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Results in Journal Journal of Stem Cells Research, Development & Therapy: 92

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, Cristina Grange, Luca Marozio, Chiara Benedetto, Laura Perin, Benedetta Bussolati
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-8; https://doi.org/10.24966/srdt-2060/100041

Ana I García-Guillén, University Of Murcia
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-6; https://doi.org/10.24966/srdt-2060/100037

Stavroula D Manolakou, University Hospital Of Heraklion
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-9; https://doi.org/10.24966/srdt-2060/100040

L Vriend, University Of Groningen And University Medical Center Groningen
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-7; https://doi.org/10.24966/srdt-2060/100036

Soon Koo Baik
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-5; https://doi.org/10.24966/srdt-2060/100049

Abstract:
Based on the therapeutic potential of MSCs, including homing to damaged sites, trans-differentiation, secretion of trophic factors, and immunomodulation, approximately 1,100 clinical studies have been registered in the ClinicalTrials.Gov, and several drugs using MSCs have been approved worldwide. However, despite their therapeutic potential, MSCs have not yet shown sufficient therapeutic effects in humans. Therefore, in order to increase the therapeutic potential of MSCs, methods such as MSC priming, genetic modification, Three-Dimensional (3-D) culture, and MSC-derived exosomes are being studied intensively. Among them, genetic modification increases the expression of therapeutic genes, leading to increased homing of MSCs to the damaged sites, increased engraftment rates, and increased survival durations of transplanted MSCs.
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-3; https://doi.org/10.24966/srdt-2060/100048

Abstract:
In this study, we showed that proteasome inhibitors selectively suppress the synthesis of Alpha One Antitrypsin (?1AT) by inducing phosphorylation of eukaryotic translation initiation factor 2? and increasing the association of stress granule RNA binding proteins with ?1AT mRNA.
, 49210 Zabok/ 10000 Zagreb St. Catherine Specialty Hospital
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-6; https://doi.org/10.24966/srdt-2060/100050

Abstract:
Osteoarthritis is the most common musculoskeletal progressive disease, affecting 303 million people worldwide. The prevalence of knee OA among adults 60 years-of-age and older is approximately 10% in men and 13% in women. Although surgical treatment still provides the gold standard in knee osteoarthritis therapy, mesenchymal stem cell therapy is increasingly gaining the attention of physicians. Therefore, a thorough understanding of osteoarthritis pathogenesis is essential for successful treatment.
, University of Pittsburgh School of Medicine
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-8; https://doi.org/10.24966/srdt-2060/100047

Abstract:
The plantar fascia is a ligament connecting the heel bone to the toes and is constantly subjected to mechanical loads during daily activities. Despite being one of the most common foot diseases in orthopedics, the mechanism of plantar fasciitis remains largely unknown and there is no effective treatment.
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-9; https://doi.org/10.24966/srdt-2060/100046

Abstract:
Tissue engineering aims to develop constructs that maintain, restore, or improve tissue function. Recent advancements in Three-Dimensional (3D) bioprinting have brought great potential for tissue engineering of many different tissues and organs, such as skin and heart.
Matias Cristian Fernández Viña, Universidad Abierta Interamericana Facultad De Medicina Y Cs De La Salud
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-5; https://doi.org/10.24966/srdt-2060/100044

Abstract:
Since there are no currently accepted therapies for corona virus disease 2019 worldwide search for treatment options are ongoing. Past experiences with viral infections are important in this respect.
Teruhide Yamaguchi, Kanazawa Institute of Technology
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-5; https://doi.org/10.24966/srdt-2060/100042

Abstract:
Matrix Metalloproteinase-9 (MMP-9) plays an important role in the migration of and tissue invasion by vascular endothelial cells. Additionally, early Endothelial Progenitor Cells (EPCs) are known to play a key role in the recruitment of endothelial cells in angiogenesis
, Tongji University
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-6; https://doi.org/10.24966/srdt-2060/100043

Abstract:
This review aims to summarize stem cells biology and types, and their potential use in many dermatological conditions. This article also summarizes about the stem cells present in the skin, their usage and identification.
, THomas Jefferson University
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-12; https://doi.org/10.24966/srdt-2060/100045

Abstract:
HOX genes are best known for their ability to control embryonic Stem Cells (SCs) that specify body pattern segmentation during development. HOX genes also regulate adult SCs by specifying SC differentiation into specialized cell lineages.
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-6; https://doi.org/10.24966/srdt-2060/100035

Abstract:
In this study, we used decellularized canine placentas for recellularization with mesenchymal stem cells derived from fetal canine bone marrow and canine dental pulp. It was demonstrated by immunofluorescence analysis that the placental matrices cultured with two cell types for 7 days obtained satisfactory results, evidencing the interaction of the cells by the positive expression of CD90+ and CD105+ mesenchymal stem cells markers in the extracellular matrix.
, Buenos Aires Mater Cell
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-3; https://doi.org/10.24966/srdt-2060/100034

Abstract:
In this brief review, we describe different culture supplements used for in vitro stem cell expansion and summarize our previous work in which we developed a methodology to obtain human serum and platelet lysate to be used as culture supplements.
Xiaojian Ye
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-4; https://doi.org/10.24966/srdt-2060/100033

Abstract:
The incidence of lower back pain caused by Intervertebral Disc Degeneration (IDD) is increasing due to changes in modern living and working, which places severe family and social burdens [1]. The clinical treatments for IDD are mainly symptomatic conservative and surgical operations. None of the current methods can reverse IDD, and surgery may even accelerate the process of IDD in adjacent segments [2].
, (Eu European Wellness Aesthetic Academy
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-7; https://doi.org/10.24966/srdt-2060/100032

Abstract:
This study was done to elicit the efficacy and potency of mesotherapy using a cocktail of triple strength nano-sizedpeptides from the skin, placenta, mesenchyme fortified with collagen and Hyaluronic Acid (HA) in the revitalisation of the skin of the dorsum of the hand.
Xavier Santamaría Costa
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-4; https://doi.org/10.24966/srdt-2060/100031

Abstract:
The endometrium is a highly dynamic tissue that is fully reconstitued after each menstrual cycle during the reproductive period, and throughout the entire life-span if hormonal supplementation is administered [1]. Functionally, the endometrium is composed of two functionally distinct layers, the superficial stratum called functionalis and the deeper stratum, called basalis.
Verónica Cantarín-Extremera, Alfonsa Friera, África González-Murillo, Gustavo J Melen, Inmaculada De Prada-Vicente, María C Fournier Del Castillo, María A Pérezjiménez, María L Ruiz-Falcó-Rojas,
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-8; https://doi.org/10.24966/srdt-2060/100030

Abstract:
Rasmussen’s Encephalitis (RE) is a devastating pediatric syndrome. Patients receive different therapies, and eventually undergo functional hemispherectomy as the only treatment to achieve complete control of epileptic seizures. New therapies are needed to improve the prognosis of this rare disease. Since cytotoxic T lymphocytes have an active role in the pathogenic process of RE, we evaluated the feasibility of Mesenchymal Stem Cells (MSCs) for patients with RE based on the known immunomodulatory potential of these cells.
, Second Military Medical University
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-5; https://doi.org/10.24966/srdt-2060/100028

, Mansoura University
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-5; https://doi.org/10.24966/srdt-2060/100027

Abstract:
Cell transplantation for the control of diabetes may be carried out within a scaffold or an encapsulation device. The use of Mesenchymal Stromal Cells (MSCs) as a source for Insulin-Producing Cells (IIPCs) provides a chance for an autologous application.
, University Of Miami Leonard M. Miller School Of Medicine
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-7; https://doi.org/10.24966/srdt-2060/100024

Abstract:
Peripheral Arterial Disease (PAD) is a progressive, atherosclerotic disease that at its end stage, Critical Limb Ischemia (CLI), results in severely diminished limb perfusion and causes leg pain at rest, non-healing ulcers, and tissue gangrene. Many patients with CLI fail current medical and surgical therapies and thus are deemed “no option” and require limb amputation.
, Army Medical University
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-8; https://doi.org/10.24966/srdt-2060/100025

Abstract:
Cardiovascular grafts often cause serious complications and risks due to thrombosis. The immune rejection and inflammatory response induced by the implantation of cardiovascular grafts often lead to platelet adhesion, activation, aggregation and chemotaxis of inflammatory cells and further lead to thrombosis.
, São Leopoldo Mandic Dental Institute and Research Center
Journal of Stem Cells Research, Development & Therapy, Volume 5, pp 1-6; https://doi.org/10.24966/srdt-2060/100018

, The Fourth Military Medical University
Journal of Stem Cells Research, Development & Therapy, Volume 5, pp 1-5; https://doi.org/10.24966/srdt-2060/100021

Xusehng Wang, Sun Yat-Sen University
Journal of Stem Cells Research, Development & Therapy, Volume 5, pp 1-5; https://doi.org/10.24966/srdt-2060/100016

Fernández Viña Matías, Cardiology And Hemodynamic Service San Nicolas Clinic
Journal of Stem Cells Research, Development & Therapy, Volume 4, pp 1-5; https://doi.org/10.24966/srdt-2060/100010

, California Stem Cell Treatment Center
Journal of Stem Cells Research, Development & Therapy, Volume 4, pp 1-6; https://doi.org/10.24966/srdt-2060/100011

Abstract:
The fascinating story of Stromal Vascular Fraction (SVF) and its prominent role in autologous regenerative therapies (or Personal Cell Therapy - PCT) continues to evolve as scientific and regulatory issues develop. The primary objective of this special report will elucidate the history, composition and scientific analysis of SVF as an autologous biologic experiencing widespread clinical use
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