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Results in Journal Studies in Synthetic Chemistry: 59

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丽王 杨
Published: 1 January 2021
Studies in Synthetic Chemistry, Volume 09, pp 1-7; https://doi.org/10.12677/ssc.2021.91001

Abstract:
β-羰基砜是一类重要的有机合成砌块,合成该类化合物一直是研究热点。本文以四丁基碘化铵为媒介,在电化学条件下实现烯醇硅醚与各种取代的磺酰肼发生自由基磺酰化反应,经自由基加成和氧化,在最优条件下以55%~76%的收率合成了8种具有不同取代基的β-羰基砜类化合物。采用核磁共振和质谱等手段对产物结构进行表征,并提出了可能的反应机理。 β-carbonyl sulfone is a kind of important organic synthesis block, and the synthesis of this kind of compounds has been a research hotspot. In this paper, β-carbonyl sulfones with different substi-tuents were synthesized by the free radical sulfonation of enol silyl ethers with various substituted sulfonyl hydrazides in the medium of tetrabutylammonium iodide under electrochemical conditions. Through radical addition and oxidation, eight β-carbonyl sulfones with different subs-tituents were synthesized in 55%~76% yield under the optimal conditions. The products were characterized by NMR and MS, and the possible reaction mechanism was proposed.
强庞 久
Published: 1 January 2020
Studies in Synthetic Chemistry, Volume 8, pp 16-24; https://doi.org/10.12677/ssc.2020.81002

Abstract:
光开光在很多光化学和光物理应用中起到非常重要的作用。本论文中,我们通过将BiCl3,4,4’-联吡啶,甲醇和浓盐酸混合,采用溶剂热方法制备了一例铋基光致变色无机–有机杂化材料,并对其光电导和光致发光调制性能进行了研究。光照前后,电导率由0.43 × 10−5 S·cm−1 减小到0.21 × 10−5 S·cm−1 ,并且获得了高达4次的循环稳定性,同时,光致变色过程实现了高达8倍的发光对比度。 Photoswitchable properties are very important in many photochemical and photophysical applications. In this work, a Bismuth-based photochromic inorganic-organic hybrid was prepared by solvothermal reaction with the mixture of BiCl3, 4,4’-bipyridine, CH3OH and concentrated HCl. The photoconduction and photoluminescence switchable properties have been studied. In the photochromic process, the electrical conductivity was dropped from 0.43 × 10−5 S·cm−1 to 0.21 × 10−5 S·cm−1 , with the stability of 4 cycles, and the process reached a luminescence contrast up to 8 times.
秀马 良
Published: 1 January 2020
Studies in Synthetic Chemistry, Volume 8, pp 48-53; https://doi.org/10.12677/ssc.2020.82006

Abstract:
以N-正丙基-1H-1,2,4-三唑-3,5-二胺为起始原料与苯甲醛反应合成化合物I;化合物1与3-甲氧基-2-甲基丙烯酸甲酯反应生成化合物II,化合物II脱去苯甲醛保护得到目标产物2-氨基-6-甲基-4-正丙基-1,2,4-三唑[1,5-a]并嘧啶-5-酮(化合物III)。考察催化剂、摩尔比、反应温度对反应的影响,考察苯甲醛的回收利用情况。结果表明:化合物I的最佳工艺条件为冰醋酸催化剂,回流反应,化合物II的最佳催化剂为甲醇钠,115℃反应;酸性条件下脱保护得到目标产物。在最佳工艺条件下,化合物I的收率为96%以上,化合物II的收率达到90%以上,化合物III的收率在95%以上。 Compound I was synthesized from N-propyl-1H-1,2,4-Triazole-3,5-diamine as the starting material with benzene formaldehyde; which was then reacted Methyl (E)-3-Methoxy-2-Methyl propenoate obtain compound II;finally, compound II was then deprotected to obtain target product 2-Amino-6-methyl-4-propyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-5-one (compound III). The reaction was optimized by studying the catalyst, molar ratio, reaction temperature, and the recovery of benzaldehyde was further considered. The results showed that the best process conditions of compound I were ice acetic acid catalyst, reflux reaction, compound II’s best catalyst was sodium methanol, 115˚C reaction, and the target product was obtained under acidic conditions. Under the best process conditions, the yield of compound I is more than 96%, the yield of compound II is more than 90%, and the yield of compound III is more than 95%.
贾 俊
Published: 1 January 2020
Studies in Synthetic Chemistry, Volume 8, pp 25-32; https://doi.org/10.12677/ssc.2020.81003

Abstract:
本文以L-脯氨酸衍生的手性硫脲为催化剂,对苯甲醛与二乙基锌的不对称1,2-加成烷基化反应进行了研究。我们发现在最优化的催化剂反应条件下,该反应可以以高收率和中等的对映选择性得到1-苯基-1-丙醇化合物。该催化体系具有高效、低成本、反应条件温和等特点,为合成手性芳基醇类化合物提供了一条有效、方便的路径。 In this paper, a series of L-proline derived chiral thioureas were designed and synthesized. Then the resulting catalysts were applied into the 1,2-addition reation of diethylzinc to benzaldehyde, which provided 1-phenylpropan-1-ol with good to excellent yields, albeit with moderate enatioselectivity. The catalytic system is featured with high efficiency, low cost as well as mild reaction conditions, and it was proved to be an effective and convenient route for the synthesis of chiral aromatic alcohols.
贾 俊
Published: 1 January 2020
Studies in Synthetic Chemistry, Volume 8, pp 33-41; https://doi.org/10.12677/ssc.2020.81004

Abstract:
本文以一系列亚磷酸酯为催化剂,对催化芳香醛亚胺与丙烯酸甲酯的氮杂Baylis-Hillman反应进行了系统研究。经过对该反应的溶剂、反应温度、底物浓度、催化剂进行了筛选和优化,我们发现亚磷酸二乙酯和1,4-二氮杂二环[2.2.2]辛烷(DABCO)能有效催化该反应。最后对一系列底物进行测试,所有反应能以中等到良好的收率得到α-亚甲基β-磺酰胺基丙烯酸酯产物。 The aza-Bayllis-Hillman reactions of imines and methyl acrylate catalyzed by achiral phosphite were studied. The reaction conditions, such as solvent, temperature, concentration, catalysts, and substrates were screened. The target products of α-methylene--sulfonamido acrylates were obtained with 25% - 78% yield.
凡汤 佳
Published: 1 January 2020
Studies in Synthetic Chemistry, Volume 8, pp 43-47; https://doi.org/10.12677/ssc.2020.82005

Abstract:
开发了一种通过类曼尼希反应制备3,3’-双(哌啶-1-甲基)八氢联萘酚简捷的一锅法合成方法。在溶剂甲醇中,使用廉价易得的哌啶盐酸盐替代管制品哌啶,以高达81.1%的收率得到3,3’-双(哌啶-1-甲基)八氢联萘酚。该法不仅反应条件温和,后处理操作简单,而且收率高。 A concise one-pot synthetic method was developed to prepare (S)-3,3’-bis(piperidin-1-ylmethyl)- octahydrobinaphthol (H8BINOL) by Mannich-type reaction. In the solvent methanol, (S)-3,3’-bis (piperidin-1-ylmethyl) octahydrobinaphthol was obtained in high yield of up to 81.1% using cheap and readily available piperidine hydrochloride to replace the controlled chemical piperidine.
然李 轶
Published: 1 January 2020
Studies in Synthetic Chemistry, Volume 08, pp 61-66; https://doi.org/10.12677/ssc.2020.84008

Abstract:
抑制剂改性方法可以直接有效地解决沥青释放挥发性有机物(VOCs)的问题。单一种类添加剂的加入会不可避免地对沥青高低温性能产生影响,尤其吸附剂类和阻燃剂类添加剂会导致沥青的低温延伸性能劣化,且单一种类添加剂难以达到理想的抑烟效果。因此,往往将不同种类添加剂复配使用,期望在抑烟的同时不影响沥青的使用性能。本文综述了沥青VOCs的危害,介绍了沥青VOCs复合抑制剂的研究进展,并对沥青VOCs复合抑制剂研究的前景进行了展望。 The method of inhibitor modification can solve the problem of volatile organic compounds (VOCs) released from asphalt directly and effectively. The addition of a single kind of additives will inevitably affect the high and low-temperature performance of asphalt, especially the adsorbent and flame retardant additives will lead to the deterioration of asphalt low-temperature elongation performance, and it is difficult to achieve the ideal smoke suppression effect. Therefore, different kinds of additives are often used together to suppress smoke without affecting the performance of asphalt. This paper summarizes the harm of asphalt VOCs, introduces the research progress of asphalt VOCs composite inhibitors, and prospects the research prospects of asphalt VOCs composite inhibitors.
薇蔡 微
Published: 1 January 2020
Studies in Synthetic Chemistry, Volume 8, pp 1-15; https://doi.org/10.12677/ssc.2020.81001

Abstract:
研究了六种不同β-二酮类化合物或芳香羧酸类化合物作为第一配体,在水浴法下对三元铕配合物合成的影响,分别用紫外可见分光光谱法、FT-IR、ICP、分子荧光光谱对三元配合物结构进行表征,计算产物纯度,分析发光性能,比较产率。并从合成方法和条件两方面对Eu(TTA)3(TPPO)2进行工艺优化。结果表明:Eu(TTA)3(TPPO)2是其中最佳稀土铕配合物;工艺优化方面,得到微波辅助法的效率高于水浴法和超声法的结论;较优工艺条件:微波辐射反应时间20 min,微波功率200 W,料液比1:15,优化条件下的产收为68.63%。The effect of six different β-diketones or aromatic carboxylic acids as the first ligands on the synthesis of Ternary Europium Complexes by using waterbath was investigated. The structures of Ternary Europium Complexes were characterized by UV-vis spectrometry, FT-IR, ICP and molecular fluorescence spectra respectively to calculate product purity. The luminescent properties were analyzed and the yields were compared. The process of Eu(TTA)3(TPPO)2 was optimized from the aspects of synthesis method and conditions. The results show that Eu(TTA)3(TPPO)2 was the best rare earth europium complex. In terms of process optimization, the efficiency of microwave-assisted method was higher than that of water bath method and ultrasonic method. The optimal process conditions were as follows: microwave irradiation reaction time 20 min, microwave power 200 W, material solid-liquid ratio 1:15. Under the optimized conditions, the yield was 68.63%.
白 燕
Published: 1 January 2019
Studies in Synthetic Chemistry, Volume 7, pp 23-29; https://doi.org/10.12677/ssc.2019.73005

Abstract:
在LED蓝光激发下,以氯离子为氯源,甲苯为底物,双氧水为氧化剂,采用氧化氯化法制备氯化苄。考察了光源及功率、反应物配比、反应温度、反应时间对产物氯化苄转化率的影响,得到了优化工艺条件,优化工艺条件下氯化苄收率40%。产物结构经IR和1HNMR确认,并采用气相色谱进行纯度检测。 Under the excitation of LED blue light, benzyl chloride was prepared through the oxidative chlorina-tion while chlorine ion was served as chlorine source, toluene as substrate and hydrogen peroxide as oxidant. Factors influencing the reaction were studied, including the light source and power, the ratio of reactant, reaction temperature and reaction time. Under the optimum conditions, the yield of benzyl chloride was 40%. The structure of the product was characterized by IR and 1HNMR. The purity of the product was determined by GC.
唐 璇
Published: 1 January 2019
Studies in Synthetic Chemistry, Volume 7, pp 37-45; https://doi.org/10.12677/ssc.2019.74007

Abstract:
本文以硝酸钴为钴源、钼酸铵为钼源,γ-Al2O3为载体,采用浸渍法得到一系列不同钴钼含量的Co/Mo/γ-Al2O3催化剂。采用热失重分析、扫描电镜、X射线衍射、NH3程序升温脱附、X射线光电子能谱及BET物理吸附等方法对样品进行了表征,并考察了催化剂在邻苯二甲醇过氧化氢氧化反应中的催化性能。结果表明,所制备的Co/Mo/γ-Al2O3具有较大的比表面积和孔径,有利于邻苯二甲醛的生成,可使目标产物获得较高转化率。 A series of Co/Mo/γ-Al2O3 with different cobalt and molybdenum loadings were synthesized under the impregnation method, using cobalt nitrate as the cobalt source and ammonium molybdate as the molybdenum source respectively. The catalyst samples were characterized by thermogravi-metric analysis, scanning electron microscope, X-ray diffraction, NH3 temperature programmed desorption, X-ray photoelectron spectroscopy and BET. The catalytic performance of the catalysts was evaluated for oxidation of 1,2-benzenedimethanol into phthalaldehyde by H2O2. The results show that the prepared catalysts have larger surface area and pore size, which was beneficial to the formation of phthalaldehyde, and could make the target product obtain high conversion rate.
阳李 丹
Published: 1 January 2019
Studies in Synthetic Chemistry, Volume 7, pp 1-6; https://doi.org/10.12677/ssc.2018.71001

Abstract:
本文针对克拉玛依油田现有的稠油破乳剂破乳效果较差这一现状,以OF271型多胺类嵌段聚醚为基础物,通过甲基丙烯酸先酯化后聚合的方法进行改性。在预混合温度为120℃,酯化温度为85℃,酯化时间8 h,聚合温度85℃,聚合时间5 h,的最佳条件下合成了甲基丙烯酸改性的OF271型破乳剂。采用红外光谱(IR)对其结构进行了表征,并对其不同浓度水溶液的表面张力进行了测定。在75℃下,改性后的OF271原油破乳剂在有效加药浓度减少40%的条件下破乳效果高于现有破乳剂。 In order to solve the poor effect of demulsifier in Karamay oilfield, methacrylic acid esterification and polymerization with the base material of polyamine block polyether OF271 to improve the dehydration effect. The modified demulsifier was synthesized under the optimum conditions of pre-mixing temperature 120˚C, esterification temperature 85˚C, esterification time 8 h, polymeri-zation temperature 85˚C, polymerization time 5 h, mechanical stirring. With a 60% effective dosing concentration at 75˚C, the demulsification effect is higher than the existing demulsifier. The modified demulsifier was characterized by infrared spectroscopy (IR) and indicating the acrylic acid complete reaction.
乐杨 万
Published: 1 January 2019
Studies in Synthetic Chemistry, Volume 7, pp 18-22; https://doi.org/10.12677/ssc.2019.72004

Abstract:
本文以2-二甲氨基吡啶作为一种有机催化剂,催化α-溴代肉桂醛、1,3-二羰基化合物在二氯甲烷中反应合成了一系列2H-吡喃类化合物。该方法具有环境友好、操作简单的特点。 In this paper, a series of 2H-pyrane compounds were synthesized by the reaction of α-bromocinna- maldehydes with 1,3-dicarbonyl compounds in dichloromethane using 2-dimethylaminopyridine as an organic catalyst. The method is environment friendly and easy to operate.
霞胡 海
Published: 1 January 2019
Studies in Synthetic Chemistry, Volume 7, pp 30-36; https://doi.org/10.12677/ssc.2019.73006

Abstract:
研究了端氨基聚脲增韧环氧树脂基复合材料在水润滑条件下的摩擦磨损性能,利用扫描电子显微镜和激光扫描共聚焦显微镜对环氧树脂磨损后的表面形貌进行观察与分析。结果表明:聚脲/环氧树脂复合材料在水润滑条件下表现出良好的耐磨性能,摩擦系数和磨损质量损失都比纯环氧树脂低;聚脲共聚体的加入显著提高了复合材料的韧性。聚脲/环氧树脂复合材料中颗粒的分布比较均匀,而且形状比较规则,磨损表面部分粒子发生了塑性变形,聚脲颗粒的加入,提高了复合材料的耐磨性。Friction and wear behavior properties of epoxy resin matrix composites toughened with polyu-rethane were investigated under the condition of water lubricated sliding. The worn surface morphologies of epoxy resin and the composite were observed and analyzed by scanning electron microscope (SEM) and laser scanning confocal microscope (CLSM). It has been found that the epoxy/ployurea composite exhibits favorable wear resistance under water lubricated sliding. Fric-tional coefficients and wear mass losses of Polyurea/Epoxy composites were all lower than that of epoxy samples. The toughness was improved with the addition of polyurea copolymer. The polyurea particles distributed uniformly in epoxy/polyurea composite substrate. In addition, plastic defor-mation of some polyurea particles occurred on the worn surface of the epoxy/polyurea composite. The wear resistance was improved with the addition of polyurea particles.
王 君
Published: 1 January 2019
Studies in Synthetic Chemistry, Volume 7, pp 7-10; https://doi.org/10.12677/ssc.2019.72002

Abstract:
以1-苄基哌啶酮为原料,先与苯胺和三甲基硅氰发生Strecker反应得到化合物2,再经过酰胺化、甲酯化、N-丙酰化等三步反应,以26%的总收率合成了1-苄基哌啶酮衍生物,产物结构经1H NMR、13C NMR和HRMS表征。该方法具有绿色、简便的特点。 The compound 2 was prepared by the Strecker reaction of 1-benzylpiperidone with aniline and trimethylsilyl cyanide. Then 1-benzylpiperidone derivatives were synthesized in 26% overall yield by amidation, methyl esterification and N-propionylation. The structure of the product was characterized by 1H NMR, 13C NMR and HRMS. The method is green and simple.
阳李 丹
Published: 1 January 2019
Studies in Synthetic Chemistry, Volume 7, pp 1-6; https://doi.org/10.12677/ssc.2019.71001

Abstract:
本文针对克拉玛依油田现有的稠油破乳剂破乳效果较差这一现状,以OF271型多胺类嵌段聚醚为基础物,通过甲基丙烯酸先酯化后聚合的方法进行改性。在预混合温度为120℃,酯化温度为85℃,酯化时间8 h,聚合温度85℃,聚合时间5 h,的最佳条件下合成了甲基丙烯酸改性的OF271型破乳剂。采用红外光谱(IR)对其结构进行了表征,并对其不同浓度水溶液的表面张力进行了测定。在75℃下,改性后的OF271原油破乳剂在有效加药浓度减少40%的条件下破乳效果高于现有破乳剂。 In order to solve the poor effect of demulsifier in Karamay oilfield, methacrylic acid esterification and polymerization with the base material of polyamine block polyether OF271 to improve the dehydration effect. The modified demulsifier was synthesized under the optimum conditions of pre-mixing temperature 120˚C, esterification temperature 85˚C, esterification time 8 h, polymeri-zation temperature 85˚C, polymerization time 5 h, mechanical stirring. With a 60% effective dosing concentration at 75˚C, the demulsification effect is higher than the existing demulsifier. The modified demulsifier was characterized by infrared spectroscopy (IR) and indicating the acrylic acid complete reaction.
张 合
Published: 1 January 2019
Studies in Synthetic Chemistry, Volume 7, pp 11-17; https://doi.org/10.12677/ssc.2019.72003

Abstract:
以含溴的Co(Salphen) (双水杨醛缩邻苯二胺合钴)和1,4-苯二硼酸通过Suzuki偶联合成了一种含有Co(Salphen)的线型聚合物,其分子量通过凝胶渗透色谱测定,该聚合物用于催化2,3,6-三甲基苯酚氧化,24 h 2,3,6-三甲基苯酚的转化率可以达到99%,且该催化剂可以循环使用3次无明显的转化率和选择性下降。 A linear polymer containing Co(Salphen) was synthesized by Suzuki coupling with bromine-containing Co(Salphen) and 1,4-benzenediboronic acid. The molecular weight was determined by gel permeation chromatography. The polymer was used to catalyze the oxidation of 2,3,6-trimethylphenol, the conversion of 2,3,6-trimethylphenol could reach 99% at 24 h and the catalyst could be recycled for 3 times without significant reduction in conversion.
祥张 小
Published: 1 January 2018
Studies in Synthetic Chemistry, Volume 6, pp 49-54; https://doi.org/10.12677/ssc.2018.63008

Abstract:
随着国内国民经济连续几年不断增长,由此引发的环境污染不容忽视,尤其是在国内北方地区雾霾天气连续几年有持续加重趋势,传统的防雾霾产品,出行口罩,室内空气过滤器、窗帘,近几年在我国北方地区销售行情一直看好,调查发现这些传统防雾霾产品存在过滤空气中颗粒粒径范围窄、过滤效率低、力学性能差等缺点,本研究基于以上缺点,主要采用静电纺丝技术,首先以聚丙烯腈(PAN)为原料,N-N二甲基甲酰胺(DMF)为溶剂(1:9),混合适量改性石墨烯通过调整工艺参数制备出了不同浓度的PAN纤维膜,开发出一种过滤空气中颗粒粒径范围较广、过滤效率较高、具有一定力学强度的过滤布用纤维。当纤维膜克重约为250 g/m2左右、空气流量为30 L/min时,300~500 nm尺寸范围内的氯化钠和油性气溶胶颗粒的过滤效率分别达99.89%和99.88%,阻力压降仅为115和117 Pa。 As domestic national economy growing for several years, the environmental pollution is getting worse and worse, especially in northern areas of the country. For several years, with the growing trend of traditional products, prevent mist haze travel masks, indoor air filter, curtain, in recent years in north China regional sales market has been bullish. The survey found that these traditional products have shortcomings of preventing mist haze filter with narrow particle size range, low efficiency and poor mechanical properties. Based on the above shortcoming, this study mainly uses the electrostatic spinning technique, taking the first with polyacrylonitrile (PAN) as raw material, N-N dimethylamide (DMF) as the solvent (1:9). By blending appropriate amount of modified graphene, PAN fiber films of different concentrations were prepared by adjusting process parameters, and a kind of filter fabric used for filtering air with wide particle size range, high filtration efficiency and certain mechanical strength was developed. When the weight of fiber membrane is about 250 g/m2 and the air flow is 30 L/min, the filtration efficiency of sodium chloride and oily aerosol particles within the size range of 300 - 500 nm reaches 99.89 and 99.88, and the drag pressure drop was only 115 and 117 Pa.
俊陈 俊
Published: 1 January 2018
Studies in Synthetic Chemistry, Volume 6, pp 43-48; https://doi.org/10.12677/ssc.2018.63007

Abstract:
鉴于3,4-亚甲二氧苯基片段在许多药物中均为重要的药效团,本研究以经典的二芳基嘧啶类HIV-1抑制剂代表性化合物TMC125为先导化合物,将其左翼苯基替换为3,4-亚甲二氧苯基设计得到具有双环左翼的目标分子,以期得到活性更佳的新化合物。分子对接验证了设计的合理性。目标化合物的合成方法如下:以2-硫脲嘧啶为起始原料,通过三步反应得到关键中间体2-(对氰基苯胺基)-4-氯嘧啶;该中间体与芝麻酚发生亲核取代反应得到目标化合物,收率为89%。采用核磁共振氢谱(1H NMR)、核磁共振碳谱(13C NMR)和质谱(MS)表征了其结构。 Considering that 3,4-methylenedioxyphenyl fragment was an important pharmacophore in many drugs, in this work, the left wing phenyl of TMC125 as lead compound, a representative compound of classical diarylpyrimidine HIV-1 inhibitors, was replaced by 3,4-methylenedioxyphenyl to design a new target molecule bearing a bicyclic left wing, which is aimed to obtain a new compound with better biological activities. Molecular docking verified the rationality of this design. The synthetic method of the target compound was as follows: firstly, the key intermediate 2-(4-cyanoani-lino)-4-chloropyrimidine was prepared via three-step reactions from 2-thiouracil as the starting material. Next, the nucleophilic substitution of sesamol with the intermediate afforded the target compound in a yield of 89%, which was characterized by 1H NMR, 13C NMR and MS.
习 娟
Published: 1 January 2018
Studies in Synthetic Chemistry, Volume 6, pp 55-59; https://doi.org/10.12677/ssc.2018.64009

Abstract:
对化妆品用防腐剂氯苯甘醚的合成方法、作用机理及色谱分析进行了详述,并对防腐剂氯苯甘醚的发展趋势及存在问题进行了展望。 The synthetic method, mechanism and chromatographic analysis of preservative chlorphenesin in cosmetics were described, and the development trend and problems of preservative chlorphenesin were prospected.
冯胜 鹏
Published: 1 January 2018
Studies in Synthetic Chemistry, Volume 6, pp 37-42; https://doi.org/10.12677/ssc.2018.62006

Abstract:
Brønsted酸性离子液体1,3-二羧甲基咪唑硫酸氢盐[DC2O2IM][HSO4]催化芳香醛、β-萘酚和酰胺在无溶剂条件下90˚C反应10 min合成了一系列氨基萘酚化合物。该方法有操作简单、反应时间短等特点。 A series of amino naphthol compounds were synthesized via three component condensations of aromatic aldehyde, β-naphthol and amide employing Brønsted acid ionic liquid [DC2O2IM][HSO4] as a catalyst at 90˚C for 10 minutes under solvent-free conditions. The method has the advantages of simple operation and short reaction time.
瑞 郭
Published: 1 January 2018
Studies in Synthetic Chemistry, Volume 6, pp 29-36; https://doi.org/10.12677/ssc.2018.62005

Abstract:
离子液体4-苯基-3-丙基磺酸基四氢噻唑-2-硫酮硫酸氢盐催化芳香醛、1,3-二羰基化合物和脲或硫脲发生Biginelli反应合成了一系列3,4-二氢嘧啶-2(1H)-(硫)酮类化合物。本实验方法操作简单、反应条件温和、后处理方便。离子液体催化剂重复使用6次后,产率无明显变化。 A series of 3,4-dihydropyrimidine-2(1H)-(thio)ones were synthesized via the Biginelli reaction of aromatic aldehydes, 1,3-dicarbonyl compounds and urea or thiourea catalyzed by ionic liquid 4-phenyl-3-(3-sulfopropyl)tetrahydrothiazole-2-thione hydrogen sulfate. The experiment method has the advantages of simple operation, mild reaction condition, and convenient treatment. When the ionic liquid catalyst was reused for 6 times, the yield had no obvious change.
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