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(searched for: doi:10.4103/jcrt.JCRT_1194_16)
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Ming-Yu Ren, Jing Li, Yi-Xiang Wu, Rui-Miao Li, Chi Zhang, Li-Min Liu, Jing-Jing Wang, Yu Gao
Published: 26 September 2022
World Journal of Clinical Cases, Volume 10, pp 9670-9679; https://doi.org/10.12998/wjcc.v10.i27.9670

Abstract:
Solitary fibrous tumor (SFT) is predominant within the pleura but very rare in the orbit, which is why the diagnosis of orbital SFT poses challenges in clinical practice. Accordingly, an integrated approach that incorporates specific clinical features, histological, histopathological, and immunohistochemical (IHC) examinations, and molecular analyses is warranted. To retrospectively explore the clinical and imaging characteristics, treatment, outcomes of a series of patients with orbital SFT. We conducted a retrospective review of a series of patients diagnosed with a histopathologic orbital SFT treated at a single institution. All data on demogra phics, clinical characteristics, imaging, treatment, postoperative histopathological and IHC examinations, and prognosis were collected. In total, 13 patients were enrolled, 7 (53.8%) of whom had the tumor located in the superomedial quadrant of the orbit. Computed tomography revealed a solitary ovoid lesion in 10 (76.9%) patients and irregular lesion in 3 (23.1%) patients. Magnetic resonance imaging results were as follows: On T1 weighted images, 3 (23.1%) patients had hypointense mixed signals, whereas 10 (76.9%) patients showed isointense mixed signals; on T2 weighted images (T2WI), 3 (23.1%), 4 (30.8%), and 6 (46.2%) patients exhibited hypointense mixed, isointense mixed, and hyperintense signals, respectively. Notably, 12 (92.3%) patients showed significant enhancement, whereas there were patchy slightly enhanced areas in the tumor. All patients were treated by surgery. IHC analysis demonstrated that the tumor cells were immunoreactive for CD34, CD99, STAT-6, and vimentin in all patients. The lesions showed Ki-67 positivity < 5% in 1 (7.7) patient, 5%-10% in 10 (76.9%), and > 10% in 2 (15.4%). Two (15.4%) patients exhibited tumor recurrence. The clinical manifestations and radiologic characteristics of orbital SFT are diverse and not specific. Accurate diagnosis and treatment require detailed radiological and histopathological/ IHC evaluation.
Kasturi Bhattacharjee, Vatsalya Venkatraman
Published: 19 October 2021
The publisher has not yet granted permission to display this abstract.
, , Dana Niry, Igal Leibovitch, Robert A. Goldberg
Published: 19 October 2021
The publisher has not yet granted permission to display this abstract.
, , Dana Niry, Igal Leibovitch, Robert A. Goldberg
Published: 2 September 2021
The publisher has not yet granted permission to display this abstract.
Kasturi Bhattacharjee, Vatsalya Venkatraman
Published: 11 June 2021
The publisher has not yet granted permission to display this abstract.
Xiao Wei Ting, Shankari Sothiraghagan, ,
Published: 24 May 2020
Journal: Cureus
Abstract:
Objective To describe the patient demographics, clinical findings, investigations, surgical outcomes, and histopathological findings of seven cases of orbital solitary fibrous tumours. Method This was a retrospective review of seven cases of orbital solitary fibrous tumour, which were followed up in Hospital Serdang, a national oculoplastic centre, from years 2008-2017. Results This study included seven patients with ages between 21 and 35 years old; two were males and five were females. All seven patients presented with painless chronic unilateral proptosis. Radiological imaging of the orbit showed a localized contrast enhancing intraorbital mass. All patients underwent orbitotomy and excisional biopsy. Intraoperative findings showed a well-encapsulated and vascularized mass. Histological findings of spindle-shaped cells were noted. All cases had positive staining for cluster of differentiation (CD) 34, five were positive for CD 99, four were positive for B-cell lymphoma (BCL-2), and five patients had positive staining for S-100. Three of the patients did not have clear margins during the primary operation and subsequently had a recurrence within two years. Conclusion A solitary fibrous tumour is a rare mesenchymal tumour with a pleural origin. The orbit is the most common extrapleural site of the tumour and they are usually benign. Immunohistochemistry is important to differentiate it from other, more aggressive forms of orbital tumours. Regular follow-up is important to monitor for recurrence.
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