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Results in Journal Toxicology: 11,117

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Cássia R. Roque, Letícia R. Sampaio, Mayumi N. Ito, Daniel V. Pinto, Juan S.R. Caminha, Paulo I.G. Nunes, Ramon S. Raposo, , Cláudia C. Windmöller, , et al.
Published: 17 October 2021
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Mary Nellis, Caitlin O. Caperton, Ken Liu, Vilinh Tran, Young-Mi Go, Lance M. Hallberg, Bill T. Ameredes, Dean P. Jones,
Published: 11 October 2021
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Jana Slováčková, Josef Slavík, Pavel Kulich, Josef Večeřa, Ondrej Kováč, Hana Paculová, Nicol Straková, Radek Fedr, , , et al.
Published: 7 October 2021
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Vedran Mužinić, Anja Katić, Vilena Kašuba, Vedran Micek, Mirta Milić,
Published: 7 October 2021
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María Isabel Martínez-Martínez, ,
Published: 6 October 2021
Abstract:
Phthalates are chemicals widely used in packaging and consumer products, which have been shown to interfere with normal hormonal function and development in some human and animal studies. In recent decades, pregnant women’s exposure to phthalates has been shown to alter the cognitive outcomes of their babies, and some studies have found delays in motor development. Methods: electronic databases including PubMed/MEDLINE and Scopus were searched from their inception to March 2021, using the keywords "phthalate", "cognitive" and "motor". Results: most studies find statistically significant inverse relationships between maternal urinary phthalate concentration during pregnancy and subsequent outcomes in children's cognitive and motor scales, especially in boys rather than girls. However, many associations are not significant, and there were even positive associations, especially in the third trimester. Conclusion: the relationship between exposure to phthalates during pregnancy and low results on neurocognitive scales is sufficiently clear to adopt policies to reduce exposure. Further studies are needed to analyze sex differences, coordination and motor scales, and phthalate levels during breastfeeding.
Yejin Yang, Sugyeong Ha, Somi Jeong, Chae Won Jang, Jeongwon Kim, Dong-Soon Im, Hae Young Chung,
Published: 4 October 2021
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Lauren G. Poole, Anna-Katherine Fournier, Holly M. Cline-Fedewa, Anna K. Kopec, James P. Luyendyk,
Published: 4 October 2021
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, Jonathan E. Forman, Mohammad Abdollahi, Abdullah Saeed Al-Amri, Augustin Baulig, Djafer Benachour, Veronica Borrett, Flerida A. Cariño, , Michael Geist, et al.
Published: 4 October 2021
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Cynthia E. Francis, Logan Allee, Helen Nguyen, Rachel D. Grindstaff, ,
Published: 2 October 2021
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Binbin Song, Shigeki Aoki, Cong Liu, Takeshi Susukida, Saki Kuwahara,
Published: 1 October 2021
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, Noömi Lombaert, Carol Mackie, Alain Renard, , Violaine Verougstraete, Nicky J.J. Lourens
Published: 1 October 2021
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Yujie Huang, Jie Zhang, Yizhou Tao, Cheng Ji, Stanley Aniagu, ,
Published: 28 September 2021
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Olakkaran Shilpa, Kizhakke Purayil Anupama, Anet Antony,
Published: 21 September 2021
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, Nadgrita Phutubtim, Bunkuea Chantrathonkul, , Somsak Ruchirawat,
Published: 21 September 2021
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Chunli Xia, Jian Wang, Zhiyong Wu, Yusong Miao, Chunli Chen, Rui Li, ,
Published: 21 September 2021
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Jiaming Yuan, Chenjuan Yao, Jing Tang, Yingqi Liu, Chunyan Huang, Shali Yu, Haiyan Wei, ,
Published: 21 September 2021
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Ebrahim Bani Hassan, Nancy Doyle, Jean-Guy Bienvenu, Andrew Stent, ,
Published: 20 September 2021
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Courtney Sakolish, Yu-Syuan Luo, Alan Valdiviezo, Lawrence A. Vernetti, Ivan Rusyn,
Published: 17 September 2021
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, , Varvara G. Nikonorova, Vladimir A. Mironov
Published: 17 September 2021
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Yuanliang Li, Jiangnan Yi, Qiwen Zeng, Yingwei Liu, Bijing Yang, Bingxian Liu, Yangwei Li, Khalid Mehmood, Riaz Hussain, Zhaoxin Tang, et al.
Published: 16 September 2021
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Published: 16 September 2021
Abstract:
Outdoor air pollution is classified as carcinogenic to humans and exposure to it contributes to increased incidence of various diseases, including cardiovascular, neurological or pulmonary disorders. Vehicle engine emissions represent a significant part of outdoor air pollutants, particularly in large cities with high population density. Considering the potentially negative health impacts of engine emissions exposure, the application of reliable test systems allowing assessment of the biological effects of these pollutants is crucial. The exposure systems should use relevant, preferably multicellular, cell models that are treated with the complete engine exhaust (i.e. a realistic mixture of particles, chemical compounds bound to them and gaseous phase) at the air-liquid interface. The controlled delivery and characterization of chemical and/or particle composition of the exhaust should be possible. In this mini-review we report on such exposure systems that have been developed to date. We focus on a brief description and technical characterization of the systems, and discuss the biological parameters detected following exposure to a gasoline/diesel exhaust. Finally, we summarize and compare findings from the individual systems, including their advantages/limitations.
Ling Huang, Jieping Liu, WanBo Li, Fasheng Liu, Mengqi Wan, Guilan Chen, Meile Su, Chen Guo, Fang Han, Guanghua Xiong, et al.
Published: 15 September 2021
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Marie Gilardoni, Daniel Léonço, Fanny Caffin, Fanny Gros-Désormeaux, Camille Eldin, David Béal, Sadia Ouzia, Christophe Junot, , Christophe Piérard, et al.
Published: 14 September 2021
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Ying Huang, Jia Wang, Shuo Wang, Xiaotian Xu, Weichao Qin, , , Christopher J. Martyniuk
Published: 13 September 2021
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Qiang Xu, Quanxu Chen, Liben Lin, Pu Zhang, Zengqiang Li, Yige Yu, Feifei Ma, Yingfen Ying, Xiaoheng Li,
Published: 9 September 2021
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, Alessandro Mariani, Davide Comolli, Roberto Fanelli, Enrico Davoli, Massimiliano De Paola, Renzo Bagnati
Published: 9 September 2021
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Ji-Eun Seo, Kelly Davis, Pritpal Malhi, Xiaobo He, Matthew Bryant, John Talpos, Susan Burks, Nan Mei,
Published: 9 September 2021
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Zhaoyu Zhang, Jun Yu, Jie Xie, Duanya Liu, Yongsheng Fan, Haitao Ma, ,
Published: 9 September 2021
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Yanxian Bai, Ziting Gu, Tong Zhang, Yuyou Luo, Chunmei Zhang, Li Luo, Yuxin Ma,
Published: 9 September 2021
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Tingting Zhang, Xiaomei He, Lanlan Sun, Dong Wang, Shuya Zhang, Jianping Mao, Fengjiao Zhang
Published: 4 September 2021
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Sadiya Sadiq Shiek, Monica Shirley Mani, ,
Published: 4 September 2021
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Liye Zhu, Haomiao Wang, Jieyu Yuhan, Boyang Zhang, Hongyu Li, Charles Asakiya, Kunlun Huang, Xiaoyun He,
Published: 3 September 2021
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Published: 2 September 2021
Abstract:
Contemporary approaches to human health risk assessment for respiratory tract irritants are variable and controversial. This manuscript provides an in-depth analysis and assessment of the applicability of the classical respiratory depression 50 % (RD50) assay with focus on the Log-linear extrapolation of the non-sensory irritant threshold (RD0 or RD10) relative to the contemporary Point of Departure (POD) U.S.-EPA benchmark approach. Three prototypic volatile chemically reactive irritants are used to exemplify the pros and cons of this alternative approach. These irritants differ in physicochemical properties affecting water-solubility and lipophilicity. Depending on these variables, a vapor may preferentially be retained in the extrathoracic region (ET), the tracheobronchial region (TB), and the pulmonary region (PU); although a smooth transition between these regions occurs at increasingly high concentrations. Each region has its specific nociceptors sensing irritants and regional-specific response to injury. The alternative approach using rats identified the chemical-specific critical region of respiratory tract injury. Statistically derived PODs on ET-TB related sensory irritation provide important information for ET-TB irritants but not for PU irritants. The POD of ET-TB irritants from acute and repeated studies decreased substantially. In summary, statistically derived PODs improve the risk assessment of respiratory tract irritants; however, those from repeated exposures should be given preference to those from acute exposures.
, Wenwen Gui, Biyang Jiao, Lei Han, Feng Wang
Published: 2 September 2021
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Hasenbilige, Junjie Mei, Mongameli B. Dlamini, Zeyun Gao, Liping Jiang, Qiujuan Li, Chengyan Geng, Xiaoxia Shi, , , et al.
Published: 2 September 2021
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Yunyun Shao, Xinqi Wang, Ying Zhou, Yiming Jiang, Ruoman Wu,
Published: 30 August 2021
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Moonjung Hyun, Laxmi Rathor, Hye-Jin Kim, Taylor McElroy, Kwang Hyun Hwang, Stephanie Wohlgemuth, Shayla Curry, , Christiaan Leeuwenburgh, Jeong-Doo Heo, et al.
Published: 30 August 2021
Abstract:
Bisphenol A (BPA) is a chemical compound commonly used in the production of plastics for daily lives and industry. As BPA is well known for its adverse health effects, several alternative materials have been developed. This study comprehensively analyzed the toxicity of BPA and its three substitutes including bisphenol S (BPS), bisphenol F (BPF), and tetramethyl bisphenol F (TMBPF) on aging, healthspan, and mitochondria using an in vivo Caenorhabditis elegans (C. elegans) model animal and cultured mammalian fibroblast cells. C. elegans treated with 1 mM BPA exhibited abnormalities in the four tested parameters related to development and growth, including delayed development, decreased body growth, reduced reproduction, and abnormal tissue morphology. Exposure to the same concentration of each alternative including TMBPF, which has been proposed as a relatively safe BPA alternative, detrimentally affected at least three of these events. Moreover, all bisphenols (except BPS) remarkably shortened the organismal lifespan and increased age-related changes in neurons. Exposure to BPA and BPF resulted in mitochondrial abnormalities, such as reduced oxygen consumption and mitochondrial membrane potential. In contrast, the ATP levels were noticeably higher after treatment with all bisphenols. In mammalian fibroblast cells, exposure to increasing concentrations of all bisphenols (ranging from 50 µM to 500 µM) caused a severe decrease in cell viability in a dose-dependent manner. BPA increased ATP levels and decreased ROS but did not affect mitochondrial permeability transition pores (mPTP). Notably, TMBPF was the only bisphenol that caused a significant increase in mitochondrial ROS and mPTP opening. These results suggest that the potentially harmful physiological effects of BPA alternatives should be considered.
, Nona Struyf, Vivien Steffensen, Jonas Bergquist, , Eva Brittebo, Malin Andersson
Published: 30 August 2021
Abstract:
Glyphosate, the most used herbicide worldwide, has been suggested to induce neurotoxicity and behavioral changes in rats after developmental exposure. Studies of human glyphosate intoxication have reported adverse effects on the nervous system, particularly in substantia nigra (SN). Here we used matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry (IMS) to study persistent changes in peptide expression in the substantia nigra (SN) of 90-day-old adult male Wistar rats. The animals were perinatally exposed to 3% GBH (glyphosate-based herbicide) in drinking water (corresponding to 0.36% of glyphosate) starting at gestational day 5 and continued up to postnatal day 15 (PND15). Peptides are present in the central nervous system before birth and play a critical role in the development and survival of neurons, therefore, observed neuropeptide changes could provide better understanding of the GBH-induced long term effects on SN. The results revealed 188 significantly altered mass peaks in SN of animals perinatally exposed to GBH. A significant reduction of the peak intensity (P < 0.05) of several peptides from the opioid-related dynorphin family such as dynorphin B (57%), alpha-neoendorphin (50%), and its endogenous metabolite des-tyrosine alpha-neoendorphin (39%) was detected in the GBH group. Immunohistochemical analysis confirmed a decreased dynorphin expression and showed a reduction of the total area of dynorphin immunoreactive fibers in the SN of the GBH group. In addition, a small reduction of dynorphin immunoreactivity associated with non-neuronal cells was seen in the hilus of the hippocampal dentate gyrus. Perinatal exposure to GBH also induced an increase in the number of nestin-positive cells in the subgranular zone of the dentate gyrus. In conclusion, the results demonstrate long-term changes in the adult male rat SN and hippocampus following a perinatal GBH exposure suggesting that this glyphosate-based formulation may perturb critical developmental neuronal processes.
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