Results in Journal BAOJN: 28
(searched for: journal_id:(1710091))
BAOJN, Volume 2; doi:10.24947/baojn/2/3/125
Neurology and Neurosurgery Clinical Neurology Journal Impact Factor. Bioaccent wishes to give out the best neurology journal for the readers, clinicians and practitioners.
BAOJN, Volume 2, pp 1-5; doi:10.24947/baojn/2/1/111
BAOJN, Volume 1, pp 1-7; doi:10.24947/baojn/1/1/110
BAOJN, Volume 2; doi:10.24947/baojn/2/3/126
BAOJN, Volume 1, pp 1-6; doi:10.24947/baojn/1/1/105
BAOJN, Volume 2; doi:10.24947/baojn/2/3/124
BAOJN, Volume 2; doi:10.24947/baojn/2/2/121
BAOJN, Volume 2; doi:10.24947/baojn/2/1/113
BAOJN, Volume 1, pp 1-5; doi:10.24947/baojn/1/2/107
Background Enteral (duodenal or jejunal) levodopa-carbidopa gel infusion is increasingly used for the treatment of patients with fluctuating advanced Parkinson’s disease (PD). It has been argued that delayed and inconsistent gastric emptying cause erratic absorption of oral levodopa and may play a role in the loss of efficacy of oral therapy. However, the experience with therapeutic strategies in the advanced phase of the disease is still limited. Methods Three patients with technical problems and transient gastric levodopa infusions were retrospectively evaluated. A motor examination (on status) and gastric motility studies (off status) were performed. Gastrointestinal motility was assessed by scintigraphy with (99m) Tc-DTPA-labeled meal. Results Two women aged 74 years and one man aged 66 years with advanced PD were treated with transient continuous levodopa infusion into the stomach due to technical problems. No changes in the Unified Parkinson’s Disease Rating Scale (UPDRS) scores, Hoehn and Yahr stage, or global score of the Clinical Global Impression (CGI) scale were documented. Adverse effects were not observed. Two of the patients had a lower gastric emptying on scintigraphy. Conclusion Gastric levodopa infusion could be as effective as enteral levodopa infusion without significant adverse outcomes in certain cases. Impairment of gastrointestinal motility appears to be unrelated to the effectiveness of infusion levodopa therapy in some patients with fluctuating advanced PD. Further studies are needed to confirm these results.