of Alzheimer's disease. Treatment data is overall limited. However, multiple non-pharmacological and pharmacological interventions are available for consideration for management
Anjali Kumar, Swansea University
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-2; https://doi.org/10.24966/acim-7562/100206

Abstract:
Currently, 510 self-certified products containing probiotics are listed on the Australian Register of Therapeutic Goods (ARTG). We found 48% contained only probiotic ingredients; the remainder had multiple additional ingredients. The indications used (and claims made) were mainly non-specific, appeared to lack evidence, and encouraged unnecessary use.
Ling Guan, Capital Medical University
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-9; https://doi.org/10.24966/acim-7562/100205

Abstract:
HMT shows a stronger effect on the parasympathetic nervous system as expressed by increase in HFnu with decrease in HR, diastolic blood pressure and body tension, compared with RR and also MHM. More studies are needed to understand how different relaxing interventions may modulate the autonomic nervous system
, University Of Gabes
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-7; https://doi.org/10.24966/acim-7562/100202

Abstract:
Similarly, the bacterial strains tested were most sensitive to fruit peels than especially against Staphylococcus aureus with inhibition zones (DIZ), minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 15.22±2.14 mm, 4.68 mg/mL and 37.5 mg/mL respectively. However, aqueous extract of cladodes have high antifongical activity particularly against Fusarium oxysporum with DIZ (20±0.2 mm), MIC (4.68mg/mL) and MFC (75 mg/mL) value
Goulnar Kasymjanova, Peter Brojde Lung Cancer Centre Jewish General Hospital
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-8; https://doi.org/10.24966/acim-7562/100201

Abstract:
Our study is the first prospective clinical study using combination of curcumin and EGFR-TKIs in metastatic lung cancer patients. The future randomized larger-scale clinical trials using this combination is feasible and safe. RCT will seek to assess the potential effects on survival and response to TKIs.
, Hunan University Of Chinese Medicine
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-7; https://doi.org/10.24966/acim-7562/100195

Abstract:
Corona Virus Disease 2019 (COVID-19) caused by SARS-CoV-2 has become a global pandemic. COVID-19 can result in acute respiratory distress syndrome and multiple organ failure due to its strong infectivity and extensive spread, so it is urgent to prevent and control the epidemic. Traditional Chinese medicine (TCM) has played a pivotal role in the early prophylaxis, clinical treatment and recovery of COVID-19. At present, the epidemic situation of COVID-19 in China has been controlled in stages, and most of the confirmed cases have obtained favourable results due to the interventional diagnosis and therapy of TCM. Given different individual conditions, different TCM treatment strategies have been provided, such as moistening dryness and storing fluid, dispelling heat and detoxification, aroma penetrating filth and releasing lung and reducing turbidity.. To provide some references to the treatment of COVID-19 and related diseases and to lay a certain foundation for subsequent new drug research, this paper generalized the application and potential mechanisms of TCM in the prevention and treatment of COVID-19.
, Nutrition Institute Of America
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-4; https://doi.org/10.24966/acim-7562/100193

Abstract:
A 60-day observational study was conducted to evaluate how lifestyle modification principles relying upon a customized regimen of aerobic and muscle strength exercise, a plant-based diet and meditative stress reduction techniques may improve physical endurance and strength, mental health, and reverse normal aging associated with the average American lifestyle. All enrolled participants were generally in good health respective to their age. Several subjects had overlapping mild medical conditions. The results demonstrate that the intervention of a customized lifestyle modification regimen of regular daily exercise, a plant-based diet, and daily stress reduction practices, such as meditation and yoga, may provide a viable and beneficial preventative strategy as an anti-aging and wellness model to increase the physical and mental health of elderly men and women.
Kaicheng Wang, People’S Hospital Of Huishan, Tingwang Jiang, The Affiliated Changshu Hospital Of Xuzhou Medical University
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-9; https://doi.org/10.24966/acim-7562/100191

Abstract:
To explore the mechanism of hypertension caused by sorafenib in liver cancer-bearing rats based on Vascular Endothelial-Growth Factor (VEGF) signal pathway. After the three groups (blank, liver cancer and Spontaneously Hypertensive Rat (SHR) groups, n = 30) were administered orally with sorafenib (2 mg/kg), the non-invasive tail arterial pressure measurement was employed to determine the changes in blood pressure (BP). Enzyme-linked immunosorbent assay measured the changes of VEGF and Nitric Oxide (NO) in serum. The expressions of Kinase insert Domain Receptor tyrosine kinase (KDR-CD), endothelial Nitric Oxide Synthase (eNOS), Bax and Bcl-2 were detected by Western blot. TUNEL assay detected the Apoptosis Index (AI) of cardiomyocyte. CD31 immunohistochemical staining was observed the changes of Myocardial Capillary Density (MCD). The BP and VEGF levels of the blank and SHR groups were not significantly (P > 0.05) different from those in the before treatment cohort, while the BP of the liver cancer group was significantly (P < 0.05) higher. VEGF level was significantly (P < 0.05) lower than before. Compared with the blank group, the levels of NO, KDR-CD, eNOS, Bcl-2/Bax and MCD in the liver cancer group were significantly (P < 0.05) lower than those in the after administration, while the myocardial cell AI increased significantly (P < 0.05). After antagonist intervention, the BPs and myocardial AI of the liver cancer and SHR groups were significantly lower than before the intervention. Besides, levels of KDR-CD, eNOS, Bcl-2/Bax protein, MCD, serum VEGF and NO were significantly higher than before the intervention (P<0.05). Induction mechanism of hypertension induced by sorafenib may be owing to the inhibition of the VEGF signaling pathway, and reduction of endothelial cells proliferation leading to blockade of NO synthesis. This causes vasoconstriction, while promoting myocardial cell apoptosis and decreasing capillary density, thereby inducing the occurrence of hypertension.
, University Of The Region Of Joinville
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-5; https://doi.org/10.24966/acim-7562/100194

Abstract:
Obesity is a chronic disease described by the large amount of body fat that leads to an increase in Body Mass Index (BMI). It is subdivided into three levels, being grade I with a BMI between 30 and 34.9 kg/m2, grade II between 35 and 39.9 kg/m2 and grade III or morbid obesity with a BMI above 40 kg/m2. Aiming at reversing the morbid condition caused by the disease, the bariatric surgical technique presents itself as the most effective option to contain grade III obesity, as well as the associated co morbidities. The objective of surgical techniques is to improve the quality of life of the obese, reducing both physical and psychosocial problems. As endocrine disease is related to several co morbidities, such as high blood pressure, sleep apnea and even some types of cancer, it is necessary to carry out an investigation into the surgical technique to be applied as well as its effectiveness during and after the surgical procedure.
Rong Li, The First Affiliated Hospital Of Guangzhou University Of Chinese Medicine
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-2; https://doi.org/10.24966/acim-7562/100196

Abstract:
Sick Sinus Syndrome (SSS) refers to a group of heart rhythm disorders caused by problems relating to the sinus node. Currently, there is no effective treatment for SSS, and an electronic pacemaker is required to support heart function in SSS patients. However, electronic pacemakers are associated with several defects. For example, external magnetic noise commonly interferes, leading to complications. In addition, some patients, especially children with congenitals inoatrial node dysfunction, are not suitable subjects for pacemaker insertion. Therefore, the search for new therapeutic strategies for treating cardiovascular diseases has become imperative. Shenfu injection (SFI), a Chinese herbal medicine, is effective in improving bradyarrhythmia. However, the underlying mechanism of SFI's therapeutic effect remains elusive.
Fei Teng, The Beijing Genomics Institute, Zhong Wang, China Academy Of Chinese Medical Sciences
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-6; https://doi.org/10.24966/acim-7562/100192

Abstract:
O investigate the characteristics and find more effective biomarkers at gene expression level of Stable Angina (SA) pectoris.
Xiaoyong Qi, Hebei Medical University
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-5; https://doi.org/10.24966/acim-7562/100179

Abstract:
Ginsenoside Rg2 inhibited the deterioration of cardiac function in rats, ginsenoside Rg2 inhibited cardiomyocyte apoptosis, increased the expression of Caspase-3,Caspase-9 and BAX in cell experiment. Conclusions: Ginsenoside Rg2 could protect cardiomyocytes in TZM-induced toxicity and it might be via inhibiting cell apoptosis.
, Florida Gulf Coast University, , Northwest A & F University
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-5; https://doi.org/10.24966/acim-7562/100171

Abstract:
As a complementary and alternative medicine in the western countries for decades, Traditional Chinese Medicine (TCM) has been used for more than 2000 years in China. Because of the characteristics of the philosophical style and the unknown mechanism of action, TCM sometimes has been biasedly described as "fraught with pseudoscience". From the scientific basis of the systems biology, here we promoted a novel medical model called the entropic systems medicine which could be applied to scientize TCM in future. In entropic systems medicine, TCM and Western modern biomedicine target the different variables of the entropic system. For instance, while Western modern biomedicine directly targets the phenotypes and its SOCs of macrostates, TCM differently targets the microstates, entropy and entropic force to generate SOTFs gradually causing the differentiated syndromes to be slowly rearranged. The prerequisites to modernize TCM are the entropic systems biology having been well established so that the variables could be precisely monitored and mathematically calculated.
, Veterinary Scientist Working For Animal Welfare
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-4; https://doi.org/10.24966/acim-7562/100183

Abstract:
There might be difference in dose, administration or combinations based on the species, body weight, digestion pattern or habitat but the family of medicines are mostly the same.
, The Chinese University Of Hong Kong
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-11; https://doi.org/10.24966/acim-7562/100177

Abstract:
The body acting as a whole could function positively. In the body comprehensive functional-anatomical framework, adaptations start with core-to-match to the environment, and being fit and snug in living is important. For an individual to actuate and assert in confronting the surrounding environment, the body is prepared by a nervous and vascular co-directed development whence information and perfusion go together. This coupled nervous-perfusional adaptivity is for the first time expressed in this paper. Correspondingly, Chinese medicine describes the concept with Qi (Energy process) and Xue (Blood); and also related Yin Yang dynamics. Positivity in living in an individual can be ensured by the fit and snug processes with these body assets working together for advantages in living. The whole functional-anatomical body is involved from the heart, brain and other systems and managed in this perspective.
, Florida Gulf Coast University
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-7; https://doi.org/10.24966/acim-7562/100184

Abstract:
Respondents reported an overall positive attitude toward and interest in CAM. Ninety percent had heard of and three-quarters reported previous experience with CAM practices. Respondents alluded to personal experience but also to knowledge gained about CAM in classes and clinical assignments. Acupuncture, yoga, massage therapy, meditation, cupping, aromatherapy, and chiropractic care were the CAM practices most respondents had heard about; yoga, meditation, massage therapy, aromatherapy, and chiropractic care were the CAM practices most respondents reported personal experience with. The top five practices students planned on making part of their career were yoga, meditation, massage therapy, diet-based therapy, and music therapy. Graduating health professions students had a more positive attitude toward CAM than pre-health professions students. They also had a higher average score for their interest in learning about CAM practices. Three-quarters of respondents planned on making CAM part of their career.
Tingwang Jiang, The Affiliated Changshu Hospital Of Xuzhou Medical University
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-9; https://doi.org/10.24966/acim-7562/100180

Abstract:
Primary Biliary Cholangitis (PBC) is a chronic autoimmune cholestatic liver disease. This study investigated changes of adenosine metabolism pathway related molecules and their contribution to inflammatory injury in PBC. Clinical results showed that the concentrations of alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP) and g-Glutamyl Transferase (GGT) in serum of 64 PBC subjects increased compared with 60 Healthy Controls (HC). The proportion of CD39+CD4+ cells was decreased in PBMCs from PBC patients in comparsion to HC. Moreover, the proportion of CD39+ Treg cells in PBMCs from PBC patients also significantly decreased in comparsion to HC. A PBC murine model results showed that, compared with the normal mice, the concentrations of ALT, AST and GGT in serum significantly increased induced by polyinosinic-polycytidylic acid (poly I:C). Histopathology result revealed that poly I:C induced liver inflammation in mice. The proportion of CD39+ cells in PBMCs from poly I:C-treated mice was decreased compared with the normal mice. Meanwhile, the proportions of CD39+CD4+ cells and CD39+Treg cells were markedly reduced in poly I:C-induced mouse spleen. Finally, poly I:C significantly induced a global reduction of CD39 and adenosine receptor A2a expression in mouse liver. In addition, poly I:C treatment didn’t alter the proportions of CD39+CD8+ and CD39+CD19+ cells in mouse liver. In conclusion, our results suggest that the proportion of CD39+ Treg cells decreasing in PBC patients and animal model are closely associated with the disease progression. Our study offers a novel perspective on the role of adenosine metabolism pathway in PBC pathogenesis.
, New York College Of Traditional Chinese Medicine
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-5; https://doi.org/10.24966/acim-7562/100156

Abstract:
After 40 treatments, the patient no longer had any dripping, and had no recurrence of her symptoms by her 47th treatment in April 2017. In March 2021, she returned to the clinic for other complaints, and reported that her incontinence symptoms have not returned. Although our case study only represents the experience of one patient, the complete remission of her symptoms warrants additional research into the use of Master Tung’s points for the treatment of urinary incontinence.
, Creighton University Medical Center
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-8; https://doi.org/10.24966/acim-7562/100160

Abstract:
In addition, FEH treatment increased ACh and BDNF levels, and reduced the levels of IL-1β, TNF-α and IL-6 in brain hippocampal tissue of mice with scopolamine-induced memory and learning impairment. Furthermore, FEH treatment enhanced the expression of phosphorylated cAMP response element-binding protein (p-CREB) and BDNF via the stimulation of the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin/postsynaptic density protein 95 (p-PI3K/p-AKT/mTOR/PSD95) pathway, and activation of Extracellular Signal-Regulated Kinases (ERK) and Ca2+/calmodulin-dependent protein kinase II (CaMKII). These results provide extensive information regarding the protective mechanism of action of FEH, and support the potential of FEH supplementation to prevent learning and memory impairment.
, Swedish Herbal Institute R&D (SHIRD)
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-8; https://doi.org/10.24966/acim-7562/100161

Abstract:
In this study, we also found that the sick leave for the placebo group was 1.79 days, while the sick leave in the Kan Jang group was reduced to 0.44 days.
, Summit Innovation Labs
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-6; https://doi.org/10.24966/acim-7562/100170

Abstract:
The results indicate that OGB alone or together with Metformin works significantly faster in lowering glucose and to a healthy level without side effects when compared to clinical findings with current pharmaceutical treatment options, which take 3 months to 6 months to show clinically meaningful results. OGB’s speed of action also suggests that it works more holistically to address the various cellular disease onset mechanisms at the same time. The learning’s also suggest that the select polyphenols and magnesium in OGB may safely and more effectively supplement and or potentially replace T2DM pharmaceutical medications.
Manami Tanaka, Bradeion Institute Of Medical Sciences
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-10; https://doi.org/10.24966/acim-7562/100162

Abstract:
The induced normal tissue regeneration was the results of transcriptional control of iPS/ES cell production. Among the gene families to control iPS/ES production, especially c-my expression level played a major role among the other genes or gene families. These results provide a clue to clarify the Huaier effects not only for recovery from cancer, but also for the prevention of many related diseases and disorders caused by daily accumulation of environmental stresses and ageing by controlling normal tissue regeneration by stem cell control.
, University Hospital Schleswig-Holstein
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-6; https://doi.org/10.24966/acim-7562/100151

Abstract:
To conclude, universities should react to the medical students‘ needs by extending their CM curriculum allowing for positive, personal experiences. Nutrition therapy, manual medicine and relaxation techniques should be included in medical education since most students imagined to use these CM therapies as physicians. Critical appraisal of and training in homeopathy and manual medicine might positively influence students‘ attitudes towards CM.
, New Alliance Integrative Research
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-4; https://doi.org/10.24966/acim-7562/100172

Abstract:
Many Christians are battling Cancer and there is a chaotic vortex of emotions that need resolving. They think they are alone. Religion and spirituality are fundamental to the human condition and play a role in our mental health and wellbeing. Initially, religion and science thrived in a complimentary relationship, only to be polarized with the aggressive secularization of science. We know that with the introduction of Neurotheology as a unique filed of scholarship and investigations that seek to understand the relationship specifically between the brain and theology, the cancer patients will feel more the Grace of God. More investigations and healthcare professionals need to be involved in this area.
Ting-Kai Leung, Taipei Medical University
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-8; https://doi.org/10.24966/acim-7562/100147

Abstract:
By combing these results and our previous objective data of electroencephalographic brain wave activity and the locations of brain activation during 3T functional MRI scanning, we hypothesis that the phenomenon observed in this study mimics the psychotherapeutic effects of transcranial brain stimulation, which may probably explain by induction of cerebral electrical discharge and change of synchronous neuronal activity. We discussed the possibility of complementary and alternative therapy on different psychiatric and neurological disorders.
Alexzander Asea, University Of Toledo College Of Medicine And Life Sciences
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-7; https://doi.org/10.24966/acim-7562/100148

Abstract:
Our study for the first time, demonstrates that ES, AP, and their combinations significantly inhibits SARS-CoV-2 viral growth in Vero E6 cells in a dose-dependent manner. The antiviral activity of the combinations of ES and AP are greater than expected.
, University Of West Attica
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-4; https://doi.org/10.24966/acim-7562/100141

Abstract:
The aim of the present report was to find out the effect of 448 kHz Capacitive Resistive Monopolar Radiofrequency (CRMRF) in acute ankle sprain. A patient with right unilateral acute ankle sprain participated in the present case study. The patient followed a course of 448 kHz CRMRF twice per day for seven consecutive days. Evaluations included self-reported pain via a visual analogue scale, degree of ankle edema and ankle range of motion via goniometry carried out before the treatment and at the end of the treatment. There was a decline in pain and a rise in function in all evaluations. The results of the present trial suggest that a course of 448 kHz CRMRF as described in the present trial can produce significant improvements in terms of pain and disability in acute ankle sprain; however, larger studies are required confirming these results.
, Florida International University
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-13; https://doi.org/10.24966/acim-7562/100143

Abstract:
Mediation reconciliation is a process that is crucial for ensuring drug safety among patients who demonstrate low medication adherence. Medication reconciliation at the Primary Care office is achieved by educating patients about the purpose of prescribed medicines, drug-to-drug, and drug-to-food interactions. Besides, patients are consulted about interactions between conventional and complementary and alternative medicine, and the dangers of consuming substances (illicit drugs, alcohol, nicotine) together with prescribed drugs. This approach is planned to be accomplished by means of combining printed medication reconciliation lists followed by open-ended questions included to check patients’ pharmacovigilance and conduct patient engagement. In addition, the innovative approach of the present project is inclusion of patients’ significant others in the process of advancing their treatment adherence. Direct participation of patients and their family member in medication reconciliation is expected to bring significant positive results. This project is valuable for advanced nurse practicing because it demonstrates the new ways to improve nurse-patient interactions, advance communication with patients’ family members and in overall, advance their pharmacovigilance.
, Buenos Aires University
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-5; https://doi.org/10.24966/acim-7562/100144

Abstract:
In the variceal ulcer acupuncture treatment was to be effective as a complementary therapy in the 80% of the cases treated.
Manami Tanaka, Bradeion Institute Of Medical Sciences
Journal of Alternative, Complementary & Integrative Medicine, Volume 7, pp 1-10; https://doi.org/10.24966/acim-7562/100146

Abstract:
Prostate cancer is classified as mild malignant tumor, since the growth is slow, and also the early detection and monitoring of PSA and other cancer cell-specific markers are available among the target population in walk-in clinic even effect the bones and lymph nodes, it requires long term treatments which significantly decrease the lifespan in patients. Trametes robiniophila Murr (Huaier) has proved broad spectrum anti-cancer effects, which initiates the recovery of damaged bio physiological functions in the end by dose-dependent manner which proved the molecular basis of Huaier effects by total RNA and small non-coding RNA sequencing (“genome-scope” project) and that is based on the rescue of the disrupted transcriptional control based on individual capability and flexibility of genomic potential. Here we focused to show MEGA-DATA genome analysis results on inhibition of active progression in cancer in situ, and also prevents relapse of prostate cancer. Total sequencing of RNAs revealed massive SNP variances (average 89,473SNP variances per individual), however, it is unlikely that specific type variants influenced to the malignancy, process, and prognosis. On the other hand, the significant up-regulation and alteration of major ontogenesis and tumor suppressor genes were detected in transcribed genes, especially in altered (normalized) NFkB, TGFb, BRCA2 and p53 genes and their leading signaling pathways. These genetic alterations in transcriptomes were based on miRNA-mediated transcriptional control as reported drugs have not shown any effect. Thus, the present study provides the safe and effective treatment to prevent and inhibit prostate cancer progression, and also to maintain homeostasis in a long-range of stressful human life without excessive medical treatments.
Rui Chen, Macau University of Science and Technology
Journal of Alternative, Complementary & Integrative Medicine, Volume 6, pp 1-3; https://doi.org/10.24966/acim-7562/100136

Abstract:
The method of TCM observation and analysis of the human body is to use different coordinate reference systems. The article “Traditional Chinese medicine Qi model” describes the observation and recognition of objects using time periods or yin and yang as the coordinate reference system, and the analogy of the characteristics of unknown things by analogy of the characteristics of known things
, PRO-health.org
Journal of Alternative, Complementary & Integrative Medicine, Volume 6, pp 1-6; https://doi.org/10.24966/acim-7562/100131

Abstract:
Participants highly evaluated the offer and use of CAM. This is a profit compared to offer by the traditional psycho-oncology. Insight in effects of CAM is still limited, also on the comparison with other countries due to incomparability of health care organizations. More studies are needed to show content and effects of CAM for cancer patients.
, Technical University Munich
Journal of Alternative, Complementary & Integrative Medicine, Volume 6, pp 1-8; https://doi.org/10.24966/acim-7562/100133

Abstract:
Our data demonstrates a high overall interest in CAM in patients with gynecological cancer. Health care professionals should be aware of this in order to be able to better address their patients´ needs. In the interest of the patients’ overall well-being and safety, it is necessary to explore the use of CAM with cancer patients, educate them about potentially beneficial therapies even in the light of the limited available evidence and to work towards an integrated model of health-care.
Young-Ran Yoon, Kyungpook National University School Of Medicine And Hospital, Sook Jin Seong
Journal of Alternative, Complementary & Integrative Medicine, Volume 6, pp 1-8; https://doi.org/10.24966/acim-7562/100138

Abstract:
Characterizing potential interactions between red ginseng, an herb with desirable health effects, and metformin, a commonly used drug for the treatment of type 2 diabetes mellitus, is of high clinical importance. In this study, we evaluate the effects of Korean red ginseng on the pharmacokinetic and pharmacodynamic properties of metformin in healthy subjects. The study was conducted in an open-label, two-period and single-sequence design. A total of 11 subjects received multiple doses of metformin in the first study period followed by multiple doses of metformin and red ginseng in the second study period. The Geometric Mean Ratio (GMR) (90% Confidence Interval (CI)) between the groups for area under the plasma drug concentration-time curve within a dosing interval (tau) at steady state (AUCtau,ss) of metformin was out of the range of bioequivalence, indicating that the systemic exposure of metformin when combined with red ginseng was reduced compared with administration of metformin alone. However, the pharmacodynamic analysis showed that the GMR (90% CI) between the groups for area under the blood glucose values–time curve from time zero to the time of the last measurable value (AUClast) and maximum blood glucose value (Gmax) were within the range of bioequivalence. We concluded that the observed reduction in the systemic exposure of metformin when administered with red ginseng is clinically insignificant. This study demonstrated that Korean red ginseng did not have clinically significant pharmacokinetic or pharmacodynamic herb–drug interactions with metformin in healthy subjects.
, Colegio Superior De Acupuntura
Journal of Alternative, Complementary & Integrative Medicine, Volume 6, pp 1-5; https://doi.org/10.24966/acim-7562/100135

Abstract:
These acupunture points stimulated with EA have shown their hypoglycemic effect in animal models. One of the main mechanisms by which this effect is supported is the regulation of the hypothalamic-pituitary-adrenal axis, regulating the secretion of adrenal cortical hormone.
Yi-Hui Deng, HuNan University Of Chinese Medicine
Journal of Alternative, Complementary & Integrative Medicine, Volume 6, pp 1-7; https://doi.org/10.24966/acim-7562/100139

Abstract:
TongqiaoHuoxue Decoction (TONGQIAO HUOXUE DECOCTION) originated from the book "Medical Forest Correction" written by Wang Qingren in 1830. It is a prescription for activating blood circulation and dispersing stagnation, mainly for the faculties of the head and face. With more than one hundred years of clinical and experimental exploration by Chinese medicine researchers, the connotation of TONGQIAO HUOXUE DECOCTION has been enriched and developed. It can be used to treat many diseases, but it still focuses on head and face related diseases, especially cerebrovascular diseases. By collecting and sorting out the relevant literature on TONGQIAO HUOXUE DECOCTION, we systematically report the latest knowledge about TONGQIAO HUOXUE DECOCTION, mainly including the application of TONGQIAO HUOXUE DECOCTION in the treatment of cerebrovascular diseases and their secondary diseases.
, Hong Kong Baptist University
Journal of Alternative, Complementary & Integrative Medicine pp 1-12; https://doi.org/10.24966/acim-7562/100129

Abstract:
A framework describing a body perspective that can be used under Western Medicine (WM) and Chinese Medicine (CM) in parallel would facilitate a concerted look at the body in both perspectives. The major body systems may be viewed as operating systems, while closely interactive organ clusters forming whole body subsystems sub serve life functions. The whole body is viewed in layers: with the Mantle as border zone, the under-layer Interface as interactional zone, the Core with organ systems, and the Deep biostratum of resources. The mantle acts as a barrier and interface, while the under-layer of fascial, circulatory and neurohumoral elements inter-relate with deeper provisions, supporting and stabilizing activities. The operating systems and life vigor subsystems function up to a surface border-zone to interact effectively and adaptively with the surrounding environment. While current academics consider the dynamic brain tightly integrated with the body as a self-organized system, a clinical framework is lacking. This paper provides a more or less seamless framework between social, physical, biochemical and cellular perspectives, which have formerly been dichotomizing with big gaps. With such a framework, WM workers can expand onto using some parts of the CM perspectives, not losing scientific emphasis of cellular studies, while recognizing that whole body processes in many clinical occasions can explain problems and be handled more effectively. This has implications in diagnosis and understanding pathophysiology. Accordingly, a spectrum of practice modes in medicine presented helps to understand clinical approaches, from lesion to complexity treatment.
Mariana Chiste Pontes, Universidade Federal do Rio Grande do Sul (UFRGS)
Journal of Alternative, Complementary & Integrative Medicine pp 1-7; https://doi.org/10.24966/acim-7562/100128

Abstract:
Obesity is considered a disease of the century and several treatment methods have been researched. Traditional Chinese medicine describes several findings that can be used to treat this disease. Thus, the aim of the present study was to evaluate, from an experimental perspective of Western medicine, the biochemical and behavioral effects of pharmacopuncture (21 and 40) in obese Wistar rats. The HDP21 group, treated with pharmacopuncture, exhibited a reduction in body weight compared to controls, who were also fed a high-calorie diet. In the eating behavior test, the latency was lower in the HDP40 group, and in this group, animals consumed with a higher number of cereals compared to other obese groups, or with suggestions of high acupuncture or appetite in this group. The HDP21 group, on the other hand, exhibited the shortest time in closed arms when compared to the other groups, suggesting a reduction in anxiety. Regarding the perirenal fat weight and abdominal postmortem of groups fed a high calorie diet, the HDP21 group had the lowest weight of perirenal fat and abdominal fat compared to the others. Similarly, a reduction in cholesterol, triglyceride and glucose levels was observed in the HDP21 group compared to other groups that received a high calorie diet. In conclusion, the present study demonstrated the effectiveness of the pharmacopuncture that uses bee venom in ST21 with weight loss in obese rats, as well as the reduction in biochemical tests and with loss of anxiety.
, IMC University of Applied Sciences Krems
Journal of Alternative, Complementary & Integrative Medicine pp 1-6; https://doi.org/10.24966/acim-7562/100125

Abstract:
This study showed that the EFS was able to evoke an emotional response in young women, which was correlated to empathy. Verification of these results is needed with a larger, more representative sample. The film could be used to evaluate the effectiveness of empathy training in health professions.
Shaodong Chen, Xiamen University
Journal of Alternative, Complementary & Integrative Medicine pp 1-6; https://doi.org/10.24966/acim-7562/100130

Abstract:
Objective: To perform molecular docking of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) 3CL hydrolytic enzyme (3CLpro) and Angiotensin-Converting Enzyme II (ACE2) receptors, and to seek potential natural anti-COVID-19 drugs using computer virtual screening technology. Methods: In this study, the Autodock Vina software was first used to achieve the molecular docking of the targets, namely, sars-cov-2 3CL hydrolase and ACE2. Then, the herbals acting on 3CLpro and ACE2 receptors were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the active ingredients were also selected. After that, the chemical-target network was constructed based on the network pharmacology, and the functional enrichment analysis of Gene Ontology (GO) and the pathway enrichment analysis of Kyoto Gene and Genome Encyclopedia (KEGG) were carried out by DAVID to speculate about the mechanism of action of the core drug. Results: A total of six potential anti-COVID-19 active ingredients were selected from natural herbs. They were evaluated by the “ADME” and "Lipinski” rules and their content in the natural herbs were determined by the literature mining method. Finally, Bicuculline was selected as the anti-covid-19 candidate drug. Conclusion: Bicuculline has a stronger ability to combine with 3CLpro and ACE2 than chemical drugs recommended in the clinical practice. Internet pharmacological analysis confirms that Bicuculline can effectively resist COVID-19 pneumonia through multiple pathways.
, Creighton University Medical Center
Journal of Alternative, Complementary & Integrative Medicine pp 1-7; https://doi.org/10.24966/acim-7562/100127

Abstract:
Alzheimer’s disease is characterized by the deposition of amyloid plaques and subsequent formation of neuro-fibrillary tangles in the brain. A lack of safe and effective treatments exists to slow progression and prevents neurodegenerative diseases. In this study, amyloid beta (AB)(2 μg/3 μL) was injected (intrahippocampal) into mice to induce memory loss to investigate the beneficial effects of a silk fibroin enzymatic hydrolysate (FEH) with an average molecular weight of 2700 Daltons on memory and learning impairment which were assessed using the Morris water maze, passive avoidance, and Y-maze tests. Protein expression of BDNF-associated and p75 apoptotic signaling pathways were determined to investigate mechanistic effects of FEH. Oral FEH supplementation (10 mg/kg) significantly ameliorated AB-induced memory and learning impairment with higher doses producing small, additional increases. FEH treatment increased the levels of brain-derived neurotrophic factor (BNDF) and reduced the levels of pro-inflammatory cytokines (tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and IL-6) in brain hippocampal tissues of AB-treated mice.FEH stimulated the BDNF/tropomyosin receptor kinase B/phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin/postsynaptic density protein 95 pathway and suppressed the expression of proteins of the p75 apoptotic signaling pathway, including tumor necrosis receptor-associated factor 6, B-cell lymphoma 2 (Bcl2)/Bcl2-associated X protein, caspase-3, and nuclear factor-kappa B (NF-κB) in the brain hippocampus of amyloid beta-administered mice. These results support previous human studies indicating the potential of FEH supplementation to prevent memory and learning impairment, and provide data concerning its underlying mechanism of action.
, Chengdu Medical College, , Chengdu University of Traditional Chinese Medicine
Journal of Alternative, Complementary & Integrative Medicine pp 1-6; https://doi.org/10.24966/acim-7562/100126

Abstract:
Methicillin-Resistant Staphylococcus Aureus (MRSA) is one of the most serious health concerns bacterial owing to its incidence and the severity of the associated infections. It is necessary to find new chemical compounds with anti-MRSA activity. A model of MRSA infection was prepared by intraperitoneal injection of MRSA. A. tasao-ko essential oil was used for pretreatment and treatment of MRSA-infected animals and the 50% effective dose (ED50) was calculated according to improved Karber’s method respectively. The levels of serum interleukin (IL)-1β, IL-6, Tumor Necrosis Factor alpha (TNF-α), Malondialdehyde (MDA), Glutathione Peroxidase (GSH-Px) and Hydroxyl Radical (·OH) were measured using dedicated assay kits. The statistical analysis of inflammatory factors and oxidative stress factors was tested using one-way ANOVA computed by SPSS software. The ED50 values for the prevention and treatment of MRSA infection in A. tasao-ko essential oil were 0.15 g/kg and 0.18 g/kg, respectively. A. tasao-ko essential oil significantly reduced the inflammatory factors (IL-1β, IL-6, TNF-α), oxidative stress factors (MDA, ·OH) and increased the GSH-Px content in mice infected with MRSA. In the high-dose group, 7 days after treatment, the cytokine contents have no difference with control group (P > 0.05). A. tasao-ko essential oil exhibited anti-MRSA effect in vivo and can also ameliorate the abnormal changes in inflammatory factors and oxidative stress that arise from MRSA.
Shoeb Ahmed Ansari, Drug Standardization Research Institute
Journal of Alternative, Complementary & Integrative Medicine, Volume 6, pp 1-6; https://doi.org/10.24966/acim-7562/100118

Abstract:
Despite the enormous use of Khamira Khas as cardiac tonic in Unani system of medicine, there has been a deficit of scientific affirmation of its purity. Its magnificent benefits impel the commercial manufacturers to carry out itsproduction at large scale to meet the demand. Sometimes large production in short time leads to negligence of quality check of the product
Li Xiaoguang, Traditional Chinese Medicine In Shaanxi Province
Journal of Alternative, Complementary & Integrative Medicine, Volume 6, pp 1-4; https://doi.org/10.24966/acim-7562/100121

Abstract:
Modern medicine tells us that the human body is an organism composed of heart, lung, liver, kidney, spleen, stomach, brain, nerves, muscles, bones, blood vessels, blood and so on, while Traditional Chinese Medicine believes that besides these tissues and organs
, The University of Texas MD Anderson Cancer Center
Journal of Alternative, Complementary & Integrative Medicine, Volume 6, pp 1-3; https://doi.org/10.24966/acim-7562/100119

Abstract:
Yoga has been promoted for cancer patients as a tool for symptom management and improving quality of life. Many cancer patients have bone metastasis, are not fully aware of its impact. Improper movements during exercise and yoga can increase the risk for skeletal-related events. This short commentary alerts clinician and yoga teacher to assess bone integrity prior to recommending and teaching yoga.
Hwa-Jung Choi, Youngsan University
Journal of Alternative, Complementary & Integrative Medicine, Volume 6, pp 1-7; https://doi.org/10.24966/acim-7562/100114

Abstract:
The regulatory mechanism of Nandina domestica leaves on various inflammatory diseases is still not clear
Jih-Huah Wu, Ming Chuan University
Journal of Alternative, Complementary & Integrative Medicine, Volume 6, pp 1-3; https://doi.org/10.24966/acim-7562/100120

Abstract:
Photobiomodulation Therapy (PBMT) is regarded as an alternative or complementary medicine in the current therapy, however, this medical treatment will be one of the most recent trends in healthcare. In the modern world, the life span of human beings has been prolonged by the progress of science and technology.
, State Universty Of Campinas
Journal of Alternative, Complementary & Integrative Medicine, Volume 6, pp 1-6; https://doi.org/10.24966/acim-7562/100116

Abstract:
The objective of this study is to evaluate the energy flow promoted by the application of medical Chi Kung therapy, having as comparison a group treated with acupuncture. The sample was 20 adult patients of both sexes, from a larger study, who sought treatment for temporomandibular joint dysfunction.
, Ioffe Institute
Journal of Alternative, Complementary & Integrative Medicine, Volume 6, pp 1-9; https://doi.org/10.24966/acim-7562/100112

Abstract:
The characteristics of Terahertz (THz) irradiation generated by a Silicon Nanosandwich Structure (SNS) under the conditions of a stabilized drain - source current are demonstrated. The frequency of irradiation arising from the quantum Faraday Effect is determined by the parameters of micro cavities embedded in the edge channels of a silicon nanosandwich structure confined by the negative-U centers.
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