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(searched for: doi:10.1016/
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Yifan Wu, Yongkuan Suo, Zheng Wang, Yifeng Yu, Shuang Duan, Hongguang Liu, Baiwen Qi, Chao Jian, Xiang Hu, Dong Zhang, et al.
Frontiers in Bioengineering and Biotechnology, Volume 10;

In microsurgery, it is always difficult to accurately identify the blood supply with ease, such as vascular anastomosis, digit replantation, skin avulsion reconstruction and flap transplantation. Near-infrared window I (NIR-I, 700—900 nm) imaging has many clinical applications, whereas near-infrared window II (NIR-II, 1,000–1700 nm) imaging has emerged as a highly promising novel optical imaging modality and used in a few clinical fields recently, especially its penetration distance and noninvasive characteristics coincide with the needs of microsurgery. Therefore, a portable NIR-II imaging instrument and the Food and Drug Administration (FDA) approved indocyanine green (ICG) were used to improve the operation efficiency in microsurgery of 39 patients in this study. The anastomotic vessels and the salvaged distal limbs were clearly visualized after intravenous injection of ICG. The technique enabled identification of perforator vessels and estimation of perforator areas prior to the flap obtention and made it easier to monitor the prognosis. Overall, this study highlights the use of the portable NIR- II imaging with ICG as an operative evaluation tool can enhance the safety and accuracy of microsurgery.
, Diana Chang, Michael Travis Caton Jr., , Cecilia L. Dalle Ore, Thomas A. Wozny, Taemin Oh, Albert S. Wang, , Kurtis I. Auguste, et al.
Published: 4 May 2022
Pediatric Neurosurgery pp 1-15;

Introduction: The benefits of performing open and endovascular procedures in a hybrid neuroangiography surgical suite include confirmation of treatment results and reduction in number of procedures, leading to improved efficiency of care. Combined procedural suites are infrequently used in pediatric facilities due to technical and logistical limitations. We report the safety, utility, and lessons learned from a single-institution experience using a hybrid suite equipped with biplane rotational digital subtraction angiography and pan-surgical capabilities. Methods: We conducted a retrospective review of consecutive cases performed at our institution that utilized the hybrid neuroangiography surgical suite from February 2020 to August 2021. Demographics, surgical metrics, and imaging results were collected from the electronic medical record. Outcomes, interventions, and nuances for optimizing preoperative/intraoperative setup and postoperative care were presented. Results: Eighteen procedures were performed in 17 patients (mean age 13.4 years, range 6–19). Cases included 14 arteriovenous malformations (AVM; 85.7% ruptured), one dural arteriovenous fistula, one mycotic aneurysm, and one hemangioblastoma. The average operative time was 416 min (range 321–745). There were no intraoperative or postoperative complications. All patients were alive at follow-up (range 0.1–14.7 months). Five patients had anticipated postoperative deficits arising from their hemorrhage, and 12 returned to baseline neurological status. Four illustrative cases demonstrating specific, unique applications of the hybrid angiography suite are presented. Conclusion: The hybrid neuroangiography surgical suite is a safe option for pediatric cerebrovascular pathologies requiring combined surgical and endovascular intervention. Hybrid cases can be completed within the same anesthesia session and reduce the need for return to the operating room for resection or surveillance angiography. High-quality intraoperative angiography enables diagnostic confirmation under a single procedure, mitigating risk of morbidity and accelerating recovery. Effective multidisciplinary planning enables preoperative angiograms to be completed to inform the operative plan immediately prior to definitive resection.
, Valery V. Zaytsev, Alexander V. Lodygin, Victor A. Kashchenko
Published: 21 January 2022
Scientific Reports, Volume 12, pp 1-9;

Evaluation of tissue perfusion at various stages of surgery is of great importance for the implementation of the concept of safe surgery, including operations on the abdominal organs. Currently, there is no accurate and reliable intraoperative method for assessing tissue perfusion that could help surgeons determine the risks of ischemia and improve outcomes. We propose novel method of intraoperative assessment of tissue perfusion using video camera synchronized with the electrocardiogram. The technique is referred to as imaging photoplethysmography (iPPG). It can be used continuously for monitoring blood supply to organs e.g., before and after anastomosis. In our study, we followed 14 different surgical cases (four stomach and ten colorectal cancers) requiring reconstruction of various organs with anastomosis. With iPPG, intraoperative blood perfusion was successfully visualized and quantified in all 14 patients under study. As most indicative, here we describe in detail two clinical demonstrations during gastrectomy for gastric cancer and right-sided hemicolectomy for cancer of the ascending colon. Feasibility of the iPPG system to assess blood perfusion in organs before and after anastomosis during open surgery was demonstrated for the first time.
N. Tahhan, B. Balanca, J. Fierstra, T. Waelchli, T. Picart, C. Dumot, O. Eker, S. Marinesco, I. Radovanovic, F. Cotton, et al.
Published: 10 December 2021
Journal: Neurochirurgie
Neurochirurgie, Volume 68, pp 414-425;

The publisher has not yet granted permission to display this abstract.
Evgenii Belykh, Xiaochun Zhao, Brandon Ngo, Dara S. Farhadi, Adam Kindelin, Saif Ahmad, Nikolay L. Martirosyan, Michael T. Lawton,
Published: 8 February 2021
by Wiley
Journal: Microcirculation
Microcirculation, Volume 28;

Qualitative and quantitative analyses of blood flow in normal and pathologic brain and spinal cord microvasculature was performed using confocal laser endomicroscopy (CLE). Blood flow in cortical, dural, and spinal cord microvasculature was assessed in vivo in swine. We assessed microvasculature under normal conditions and after vessel occlusion, brain injury due to cold or surgical trauma, and cardiac arrest. Tumor-associated microvasculature was assessed in vivo and ex vivo in 20 patients with gliomas. We observed erythrocyte flow in vessels 5-500 µm in diameter. Thrombosis, flow arrest and redistribution, flow velocity changes, agglutination, and cells rolling were assessed in normal and injured brain tissue. Microvasculature in in vivo CLE images of gliomas was classified as normal in 68% and abnormal in 32% of vessels based on morphological appearance. Dural lymphatic channels were discriminated from blood vessels. Microvasculature CLE imaging was possible for up to 30 minutes after a 1 mg/kg intravenous dose of fluorescein. CLE imaging allows assessment of cerebral and tumor microvasculature and blood flow alterations with subcellular resolution intraoperative imaging demonstrating precise details of real-time cell movements. Research and clinical scenarios may benefit from this novel intraoperative in vivo microscopic fluorescence imaging modality.
Published: 6 September 2020
Journal: Applied Sciences
Applied Sciences, Volume 10;

Intraoperative evaluation of blood perfusion in the brain cortex is an important but hitherto unresolved problem. Our aim was to demonstrate the feasibility of cerebral microcirculation assessment during open brain surgery by using camera-based photoplethysmography (cbPPG) synchronized with an electrocardiograph. Cortical blood flow was monitored in five patients with different diagnoses. Two cases (tumor resection and extra-intracranial bypass grafting) are presented in detail. Blood-flow parameters were visualized after processing cortex images recorded under green-light illumination before and after surgical intervention. In all cases, blood flow was successfully visualized in >95% of open brain. Distributions of blood pulsation amplitude, a parameter related to cortical blood perfusion; pulse arrival time; and blood-pressure-pulse shape were calculated with high spatial resolution (in every pixel). Changes in cerebral blood supply caused by surgical intervention were clearly revealed. We have shown that the temporal spread of pulse arrival time and the spatiotemporal variability of pulse shape are very sensitive markers of brain circulatory disturbances. The green-light cbPPG system offers a new approach to objective assessment of blood-flow changes in the brain during surgical intervention. The proposed system allows for contactless monitoring of cortex blood flow in real time with high resolution, thus providing useful information for surgery optimization and minimization of brain tissue damage.
Jonas Hedelund Rønn, , Rune Broni Strandby, , Rikard Ambrus, ,
Langenbecks Archiv Fur Chirurgie, Volume 404, pp 505-515;

Indocyanine green fluorescence angiography (ICG-FA) is an established technique for assessment of intestinal perfusion during gastrointestinal surgery, whereas quantitative ICG-FA (q-ICG) and laser speckle contrast imaging (LSCI) are relatively unproven. The study aimed to investigate whether the techniques could be applied interchangeably for perfusion assessment.
, , Luís Sanroman, Ana Rodríguez-Hernández, Luís Reyes, Javier Tercero, Joaquim Enseñat
Published: 14 April 2019
World Neurosurgery, Volume 127;

The publisher has not yet granted permission to display this abstract.
, Alfred P. See, Robert J. Smalley, Wenya Linda Bi, , Kai U. Frerichs, Alexandra J. Golby, E. Antonio Chiocca, M. Ali Aziz-Sultan
Published: 18 March 2019
World Neurosurgery, Volume 126, pp 322-330;

The publisher has not yet granted permission to display this abstract.
, Alessandro Frati, , , , Marco Cimatti, Donatella Valente,
Published: 27 August 2018
World Neurosurgery, Volume 120, pp 190-199;

The fundamental role of technological instruments in contemporary Neurosurgery is undisputed and the Intraoperative-MRI represents one of the best examples. The use of modern high-field magnet and the possibility to match the MRI with the Operative Microscope and an integrated Neuronavigation system has led to successful results in the surgical treatment of different diseases. In our Institute we routinely performed surgery with the aid of the Io-MRI over the last 15 years and the aim of this paper is to report our experience in the management of Neurovascolar lesions with the usage of this device. We experienced that Io-MRI enhances the surgical experiences, leading to an improved post-operative outcome in the treatment of different lesions, such as: Arterovenous Malformations, Dural Arterovenous Fistulas, Intracranial Cavernous Angiomas and Intracranial Aneurysms. There are several advantages provided by the usage of Io-MRI. The usage of Io-MRI coupled to the Planning station and to the Neuronavigation system allows to obtain preoperative three-dimensional reconstructions of the vessels, in order to finely define the anatomy of each Neurovascolar lesion. Futhermore, the possibility to perform an Intraoperative scan allows a comparison with pre-operative images and, subsequently, to update the surgical strategy. Io-DWI can detect possible territorial ischemia amenable of further intensive treatments. Even though increased costs, increased surgical times, increased anesthesiological times and possible increased risk of surgical infection may represent some major limitation, the usage of Io-MRI equipped operative theatres with integrated Neuronavigation systems can prove extremely helpful in the management of Neurovascular conditions.
Can Xin, Zhengwei Li, Jianjian Zhang, Zhongwei Xiong, Xiaolin Wu, Shiyu Zhao, Mingjun Cai, Wenyuan Zhao,
Published: 12 May 2018
World Neurosurgery, Volume 116, pp 383-386;

Although clipping and coiling of intracranial aneurysms are effective treatment options, they each have respective limitations. With the advent of hybrid operating room, combined clipping and coiling for complex aneurysms at one stage becomes feasible. In this article, we report a successful case of a left posterior communicating artery (PCoA) aneurysm where combined clipping and endovascular treatment were applied. A 57-year-old man had been complaining of severe headache for 10 days. The computing tomography (CT) from a previous hospital revealed a parasellar lesion, and the CT angiography in our hospital showed a 16mm PCoA aneurysm. Clipping of the aneurysm was scheduled in our hybrid operating room, which enabled intervention of intraoperative digital subtraction angiography (DSA). However, once the aneurysm was clipped, intraoperative DSA revealed that the aneurysm was remnant. We readjusted the clip and reran DSA, but the residual neck was still present. In an effort to preserve the parent artery and perforators, we decided to perform endovascular treatment. Coiling was achieved, followed by angiography, indicating that the aneurysm was almost eliminated. Overall, the patient underwent four angiographic explorations during surgery. Combined open surgical and endovascular approaches to treating complex cerebral aneurysms in hybrid operating room could offer an alternative when the aneurysms appear unclipped or remnant intraoperatively. In our experience, simultaneous clipping and coiling is a safe and effective procedure for efficient treatment of aneurysms.
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