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(searched for: doi:10.3816/clml.2011.n.018)
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Published: 10 May 2018
by Wiley
Cytometry Part B: Clinical Cytometry, Volume 96, pp 338-350; doi:10.1002/cyto.b.21844

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Ali El-Ayoubi, James Q. Wang, Nadine Hein,
Published: 1 June 2017
Pathology, Volume 49, pp 337-345; doi:10.1016/j.pathol.2017.02.004

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Plasma Cell Neoplasms pp 99-108; doi:10.1007/978-3-319-42370-8_5

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, Wilson I. Gonsalves, Stephen M. Ansell, Patricia T. Greipp, Lori A. Frederick, David S. Viswanatha, Rong He, Robert A. Kyle, Morie A. Gertz, Prashant Kapoor, et al.
American Journal of Clinical Pathology, Volume 145, pp 843-851; doi:10.1093/ajcp/aqw072

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Diagnostic Pathology: Molecular Oncology pp 6-40; doi:10.1016/b978-0-323-37678-5.50093-1

Indian Journal of Hematology and Blood Transfusion, Volume 32, pp 173-177; doi:10.1007/s12288-015-0512-7

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Amir Behdad, Charles W. Ross, Joshua Jacques, Mt(Ascp) Usha Kota, David Keren,
American Journal of Clinical Pathology, Volume 142, pp 398-410; doi:10.1309/ajcpo5gqpxf8qcec

Abstract:
Multiparameter flow cytometry (MFC) is a widely available laboratory platform for the evaluation of plasma cell (PC) neoplasms. We assess the performance of a nine-color MFC assay that uses stain-lyse-fix processing of bone marrow aspirates, minimal wash steps, and high acquisition rates with analysis of up to 1.8 × 106 cells. MFC results were compared with microscopic examinations, immunohistochemical studies, and serum/urine M-protein measurements from patients with documented or suspected PC neoplasms. Sensitivity exceeded that of microscopic examinations, with or without immunohistochemistry. In patients with PC myeloma, clonal PC detection by MFC fell in concert with M-protein levels. However, in a subset of patients, MFC detected clonal PCs after serum/urine studies turned negative. The nine-color analytic cocktail eliminates duplication of PC gating reagents required for evaluation of the same epitopes using a five- or six-color approach. Fewer analytic cocktails result in lower instrument acquisition times per case, a significant factor for the large data sets required for optimal residual disease assessment. Finally, concurrent analysis of nine epitopes and two light scatter parameters aids detection of residual disease, particularly when it is mixed with polyclonal PCs.
, Matthew T. Howard, Janice M. Hodnefield, William G. Morice
American Journal of Clinical Pathology, Volume 140, pp 519-524; doi:10.1309/ajcp0n7ielyunjgz

Abstract:
To delineate the pathology of immunoglobulin M–producing multiple myeloma (IgM MM). Clinicopathologic data were reviewed for 15 cases meeting World Health Organization criteria for MM and having a serum IgM paraprotein. Immunohistochemistry was performed on diagnostic bone marrow specimens for common B-cell and plasma cell markers. Of the 15 IgM MM bone marrows reviewed, 6 (40%) had lymphoplasmacytoid cytology, and 12 (80%) expressed CD19, CD20, and/or CD45. Cyclin D1 expression was common (11 cases, 73%) and usually associated with t(11;14). No cases expressed CD5 or had an associated CD5-positive B-cell population. CD117 was positive in 20% of cases. The frequent B-cell–associated antigen expression by IgM MM distinguishes it from other MM types, causing significant pathologic overlap with lymphoplasmacytic lymphoma (LPL). However, IgM MM is usually distinguished from LPL by aberrant cyclin D1 expression or t(11;14). Therefore, assessing for these abnormalities is recommended when evaluating bone marrow involvement by IgM-associated lymphoplasmacytoid disorders.
B Paiva, M C Montes, R García-Sanz, , J Alonso, , F Escalante, R Cuello, A G De Coca, J Galende, et al.
Leukemia, Volume 28, pp 166-173; doi:10.1038/leu.2013.124

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Giovanni Carulli, Eugenio M Ciancia, Antonio Azzarà, Virginia Ottaviano, Susanna Grassi, Elena Ciabatti, Maria I Ferreri, Melania Rocco, Alessandra Marini, Mario Petrini
Journal of Clinical and Experimental Hematopathology, Volume 53, pp 29-36; doi:10.3960/jslrt.53.29

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