Refine Search

New Search

Results: 4

(searched for: doi:10.5155/eurjchem.5.4.676-680.1110)
Save to Scifeed
Page of 1
Articles per Page
by
Show export options
  Select all
European Journal of Chemistry, Volume 11, pp 276-279; doi:10.5155/eurjchem.11.4.276-279.2009

Abstract:
A simple and eloquent procedure for the synthesis of a new series of thienyl benzo[b]1,4-diazepines is reported. They were synthesized by the condensation of o-phenylenediamine (o-PDA) with distinct hetero chalcones using NaOH in polyethylene glycol (PEG-400) as green and alternative reaction solvent. The significances of this present method are shorter reaction time, easy work-up, high yields, and mild reaction conditions. Furthermore, this method is environment friendly and without use of an expensive catalyst. The all newly synthesized compounds are characterized by the spectroscopic methods.
Published: 14 April 2020
by MDPI
Catalysts, Volume 10; doi:10.3390/catal10040429

Abstract:
The solvents used in chemistry are a fundamental element of the environmental performance of processes in corporate and academic laboratories. Their influence on costs, health safety, and nature cannot be neglected. Quantitatively, solvents are the most abundant constituents of chemical transformations; therefore, acting on solvents and replacing standard solvents with safer products can have a great ecological impact. However, not all green solvents are suitable for the wide scope of organic chemistry reactions. A second point to consider is that 50% of pharmaceutical drugs are nitrogen heterocycles compounds. It therefore appeared important to provide an overview of the more ecological methodologies for synthesizing this class of compounds. In this review, all publications since 2000 that describe green reactions leading to the formation of nitrogen heterocycles using safe solvents were considered. We chose water, PEG, and bio-based solvents for their negligible toxicity. The synthesis of five-, six-, and seven-membered aromatic nitrogen heterocycles using green reactions reported in the literature to date is described.
Mohamed Loubidi , Catherine Manga, Zahira Tber, Ibtissam Bassoude, El Mokhtar Essassi, Sabine Berteina-Raboin
Published: 10 July 2018
by Wiley
European Journal of Organic Chemistry, Volume 2018, pp 3936-3942; doi:10.1002/ejoc.201800580

The publisher has not yet granted permission to display this abstract.
Douaa Salman Almarzouq, Omniya Sayed Zaky, Abdulaziz Abdulrazaq Alnajjar, Kamal Usef Sadek
European Journal of Chemistry, Volume 7, pp 347-351; doi:10.5155/eurjchem.7.3.347-351.1473

Abstract:
Pyrazole molecules are in the forefront of organic chemistry due to their various encompass substituents, which have many biological activity sequence. The biological and medicinal activities of pyrazolo[1,5-a]pyrimidines have received considerable interest in this regard. We reported here a comparison between reaction of 4-phenylazo-3,5-diaminopyrazole (4) with ethyl propiolate (15), dimethylacetylene dicarboxylate (20), diethyl fumarate (25) and benzylidenemalononitrile (11) in the presence of catalytic amount of piperidine. We initially followed literature procedure (method A), then utilizing ultrasound irradiation (method B), microwave heating (method C) and in a Q-tube (method D). We confirmed the structure of the product by analytical spectroscopic methods. Method (D) gave a good yield with a record reaction time.
Page of 1
Articles per Page
by
Show export options
  Select all
Back to Top Top