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Results in Journal International Journal of Advanced Research in Medicine: 77

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Bhaskara, Sharana Basava H
International Journal of Advanced Research in Medicine, Volume 2, pp 225-227; doi:10.22271/27069567.2020.v2.i2d.71

Abstract:
CRP has a relatively long half-life of 18 to 20 h, owing to its stable pentraxin structure. In addition, CRP levels are stable as these do not exhibit diurnal variations or variations in relation to food intake. In the past decade, high-sensitivity assays with rapid turnaround times for measurement have become available. High-sensitivity assay techniques such as immunonephelometry, immunoturbidimetry, high-sensitivity enzyme-linked immunosorbent assay (ELISA) and resonant acoustic profiling (RAP) can detect CRP with a sensitivity range of 0.01 to 10 mg/ l. The previously formulated proforma used to collect the clinical and demographic details of the samples. Detailed history related to the present as well as a thorough history pertaining to other diseases were taken. Each patient was enquired about previous drug history, coronary artery disease, hypertension, diabetes and any other comorbid conditions.
Bhaskara, Sharana Basava H
International Journal of Advanced Research in Medicine, Volume 2, pp 222-224; doi:10.22271/27069567.2020.v2.i2d.70

Abstract:
In type 2 diabetic patients CAD constitutes major determining factor of morbidity and mortality. It is two times more common in diabetic patients than general population. Surprisingly two third of patients who develop acute myocardial infarction or any other cardiovascular complications after 40 years of age have either diabetes mellitus or impaired glucose tolerance. The previously formulated proforma used to collect the clinical and demographic details of the samples. Detailed history related to the present as well as a thorough history pertaining to other diseases were taken. Each patient was enquired about previous drug history, coronary artery disease, hypertension, diabetes and any other comorbid conditions. Smoking and Hypertension were associated with diabetes.
Shameem N, Krishna Kumar Mk, Bhaskar Mk
International Journal of Advanced Research in Medicine, Volume 2, pp 232-235; doi:10.22271/27069567.2020.v2.i2d.73

Abstract:
Introduction: Patients who seek medical care because of the symptoms of naso bronchial allergies are increasing. The distribution of allergens and its effect on the population differs in different parts of India. For the management and effective treatment of allergen induced respiratory illnesses, it is very important to find out the specific allergens responsible. To determine the common allergens causing naso-bronchial allergy in atopic patients. Materials and Methods: Atopic patients who attended a tertiary care centre as outpatients for an year with symptoms of naso-bronchial allergy for more than a year who were not responding to regular medications were selected for the study after taking a detailed history. An intradermal allergy test was done in the volar aspect of the patients arm and forearm with antigens of the common allergens prevalent in south India. Results: Out of 51patients tested by 39 allergens, 47 persons turned positive for at least one antigen. Among pollen antigens, Acacia species showed highest number of positive reactions. Among dust, house dust and wheat dust showed higher positivity. Among antigens of animal origin, house fly was highest and among fungal origin, Aspergillus fumigatius showed high positivity. Conclusion: The commonest antigen identified was that of house dust followed by house fly.
Saurabh Setiya, Ps Ghalaut, Harminder, Mohd. Younus Shah, Anurag Bajpai, Spa Aboobecker
International Journal of Advanced Research in Medicine, Volume 2, pp 228-231; doi:10.22271/27069567.2020.v2.i2d.72

Abstract:
Introduction: Hypertension represents a major health problem primarily because of its role in contributing to the initiation and progression of major cardiovascular diseases. This cross-sectional observational study aims at analysing the utilization pattern of antihypertensives used for the treatment of hypertension at a tertiary care hospital in perspective of standard treatment guidelines. Materials and Methods: This is a prospective, cross sectional and observational study carried out in the outpatient of Department of General Medicine of NC Medical College and Hospital. All patients with proven hypertension and put on antihypertensive medications were recruited from the Department of Medicine. The total duration of the study was 1 year i.e. December 2019 to November 2020. Results: In our study, the mean systolic blood pressure (mean±S.D) of the patients was 154.34±9.43 and the median was 153. Test of proportion showed most of the patients 53 (44.1%) were significantly higher systolic blood pressure ranging from 160-179 mmHg. The mean diastolic blood pressure (mean±S.D) of the patients was 98.32±8.43. Test of proportion showed most of the patients 51 (42.5%) were significantly higher diastolic blood pressure ranging from 100-119 mmHg. Test of proportion showed most of the patients 62 (51.6%) were on Mono therapy significantly higher than dual therapy, triple therapy and poly therapy, 34 (26.6%), 13 (10.8%), 11 (9.1%) respectively. Causality assessment of ADRs was done using WHOUMC scale which categorizes ADRs as “certain”, “probable”, “possible” and “unlikely”. Table 8 shows that type of reactions and their percentage are as certain (9.6%), Probable/ Likely (67.7%), Possible (19.3%), and Unlikely (3.2%). Conclusions: In this study usage of anti-hypertensive drugs were prescribed rationally in tertiary care hospital. The study emphasizes that need for effective continuing medical education and also preventive measures in hypertensive individuals.
Abhishek Bhadani, Kaushal Kumar Sinha
International Journal of Advanced Research in Medicine, Volume 2, pp 05-08; doi:10.22271/27069567.2020.v2.i2a.40

Abstract:
To assess clinical profile of oral glucose tolerance in pulmonary tuberculosis patient
Shaymaa Sn Mehdi, Alaa F Ibrahem, Maha R Darweesh
International Journal of Advanced Research in Medicine, Volume 2, pp 91-97; doi:10.22271/27069567.2020.v2.i2b.52

Pooja Kumari, Bishan Dhiman, Rohini Rao
International Journal of Advanced Research in Medicine, Volume 2, pp 39-41; doi:10.22271/27069567.2020.v2.i2a.48

Abstract:
Aim: Comparison of bone mineral density (BMD) in perimenopausal women with surgical menopausal women. Methods: The present analytical cross sectional study was conducted on patients (out patients and in patients) in Department of Obstetrics and Gynecology, Kamla Nehru Hospital, attached to IGMC Shimla. Group 1 (N=60): Perimenopausal women aged 40-45years as control. Group 2 (N=60): Women who had undergone hysterectomy with bilateral salphingoophorectomy at least 6 month ago. BMD measurements were measured by whole body dual energy X-ray absorptiometery (DEXA), with the help of Hologic Discovery QDR machine available in department of radiology. Results: In the present study the mean age of post-surgical menopausal group was 46.0 years and in the perimenopausal group the mean age was 42.4 years. Mean parity in post-surgical menopausal group was 3.03 and 2.5 in the perimenopausal group. Conclusions: The prevalence of osteoporosis is very high in this part of India. Both perimenopausal and post-surgical menopausal women have lower levels of BMD. Bone mineral density (BMD) can be taken as a useful marker to assess and treat osteoporosis and also to prevent complications in post-menopausal women.
Sweetha Nayak Nagar, Sohan Rodney Bangera
International Journal of Advanced Research in Medicine, Volume 2, pp 42-49; doi:10.22271/27069567.2020.v2.i2a.49

Abstract:
Background: Dermatophytes are a group of closely related fungi that have the capacity to invade keratinized tissue (skin, hair, and nails) of humans and other animals to produce an infection. Infection by this fungi are restricted to the non-living cornified layers as they lack the ability to penetrate the deeper tissues of immuno competent hosts. The great variation in clinical presentation is related to the involved species of fungus, size of the inoculum, involved site and immune status of the host. There are three genera of dermatophyte fungi: Trichophyton, Microsporum and Epidermophyton based on microscopic features. Each genus is characterized by a specific pattern of growth in culture and by the production of macroconidia or microconidia. The Trichophyton species usually infect the skin, hair and nails. Microsporum species infect the skin and hair but not the nails. Epidermophyton species infect the skin as well as nails but not hair. This study was carried out to determine the etiological agents in different forms of dermatophytosis and to compare the various laboratory techniques in the diagnosis of dermatophytosis. Materials and method: The study was conducted at the department of Microbiology, Srinivas Institute of Medical Sciences and Research Centre, Mangalore, India. 270 specimens obtained from clinically suspected cases of dermatophytoses between December 2017 to December 2019 were included in the study. The samples included skin scraping, nail clipping and plucked hair. The specimen was then subjected to Microscopic examinations like KOH, PAS, and Calcofluor white stain and Culture on SDA, SDA with Chloramphenicol and DTM. Results: Male patients infected were found to be 48.88% and female patients were 51.11%. The most common affected age group was 21-30 years (25.1%). More than 92.59% of samples were from Tinea unguium. Fungi was demonstrated in 31.85% of cases, by KOH wet mount, 41.48% by calcofluor white stain and 49.62% by PAS. Out of 135 specimens, 48 specimen yielded growth giving 35.55% culture positivity on SDA with chloramphenicol. Conclusion: A success rate of 41.48% was achieved for detecting fungal elements by microscopy as compared to culture. PAS Stain shows high reliability and sensitivity for detecting onychomycosis compared to KOH and mycological culture. PAS and the culture combination is superior to combined KOH and culture for detection of dermatophyte infection. Ninety six isolates were obtained from 270 patients which shows the prevalence of the isolate in and around Mangalore
Bodepudi Sarath, Chodagiri Vamsi Krishna, Kamuju Narsimhareddy
International Journal of Advanced Research in Medicine, Volume 2, pp 114-119; doi:10.22271/27069567.2020.v2.i2b.57

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