Refine Search

New Search

Results in Journal Journal of Surgical Oncology: 66

(searched for: journal_id:(4241199))
Page of 2
Articles per Page
by
Show export options
  Select all
Lei Xue, Chuan Bin Wu
Published: 3 May 2022
Journal of Surgical Oncology, Volume 2022, pp 1-4; https://doi.org/10.31487/j.jso.2022.02.01

Abstract:
Objectives: The aim of this study was to describe our experience in treating chronic obstructive parotitis related to diabetes. Methods: Twelve patients with chronic obstructive parotitis (COP) related to diabetes were selected for the study. A sialendoscope was introduced from the orifice to investigate the ductal wall and lumen. During the operation, chymotrypsin and gentamicin were injected. All patients were followed up for 6 months. Preoperative and postoperative visual analog scale (VAS) evaluations and salivary gland scintigraphy (SGS) examinations were applied to evaluate the therapeutic effect; differences were considered statistically significant at P < 0.05. Results: A sialendoscope was successfully used under local anaesthesia in all members of the cohort. As shown by the endoscope, mucus plugs were the most common feature. Some adhered tightly to the ductal wall. We also found ductal congestion in some cases. The postoperative VAS scores and SGS counts were both significantly lower than the preoperative values (P < 0.05). Conclusion: Chymotrypsin administration during interventional sialendoscopy is significantly effective in the treatment of diabetes-related COP.
Xue-Dong Li, Peng Xie, Juan Zhang, Shi-Xin Du
Published: 18 April 2022
Journal of Surgical Oncology, Volume 2022, pp 1-3; https://doi.org/10.31487/j.jso.2022.01.02

Abstract:
Although spinal tuberculosis and spinal tumors are difficult to distinguish in clinical manifestations, their respective imaging presentations are typical and specific, which makes it relatively easier to attain a correct diagnosis. Spinal tuberculosis is usually endemic in developing countries with conditions of poverty and malnutrition. Tuberculosis is also common in China, and we are experienced in diagnosing tuberculosis spondylitis. However, the diversification and the trend of tumor incidence in modern society are also increasing, which challenges our diagnosis of a spinal tumor. This article presents a case of spinal metastasis tumors whose imaging presentation is so similar to tuberculosis that we made a diagnostic error on it. Both computed tomography and magnetic resonance imaging of the thoracic spine highly supported the initial diagnosis of spinal tuberculosis. However, pathological examination of the excised specimen resulted in the diagnosis of spinal hemangioendothelioma.
Qing Zhou, Chuan Bin Wu, Tie Ma, Lin Ma
Published: 25 April 2022
Journal of Surgical Oncology, Volume 2022, pp 1-6; https://doi.org/10.31487/j.jso.2022.01.03

Abstract:
Objective: To investigate the effect of splint combined with PRP injection in the treatment of temporomandibular joint osteoarthritis. Methods: Ninety-three patients with temporomandibular joint osteoarthritis were retrospectively analysed. They were divided into three groups according to different treatment methods: splint group, PRP group, and splint + PRP group. All patients were asked to have VAS scores before and 6 months after treatment and the maximum comfortable mouth opening was recorded either. All data were analysed by R×C test, and P<0.05 indicated statistically significant differences. Results: The maximum comfortable opening was significantly improved, and the VAS scores were decreased (P < 0.05). Conclusion: The treatment of splint+PRP is superior to the treatment of single splint or single PRP.
Lobna Ouldamer, Emilie Serre, Christophe Destrieux, Gilles Body
Published: 14 March 2022
Journal of Surgical Oncology, Volume 2022, pp 1-7; https://doi.org/10.31487/j.jso.2022.01.01

Abstract:
Objective: To investigate the lymphatic drainage of Bartholin’s gland and its therapeutic implications in Bartholin’s gland carcinoma. Materials and Methods: Data were obtained from the anatomical study of ten fresh female cadavers with groin and pelvic dissections after lymphatic channel and node staining by injection of Lipiodol dye solution into Bartholin’s gland. Results: We distinguished three different lymphatic pathways: i) the superficial inguinal pathway, identified in 61.5% of cases, ii) the internal pudendal pathway (towards the pararectal fossa), identified in 30.8% of cases, and iii) the pelvic pathway, identified in 15.4% of cases, one after an inguinal pathway and the other following the labiocrural fold. No evidence of stained lymphatic structures was found in 31.6% of cases. The principal pathway was always ipsilateral. Conclusion: Ipsilateral groin lymphadenectomy offers the most effective ratio between oncological safety and surgery-related complications.
Peter Kern, Ramachandramoorthy V, Bittner Ak, Rezai M, Kimmig R, Hoffmann O
Published: 31 December 2021
Journal of Surgical Oncology, Volume 2021, pp 1-8; https://doi.org/10.31487/j.jso.2021.03.04

Abstract:
Introduction: Breast tumors such as cystosarcoma phylloides and fibroadenoma may show rapid growth and occur early in thelarche. In adolescents, tumor growth often remains unnoticed due to a lack of breast awareness or a sense of shame in these young girls. The necessity for surgical intervention may interfere with the normal development of the breast, however in certain cases has to be performed due to the threat of deformation of the growing breast or the malignant potential of some tumors like cystosarcoma phylloides. However, visible scars have to be avoided at any price in these young girls, as they are still in their pre-marital and psychologically vulnerable phase. The presumed size of the breast after completion of all Tanner stages of breast development has to be taken into consideration while planning the immediate or deferred reconstruction. Methods: We report on three young girls, 13, 14 and 16 years of age, who presented with a giant cystosarcoma phylloides of 9,6 cm (190 grams), a giant fibroadenoma of 14 cm (287 grams) and a giant PASH-tumor of 16,3 cm (957 grams). All patients were in their thelarche. The extension of the tumor was almost to the whole circumference of the breast with close borders to the skin envelope, resulting in a marked anisomastia due to the giant tumor size. We are proposing here scar-sparing procedures adapted to the form of the breast and the BMI of the patients. For access to the tumor, in two cases, we chose the anterior axillary line to avoid visible scars on the surface of the breast - one with autologous and one with heterologous, implant-based reconstruction. In the third case, the patient had a marked anisomastia with a massively ptotic breast with a huge broadening of the nipple-areolar-complex due to the growth of the tumor. Here we selected a tumor-size adapted, inferior-pedicled reduction mammaplasty according to Ribeiro in the modification of Rezai with a skin reduction and shortening of the diameter of the areola. Patient reported-outcome has been measured by validated Breast-Q-questionnaires. Results: We present three different types of access for the removal of giant tumors and three options for the reconstruction of patients in their thelarche. Two tumors were removed through axillary access to the breast to avoid scars in the developing breast. We achieved free margins at first surgical intervention in all three cases. One reconstruction was performed by autologous tissue through lateral thoracic wall advancement mammaplasty. Another patient had an implant-based reconstruction. The third patient – who presented with a macromastia with marked enlargement of the nipple-areola-complex was treated with a tumor-adapted reduction mammaplasty. All three young patients have reported a high degree of satisfaction in validated Breast QoL questionnaires with the outcome of the procedures.
Rene Aloisio Da Costa Vieira, Wesley Pereira Andrade, Sabas Carlos Vieira, Mauricio Romano, Gustavo Iglesias
Published: 22 December 2021
Journal of Surgical Oncology, Volume 2021, pp 1-10; https://doi.org/10.31487/j.jso.2021.03.03

Abstract:
The Brazilian Society of Oncological Surgery organized a group of oncological surgeons to discuss surgical aspects associated with locally advanced breast carcinoma. This article reviews the indications, the different surgeries (especially those associated with thoracoabdominal or myocutaneous flaps), and associated complications. It discusses special conditions such as invasion of the chest wall and interscapular thoracic disarticulation. It makes recommendations based on the literature regarding clinical findings, tumor conditions, response to neoadjuvant therapy, choice of flaps in surgery, and tumor biology.
Changku Jia, Zhuangming Yu, He Li, Fei Sun, Hongjian Chen, Fengbo Zhang, Linjiang Li, Ping Long, Yunjian Wei, Jun Wang, et al.
Published: 18 November 2021
Journal of Surgical Oncology, Volume 2021, pp 1-8; https://doi.org/10.31487/j.jso.2021.03.01

Abstract:
Background: Venous thromboembolic events (VTE) are common causes of morbidity and mortality in glioblastoma patients. Mutation in the isocitrate dehydrogenase 1 enzyme (IDH1) is frequent in secondary glioblastoma and results in altered metabolomics. Objectives: This study evaluates whether IDH-1 status correlates with incidence of VTE in glioblastoma patients. Methods: Observational study of 398 cases of patients with glioblastoma, who all underwent surgery in a regional Neurosurgical centre between April 2012 and December 2014. IDH -1 status and Tissue factor (F3) protein expression were assessed by immunohistochemistry. Deep venous thrombosis (DVT) and pulmonary embolism (PE) were diagnosed by Doppler ultrasound and pulmonary CT angiogram respectively. Results: 336 cases were wild type (WT) IDH-1 (94.1%) and 21 cases were IDH-1 mutated (R132H) (5.9%). 51 patients had a thromboembolic event (15.3%), with all cases of VTE in WT IDH-1 tumors, a rate of 21.8% within this group. IDH-1 status had a significant correlation with VTE (p=0.033 Fisher exact test). As expected, mutant IDH was associated with prolonged patient survival (p=0.024 Log rank). The mean expression in IDH-1 wild type GBM was 7.14 and in R132h mutant GBM was 4.87 (log2 scale). This was highly statistically significant with a corrected P value of less than 0.0001. Conclusion: A significant association exists between IDH1 status in glioblastoma patients and the risk of VTE. Patients with wild type IDH-1 appear at high risk of VTE and appropriate precautions should be considered.
Georgios Stefanakis, Vasileia Nyktari, Georgios Papastratigakis, Panagiotis Vardakis, Periklis Vasilos, Emmanouela Koutoulaki
Published: 20 October 2021
Journal of Surgical Oncology, Volume 2021, pp 1-3; https://doi.org/10.31487/j.jso.2021.02.05

Abstract:
We report a case of pulmonary embolism during resection of a mediastinal mass requiring intraoperative thrombolysis. The diagnosis, although difficult to establish due to simultaneous bleeding and technical difficulties with transthoracic echocardiography, was based on the patient’s history and clinical evidence of low cardiac output and was confirmed by clinical improvement post thrombolysis. When awakened in the intensive care unit, the patient was found to be blind and also required a tracheostomy. We present this case, as it requires complex clinical reasoning throughout different stages of its management and it demonstrates that, when facing an imminent disaster, a risky decision not necessarily conforming to current practice but based on individualisation of treatment can be life-saving.
Shi Bing Su, Xiaole Chen, Peng Wang, Yunquan Luo, Yi Yu Lu, Wenjun Zhou, Mengdie Yang, Jian Chen, Zhi Qiang Meng
Published: 22 September 2021
Journal of Surgical Oncology, Volume 2021, pp 1-11; https://doi.org/10.31487/j.jso.2021.02.04

Abstract:
Objective: The aim of this study was to assess the therapeutic effects of Jianpi Liqi decoction (JPLQD) in hepatocellular carcinoma (HCC) and explore its underlying mechanisms. Methods: The characteristics and outcomes of HCC patients with intermediate stage B who underwent sequential conventional transcatheter arterial chemoembolization (cTACE) and radiofrequency ablation (RFA) only or in conjunction with JPLQD were analysed retrospectively. The plasma proteins were screened using label-free quantitative proteomics analysis. The effective mechanisms of JPLQD were predicted through network pharmacology approach and partially verified by ELISA. Results: Clinical research demonstrated that the Karnofsky Performance Status (KPS), traditional Chinese medicine (TCM) syndrome scores, neutropenia and bilirubin, median progression-free survival (PFS), and median overall survival (OS) in HCC patients treated with JPLQD were superior to those in patients not treated with JPLQD (all P<0.05). The analysis of network pharmacology, combined with proteomics, suggested that 52 compounds targeted 80 potential targets, which were involved in the regulation of multiple signaling pathways, especially affecting the apoptosis-related pathways including TNF, p53, PI3K-AKT, and MAPK. Plasma IGFBP3 and CA2 were significantly up-regulated in HCC patients with sequential cTACE and RFA therapy treated with JPLQD than those in patients not treated with JPLQD (P<0.001). The AUC of the IGFBP3 and CA2 panel, estimated using ROC analysis for JPLQD efficacy evaluation, was 0.867. Conclusion: These data suggested that JPLQD improves the quality of life, prolongs the overall survival, protects liver function in HCC patients, and exhibits an anticancer activity against HCC. IGFBP3 and CA2 panels may be potential therapeutic targets and indicators in the efficacy evaluation for JPLQD treatment, and the effective mechanihsms involved in the regulation of multiple signaling pathways, possibly affected the regulation of apoptosis.
Je García Villayzán, Mt Marichal de la Fuente, J Utrilla Layna Trigo, J Garcia Foncillas Lopez, L. Chiva de Agustin, M. Albi Gonzalez
Published: 10 September 2021
Journal of Surgical Oncology, Volume 2021, pp 1-10; https://doi.org/10.31487/j.jso.2021.02.02

Abstract:
Background: Sentinel Lymph Node Biopsy is a technique developed to predict lymphatic involvement in patients with early endometrial cancer, decreasing the morbimortality associated with routine systematic lymphadenectomy and improving quality of life. Main Objective: To determine the detection rate and negative predictive value of the Sentinel Lymph Node Biopsy by Immunofluorescence in patients with early endometrial cancer. Methods: A descriptive observational study in patients with early endometrial cancer (FIGO stage I-II) for all histological types and grades, who underwent the Sentinel Lymph Node by immunofluorescence Technique, between June 2019 and March 2020 at the Fundación Jiménez Díaz University Hospital. We used indocyanine green powder for injection, with a concentration of 25 milligrams (mg). We proceeded to dissolve it in 10 cubic centimeters (cc) of distilled water to. After which, we injected 2 cc of the prepared solution into the cervix at the 3 and 9 o’clock positions at a depth of 1 centimeter. Results: Eighteen patients were included, analysing a total of 26 sentinel nodes: 24 pelvic and 2 paraortic; and a total of 273 lymph nodes (sentinel and non-sentinel nodes): 83 right pelvic, 86 left pelvic and 104 paraortic. All nodes were negative for metastasis. Global and bilateral detection rates were 77.78% and 50% respectively. The Negative Predictive Value and sensitivity were 100%. No significant difference in morbimortality was found between performing only Sentinel Lymph Node technique or systematic lymphadenectomy, but the association with quality of life was significant, with better results for those who only underwent the sentinel lymph node technique versus systematic lymphadenectomy (0% vs 77%). Conclusion: The global and bilateral detection rates of the Sentinel Lymph Node Technique by immunofluorescence were 77.78% and 50% respectively, obtaining a Negative Predictive Value and Sensitivity of 100%. Sentinel Node Biopsy is a valid technique to predict lymphatic affectation in early endometrial cancer, with lower morbimortality than systematic lymphadenectomy.
Khaled Saleh Ben Salah, Sara Glessa, Fatma Emaetig, Hisham Abudabbous, Abdulla Jebril, Nabil Elnattah, Kari Syrjanen, Mamduh Jaber, Abdulsalam Elrabie, Mohamed Elfagieh, et al.
Published: 1 September 2021
Journal of Surgical Oncology, Volume 2021, pp 1-10; https://doi.org/10.31487/j.jso.2021.02.01

Abstract:
Aim: To assess the prognostic significance of Survivin and Livin expression in invasive breast cancer and their lymph node metastases. Materials and Methods: The present series consists of archival samples from 78 women with invasive breast cancer diagnosed and treated during 2010-2014 at National Cancer Institute, Misurata, Libya. Tumor biopsies were analysed for expression of Survivin and Livin by immunohistochemistry, and different grading systems were tested for their expression. Results: In the cancer samples, a significant correlation was established between Survivin expression and site of the tumor (p=0.021), tumor recurrence (p=0.036), and unifocal tumor (p=0.001). Moreover, Her-2 negative tumors had higher Survivin expression than Her-2 positive tumors (p= 0.047). There were no associations between Survivin expression and histological grade, histological type, lymph node status, tumor stage, TNM classification, estrogen and progesterone receptors, distant metastases, chemotherapy, radiotherapy, hormone replacement, vascular invasion, surgical margin, positive family history. Livin expression in primary breast cancer showed a significant correlation (p=0.025) with positive family history, but no significant association with other clinicopathological parameters. In addition, we found that primary tumors showed higher Survivin expression (82%) compared with the lymph node metastases (34%), whereas Livin expression did not differ between the primary (71%) tumors and their metastases (84%). Conclusion: Survivin expression in primary breast cancer is significantly associated with several characteristics of favourable prognosis. Livin expression in primary breast cancer is significantly associated only with a positive family history of breast cancer.
Sergey K. Efetov, Petr V. Tsarkov, Sofia A. Gorodetskaya, Valery M. Nekoval, Inna A. Tulina, Yuliia S. Medkova, Yury E. Kitsenko, Vladimir V. Balaban
Published: 26 April 2021
Journal of Surgical Oncology, Volume 2021, pp 1-7; https://doi.org/10.31487/j.jso.2021.01.05

Abstract:
Background: The aim of the study is to compare the short-term and long-term results in the treatment of colon cancer in older patients with different extents of Lymph Node Dissection (LND). Materials and Methods: A retrospective multicenter study in general surgical geriatric department and specialized coloproctological hospitals of Sechenov University was performed between 2006 and 2015. Patients aged 75 years or older who underwent stage I-III colon cancer surgical treatment were included in the study. Groups were divided according to the extent of surgery: colon resection with D3 LND formed the study group and with D2 LND - the control group. Results: The mean age of patients in the study was 81±4 years. Charlson’s comorbidity index before surgery was higher in the D3 LND group (p <0.001). Surgical and anaesthetic risk had no significant differences between the groups (p=0.580). Operation time with D3 LND was 25 min longer than with D2 LND, with no differences in blood loss between the groups. Despite the increased surgery duration, prolonged ventilation time was similar (p=0.093). D3 LND results in increasing in postoperative morbidity (p=0.013) with no significant differences in 30-day, 90-day and 1-year mortality between the groups. D3 LND demonstrated significant improvement in five-year overall and disease-free survival. According to the multivariate analysis, male gender, stage III tumors and D2 LND increase the risk of death within five years after surgery. Conclusion: D3 LND in colon cancer surgical treatment in older patients does not affect the 30-day, 90-day, and one-year mortality and improves five-year overall and disease-free survival.
Yuliia S. Medkova, Dodusov Veniamin Viktorovich, Yury E. Kitsenko, Sergey K. Efetov, Inna A. Tulina, Petr V. Tsarkov
Published: 29 April 2021
Journal of Surgical Oncology, Volume 2021, pp 1-3; https://doi.org/10.31487/j.jso.2021.01.07

Abstract:
Introduction: A rare benign lymphoid proliferative disorder called Castleman’s disease is the most commonly presented as a solitary mass in the mediastinum, although sometimes with sites at the neck, axilla, mesentery, pancreas, pelvis and retroperitoneum. We report a case of Castleman’s disease in the mesorectum. According to the literature, such localization was visualized just in few cases all over the world. Case History: The patient was a 48-year-old man, who complained of lumbar pain. MRI was performed in 2014 on which the formation in the presacral mass of mesorectal fat (size up to 4,9*5,2*4,0 cm) on the level of S2 vertebrae was found, which is considered as a lymph node with the tendency to increase during 3, 5 years (+1cm). Upon admission to the clinic, differential diagnosis with lymphoma and malignant tumor were carried out. According to the colonoscopy, there were no evidence about any malignancies in the bowel. After laparoscopic removing of the mesorectal tumor and histological examination of the specimen immunohistochemistry assay was recommended. Following the analysis, the hyaline-vascular type of Castleman's disease was confirmed. Chemotherapy wasn’t recommended, because of radical surgical treatment. According to the results of monitoring in two years, no data of recurrence were identified. Conclusion: Castleman’s disease should be taken into consideration in the differential diagnosis of lymphoid formations in mesorectum.
Kevin Keating, Matthew Rohloff, Thomas J. Maatman
Published: 9 April 2021
Journal of Surgical Oncology, Volume 2021, pp 1-4; https://doi.org/10.31487/j.jso.2021.01.04

Abstract:
Introduction: Robotic surgery has transformed the standard treatment for localized prostate cancer. Oncologic control is at the foremost concern when treating prostate cancer. Previous studies have detailed the use of a periurethral suspension stitch during robotic assisted radical prostatectomy (RARP), but none have demonstrated significant improvement in surgical margins. Objective: The purpose of this study is to illustrate the use of a periurethral suspension stitch during RARP and its impact on apical surgical margin status. Methods: This study retrospectively analysed 97 patients who underwent RARP by a single high-volume robotic surgeon (TJM) between November 2011 and February 2014. The patients were split into two cohorts with one group (Suspended Stitch) having the dorsal venous complex (DVC) ligation stitch suspended while the second group having the DVC ligation stitch unsuspended (Unsuspended Stitch). Results: Positive margins were seen in 39.6% of patients in the Unsuspended Stitch group and 20.4% of patients in the Suspended Stitch group (p=0.04). Patients in the Unsuspended Stitch group had a Gleason score > 7 in 33.3% of cases, where patients in the Suspended Stitch group had a Gleason score > 7 in 57.1% of cases. Conclusion: Localized prostate cancer treatment has significantly changed with RARP. This study provides an additional technique for achieving improved oncologic control.
Pompilia Radu, Guillaume Aeby, Birgit Schwacha-Eipper, Philippe Kolly, Codruta Mare, Vanessa Banz, Jeanfrançois Dufour
Published: 8 February 2021
Journal of Surgical Oncology, Volume 2020, pp 1-7; https://doi.org/10.31487/j.jso.2020.06.07

Abstract:
Background and Aim: Although cirrhosis is a classical risk factor for the development of hepatocellular carcinoma (HCC), its absence does not exclude this risk. We aimed to assess the clinical characteristics and outcomes of cirrhotic HCC (C-HCC) and non-cirrhotic HCC (NC-HCC) patients. Methods: Patients consecutively included in a prospective HCC cohort (University Hospital Bern) were analysed. They were categorised into two groups, based on the basis of histology or combined radiological and laboratory characteristics. Results: 20.4% of patients were NC-HCC. This group was characterized by a higher median age and a higher female prevalence compared to the C-HCC group. Non-alcoholic fatty liver disease (NAFLD) (25.7%) and HBV infection (14.9%) were the main risk factors in this group, whereas alcohol abuse (26%) and HCV (21.6%) in C-HCC, P
Jeremie Benichou, C Owen, K Kolanska, V Loi, S Feray, M Bazot, D Ghebriou, S Bendifallah, E Darai
Published: 2 February 2021
Journal of Surgical Oncology, Volume 2021, pp 1-5; https://doi.org/10.31487/j.jso.2021.01.02

Abstract:
Pneumothorax can be spontaneous or secondary to a pre-existing disorder or trauma. Pneumothorax associated with pneumoperitoneum without thoraco-abdominal communication is a rare event poorly described in the literature. We report the case of a 73-year-old patient undergoing abdominal debulking surgery for advanced stage ovarian cancer complicated by a pneumoperitoneum and a right-sided pneumothorax without hernia or evidence of diaphragmatic trauma. Several physio-pathological hypotheses have been suggested, including a potential COVID-19 infection without clear etiology. Our case report emphasizes the possible association of pneumothorax with pneumoperitoneum related to a colon perforation without visible diaphragmatic or mediastinal defects.
Jie Sun, Liqun Xing, Houcheng Cheng
Published: 18 January 2021
Journal of Surgical Oncology, Volume 2021, pp 1-11; https://doi.org/10.31487/j.jso.2021.01.01

Abstract:
Objective: To investigate the combined effects of the pollutants in source of drinking water for local populations, mice models were used to test the subchronic toxicity for three months and chronic toxicity for six months. Methods and Results: By using proteomics approach (iTRAQ), we had identified 29 differentially expressed proteins, which were related to amino acids metabolism, cell skeleton reorganization, apoptosis and cancer genesis. Moreover, 12 out of these 29 identified proteins are located in mitochondria, indicating drinking water source from Yangtze River Delta may exert oxidative damage stress to liver cells. All these cellular processes had been verified by hepatic histopathology, real time-PCR, flow cytometry test and our previous metabolic profile results. Conclusion: All these tests indicated that drinking water source from Yangtze River Delta could accelerate aging, enhance apoptosis and carcinogenesis risk.
Aliyu Muhammad Koko, Nasiru Jinjiri Ismail, Lasseini Ali, Bello Bala Shehu
Published: 22 December 2020
Journal of Surgical Oncology, Volume 2020, pp 1-4; https://doi.org/10.31487/j.jso.2020.06.03

Abstract:
Introduction: Brain tumor is a common neurosurgical condition encountered by neurosurgeons in clinical practice. Hydrocephalus could be associated with brain tumor thereby increasing the burden of the disease to the affected patients. Characteristics and outcome of hydrocephalus resulting from brain tumors are almost unknown in our setting. The objectives of this study were to describe the characteristics and outcome of hydrocephalus caused by brain tumor in our center. Methods: A retrospective analysis of all cases of hydrocephalus resulting from brain tumor managed in our center between January 2015 to December 2019. Relevant data extracted from patient’s case files and operation register was analysed. Results: Out of the total sixty-eight cases of brain tumors, thirty (44.1%) cases of hydrocephalus caused by brain tumor were managed over the study period. The mean age of presentation was 14 years ± 2 SD with a slight male preponderance (M: F = 1.07:1). The most common clinical presentations were headache, progressive visual impairment, altered conscious level and ataxia. Posterior fossa tumors were the commonest (21/30), followed by craniopharyngioma (6/30) and one case each for pituitary macroadenoma, pineal region tumor and choroid plexus papilloma respectively. Pediatric age group was the most affected (19/30). All patients had ventriculoperitoneal shunting before definitive surgery. Postoperative outcome was good in the majority of cases (27/30), mortality was recorded in one patient (1/30). Conclusion: Hydrocephalus is a common association in patients with brain tumor in our center. Most cases of brain tumor associated hydrocephalus occur in children and posterior fossa tumor is the commonest aetiology. The outcome of ventriculoperitoneal shunting is relatively good in our setting.
Gustavo Machado Badan, Ana Cristina Lessa, Marcos Lessa, Guilherme Novita, Amanda Neves Machado
Published: 21 December 2020
Journal of Surgical Oncology, Volume 2020, pp 1-3; https://doi.org/10.31487/j.jso.2020.05.04

Abstract:
Occult breast cancer (OBC), which is defined as clinically recognizable axillary metastatic carcinoma from an undetectable primary breast tumor, occult from conventional breast cancer screening imaging methods. This case reveals an unexpected OBC in a patient with predominantly adipose breasts, with only a few scattered areas of fibroglandular density tissue (BI-RADS® breast composition B), in which the mammographic sensitivity is approximately 90% for the diagnosis of primary breast câncer.
Maha Saad, Mansour Mohamed Kabash, Aymn El Sayed Shafei, Rawan Ellackany, Ahmed Atef, Mostafa Wael, Marwa Matboli
Published: 16 December 2020
Journal of Surgical Oncology, Volume 2020, pp 1-11; https://doi.org/10.31487/j.jso.2020.05.03

Abstract:
Every person has a characteristic “enterotype,” the gut components and the environment. Recently, a strong biological correlation has emerged among the microbiome of the gut, the immune system, cancer development and pharmacological effects of chemotherapy. In this review, we outline the role of gut microbiota in the gastrointestinal tract (GIT) cancers pathogenesis and their implications for enhancing the efficacy of GIT cancer management in clinical practice. We also summarize the molecular pathways linking gut microbiota and GIT cancers and the effectiveness of manipulating microbiota in GIT cancer therapies such as personalized cancer therapy.
Alexander Spiessberger, Varun Arvind, Mansoor Nasim, Basil Grueter, Edin Nevzati, Silvia Hofer, Samuel K Cho
Published: 18 December 2020
Journal of Surgical Oncology, Volume 2020, pp 1-8; https://doi.org/10.31487/j.jso.2020.06.04

Abstract:
Background: En-bloc spondylectomy in the treatment of spinal tumors is a complex procedure with potential complications. This study aims at identifying predictors of postoperative complications, lesion recurrence and overall survival. Methods: A systematic review of the literature was conducted, and patient-level data extracted from the included studies. Multiple linear-regression models were calculated to predict the occurrence of postoperative complications, lesion recurrence and overall survival based on age, tumor etiology, surgical approach, mode of resection (en-bloc versus intralesional), tumor extension based on Weinstein-BorianiBiagini classification system and number of levels treated. Results: Data of 582 individual adult and pediatric patients were extracted from the literature; Patient characteristics are: 45% female, median age of 46 years (range 5-78); most common etiologies were: sarcoma (46%), metastases (31%) and chordoma (11%). The surgical technique was: anterior (2.5%), combined (45%) and posterior approach (52.4%); 68.5% underwent en-bloc spondylectomy; average levels resected were 1.6 (1-6); 65% of patients had neurologic deficits at presentation, average survival was 2.6 years; Direct procedure-related complications were observed in 17.7%, with the most prevalent being CSF leaks, wound infections and neural injury. For postoperative complications, recurrence and 5-year survival significant regression equations were found (F(7,90)=2.57, p=0.018) with an R2 of 0.1; (F(5,147)=2.35, p=0.044) with an R2 of 0.07 and (F(4,101)=7.2, p=0.01) with an R2 of 0.38. Odds ratio for predicted complications was 1.35 for en-bloc resection and 1.25 for more than one level treated. The odds ratio for tumor recurrence was 0.78 for en-bloc resection; odds ratio for 5-year survival were 0.79 for increased patient age, 0.65 for increasing tumor grade, 0.79 for tumor dissemination at diagnosis and 1.68 for en-bloc resection. Conclusion: En-bloc spondylectomy provides improved survival and lower recurrence rates but also higher operative complication rates when compared to intralesional resections. Interestingly the complication rate was not influenced by tumor stage (WBB scale) and tumor etiology.
Kaijian Lei, Qiu-Yuan Liang, Shan-Bing Wang, Yue Ren, Yan Xu
Published: 23 December 2020
Journal of Surgical Oncology, Volume 2020, pp 1-3; https://doi.org/10.31487/j.jso.2020.06.06

Abstract:
Neoplastic fever, a common symptom of tumors, can be mainly controlled by nonsteroidal antiinflammatories (NSAIDs) and corticosteroids. However, there is no standard treatment guideline for refractory neoplastic fever, which cannot be controlled by the medicines mentioned above. This report presents a case of advanced cholangiocarcinoma with persistent fever lasting 3 weeks. After ineffective treatment with various antibiotics, ibuprofen, and corticosteroids, the body temperature returned to normal after a 48-hour treatment with celecoxib + thalidomide. Finally, the overall survival (OS) of the patient reached 8 months with radiotherapy and chemotherapy.
Liqun Xing, Lichao Wang, Jie Sun, Liye Yang
Published: 23 December 2020
Journal of Surgical Oncology, Volume 2020, pp 1-7; https://doi.org/10.31487/j.jso.2020.06.05

Abstract:
Metals cause popular attention worldwide due to their non-degradability and universal distribution in the aquatic ecosystem. In this study, the single, binary, and ternary combined toxicity of copper, cadmium, and lead toward survival rate of Daphnia magna were investigated based on different level fixed equivalenteffect concentration ratios. Furthermore, the combined toxicity was predicted by concentration addition and independent action models based on an established concentration-response relationship of a single toxicant and compared with the experimental data. The results indicated both binary and ternary mixture of the three metals had a strongly synergistic effect (EC50mix
Maria Peraire Lores, Jose Luis Bauza Quetglas, Laura Aizpiri Antoñana, Luis Ladaria Sureda, Carles Aliaga Ayuni, Iris Coello Torà, Valentí Tubau Vidaña, Ana Isabel Martínez Moreno, Enrique Pieras Ayala
Published: 30 November 2020
Journal of Surgical Oncology, Volume 2020, pp 1-7; https://doi.org/10.31487/j.jso.2020.05.02

Abstract:
Background: RENAL and PADUA scoring systems have been designed and validated as a method to assess the complexity of renal masses and predict the risk of perioperative complications. We aimed to evaluate if there is an association between RENAL and PADUA nephrometry scores with the Trifecta and Pentafecta achievement. Materials and Methods: We retrospectively analysed the data from 102 patients with renal cell carcinoma who underwent partial nephrectomy from January 2011 to October 2018 at our institution. Radiological characteristics of the renal masses were scored according to the RENAL and PADUA classification. Trifecta and Pentafecta achievement were collected. We performed a descriptive analysis and used de χ2 test to evaluate the relationship between PADUA and RENAL scores and Trifecta and Pentafecta achievement. Result: Among 102 patients, the median tumor size was 2.7 cm (IQR 0.8-7.5), the median RENAL score was 7 (IQR 4-11) and PADUA score 8 (IQR 6-14). The overall rate of postoperative complications was 21.6% (n=22). The rates of Trifecta and Pentafecta achievement were 50% (n=51/102) and 46.1% (n=47/102), respectively. Trifecta and Pentafecta achievement were higher when the PADUA score was ≤10 (OR 3.62; IC95% (1.08-12.11); p=0.0317) and (OR 4.98; IC95% (1.32-18.7); p=0.0175), respectively. Likewise, Trifecta and Pentafecta achievement were higher in patients with RENAL score ≤ 8 (OR 4.09; IC95% (1.46-11.42); p=0.0072) and (OR 4.92; IC95% (1.66-14.51); p=0.0039), respectively. Conclusion: There is an association between the RENAL and PADUA nephrometry scores and the Trifecta and Pentafecta achievement.
Domenico Parmeggiani, Mallitti C, Lanza Volpe M, Parisi S, Rinaldi S, Nesta G, Gualtieri G, Fiorentino F, Terracciano Gm, Bottino V, et al.
Published: 7 December 2020
Journal of Surgical Oncology, Volume 2020, pp 1-6; https://doi.org/10.31487/j.jso.2020.06.02

Abstract:
Background: The nipples-saving mastectomy (NSM), most recent technique, allows the whole mammary gland removal preserving the nipple-areola compound (NAC), obtaining oncologic safe results. When indicated, NSM is validated by the great aesthetic results obtained. Objectives: The objective of this review is the evaluation of the effectiveness and oncologic safety of the nipple-saving mastectomy, marking the most frequent complications. Moreover, the possibility to use the NSM procedure as prophylactic mastectomy in patients at high risk has been evaluated. Research Methods: A bibliographic research about clinical studies and previous reviews related to nipplessaving mastectomy has been conducted. No limitation about language was performed. Results: The study included 12 articles, for a total of 2859 patients and 3849 NSM. Patients candidate to NSM, either as a prophylactic or curative treatment of mammary carcinoma, must undergo a careful selection screening. Most frequently occurring surgery-related complications were necrosis and infections; though not altering the cosmetic results, that have been positively evaluated in almost all patients. Conclusion: Preservation of the areola-nipple compound seems to be oncologically safe and does not increase local recurrences, compared to the previous techniques. Moreover, it is associated with better aesthetic results and patients’ higher satisfaction.
Domenico Parmeggiani, Roberto Ruggiero, Giuseppe Chiacchio, Franco Faccenda, Davide Brunelli, Chiara Lanza Volpe, Bruno Carriero, Francesco Fiorentino, Giorgia Gualtieri, Ludovico Docimo
Published: 24 November 2020
Journal of Surgical Oncology, Volume 2020, pp 1-4; https://doi.org/10.31487/j.jso.2020.06.01

Abstract:
Background: Verneuil’s disease is a rare suppurative pathology of apocrine glands and pilosebaceous system of the inguinal-pelvis and perianal region with a multifactorial aetiology. The disease produces skin fistulas, draining a serum-purulent material on the skin, and finally with spontaneous healing. Verneuil’s disease can be complicated by recurrence, and unfortunately, by squamous carcinoma. We have found in literature, just 2 cases of Hidradenitis Suppurativa, complicated by Verrucous Carcinoma. Main Observation: we describe a patient F, 34-year-old, comes to our observation at 4th gestational month, with suppurative sinus pilonidalis diagnosis and with the absolute indication of the gynaecologist to the abortion. We decided to continue the pregnancy. The patient gives birth with C. to 9 months; the new-born baby was perfectly healthy and after the maternal milk analysis, the baby also nursed for about 2 months. Finally, we decided to perform a wide excision biopsy and after a controversial histology (first Warty Carcinoma, then after a “second view” Suppurative Hidradenitis), we started a series of medical treatments, including biological therapy with Infliximab, but unfortunately with fleeting results. The patient did not answer substantially. Therefore, the last chance appears a combined demolitive and plastic surgical treatment. The histology described a Verrucous squamous cell carcinoma maximum diameter of 38 x 26 cm, with lateral deep margins free of neoplastic involvement. Conclusion: This very advanced clinical behaviour of the Hidradenitis Suppurativa can present in pregnancy, therefore, motivating the interruption of the same one. Our experience contributes to underlining the possibility to bring to term the pregnancy. This case report shows how the hormonal activity can anyway influence the development of the hidradenitis and an interesting hypothesis could consider the hormonal activity of the pregnancy and the HPV promoting gene regulation (RB) from inflammatory pathology to neoplastic pathology in VC like a model to study.
, Qiliang Yin, Shijie Lan, Fengming Jiang
Published: 7 October 2020
Journal of Surgical Oncology, Volume 2020, pp 1-4; https://doi.org/10.31487/j.jso.2020.05.01

Abstract:
Introduction: Sarcomatoid carcinoma is one of the malignant neoplasms characterized by the ability to differentiate into both epithelial tissue and mesenchymal tissue. And it is rare in urinary system with a high degree of malignancy and prognosis is poor. Patient Concerns: The present article reports a 63-year-old man presented with recurrent left flank pain for two years. Radiological tests suggested a space-occupying lesion in left kidney with enlarged paranephric /retroperitoneal lymph nodes. Diagnosis: The pathological diagnosis following left nephrectomy indicated renal pelvis and renal calices sarcomatoid carcinoma; pTNM: T4N0M0. Interventions: No radiotherapy or chemotherapy were performed after the surgery and underwent rapid growth. Outcomes: The patients died six months later. Conclusion: Renal pelvis and renal calices sarcomatoid carcinomas is a highly malignant tumor and difficult to diagnose at its early stage. Definite diagnosis relies on the combination of immunohistochemistry (IHC) and morphological analyses and there currently is no effective treatment.
Amal Algarni, Yaser Orz, Sofia Muzzafar, Wafa Alshakweer
Published: 31 August 2020
Journal of Surgical Oncology, Volume 2020, pp 1-4; https://doi.org/10.31487/j.jso.2020.04.04

Abstract:
Endolymphatic sac tumor is rare, locally aggressive and non-metastasizing neoplasm arising from the endolymphatic sac of the petrous portion of the temporal bone. Most occur in adult and present with ipsilateral hearing loss. They can be sporadic or associated with Von-Hippel-Lindau disease. Patient with endolymphatic sac tumor should be screened for VHL disease. We report a case of 52-year-old female with dizziness and headache. Histopathology was consistent with typical features of endolymphatic sac tumor. This was confirmed by cytokeratin and EMA positivity and TTF-1 negativity. This case is presented for its rarity with only few cases reported.
Sidra Batool, Muhammad Sibte Hasan Mahmood, Tiyyaba Furqan
Published: 19 September 2020
Journal of Surgical Oncology, Volume 2020, pp 1-14; https://doi.org/10.31487/j.jso.2020.04.11

Abstract:
MicroRNAs (miRNAs) are small non-coding RNA’s that controls the regulation of a gene. Due to the over expression or under expression of miRNAs it leads to cause tumor or any other type of cancers such as, melanoma, lymphoma, cardiovascular issue, breast cancer etc. So, miRNAs can be used as a drug target for cancer therapy. This study aimed to check binding cavities of microRNA's involved in regulation of CDK6 protein. There are 23 different families of miRNAs that are involved in regulation of CDK6. Each family has one or more miRNAs. All these miRNAs are involved in the up regulation or downregulation of a gene, which lead to different type of cancers. All miRNAs of each family docked with mRNA CDK6 protein. After performing in silico analysis of binding interactions of mRNA with miRNAs the results were further refined by their comparison with information regarding their energies, interaction of the mRNA and miRNAs. The results show that all miRNAs lie in Protein Kinase domain, but the residues that lie is different within the families and across the families.
Feriel Sellam, Dramane Diallo, Lazéni Konate, Noria Harir
Published: 28 August 2020
Journal of Surgical Oncology, Volume 2020, pp 1-5; https://doi.org/10.31487/j.jso.2020.04.02

Abstract:
Objective: A statistical clinical assessment of the effects of bilirubin and others hem catalyze biochemical parameters over the main signaling pathways involved in pancreatic head cancer to determine their carcinogenic impact using a molecular approach. Material and Methods: Patients’ data were collected at surgery department Sidi bel Abbes University Hospital (North Africa) patients were diagnosed with pancreatic cancer between 2013 and 2016. The data inclusion criteria were: Age, gender, medical history, surgical history, the year of diagnosis, as well as biological records such as: bilirubin, fibrinogen, creatinine and urea rates. Results: 44 patients with pancreatic cancer were included in our study (sex ratio=1.75). The mean age was 67.61 years. The most recorded medical history was diabetes with a rate of 43.2%, concerning surgical histories, 27.3% patients underwent a cholecystectomy. M1 was the most common diagnosis stage (27%). 81.81% of patients had hyperbilirubinemia, 6.81% had a normal bilirubinemia, 25% had high level of fibrinogen, 3.6% had a normal level. 77.3% had normal ureanemia, 18.2% had hyper-ureanemia and 15.9% had hypocreatininemia, 68.2% had normal level, 13.6% had hypercreatininemia. We matched patients’ groups with bilirubin level using Spearman’s correlation test and found a significant P value (P=0.015). We calculated the correlation between bilirubinemia and the stage of diagnosis, using the one-way ANOVA test and we found a significant P value (P=0.013). Conclusion: Our results represent an interesting shortcut to synthetize specific biochemical antibodies for bio-marking and diagnosis use, or even to lower serum level to reduce cancer aggressiveness.
Chunfu Zhu, Shiting Shan, Yuting Wang
Published: 28 August 2020
Journal of Surgical Oncology, Volume 2020, pp 1-7; https://doi.org/10.31487/j.jso.2020.04.08

Abstract:
Objective: In recent years, the incidence of thyroid cancer has been increasing. Papillary thyroid cancer (PTC) is the most common type of malignant thyroid tumor, accounting for approximately 85% of thyroid cancer cases. Although the genetic background of PTC has been studied extensively, relatively little is known about the role of small non-coding RNA (sncRNA) in this disease. tRNA-derived fragments (tRFs) represent a newly discovered class of sncRNAs that exist in many species and play a role in many biological processes. Methods: In this study, we used RNA sequencing to analyse the expression of tRFs in fresh frozen specimens from PTC tissues and normal tissues adjacent to the tumors. Through this analysis, we identified 49 unique tRFs and transfer RNA halves and then performed quantitative PCR to determine the expression levels of these molecules and to make bioinformatic predictions. Conclusion: In this report, we provide a comprehensive catalog of tRFs in PTC and assess the abnormal expression of these fragments. These preliminary findings can be used as the basis for further research regarding the functional role of tRFs in patients with PTC.
Lifeng Zhang, Ze Zhang, Hao Wu, Shenglin Gao, Jiasheng Chen, Chao Lu, Weijiang Mao, Xingyu Wu, Tianle Cheng, Li Zuo
Published: 26 August 2020
Journal of Surgical Oncology, Volume 2020, pp 1-5; https://doi.org/10.31487/j.jso.2020.04.09

Abstract:
Introduction: In this study, the efficacy, advantages, and disadvantages of transurethral cystoscopic silver nitrate renal pelvic instillation and retroperitoneoscopic renal pedicle lymphatic disconnection for chyluria were compared to provide a clinical reference. Methods: Forty patients with chyluria who were admitted to our hospital between June 2007 and June 2017 were selected as the research subjects and divided into two groups. The patients in group A (n=25) were treated with transurethral cystoscopic silver nitrate renal pelvic instillation regimen, while those in group B (n=15) were treated by retroperitoneoscopic renal pedicle lymphatic disconnection. Operative time, intraoperative blood loss volume, length of postoperative hospital stay, cure rate, complication rate and recurrence rate were compared between the two groups. Results: All the 40 patients were successfully treated. Group B had a higher cure rate, lower complication rate and lower recurrence rate than in group A, the differences were statistically significant (P < 0.05). But group A had a shorter length of hospital stay and less surgical trauma, the differences were statistically significant (P < 0.05). Conclusion: Retroperitoneoscopic renal pedicle lymphatic disconnection for chyluria can be used as one of the first choices of treatment for chyluria. Although the recurrence rate with transurethral cystoscopic silver nitrate renal pelvic instillation is high, the treatment can be administered again when the disease recurs. At the same time, it is less invasive to the patients and they are more receptive.
Lifeng Zhang, Quanxin Su, Shenglin Gao, Jiasheng Chen, Li Zuo
Published: 14 August 2020
Journal of Surgical Oncology, Volume 2020, pp 1-4; https://doi.org/10.31487/j.jso.2020.04.07

Abstract:
Objective: To compare the clinical effects and safety of two methods of laparoscopic total cystectomy for female bladder cancer patients with retention and resection of the urethra. Methods: Female bladder cancer patients with bladder invasive urothelial carcinoma were selected in grade II~III from January 2008 to March 2018. Patients were divided into two groups based on the surgical method: group A laparoscopic radical cystectomy, and group B laparoscopic radical cystectomy + urethrectomy, to observe the clinical efficacy, operation duration, blood loss during surgery, hospitalization time, and complications. Results: The operation times in groups A and B were 262.54 ± 27.95 min and 310.28 ± 32.99 min, respectively. The volumes of intraoperative blood loss in groups A and B were 439.46 ± 44.52 mL and 456.74 ± 47.18 mL, respectively. There were no discernable differences in the probability of postoperative complications in the two groups. In group A, four patients experienced bladder cancer recurrence and metastasis, and 50% of these cases had a urethral recurrence. In group B, one patient experienced bladder cancer recurrence and metastasis; however, there was no urethral recurrence. Conclusion: Although laparoscopic radical cystectomy + urethrectomy extended the operation times; prophylactic urethrectomy can further shorten the bladder cancer recurrence and metastasis and improve patient prognosis without an increase in complications. However, its long-term clinical efficacy needs further study and supplement.
Dongmei Guo, Chunpu Li, Sicheng Wang, Lili Zhao, Jilong Yang
Published: 12 August 2020
Journal of Surgical Oncology, Volume 2020, pp 1-7; https://doi.org/10.31487/j.jso.2020.04.06

Abstract:
Background: SP6 (Specificity protein 6) has been explored as a prospective biomarker in several cancers. In this research, the prognostic value of SP6 expression in osteosarcoma was predicted by bioinformatics analysis. Data were obtained from the Gene Expression Omnibus (GEO) database. Methods: Gene expression data and clinical materials were downloaded from the GSE21257 dataset. The mRNA expression of SP6 was compared between metastatic and non-metastatic tissues with the Wilcoxon rank-sum test, and the relationship between SP6 and clinicopathological characters was analysed using logistic regression. In addition, the correlation between SP6 and survival rate was assessed using KaplanMeier and Cox regression. Moreover, receiver operating characteristic (ROC) curve analysis was conducted to determine the prognostic merit of SP6 for osteosarcoma. The biological functions of SP6 were annotated and evaluated through gene set enrichment analysis (GSEA) and gene set variation analysis (GSVA). Results: SP6 was significantly highly expressed in metastatic osteosarcoma tissues (p = 0.002). High SP6 expression showed a positive correlation with Huvos grade (OR = 6.60 for I vs. II, p = 0.028). The overall survival (OS) of the patients with high SP6 expression was significantly poorer than the low SP6 expression group (p = 0.027). The multivariate analysis revealed that SP6 expression (p = 0.002, HR = 15.40 (95% CI [2.84–83.44])) was independently correlated with OS. GSEA and GSVA showed that "spliceosome" and "base excision repair" were significantly upregulated in the high expression group of SP6. Conclusion: SP6 may serve an independent prognostic biomarker in osteosarcoma.
Koji Kawaguchi, Hisako Fujihara, Mitsuhiko Hasebe, Mami Suzuki, Shuji Koyama, Masaaki Yasukawa
Published: 29 July 2020
Journal of Surgical Oncology, Volume 2020, pp 1-4; https://doi.org/10.31487/j.jso.2020.04.05

Abstract:
Vessel sealing devices have been described to be effective, allowing to perform procedures with reduced blood loss and shorter operative times in head and neck surgery. Since the traditional vessel sealing devices are all disposable and expensive, there are not often used even in advanced cancer surgery in terms of cost. On the other hand, ‘marClampCut IQ’ (KLS Martin, Tuttlingen, Germany) is a new reusable vessel sealing device. In this clinical study, a traditional disposable device ‘LigaSure small jaw’ and a reusable device ‘marClampCut IQ’ were particularly compared regarding medical expenses and efficacy in modified total neck dissection. Between October 2014 and April 2020, modified total neck dissections were performed using the ‘LigaSure small jaw’ for 56 patients aged from 26y/o to 88y/o (median:66.0y/o). The ‘marClampCut IQ’ was mainly used between November 2018 and April 2020 for 64 modified total neck dissections in patients aged from 31y/o to 91y/o (median:70.5y/o). The amount of blood loss was significantly more in the ‘LigaSure small jaw’ group than in the ‘marClampCut IQ’ group (U-test, P = 0.006). There were no significant differences in age and operation time between the ‘LigaSure small jaw’ group and the ‘marClampCut IQ’ group. When calculated based on the list price in Japan, ‘LigaSure small jaw’ costed $1,000 each; on the other hand, ‘marClampCut IQ’ costed $240 per operation. We found that we could save $760 per operation using ‘marClampCut IQ’. The new reusable device ‘marClampCut IQ’ provided similar clinical efficacy and safety with a highly reduced cost when compared to the disposable device ‘LigaSure small jaw’ in this clinical study of modified total neck dissection.
Li-Feng Zhang, Bowen Tang, Shenglin Gao, Jiasheng Chen, Chao Lu, Xingyu Wu, Weijiang Mao, Li Zuo
Published: 29 May 2020
Journal of Surgical Oncology, Volume 2020, pp 1-5; https://doi.org/10.31487/j.jso.2020.03.06

Abstract:
Objective: The present study aimed to compare the efficacy, and advantages and disadvantages of laparoscopic radical cystectomy + extraperitoneal bilateral ureterocutaneostomy versus laparoscopic radical cystectomy + ileal cystoplasty (Bricker procedure) in the treatment of invasive bladder cancer. Method: Forty-five patients (retrospectively registered) with grade II–III bladder invasive urothelial carcinoma were divided into two groups to compare clinical efficacy, operative duration and blood loss, postoperative intestinal function recovery, length of hospitalization, and complications. Those in the ureterocutaneostomy group (n=25) were treated using laparoscopic radical cystectomy + extraperitoneal bilateral ureterocutaneostomy, while those in the ileal cystoplasty group (n=20) were treated using laparoscopic radical cystectomy + ileal cystoplasty. Results: Laparoscopic radical cystectomy + extraperitoneal bilateral ureterocutaneostomy shortened the operation, improved patient tolerance, and decreased postoperative intestinal function recovery time. However, its long-term clinical efficacy needs further study using larger sample sizes to confirm these results. Conclusion: Results of this study demonstrated that extraperitoneal bilateral ureterocutaneostomy after cystectomy had advantages of less trauma, a shorter learning curve, less surgical bleeding, and quicker postoperative recovery. Although early and mid-term follow-up revealed a slightly higher incidence of hydronephrosis, the severity of complications was not high in most patients. Nevertheless, the long-term clinical efficacy of this procedure needs further study using larger sample sizes.
Wickii T. Vigneswaran, Brittany C. Fields, Vijayalakshmi Ananthanarayanan
Published: 23 July 2020
Journal of Surgical Oncology, Volume 2020, pp 1-4; https://doi.org/10.31487/j.jso.2020.04.01

Abstract:
Synovial sarcomas represent an extremely rare subtype of an already rare group of malignancies, soft tissue sarcomas. Among these, primary pulmonary synovial sarcomas comprise an even smaller number, though they have become more frequently reported in the literature. This case report details a case of giant primary pulmonary synovial sarcoma in a 44-year-old male patient who presented with left-sided chest pain and shortness of breath and was found to have a large left-sided pleural effusion. No malignant cells were demonstrated on cytology of pleural fluid after thoracentesis; however, CT-guided needle biopsy of pleural nodules seen on imaging demonstrated pathologic features consistent with monophasic type synovial sarcoma. He was treated with neoadjuvant chemotherapy with minimal response; thus, he was referred for surgical management. A left extrapleural pneumonectomy with resection of the left hemi-diaphragm and Gore-Tex prosthetic reconstruction was performed. Imaging at six-month follow-up demonstrated a new nodule in the contralateral lung, suggestive of metastasis at that time and the patient later developed ascites at nine months, consistent with further intra-abdominal metastasis. Perhaps early diagnosis and aggressive multimodality therapy may have a place in the treatment of this aggressive disease.
Roman Kia Rahimi-Nedjat, Andrea Tuettenberg, Keyvan Sagheb, Stephan Grabbe, Carmen Loquai, Sarah Hümmer, Christian Walter, Bilal Al-Nawas
Published: 17 June 2020
Journal of Surgical Oncology, Volume 2020, pp 1-5; https://doi.org/10.31487/j.jso.2020.03.07

Abstract:
Background: Surgical excision remains the gold standard in the treatment of operable basal cell carcinoma (BCC). According to national guidelines, total resection with tumor-free margins should always be achieved in order to avoid recurrence. The aim of this study was to investigate surgical, histological as well as tumorspecific risk factors for the recurrence of BCC of the head and neck. Materials and Methods: In a retrospective analysis, patients who were operated on because of a BCC of the head and neck between 2011 and 2014 were included. Epidemiological as well as therapeutic and histological data were collected and investigated concerning the recurrence of the tumor. Follow-up data were controlled for recurrence. Results: 141 patients with a mean age of 72.9 years were included in this study. Most frequent tumor localizations were the nose and temple, and most of the BCC were nodular. Altogether, 8.6% of the patients showed a recurrence. In the chi-squared analysis, R-status or the resection margin did not correlate with the risk of BCC recurrence at the same localization. In contrast, the significant risk factors for recurrence were the tumor localization, size, and histological subtype. Conclusion: Incomplete total resection (R1) of a BCC does not inevitably lead to a recurrence. A reason therefore might be immune-mediated regression, which can be seen in other tumor entities as well. However, a total resection should still always be the aim for surgical therapy, especially for cases with high risk for recurrence.
Iride Porcellini, Miriam Patella, Antonio Valenti, Stefano Cafarotti
Published: 6 July 2020
Journal of Surgical Oncology, Volume 2020, pp 1-2; https://doi.org/10.31487/j.jso.2020.03.12

Abstract:
We present a case of a 20-year-old male with a rare form of malignant lung cancer. The patient had a long history of respiratory symptoms that have been repeatedly treated as a pulmonary infection. Despite several hints of the ineffectiveness of the therapy, the diagnosis and definitive surgical treatment were made 4 months after the onset of symptoms. Our aim is to highlight the importance of an efficient diagnostic process within multidisciplinary discussion and to warn clinicians on potential pitfalls related to unusual clinical presentation.
Vladimir Startsev, Anton Yu. Kolmakov, Faik R. Asfandiyarov, Vasiliy I. Oriol, Vladimir S. Luchkevich
Published: 8 June 2020
Journal of Surgical Oncology, Volume 2020, pp 1-5; https://doi.org/10.31487/j.jso.2020.03.10

Abstract:
Background and Purpose: The aim of the study was to improve the diagnostic and treatment approach for the medical care for patients with Schistosoma-associated bladder cancer (SA-BC). Material and Methods: The survey results the study of 56 patients with gross hematuria in medical institutions of the Province Benguela (Angola) since 2007 to 2012. Group A (n=35) included patients before applying the standardized diagnostic algorithm. Group B (n=21) included patients using the new organizational format, in hospital outpatient’s. Results: The progression to locally advanced stage of SA-BC was verified at significantly higher rate (80%). In patients from group A, while verified locally advanced SA-BC stays at low level (66,7%) in group B. Conclusion: The combined usage of urine cytology test, ultrasonography and cystoscopy at the increased proliferative process caused by Schistosoma haematobium (SH) allows to reveal diagnose SA-BC in early stages, subject to on condition of patient’s admission in hospital outpatient care structures of specialized medical institutions.
Sandra Díaz, Ana María Osorio, Carlos Lehmann, Carlos Duarte, Javier Angel, Luis Guzman, Marcela Nuñez-Lemus, Martha Cecilia Orozco, Mauricio García, Ricardo Sánchez, et al.
Published: 29 May 2020
Journal of Surgical Oncology pp 1-6; https://doi.org/10.31487/j.jso.2020.03.08

Abstract:
Introduction: The most frequent subtype of breast cancer is the luminal one, in 70 to 80% of cases; the poor response to neoadjuvant chemotherapy of these tumors positions neoadjuvant hormone therapy as a treatment option. Materials and Methods: An observational, descriptive, historical cohort study was conducted in patients with hormone receptor (HR positive and HER2-positive breast cancer, managed with neoadjuvant hormone therapy in the INC (National Cancer Institute, for its initials in Spanish), with the aim of evaluating their clinical and pathological response. Results: 57 patients were managed with neoadjuvant hormone therapy. Most stage IIA patients (40.3%, n = 23). 86% (n = 49) had luminal A tumors. Letrozole was the most widely used drug, in 78.9% (n = 45). The overall response rate (ORR) was reached in 94.6% (n = 53); and 10.7% of the patients (n = 6) achieved complete clinical response (cCR). Complete pathological response (pCR) was achieved only in one patient. Conservative surgery was possible in 56.9% (n = 29) of the patients. There was no difference between the type of aromatase inhibitor (AI) and the duration of neoadjuvant hormonal treatment with the clinical response. With a median follow-up of 3 years (0.6 and 6 years), no disease progression was reported in any of the patients in the study. Conclusion: The results of this study support the neoadjuvant hormone therapy recommendations for postmenopausal patients older than 65 years with luminal breast cancer, with well or moderately differentiated tumors, strongly HR positive and low Ki 67.
Sulaiman Nanji, Alexandre Menard, Diederick Jalink, Lauren O’Malley, Shannon Wong
Published: 12 May 2020
Journal of Surgical Oncology, Volume 2020, pp 1-6; https://doi.org/10.31487/j.jso.2020.03.02

Abstract:
Background: Intraoperative ultrasound (IOUS) of the liver is a useful adjunct for surgical planning during hepatic metastasectomy. This study aims to (1) report the frequency of change in operative plan as a result of IOUS findings and (2) determine whether IOUS is still beneficial after implementing a standardized, comprehensive process of preoperative hepatic imaging. Methods: First, a retrospective review of all patients undergoing hepatic metastasectomy at a single institution was conducted to identify how frequently IOUS findings altered the surgical plan. Second, a prospective study was conducted where patients underwent both preoperative CT and MRI within 30 days before surgery to determine if IOUS may still have benefit despite the implementation of a standardized preoperative imaging protocol. Results: In the retrospective review, 39 liver resections were completed; 100% and 36% of patients underwent preoperative CT and MRI, respectively. The mean time between preoperative imaging and surgery was 46 days (7-126). Operative plans were changed in 10/39 (26%) cases based on IOUS. After the standardization of preoperative imaging, 27 liver resections were performed. All patients underwent preoperative CT and MRI; the mean time between preoperative imaging and surgery was 20 days (1-98) (p=0.001). The operative plan was amended in 5/27 (19%) cases based on IOUS (χ 2=1.405, p=0.24). Conclusion: Even after standardizing the quality and timing of preoperative imaging, the operative plan was changed in nearly 1/5 patients due to IOUS. These findings demonstrate the utility of IOUS in surgical planning for hepatic metastasectomy and provide the basis for a quality improvement strategy regarding standardized preoperative imaging.
Stas Marguerite, Bechter Oliver, Boecxstaens Veerle, Garmyn Marjan, Roel Bolckmans, Van Den Oord Joost, Wolter Pascal
Published: 11 May 2020
Journal of Surgical Oncology, Volume 2020, pp 1-8; https://doi.org/10.31487/j.jso.2020.03.03

Abstract:
Introduction: Isolated limb perfusion (ILP) with delivery of high dose melphalan proved to be efficient in the treatment of in-transit metastases (ITM). Preoperative factors may carry an impact on patient outcome, including in-field or local progression-free survival (IPFS), time to distant metastases (TDM) and overall survival (OS). Materials and Methods: A retrospective analysis of 83 patients who underwent an ILP at our institution before the era of efficient upfront systemic therapy in high-risk cases. Patients were classified according to a modified M.D. Anderson score, with relevance for the outcome: 34 stage III A (patients with satellites and/or ITM), 31 stage III AB (patients with synchronous regional lymph node metastases and satellites and/or ITM), 11 at a new stage labelled III A(B) which takes into account a previous history of therapeutic regional node dissection and actual recurrence in the limb only, and 7 stage IV (metastatic cases with actual major problem of recurrence in the limb). Results: Our median follow-up time was 90.1 months (IQR 72.8-151.6). Median IPFS was 16.3 months (95% CI 9.5-78.5), median TDM 28.8 months (95% CI 15.4-69.6) and median OS 34.6 months (95% CI 21.1-59.5). The strongest significant prognostic factor regarding IPFS was LND before ILP (p=0.02). However, sex (p=0.03/0.07), LND before ILP (p=0.004/0.11) and some primary tumor characteristics (Clark level (p=0.15/0.07) and ulceration (p=0.006/0.04)) were prognostic regarding TDM and / or OS. Conclusion: ILP with melphalan can provide long-term regional and systemic tumor control in a selected group of patients and should be kept in mind for patients recurring after local surgery or radiotherapy and resistant to or ineligible for the newer systemic therapies.
, Haofan Jin, Qiliang Yin, Shijie Lan, Yan Wang, Yanping Zhong
Published: 8 May 2020
Journal of Surgical Oncology, Volume 2020, pp 1-4; https://doi.org/10.31487/j.jso.2020.02.05

Abstract:
Introduction: Sarcomatoid carcinoma describes a biphasic malignancy with features of epithelial and mesenchymal differentiation. It rarely occurs at the urinary bladder but is usually aggressive and associated with poor prognosis. Case Presentation: We here report a case of sarcomatoid carcinoma of the urinary bladder of a 48 years old man with intermittent painless haematuria over an 18-month period. Imaging examination showed intraluminal protrusion of a tumour on the right posterior wall of the bladder. Diagnosis: The patient was initially diagnosed as a right bladder mass. Interventions: The patient underwent two rounds of transurethral resection of bladder tumour (TURBT) and pathological analysis suggested the tumours were invasive urothelial carcinomas. Radical cystectomy was later performed, and pathological analysis suggested a stage T4 sarcomatoid carcinoma. The patient received 5 cycles of gemcitabine and cisplatin. Outcome: The patient died of multiple organ dysfunction syndrome 8.5 months after the diagnosis of sarcomatoid carcinoma. Conclusion: Sarcomatoid carcinoma of the urinary bladder is a highly malignant disease, and the histopathological characteristics are distinct. The diagnosis, surgical management, and chemotherapy of this patient are discussed together with previous cases reported in the literature
, Hye Chung Kang, Lucas Natã Lessa Silva, Rafael Catelli, Roger Jordan Freitas
Published: 1 May 2020
Journal of Surgical Oncology, Volume 2020, pp 1-4; https://doi.org/10.31487/j.jso.2020.03.01

Abstract:
Papillary renal cell carcinoma is an uncommon malignant tumor, which rarely metastases to the bladder and/or omentum. We report the case of a 71-year-old woman with macrohematuria for two years and a large mass on the right flank. Thus, we present a brief review of the literature regarding the classification, clinical manifestations, diagnosis, immunohistochemical profile, and treatment of this neoplasm. Special attention was given to the role of immunohistochemistry, which was decisive for the determination of multiple metastases, as well as the study by imaging exams, which defined the best surgical approach.
Abeer Eddib, Ahmed Eddib, Kenneth Fan
Published: 28 April 2020
Journal of Surgical Oncology, Volume 2020, pp 1-5; https://doi.org/10.31487/j.jso.2020.02.07

Abstract:
Background: Many women diagnosed with a gynecologic malignancy may have coinciding urogynecologic complaints, such as pelvic organ prolapse (POP) and/or urinary incontinence, with approximately 35% reporting moderate to severe symptoms. Recent National Surgical Quality Improvement Program (NSQIP) database inquiries of gynecologic cancer cases found only 2.3-2.4% of women undergoing interventional surgery for gynecologic malignancy also had a procedure for pelvic organ prolapse urinary incontinence (POPUI), and those combination cases did not show significant increase in postoperative risks. The purpose of our study is to review our cases of gynecologic cancer that underwent concomitant urogynecologic procedures and compare their perioperative outcomes to gynecologic cancer cases without concomitant urogynecologic procedures. Methods: A retrospective cohort study conducted at a teaching hospital included 29 gynecologic oncology patients who underwent robot-assisted total laparoscopic hysterectomy, bilateral salpingo-oophorectomy, and lymphadenectomy. Controls underwent standard staging procedure and were compared to women with concomitant pelvic floor dysfunction that underwent additional laparoscopic uterosacral ligament suspension for apical suspension and a sling for stress urinary incontinence (SUI). The primary outcome was operative time, defined as documented total operative time and robot console time. Secondary outcomes include delta hemoglobin, hospital length of stay, readmission rate, total pain medication, urinary retention and discharge with foley. Results: The combined case group had longer total procedure time duration (301 minutes versus 210 minutes, p-value < 0.0001), with comparable mean console time (178 minutes versus 160 minutes; p = 0.1456). Blood loss estimated by mean percent difference of Hgb showed moderate conditional dependence on surgical case (22.2% cases versus 14.9% controls, p-value 0.04). Combined cases resulted in 76.9% of subjects discharged with a foley catheter compared to none in controls (p-value < 0.0001). Otherwise, there was no difference in the other perioperative outcomes between the two groups. Conclusion: With appropriate counseling and clinical judgement, combined urogynecologic and gynecologic oncologic surgeries can be performed to improve a patient’s quality of life (QOL) with minimal increase in perioperative morbidity.
, Chao Zhang, Fangyuan Chang, Hongji Dai, Ting Li, Xiaoling Du
Published: 29 April 2020
Journal of Surgical Oncology, Volume 2020, pp 1-10; https://doi.org/10.31487/j.jso.2020.02.09

Abstract:
Background and Objectives: The dismal outcome of malignant peripheral nerve sheath tumor (MPNST) highlights the necessity of identifying new biomarkers and pathogenesis for this aggressive sarcoma. Therefore, it is necessary to detect the aberrations of the TBX2-CHK2-p53 pathway and investigate its biological role in MPNST. Methods: Genetic aberrations of TBX2, CHK2 and p53 were detected by next generation sequencing (NGS) in 10 MPNST samples. Protein expression of TBX2, CHK2, p53, Ki-67 and cyclin D1 were assessed by immunohistochemistry (IHC) in 63 MPNST samples. Results: Our present data demonstrated that there were gene mutations of TBX2, CHK2 and p53 in MPNST samples. TBX2 expression was correlated with American Joint Committee on Cancer (AJCC) stage, recurrence and metastasis. Correlation analysis found that TBX2 was positively correlated with CHK2 (p=0.045) and CHK2 was positively correlated with p53 (p=0.006). Furthermore, both CHK2 and p53 were positively correlated with Ki-67 (p
, Marc-Antoine Ricard, Motaz AlAqeel, Robert Turcotte, Sungmi Jung
Published: 27 April 2020
Journal of Surgical Oncology, Volume 2020, pp 1-4; https://doi.org/10.31487/j.jso.2020.02.08

Abstract:
Case: We describe a case of 72-year-old male with dedifferentiated chondrosarcoma with osteosarcomatous and epithelioid (squamous) dedifferentiation. As first described in the literature by Dahlin and Beabout, a well-differentiated benign chondral lesion abruptly juxtaposed to a high-grade non-cartilaginous component is the classical definition of a chondrosarcoma [1]. The non-cartilaginous component is typically an osteosarcoma, fibrosarcoma or malignant fibrous histiocytoma with rare instances of leiomyosarcoma, giant cell tumor and rhabdomyosarcoma [2]. Conclusion: We report our rare instance of squamous dedifferentiation of a dedifferentiated chondrosarcoma along with other five cases that have been reported so far in the literature
, Go Arai, Hisako Fujihara, Kazutoshi Nakaoka, Mitsuhiko Hasebe, Nanami Nakamura, Shuji Koyama, Takanori Eguchi, Tomoyuki Saito, Yoshiki Hamada
Published: 22 April 2020
Journal of Surgical Oncology, Volume 2020, pp 1-3; https://doi.org/10.31487/j.jso.2020.02.06

Abstract:
Hemangiomas require appropriate treatments with controlled intraoperative bleeding. Even for a small hemangioma, the treatment is usually provided under general anesthesia to control bleeding. However, in the case of the patients who are at high risk of surgery under general anesthesia, a surgical treatment method must be considered under local anesthesia. We performed polypectomy for the resection of a small tongue hemangioma in an 88-year-old patient under local anesthesia. The device for polypectomy is suitable for the resection of a small hemangioma of the tongue, even for a patient who is at risk for surgery under general anesthesia.
Randa Barazi, Christopher Jabbour
Published: 18 April 2020
Journal of Surgical Oncology, Volume 2020, pp 1-2; https://doi.org/10.31487/j.jso.2020.02.04

Abstract:
Crohn’s disease is an immune mediated inflammatory disease that affects the gastrointestinal tract anywhere from the oral cavity proximally, to the anus distally. A large number of patients with Crohn’s disease may present with a multitude of oropharyngeal manifestations, such as mucositis, granulomas and ulcerations. Infliximab, a monoclonal antibody that binds to TNFα, is a treatment modality used in the management of Crohn’s disease. 10% to 30% of patients with Crohn’s disease develop intra-abdominal abscesses in the course of the disease, a finding that is much less common in oropharyngeal manifestations. We herein present the case of a painless peri-tonsillar abscess in a patient with Crohn’s disease maintained on infliximab that required surgical drainage as means of treatment. To our knowledge, this is the first case demonstrating such a finding in a patient that is maintained on infliximab.
Page of 2
Articles per Page
by
Show export options
  Select all
Back to Top Top