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(searched for: doi:10.5155/eurjchem.2.1.65-69.303)
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Y. U. Shmoylova, Yu. A. Kovygin, D. Yu. Vandyshev, I. V. Ledenyova, E. A. Kosheleva, Kh. S. Shikhaliev
Russian Journal of Organic Chemistry, Volume 56, pp 1512-1518; doi:10.1134/s107042802009002x

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, Ahmed A. M. Ahmed,
Published: 11 November 2019
by Wiley
Journal of Heterocyclic Chemistry, Volume 57, pp 590-605; doi:10.1002/jhet.3789

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Ranin Kawtharani, Khalil Cherry, Mirvat Elmasri,
Published: 17 October 2019
by Wiley
ChemistrySelect, Volume 4, pp 11222-11226; doi:10.1002/slct.201902375

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Bahgat R. M. Hussein,
Published: 20 June 2019
Synthetic Communications, Volume 49, pp 2401-2410; doi:10.1080/00397911.2019.1626892

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Mallu Lavanya, Indira Viswambaran Asharani,
Published: 4 November 2018
by Wiley
Chemical Biology & Drug Design, Volume 93, pp 464-472; doi:10.1111/cbdd.13434

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R. G. Melik-Ohanjanyan, , G. S. Karakhanyan, S. G. Israelyan, L. E. Nersesyan, G. A. Panosyan
Russian Journal of Organic Chemistry, Volume 54, pp 107-111; doi:10.1134/s1070428018010104

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Chemistry Central Journal, Volume 11; doi:10.1186/s13065-017-0286-0

Abstract:
Pyridopyrimidines are of current interest because of their extensive variety of biological and pharmacological activities. A series of pyrido[2',3':4,5]pyrimido[2,1-b][1,3,5]thiadiazinones was obtained by aminomethylation of pyridopyrimidinethione with formaldehyde solution (37%) and different primary aromatic amines. Another series of pyrido[2',3:4,5]pyrimido[2,1-b][1,3]thiazinones was prepared by Michael addition reaction of pyridopyrimidinethione to the activated double bond of a number of arylidene malononitrile and 2-(benzo[d][1,3]dioxol-5-ylmethylene)malononitrile. The mechanisms of formation of the synthesized compounds were discussed and the assigned structure was established via microanalysis and spectral data (IR, 1H NMR, and Ms.). A comparative study of the biological activity of the synthesized compounds with chloramphenicol and trimethoprim/sulphamethoxazole is shown in Table 1. Generally, all synthesized compounds showed adequate inhibitory effects on the growth of Gram-positive and Gram-negative bacteria. In this study, we use a simple (synthetic) strategy for the synthesis of pyrimidothiadiazines, based on their aminomethylation through the Mannich reaction; they have also been synthesized by the application of the Michael addition to activated nitriles. Mechanisms and structures of the newly synthesized compounds were examined: the antimicrobial activity of some selected compounds was evaluated, which demonstrated adequate inhibitory effects. Graphical abstract The strategic structures of the products (7a-g).
Rachel L. Beingessner, Yiwen Fan,
Published: 3 August 2016
RSC Advances, Volume 6, pp 75820-75838; doi:10.1039/c6ra16315g

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Samir Kamel Elsaedany, Mohamed Abdellatif Zein, Elsayed Mohmoud AbedelRehim, Reda Mohammed Keshk
Published: 28 August 2015
by Wiley
Journal of Heterocyclic Chemistry, Volume 53, pp 1534-1543; doi:10.1002/jhet.2460

A. Thomann, J. Zapp, M. Hutter, ,
Organic & Biomolecular Chemistry, Volume 13, pp 10620-10630; doi:10.1039/c5ob01006c

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, Sakineh Faramarzi, Negar Lashgari, Alireza Badiei
Journal of the Iranian Chemical Society, Volume 11, pp 701-709; doi:10.1007/s13738-013-0342-1

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Muniyappapillai Jeganathan Shanmugam,
Published: 1 March 2013
Carbohydrate Research, Volume 368, pp 40-46; doi:10.1016/j.carres.2012.11.013

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