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Results in Journal Journal of Stem Cells Research, Development & Therapy: 90

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Jiuhong Kang, Tongji University
Journal of Stem Cells Research, Development & Therapy, Volume 1, pp 1-10; https://doi.org/10.24966/srdt-2060/100002

Abstract:
Herald Scholarly Open Access publishes peer-reviewed scientific research which provides an immediate free access to articles. Herald Scholarly Open Access is publishing articles in 47 peer-reviewed Open Access journals in Biology, Medicine and Clinical sciences.
, Saitama Medical University
Journal of Stem Cells Research, Development & Therapy, Volume 1, pp 1-6; https://doi.org/10.24966/srdt-2060/100001

Abstract:
Herald Scholarly Open Access publishes peer-reviewed scientific research which provides an immediate free access to articles. Herald Scholarly Open Access is publishing articles in 47 peer-reviewed Open Access journals in Biology, Medicine and Clinical sciences.
, Total Potential Cells (P) Ltd
Journal of Stem Cells Research, Development & Therapy, Volume 3, pp 1-6; https://doi.org/10.24966/srdt-2060/100008

Abstract:
Herald Scholarly Open Access publishes peer-reviewed scientific research which provides an immediate free access to articles. Herald Scholarly Open Access is publishing articles in 47 peer-reviewed Open Access journals in Biology, Medicine and Clinical sciences.
, Kyoto University
Journal of Stem Cells Research, Development & Therapy, Volume 2, pp 1-9; https://doi.org/10.24966/srdt-2060/100005

Abstract:
Herald Scholarly Open Access publishes peer-reviewed scientific research which provides an immediate free access to articles. Herald Scholarly Open Access is publishing articles in 47 peer-reviewed Open Access journals in Biology, Medicine and Clinical sciences.
, Syrian Private University
Journal of Stem Cells Research, Development & Therapy, Volume 2, pp 1-6; https://doi.org/10.24966/srdt-2060/100006

Abstract:
Herald Scholarly Open Access publishes peer-reviewed scientific research which provides an immediate free access to articles. Herald Scholarly Open Access is publishing articles in 47 peer-reviewed Open Access journals in Biology, Medicine and Clinical sciences.
, Johann-Wolfgang-Goethe University Hospital
Journal of Stem Cells Research, Development & Therapy, Volume 2, pp 1-7; https://doi.org/10.24966/srdt-2060/100004

Abstract:
Herald Scholarly Open Access publishes peer-reviewed scientific research which provides an immediate free access to articles. Herald Scholarly Open Access is publishing articles in 47 peer-reviewed Open Access journals in Biology, Medicine and Clinical sciences.
, Sheffield Hallam University
Journal of Stem Cells Research, Development & Therapy, Volume 2, pp 1-9; https://doi.org/10.24966/srdt-2060/100003

Abstract:
Herald Scholarly Open Access publishes peer-reviewed scientific research which provides an immediate free access to articles. Herald Scholarly Open Access is publishing articles in 47 peer-reviewed Open Access journals in Biology, Medicine and Clinical sciences.
, Raymond Purves Bone and Joint Research Laboratory
Journal of Stem Cells Research, Development & Therapy, Volume 3, pp 1-7; https://doi.org/10.24966/srdt-2060/100009

Abstract:
Herald Scholarly Open Access publishes peer-reviewed scientific research which provides an immediate free access to articles. Herald Scholarly Open Access is publishing articles in 47 peer-reviewed Open Access journals in Biology, Medicine and Clinical sciences.
, Fortis Memorial Research Institute
Journal of Stem Cells Research, Development & Therapy, Volume 3, pp 1-10; https://doi.org/10.24966/srdt-2060/100007

Abstract:
Herald Scholarly Open Access publishes peer-reviewed scientific research which provides an immediate free access to articles. Herald Scholarly Open Access is publishing articles in 47 peer-reviewed Open Access journals in Biology, Medicine and Clinical sciences.
Jeong-Hee Yang, 13 F Glaston Bd. 108 Bongeunsa-Ro MitoImmune Therapeutics Inc., Soon Ha Kim
Journal of Stem Cells Research, Development & Therapy, Volume 8, pp 1-4; https://doi.org/10.24966/srdt-2060/100089

Abstract:
The impact of inflammatory environments on the impaired features of MSCs, such as loss of homeostasis and stem cell senescence, still remains unclear. In the paper titled “MIT-001 Restores Human Placenta-Derived Mesenchymal Stem Cells by Enhancing Mitochondrial Quiescence and Cytoskeletal Organization”, Yu et al., investigated the phenotypes of MSCs exposed to pro-inflammatory cytokines TNF-α and IFN-γ. They further tested whether the exposed MSCs are protected from senescence by MIT-001, a novel necrosis inhibitor and an anti-inflammatory molecule
, Enzo Maria Vingolo, Mauro Budini
Journal of Stem Cells Research, Development & Therapy, Volume 8, pp 1-9; https://doi.org/10.24966/srdt-2060/100093

Abstract:
Etinal degenerative diseases, such as Stargardt’s Disease (SD), glaucoma, Retinitis Pigmentosa (RP), Age-Related Macular Degeneration (AMD) or Diabetic Retinopathy (DR), represent the main causes of a decreased quality of vision and blindness worldwide. The progression and management of these conditions have always represented a challenge, but promising new evidences about the efficacy of Mesenchymal Stem Cells (MSCs) as therapy for these diseases has been shown
Allison Podsednik, Raysa Cabrejo,
Journal of Stem Cells Research, Development & Therapy, Volume 8, pp 1-3; https://doi.org/10.24966/srdt-2060/100091

Abstract:
Peripheral nerve surgery involves suturing an injured nerve to itself or to another nerve end-to-end or side-to-end to promote regeneration of the damaged nerve. Nerve surgeries include repair, grafting, transfer, and decompression
Juan Carlos Biancotti, Nicholas Carpo, Joile Zamudio, Laurent Vergnes, Araceli Espinosa-Jeffrey
Journal of Stem Cells Research, Development & Therapy, Volume 8, pp 1-12; https://doi.org/10.24966/srdt-2060/100094

Abstract:
Microgravity and the space environment have significant impact on the physiology of organisms. Understanding the responses elicited in the Central Nervous System (CNS) such as alteration in the visual function process and the regulation of biological pathways leading to changes of the CNS function, is critical to design contra measures aiming to mitigate the impact on astronaut’s health
Swapan Kumar Maiti, Guy Wouters, Dimitry Spitkovsky, Jurgen Hescheler, Fat Stem Laboratories Scientific Director And Ceo
Journal of Stem Cells Research, Development & Therapy, Volume 8, pp 1-6; https://doi.org/10.24966/srdt-2060/100092

Abstract:
Equine multipotent mesenchymal stem cells (hrs-MSC) can be isolated from various tissues including Adipose Tissue (AT) and Umbilical Cord Blood (UCB). We have analyzed the effect of different oxygen tension on hrs-AT-MSC and hrs-UCB-MSC cultured and assessed proliferation, morphology, viability and immunophenotype and plasticity. Both type of equine MSC were cultured separately in normoxic (21% O2) and hypoxic (5% O2) environment
, 37 – 66100 Chieti Via Caduti Sul Lavoro, Sara Di Teodoro
Journal of Stem Cells Research, Development & Therapy, Volume 8, pp 1-7; https://doi.org/10.24966/srdt-2060/100090

Abstract:
Periodontal disease affects patient's health worsening people's quality of life. This clinical case reports the treatment of a 45 years old patient with periodontitis including open flap debridement in first and fourth quadrant and laser treatment on second quadrant
Yehonatan Zur, Tzila Davidov, Limor Baruch,
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-3; https://doi.org/10.24966/srdt-2060/100086

Abstract:
Aiming to restore the normal function of diseased or injured tissues, regenerative therapy approaches are generally based on the engineering of complex tissue-mimicking grafts, encompassing biomaterial scaffolds, stem cells, or their combinations [1-4]. Due to the major role of stem cells in physiological regenerative mechanisms, regenerative therapies normally rely on either stem cells transplantation or stem cell recruitment from the neighboring tissue into the implanted scaffold
, Via Caduti Sul Lavoro Private Practitioner, Sara Di Teodoro, Luisa Romondio, Luigi Zagaria
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-8; https://doi.org/10.24966/srdt-2060/100084

Abstract:
The purpose of this clinical case report is to describe a full-arch rehabilitation with one to one endosseous implant restoration. Although the proposed treatment may not be within the financial means of most patients, the aesthetical result is higher because of the close similarity between the final restorations and the natural dentition.
, A Trbolová, M Hluchý, D Cížková
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-7; https://doi.org/10.24966/srdt-2060/100083

Abstract:
Osteoarthritis (OA) is Degenerative Joint Disease (DJD) associated with pain, inflammation and cartilage degradation resulting in lameness. This state is irreversible and actual conventional therapies are not able to provide regeneration of damaged tissue. Current therapies, mainly NSAIDs, have many adverse effects and are not able to stop degenerative process
James Baumgartner, Linda Baumgartner, Llc Little Hearoes
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-3; https://doi.org/10.24966/srdt-2060/100082

Abstract:
Sensorineural Hearing Loss (SNHL) continues to be a significant public health problem with over 270 million affected people worldwide and an incidence that increases with age [1,2]. Some cases of SNHL have a genetic cause, but the majority of SHNL is the result of ototoxic insult [3]
, Universidad San Sebastián Facultad De Medicina Y Ciencias
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-6; https://doi.org/10.24966/srdt-2060/100080

Abstract:
Alzheimer’s disease is the most prevalent neurodegenerative disorder in the elderly population. The patients suffer cerebral atrophyas a consequence of extensive neuronal loss, especially in areas that play a role in memory and cognition. Cell therapies approaches have emerged as promising treatments to regenerate the brain tissue of the patients
Sophia Shaka, Nicolas Carpo, Victoria Tran, Carlos Cepeda,
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-9; https://doi.org/10.24966/srdt-2060/100088

Abstract:
There are two approaches used to study the effects of microgravity on cells -- using simulated microgravity on Earth (sim-µG) or sending cells to space (SPC-µG). We have recently reported that human neural stem cells (NSCs) proliferated seven-times more while in space than Ground Control (GC) NSCs on Earth. Here, using time-lapse microscopy, we determined that in both sim-µG and SPC-µG there are two cell subpopulations distinguished by differences in somatic diameter
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-9; https://doi.org/10.24966/srdt-2060/100076

Abstract:
This data indicates that the drug cytotoxicity assay aimed at targeting CSCs may be a useful tool for optimizing treatment selection when first-line therapy fails, and when there are multiple clinically-acceptable and -equivalent treatments available.
Marcelo Braga, Pain Physician Anesthesiologist
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-6; https://doi.org/10.24966/srdt-2060/100077

Abstract:
In this peculiar setting, the infiltrations with BMA proved to be an efficient alternative tool for the treatment of severe thoracic rib trauma and delayed union. The patient returned with no complaints and CT evidence indicated that all of the fractured ribs had complete consolidation. Pain and functional outcome of the chest wall in terms of stability improved with the help of this orthobiologic alternative.
, Grand Hôpital De L’Est Francilien Centre De Recherche Clinique
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-4; https://doi.org/10.24966/srdt-2060/100075

Abstract:
Mesenchymal Stem Cells (MSCs) are multipotent stromal cells found in bone marrow and have the capacity to differentiate into myofibroblast. In contractile myofibroblasts, the molecular motor is the non-muscle myosin (NMIIA) which differs from the muscle myosin by its ultra-slow kinetics. The differentiation of MSCs into myofibroblasts is promoted by the “Transforming Growth Factor” (TGF-b) which represents a potentially target against tissue fibrosis and cancer.
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-7; https://doi.org/10.24966/srdt-2060/100079

Abstract:
Tissue engineering has shown great promise in generating vascular grafts with properties similar to that of native blood vessels. Vascular Smooth Muscle Cells (VSMC) are the main component of the vasculature tunica media. Recreation of this layer represents a major challenge in tissue engineering due to difficulties in harvesting and culturing autologous VSMC. The use of stem cells and their inherent ability to differentiate into diverse cell types, including vascular lineages, have been proposed
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-7; https://doi.org/10.24966/srdt-2060/100073

Abstract:
We provide evidence to support the use of TotiCyte as a novel volume reduction technology capable of significantly improving CD34+ stem cell recovery
, São Paulo 05508-000 Pluricell Biotech
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-4; https://doi.org/10.24966/srdt-2060/100074

Abstract:
Recently, Biagi et al., 2021 published results of yet another successful demonstration of how hiPSC-derived cardiomyocytes can engraft in rats' hearts and improve their cardiac function [1]. According to the work, these results are probably due to the segmental improvement in areas where the grafts were found
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-6; https://doi.org/10.24966/srdt-2060/100068

Abstract:
Cells, scaffolds, growth factors and vascularity are four pillars in regenerative medicine. In the field of peripheral nerve regeneration, studies have been performed based on these four pillars. We have created an artificial nerve conduit model in rats, which can be applied to clinical settings in near future. Our artificial conduit is made of a polyglycolic acid filament-meshed tube containing a sural vascular pedicle and decellularized allogenic nerve basal lamellae implanted by bone marrow derived mesenchymal stem cells.
Sophia Shaka, Nicholas Carpo, Victoria Tran, Yao-Ying Ma, Fathi Karouia, Araceli Espinosa-Jeffrey
Journal of Stem Cells Research, Development & Therapy; https://doi.org/10.24966/srdt-2060/100069

Abstract:
Long-term travel and lengthy stays for astronauts in outer space are imminent. To date, more than 500 astronauts have experienced the extreme conditions of space flight including microgravity and radiation. For the past decade, many studies associated with long-duration spaceflight have shown the recurring occurrence of ophthalmic abnormalities. The reasons of the observed changes in some astronauts remained unclear. However, factors such as the increase in intracranial pressure and fluid shifts are among the top potential contributing elements.Here we report a study that specifically looked at the effect of space environment on the proliferation and physiology of human Neural Stem Cells (NSCs) onboard the International Space Station (ISS) as compared to ground controls. The study revealed that human NSCs proliferated seven times more while in space (SPC) when compared to on Earth (1G) control cultures. We also examined by continuous live imaging the behavior of space flown NSCs upon return to Earth. We found that after space flight, they continued proliferating at the same pace as 1G controls. Interestingly, NSCs flown to space displayed a larger diameter than control cells. These phenomena, increased proliferation while in space and larger cell soma may contribute to intracranial hypertension found in astronauts, representing a risk factor and potential limitation to long duration space missions such as travelling to the Moon or Mars. In addition, NSCs are essential to maintain Central Nervous System (CNS) function, as they are the basis for the regeneration of CNS cell populations in health and disease.
, Instituto De Cancerologia Bone Marrow Transplant Program
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-4; https://doi.org/10.24966/srdt-2060/100067

Abstract:
The use of haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide (Haplo-PTCy) is increasing in adults, but also in children; this procedure is a good alternative for transplanting pediatric patients lacking a matched family donor; indeed, this is very relevant in regions with economic constraints or with a population which is not well represented in the international donor registries which make access to unrelated cord blood units or bone marrow donors difficult.
, Via Caduti Sul Lavoro Private Practitioner
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-6; https://doi.org/10.24966/srdt-2060/100071

Abstract:
This clinical case report describes and demonstrates how advanced modern implantology can successfully handle severe vertical and horizontal bone defects.
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-4; https://doi.org/10.24966/srdt-2060/100070

Abstract:
The development of organ-like tissues is the next major challenge facing regenerative medicine. Organ-like structures have been synthesized on a small scale, but overcoming current problems with cell sourcing and scalability will facilitate the creation of cardiac assist devices and organs for transplantation. A major obstacle to generating Three-Dimensional (3D) tissues is that diffusion is inadequate for the supply of oxygen/nutrients and removal of waste products, which limits the thickness of the structure to about 0.1 mm
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-5; https://doi.org/10.24966/srdt-2060/100064

Abstract:
The Intervertebral Disc (IVD) is a fibrocartilaginous tissue instrumental in spine flexibility, allowing for the bending and twisting motion between vertebral bodies. Degenerative Disc Disease (DDD) results from the complex and chronic deterioration in IVD organization, structure, and function
, Chieti Private Practitioner
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-8; https://doi.org/10.24966/srdt-2060/100061

Abstract:
The method which I created and use in my daily routine, it’s a Soft-Surgery approach. The access can be made through an operculum or a mucoperiosteal flap, followed by an invitation to the alveolar crestal bone with a drill using different size burs and to avoid the breaking of the floor of the sinus and tearing of the schneiderian membrane, is important to stop a few millimeters from it
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-6; https://doi.org/10.24966/srdt-2060/100066

Abstract:
The management of retinitis pigmentosa (RP) and its progression has always been a difficult issue, but promising developments have been shown by the use of mesenchymal stem cells (MSCs). It has thus been evidenced how these cells have significant paracrine and immunomodulatory properties: they secrete trophic factors that stimulate RPE or that are similar to those produced by RPE.
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-4; https://doi.org/10.24966/srdt-2060/100065

Abstract:
COVID 19 pandemic has been with us for more than a year now and new insights in pathophysiology and clinical manifestations have emerged. Recent reports have shown that not only is acute COVID a life-threatening disease, but post COVID symptoms are more common than previously thought and may greatly affect quality of life. In this review, we explore the usefulness of regenerative rehabilitation with Mesenchymal Stem Cells (MSC) in post COVID symptoms based on previous knowledge in other medical conditions
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-5; https://doi.org/10.24966/srdt-2060/100062

Abstract:
Most researchers have recognized the beneficial effects of exercise on bone formation in the organism. Irisin released from muscles is considered to be the link between muscles and other organs, and its main function is to change subcutaneous and visceral adipose tissue into brown adipose tissue, with a consequent increase in thermogenesis. Irisin can regulate glucose metabolism, bone metabolic homeostasis, and systemic inflammatory response
Bonghee Lee
Journal of Stem Cells Research, Development & Therapy, Volume 7, pp 1-7; https://doi.org/10.24966/srdt-2060/100060

Abstract:
Functionally improved cell therapy has brought enormous benefits for patients suffering from serious illnesses. With the advances in biomedical science, numerous diseases are known for their correlation with post-translational modification of proteins, such as glycation, which leads to the formation of toxic Advanced Glycation End Products (AGEs). Themortality and morbidity rates of toxic AGE-induced diseases are continuously increasing globally
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-5; https://doi.org/10.24966/srdt-2060/100056

Abstract:
Adult cells are believed to maintain their differentiated status under stable homeostatic conditions, while cellular identity can become plastic when homeostasis is perturbed such as during an injury and inflammation [1]. Indeed, it is now evident that cell identity is more flexible and plastic than previously thought
, Rosario Facultad De Medicina Y Cs. De La Salud. Universidad Abierta Interamericana, San Nicolás Regenerón By Stem Cell Therapy Argentina, Argentina Clínica San Nicolás S.A
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-6; https://doi.org/10.24966/srdt-2060/100059

Abstract:
Osteoarthritis (OA) is a degenerative disorder resulting from loss of joint cartilage and underlying bone. Sports injuries are considered disorders of the musculoskeletal system or concussions that are generally caused during sportive activities such as football
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-4; https://doi.org/10.24966/srdt-2060/100055

Abstract:
Uman Pluripotent Stem Cells (hPSCs) are an essential cell source for regenerative medicine. With the increasing importance of hPSCs for cell-based therapy, the need for hPSCs in basic and clinical research is to develop live-cell imaging systems that monitor hPSCs during reprogramming or differentiation processes
Kieu C D Nguyen, Vietnam American Stem Cell Hospital Jsc & Euro Stem Cell
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-3; https://doi.org/10.24966/srdt-2060/100057

Abstract:
Although highly transmissible due to its highly infectious nature, since a large proportion of cases are asymptomatic or mild, self-awareness which promotes the spread of the disease worldwide. The public health manages against Corona virus should reduce the numbers of people infected with influenza virus to avoid the two viruses infections will be interacted
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-4; https://doi.org/10.24966/srdt-2060/100058

Abstract:
One of the most common anatomic limitation which prevents a correct implant placement, is horizontal and vertical bone deficiency. Modern surgical techniques allow predictable rehabilitation of these severe defects, using on one side the great regenerative potential of autologous growth factors, on the other side instruments that allow more bone preservation and less trauma on hard and soft tissues, crucial criteria for successful surgeries
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-8; https://doi.org/10.24966/srdt-2060/100054

Abstract:
Combining bone-marrow aspirate with xenograft and allograft particulate material has been demonstrated to produce a significant quantity of new bone growth. However, securing 1 to 4 ccs of adult autogenous stem cells by means of bone-marrow aspiration is invasive, and the aspirated stem cells are typically senescent, as the procedure most often is used in aging patients
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-5; https://doi.org/10.24966/srdt-2060/100052

Abstract:
Aim of the study is to demonstrate the influence of using growth factors in bone regeneration in advanced implantology cases, such as severe bone defects that involve maxillary sinus
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-4; https://doi.org/10.24966/srdt-2060/100053

Abstract:
The surface of mammalian cells consists of the plasma membrane lined by an underneath cortical actomyosin cytoskeleton. This pair of structures forms the Membrane-Cytoskeleton Complex (MCC), a known regulator of cellular processes, ranging from shape control and cell migration to molecule presentation and signaling [1-3].
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-10; https://doi.org/10.24966/srdt-2060/100051

Abstract:
Chronic allograft nephropathy remains the leading cause of late allograft failure after renal transplantation. Current immunosuppressive regimens significantly reduce the incidence of acute rejection but do not influence long-term graft survival
Ana I García-Guillén, University Of Murcia
Journal of Stem Cells Research, Development & Therapy, Volume 6, pp 1-6; https://doi.org/10.24966/srdt-2060/100037

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