Results in Journal The Gazette of Medical Sciences: 67
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The Gazette of Medical Sciences, Volume 2, pp 35-43; https://doi.org/10.46766/thegms.radiology.21082006
To diagnose diseases during gestation period including renal stones, appendicitis, and pulmonary embolism in pregnant patients, computed tomography (CT) can be a golden standard. Due to CT examination, the fetus is prone to receiving a considerable dose which is the result of direct or scattered (external and internal scattered radiation) beams. The effects of ionization radiation on fetus include mutagenesis and carcinogenesis, therefore, it is essential to reduce fetus dose for pregnant patients who undergo CT examination during gestation period. This article aims to review approaches that are effective in reducing fetal dose in pregnant patients.
The Gazette of Medical Sciences, Volume 2, pp 32-34; https://doi.org/10.46766/thegms.pubheal.21081005
The Gazette of Medical Sciences, Volume 2, pp 30-31; https://doi.org/10.46766/thegms.pubheal.21080204
The Gazette of Medical Sciences, Volume 2, pp 16-29; https://doi.org/10.46766/thegms.pharma.21062806
Traditional medicines, derived from plants, could present alternative treatment strategy for cancer therapy. One such plant is Momordica charantia (MC) which possesses anti-carcinogenic properties. This study investigated the anticancer effect of an ethanol extract of MC fruit, Kuguacin-J (K-J), an isolated compound from the leaves of MC and cisplatin, either alone or combination on healthy MCF-10A mammary cells and compared with breast cancer MCF-7 and MDAMB-231 cell lines. Cell viability was tested using 8 μg/mL and 80 μg/mL doses of MC extract, K-J and cisplatin individually or combined for 24 and 48 hours. Caspase-3- activity was measured in MCF-7 and MDA-MB-231 cells using established methods. The results revealed that MC extract and K-J had no effect on healthy MCF-10A cell viability as compared to cisplatin which induced dose and time-dependent cell death. Similarly, treatment of MCF-7 cells with cisplatin induced cell death at high concentration at both the time points, while MC extract and K-J only induce MCF-7 cell death at high dose after 48 hours only. During combination therapy, both doses of cisplatin enhanced MCF-7 cell death when combined with MC extract or K-J after 24 and 48 hours. In MDAMB-231 cells, the three drugs, either alone or combined, evoked significant cell death at both the doses and time points. All three drugs, at high dose, elicited significant increase in caspase-3- activity in MCF-7 and MDA-MB-231 cells as compared to untreated cells. The results revealed that either MC extract or K-J alone or combined with cisplatin, can elicit significant increase in cell death and caspase–3-activity in MCF-7 and MDA-MB-231cells as compared to untreated cells.
The Gazette of Medical Sciences, Volume 2, pp 1-15; https://doi.org/10.46766/thegms.pubheal.21071202
Introduction & Background: In recent months unexpected reports have surfaced claiming the presence of magnetic attraction in the shoulder regions of subjects who had recently received the COVID-19 vaccination. Purpose: To determine if such claims are legitimate or spurious. Methods: A prospective observational study was performed utilizing standard neodymium magnets and non-magnetized paper clips in a rigorously standardized application protocol. Magnets and paper clips were applied over various regions of both deltoid muscles. The attraction score was calculated by adding one point for each pole of the magnet that attached to each arm over the deltoid muscle for a maximum score of 4. Likewise, three sizes of paper clips were tested with a maximum score of 6. The field score was calculated by adding the magnet score to the paper clip score for a maximum score of 10 points
The Gazette of Medical Sciences, Volume 2, pp 50-52; https://doi.org/10.46766/thegms.intmed.21062302
Interest in modulating the immune response beyond glucocorticoids has existed since the COVID-19 pandemic began. Recent trials have shown promising results with IL-6 inhibitors such as tocilizumab although similar data on Sarilumab is lacking. In this report, we analyze the current evidence on Sarilumab in hospitalized COVID-19 patients to evaluate its efficacy.
The Gazette of Medical Sciences, Volume 2, pp 53-64; https://doi.org/10.46766/thegms.nufosci.21062404
Chronic degenerative diseases like obesity, metabolic syndrome, diabetes, fatty liver, have gained high prevalence in the world, due to sedentarism, improper nutritional habits as well as alcohol and tobacco consumption. Studies have shown that regular consumption of breakfast leads to a wide range of benefits, especially for the liver. The liver is a key organ for metabolic homeostasis regulating and governing energy metabolism, mostly providing nutrients for reabsorption. Benefits of a nutrimental quality breakfast seem to help lower body mass index, prevent metabolic diseases, and overall improve quality of life. Unfortunately, these include either high cholesterol or high-sugar foods including cold cuts, bread, eggs, and sugary beverages. Also, much of the population’s work schedule relates to long hours and high-level of stress, therefore malnutrition, and inadequate eating schedules are common.
The Gazette of Medical Sciences, Volume 2, pp 46-49; https://doi.org/10.46766/thegms.surgery.21062403
Multi-organ procurement was performed on a 48-year-old donor after the patient was declared brain dead. A standard approach was performed for two dissections of abdominal organs. During the cold phase of dissection, an additional left sided retro-aortic vein was identified. The second vein had separate opening to the inferior vena cava in addition to the normal positioned pre-aortic left renal vein. Both veins were divided close to the origin from the inferior vena cava. During the back table preparation, it was noticed that same volume of preservative fluid was identified to be draining from both veins. Both veins were isolated and anastomosed separately on the 61-year-old recipient. Patient was initiated on anti-platelet therapy and made successful recovery.
The Gazette of Medical Sciences, Volume 2, pp 42-45; https://doi.org/10.46766/thegms.virology.21053106
Human Papillomavirus (HPV) infection is one of the most common sexually transmitted condition in both genders and is responsible for penile, oral, neck and anal cancers in men. However, seminal HPV infection may contribute to the risk of male infertility.
The Gazette of Medical Sciences, Volume 2, pp 40-41; https://doi.org/10.46766/thegms.hepa.21052205
A 78-year-old man presented to our hospital with a 1-year history of abdominal distension and constipation. Except for hypertension, he had no documented medical history. Physical examination was unremarkable. Laboratory examination confirmed no abnormality. Although no clues for abdominal distension were found, esophagogastroduodenoscopy demonstrated a large pedunculated duodenal mass with surface erosions.
The Gazette of Medical Sciences, Volume 2, pp 10-39; https://doi.org/10.46766/thegms.intmed.21051402
It is said that no discovery is complete until its implications have been fully realized. The identification of a previously unrecognized phenomenon says little of its potential effects. What appears as a stroke of good luck can culminate in disaster; misfortune may harbor unimagined potential. Discovery is a double-edged sword that manifests only over time. Nowhere is this aphorism more applicable than in contemporary medical science.
The Gazette of Medical Sciences, Volume 2, pp 8-9; https://doi.org/10.46766/thegms.intmed.21051603
Antibiotic drugs are the most frequently prescribed medications among hospitalized patients for life-saving purposes, mainly in immunocompromised patient, like in patient with end stage renal disease on hemodialysis (HD) or those who had documented bacterial infection. Antibiotics disposition and their pharmacokinetics and pharmacodynamics properties are affected in hemodialysis patient which increases the number of antibiotics dosing errors. Several epidemiological studies found that the majority of medication error related to antibiotics occurred during the prescribing phase (30.8%). However, there is missing data about the prevalence of errors in antibiotics dosing in HD patients.
The Gazette of Medical Sciences, Volume 2, pp 1-7; https://doi.org/10.46766/thegms.neuro.21051201
Skull base osteomyelitis (SBO), also referred to as malignant otitis externa (MOE) in its typical form, is usually a complication of otitis externa and severe uncommon and life-threatening condition requiring early diagnosis and long-term treatment in order to avoid its neurologic sequelae. We report the case of 69 years old female with a history of uncontrolled type 2 diabetes, who presented refractory and chronic right-sided purulent otorrhea with temporal headaches for 6 months, treated with no improvement by multiple attempts of ambulatory empiric therapy. After the appearance of grade III facial palsy and painful swelling in the right periorbital and zygomatic areas, the patient consulted in our department where a CT scan showed massive cortical and trabecular destruction of the right petrous bone and the mastoid extended to the lateral orbital wall, the zygomatic arch and the greater sphenoid wing realising extensive osteomyelitis of the skull base and the lateral face. The treatment was started immediately based on intravenous broad-spectrum antibiotics. Despite aggressive long-term treatment, the patient passed away, underlying the increased SBO morbidity and mortality secondary to delayed diagnosis.
The Gazette of Medical Sciences, Volume 2, pp 55-62; https://doi.org/10.46766/thegms.hepa.21041705
COVID-19 is a worldwide public health problem that has attracted much attention due to its clinical and para-clinical findings. In the western Asia, Qom was the first city to report COVID-19 cases on a large scale. We report gastrointestinal (GI) manifestations, as the only primary signs of COVID-19 infection have been reported.
The Gazette of Medical Sciences, Volume 2, pp 30-54; https://doi.org/10.46766/thegms.pubheal.21032104
The incidence of adverse events in healthcare is a global problem with negative consequences for all stakeholders including patients, their family members, health professionals and the government. Patient safety and patient safety culture lie at the heart of all adverse events within healthcare settings. The culture of an organization determines its approach to problem solving and determines how individuals within that setting work; this is also true for patient safety culture and the reduction of adverse events within healthcare organizations. The aim of this study was to assess, identify and have a better understanding of the importance of patient safety culture within the healthcare organization and to create insights on the impact of cultural management systems regarding patient safety. The research method of this study is an integrated literature of the patient safety culture and perspectives of healthcare workers, assessed using the Modified Stanford Instrument (MSI) and Manchester Patient Safety Framework (MaPSaF). Analysis of the data revealed that health professionals working in the same organizations have differing opinions on the same topic; therefore, there is need for open communication and a systematic approach to establishing the right safety culture within healthcare organizations. In conclusion, establishing the right culture and having systematic ways of measurement enable improvements and the ability of organizations to learn from their mistakes. There is paucity of data with respect to the use of these tools in the respective countries (Canada and United Kingdom) even though the tools are the national tools established through rigorous research. Therefore, a study of MaPSaF in New Zealand was also analyzed. There is need for further research and publications to enable learning on patient safety, which will reduce the incidence of adverse events and associated consequences in healthcare organizations.
The Gazette of Medical Sciences, Volume 2, pp 15-29; https://doi.org/10.46766/thegms.oncol.21040502
Everybody is born with the mammary gland. Mammary gland development occurs through various stages throughout embryonic, and stays dormant for males. Although it is uncommon, male also gets breast cancer, occasionally. Male breast cancer accounts for approximately 1% of all breast cancer cases, and it is increasing. When compared with other rare diseases, male breast cancer is understudied. Typically, male breast cancer is treated in the same way as female breast cancer. In this article, the various aspects and attributes of male breast cancer and its treatment methods are reviewed.
The Gazette of Medical Sciences, Volume 2, pp 10-14; https://doi.org/10.46766/thegms.pedia.21040301
The appendix testis may be involved in the normal testicular descent and there are reports of decreased incidence of appendix testis in children with undescended testis. The aim of this study was to evaluate the incidence of appendix testis in children with undescended testis in comparison to the incidence in children with normally descended testis.
The Gazette of Medical Sciences, Volume 2, pp 4-9; https://doi.org/10.46766/thegms.oncol.21030603
Outcome of most of the biliary and pancreatic malignancy is not good. Demography and involvement of different sites of these malignancies by endoscopic retrograde cholagiopancreatography (ERCP) are not widely studied in Bangladesh. We have studied ERCP based different biliary and pancreatic malignancy and their demographic characteristics.
The Gazette of Medical Sciences, Volume 2, pp 1-3; https://doi.org/10.46766/thegms.pedia.21030202
We experienced a rare case of 9-months-old girl with an abdominal neuroblastoma that exhibited radiographic evidence of tumor extension into the mesenteric artery. Imaging studies were suggestive of neuroblastoma which also confirmed by the histologic analysis that show a diagnosis of neuroblastoma too. The patient never underwent initial chemotherapy for the treatment of neuroblastoma but experienced operation for tumor and resection was successfully achieved. This case and the treatment strategy are discussed in this paper.
The Gazette of Medical Sciences, Volume 2, pp 30-37; https://doi.org/10.46766/thegms.pubheal.21020302
The pandemic scenario created by the Severe Acute Respiratory Syndrome – Coronavirus-2 (SARS-CoV-2) brought physical and psychological distress among people who found themselves under a situation which unabled most of them to proceed with their usual routine or rites of passing to cope with losses of lifestyle, relatives, and friends.
The Gazette of Medical Sciences, Volume 2, pp 38-41; https://doi.org/10.46766/thegms.anp.21022105
Diagnosis of inflammatory myopathy are usually based on clinical examination and histopathology of the muscles and muscle biopsy, usually guided by PET-CT. This is not uncommonly presented by extramacular signs like interstitial lung disease, dysphagia, few skin signs, loss of weight, arteritis, cardiomyopathy, Pulmonary hypertension, respiratory failure, and cancer.
The Gazette of Medical Sciences, Volume 2, pp 26-29; https://doi.org/10.46766/thegms.ophthal.21020101
Extramedullary plasmacytoma is a rare disease, characterized histopathologically by infiltration of plasma cells of different maturities and producing monoclonal immunoglobulin outside the bone marrow. J.R.G., 52 years old, male, sought medical assistance due to amaurosis and blocked eye movements. We performed Magnetic Nuclear Resonance of the skull that showed discrete intermediate signal tissue, next to the optic nerve canal and homolateral superior orbital fissure, with slight extension to the lower orbital fissure, associated with thickening of the corresponding meninges, involving the proximal portion of the optic nerve, measuring 1.3 x 1.1 x 2.5 cm. Non-specific aspect, but suggestive of lymphoproliferative lesion. Right and extraorbital tumor excision was performed, in which it was not possible to completely resect the tumor. The anatomopathological examination of the piece showed a neoplasm of plasma cells (plasmacytoma). The diagnosis is made from the exclusion of Multiple Myeloma. The treatments of choice are radiotherapy, due to the high radiosensitivity in 80–100% of cases, and surgery for localized lesions.
The Gazette of Medical Sciences, Volume 2, pp 21-25; https://doi.org/10.46766/thegms.oncol.21012102
Primary adenocarcinoma of the duodenum is a rare clinical condition, accounting for only 5% of all gastrointestinal neoplasms and 0.5% of all intestinal neoplasms. Nonspecific clinical presentation contributes to the majority of cases being diagnosed in advanced stages. The prognosis is poor, with a median survival of five years, varying from 23% to 57% in patients undergoing curative surgery (cephalic duodenopancreatectomy).
The Gazette of Medical Sciences, Volume 2, pp 15-20; https://doi.org/10.46766/thegms.ophthal.21011001
We report the laboratory results of conjunctival RT-PCR tests and some clinical features of these patients infected with COVID 19 in Shenyang, China
The Gazette of Medical Sciences pp 8-14; https://doi.org/10.46766/thegms.ophthal.20123008
This retrospective study analysed patients diagnosed as penetrating ocular traumatic endophthalmitis between January 2016 to January 2019 at a hospital, Liaoning province, China. Epidemiological data including age, gender, traumatic agents, time from trauma to endophthalmitis onset, culture results, treatment, visual acuity and prognosis. Risk factor analysis was used to compare presented data
The Gazette of Medical Sciences, Volume 2, pp 1-7; https://doi.org/10.46766/thegms.ophthal.20123007
This report describes a complication of symptoms consistent with transiency visual acuity damage and hearing injury following sclerotherapy with a polidocanol injection to a facial vascular malformation. After the direct injection of 5cc polidocanol-room air emulsion into the subcutaneous malformation, a 3-year-old boy developed bilateral eyelid swelling the next day, and on 7 days later at referral, visual acuity in the left eye was light perception. Fundoscopy revealed retinal hemorrhage; fluorescein angiography (FA) disclosed hyperreflective leakage on the optic disk 15 days later, and OCT showed nerve fiber edema between the disk and macular. The orbital magnetic resonance imaging (MRI) demonstrated the normal extraocular muscles. In a month later, bilateral eyelid swelling resolved but the visual acuity remained 20/500, and 20/20 in two months later, but the hearing injury remained. It needs much more special attention in sclerotherapy for facial malformation because the sclerosants may cause severe toxicity or inflammation in retina and optic nerve, resulting in transiency visual acuity damage and acoustic nerve injury. The related examination including ophthalmic investigation after the sclerotherapy is necessary.
The Gazette of Medical Sciences, Volume 1, pp 53-68; https://doi.org/10.46766/thegms.oncol.20122003
The ongoing COVID-19 pandemic has now thrown us into turmoil by adversely affecting the entire socio-economic structure of the world. Currently (Dec20, 2020), there are 76.4 million incidences worldwide and 17.6 million in the USA, and counting. Primarily in this scenario, all the resources available at hospitals and medical care units are reasonably redirected to address the contagious COVID-19 infected patients. This is an issue for a cancer patient, who may be at risk or infected with Coronavirus needs to be managed amid multiple unknown complications. Many issues are still unanswered and an attempt to streamline various strategies is being offered by Oncologists around the world to treat cancer patients. The gravest concerns are related to deciding suitable supervision for a positive COVID-19 cancer patient undergoing a cycle of chemo/radiotherapy; handling advanced stage of cancer in regions profoundly affected by virus; evaluating the risk-benefit parameters for treatment or surgeries; planning routine screening and precaution for weak patients, medical staff and others in the community. Here we have presented the different guidelines, schemes, and strategies accessible from several Oncology departments and organizations in multiple countries.
The Gazette of Medical Sciences, Volume 1, pp 49-52; https://doi.org/10.46766/thegms.neuro.20122406
Pseudomeningoceles are rare complications of laminectomy surgery. Such clinical condition results from an inadvertent surgical dural rupture. We describe in the present study the report of a patient who developed iatrogenic pseudomeningocele in the lumbar region after performing a left laminectomy in L5 topography. After the neurological assessment of the patient, bilateral hypoaesthesia was observed, in addition to a floating bulging in the lumbar region that was accentuated during the valsalva maneuver, with the hypothesis of a pseudomeningocele.
The Gazette of Medical Sciences, Volume 1, pp 46-48; https://doi.org/10.46766/thegms.neuro.20122004
Alzheimer’s disease (AD) is the most common degenerative brain disease in the aged population . By 2050, AD prevalence is expected to increase from 4.7 million (based on 2010 census) to 13.8 million people . It is characterized by the progressive decline of cognition and memory, as well as changes in behavior and personality . Pathological hallmarks of AD include mainly formation of senile plaques consisting of amyloid-beta (Aβ) peptide in the intercellular space and neurofibrillary tangles (NFTs) in the cell bodies, which are primarily composed of abnormally modified tau protein .
The Gazette of Medical Sciences, Volume 1, pp 36-45; https://doi.org/10.46766/thegms.microb.20122105
The present study included 210 inpatients, out of them 180 were diagnosed as suspected cases of sepsis in the period over 12 months from December 2018 to December 2019, at a private hospital in Cairo, Egypt. Out of 210 investigated cases 180 (85.7%) were infected. Single bacterial isolates were recovered from 120 cases (66.7%), while 60 (33.3%) cases were found to be carrying more than one bacterial isolate. The results of the current study revealed that 34.4% (62/180) of isolates were Gram-positive and 65.6% (118/180) were Gram-negative.
The Gazette of Medical Sciences, Volume 1, pp 30-35; https://doi.org/10.46766/thegms.immuno.20121002
The aim of this work is centered on the people living in the two most populated cities in the Canary Islands. Spain, which was motivated by the observed peak of COVID-19 severe patients; and fatalities in Santa Cruz de Tenerife more than in Las Palmas de Gran Canaria over the first COVID wave. It is suggested here that this fact was due to a huge African dust storm in February 2020 during the popular Carnival festivity that was not cancelled following the Government indications for people to stay at home, contrary to other islands that obeyed the objection. Also, in the second wave, the number of cases is much higher in Santa Cruz de Tenerife as well, following the same behavior rules of coexistence for citizens in all the seven major islands. We also analyzed the incidence and mortality due to AD
The Gazette of Medical Sciences, Volume 1, pp 22-29; https://doi.org/10.46766/thegms.neuro.20120401
The Gazette of Medical Sciences, Volume 1; https://doi.org/10.46766/thegms.ortho.20110801
This prospective cohort study analyzed the role and use of tranexamic acid (ATX) in control of bleeding in patients undergoing primary total hip arthroplasty. The observation was based on administration of a single dose of venous tranexamic acid 20 mg per kg of weight of patients after anesthetic induction.
The Gazette of Medical Sciences, Volume 1, pp 13-21; https://doi.org/10.46766/thegms.ortho.2011081
The Gazette of Medical Sciences, Volume 1, pp 1-12; https://doi.org/10.46766/thegms.ortho.20110802
The Gazette of Medical Sciences, Volume 1, pp 73-77; https://doi.org/10.46766/thegms.neuro.20102304
Tuberous Sclerosis Complex or Bourneville’s disease is an autosomal dominant disease with high penetrance and variability characterized by multisystem involvement by benign lesions, originally defined by the classic triad of Vogt: sebaceous adenoma, epilepsy and mental retardation. The involvement of the brain is responsible for a significant proportion of the morbidity and mortality of this disease and skin lesions are the most common manifestations. The authors report 31-year-old patient case referred to the service by intractable epilepsy with definitive clinical criteria for tuberous sclerosis.
The Gazette of Medical Sciences, Volume 1, pp 68-72; https://doi.org/10.46766/thegms.derma.20101302
The Gazette of Medical Sciences, Volume 1, pp 62-67; https://doi.org/10.46766/thegms.pedia.20101503
The Gazette of Medical Sciences, Volume 1, pp 52-61; https://doi.org/10.46766/thegms.hepa.20092802
The Gazette of Medical Sciences, Volume 1, pp 47-51; https://doi.org/10.46766/thegms.medgen.20100501
The Gazette of Medical Sciences, Volume 1, pp 13-46; https://doi.org/10.46766/thegms.bioinfo.20091203
The Gazette of Medical Sciences, Volume 1; https://doi.org/10.46766/thegms.microb.20090201
The Gazette of Medical Sciences, Volume 1, pp 001-003; https://doi.org/10.46766/thegms.pedia.20082607
The Gazette of Medical Sciences, Volume 1, pp 36-43; https://doi.org/10.46766/thegms.nephro.20081006
The Gazette of Medical Sciences, Volume 1, pp 22-35; https://doi.org/10.46766/thegms.microvita.20080202
The Gazette of Medical Sciences, Volume 1, pp 14-21; https://doi.org/10.46766/thegms.ortho.20080905
The Gazette of Medical Sciences, Volume 1, pp 009-013; https://doi.org/10.46766/thegms.ortho.20080704
The Gazette of Medical Sciences, Volume 1, pp 001-008; https://doi.org/10.46766/thegms.ortho.20080703
The Gazette of Medical Sciences, Volume 1, pp 30-34; https://doi.org/10.46766/thegms.pharmaco.20072104
The Gazette of Medical Sciences, Volume 1, pp 18-29; https://doi.org/10.46766/thegms.virology.20072206