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(searched for: doi:10.5155/eurjchem.3.2.241-246.597)
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Mohamed H. M. AbdEl‐Azim, , Samar M. Mouneir, Ahmed F. El‐Farargy,
Published: 25 June 2020
Archiv der Pharmazie, Volume 353; https://doi.org/10.1002/ardp.202000084

Abstract:
A versatile, efficient, clean, and facile method was used for the synthesis of pyrano[2,3‐d ]pyrimidine derivatives by the one‐pot three‐component condensation reaction of thiobarbituric acid and malononitrile with p‐chlorobenzaldehyde, using Fe3O4 or ZnO or Mn3O4 as nanostructure catalysts. The catalyst could be easily recovered using an external magnet and reused for six cycles with almost a consistent activity. A series of polyheterocyclic compounds containing five and/or six rings fused with each other was designed. The anti‐inflammatory activities for some of the newly synthesized compounds were evaluated. All the synthesized compounds were characterized on the basis of their elemental analyses and spectral data.
A. Pekparlak, , S.D. Kanmazalp, N. Berber, M. Arslan, D. Avcı, , E. Tarcan, Y. Atalay
Published: 30 January 2020
Chemical Physics Letters, Volume 742; https://doi.org/10.1016/j.cplett.2020.137171

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Samareh Gorji, , Zahra Toghraei-Semiromi, Sedigheh Alavinia
Published: 23 December 2019
Polycyclic Aromatic Compounds, Volume 41, pp 1849-1861; https://doi.org/10.1080/10406638.2019.1701050

Abstract:
Some novel 5,8-diaryl-5,7,8,9-tetrahydropyrimido[5,4-e]tetrazolo[1,5-a]pyrimidin-6(4H)-one derivatives are prepared via one-pot reaction of aromatic aldehydes, 2-aminotetrazole and cyanoacetamide using two different types of catalytic systems including nano-magnetic catalyst supported with functionalized 4-amino-pyridine silica ([email protected]2-Pr-AP) and NEt3.The highlighting points of using [email protected]2-Pr-AP are easy purification, reusability of the catalyst, good yields of products with short time reactions compared with NEt3. Also the DFT calculations showed that a trans-like isomer is more stable than other possible isomers/conformers. The experimental data are also consistent with a pure compound rather than a mixture of isomers.
, Ahmed F. El-Farargy, Abdou O. Abdelhamid,
Published: 4 November 2019
Synthetic Communications, Volume 49, pp 3560-3572; https://doi.org/10.1080/00397911.2019.1679538

Abstract:
Nanoparticles supply an environmentally friendly procedure for the synthesis of pyrano[2,3-d]pyrimidines by the one-pot three-component condensation reaction of thiobarbituric acid and malononitrile with pyrrol-2-carboxaldehyde. The catalyst could be easily recovered using an external magnet and reused for six cycles with almost consistent activity. A facile synthesis of a new series of cyclic and acyclic nucleosides of pyrano[2,3-d]pyrimidines derivatives was performed. The synthesis of poly heterocyclic compounds starting from pyrano[2,3-d]pyrimidines derivatives was achieved. Structures of the newly synthesized compounds were confirmed on the bases of elemental analyses and spectral data (IR, 1H NMR, 13C NMR, and mass spectra). Compound 6 exhibited the most potent biological activity.
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