(searched for: doi:10.54105/ijac.c2013.041322)
Published: 28 February 2023
International Journal of Advanced Pharmaceutical Sciences and Research, Volume 3, pp 1-18; https://doi.org/10.54105/ijapsr.c4011.023223
Molecular oxygen and non-heme iron proteins (NHIPs) are proteins that have an iron atom bound to one or more oxygen atoms, and are found in bacteria, archaea, and some eukaryotes. NHIPs are involved in a variety of biological processes, such as respiration, electron transfer, and catalysis. They can be categorized into two classes: cytochrome proteins, which are involved in electron transfer, and oxygenases, which catalyze the oxidation of substrates by utilizing molecular oxygen. NHIPs are critical for multiple biological processes, and their impairment has been associated with diseases such as anemia, cancer, and neurological disorders.
Published: 30 October 2022
International Journal of Advanced Pharmaceutical Sciences and Research, Volume 2, pp 1-12; https://doi.org/10.54105/ijapsr.c4015.102622
Fullerenes C60 are molecules composed of carbon atoms arranged in a hollow spherical structure. They have been found to bind to transition metal complexes, which are molecules composed of a metal atom and one or more other atoms. This binding has been found to be very strong, with the fullerene molecules forming a protective shell around the transition metal complex. This has potential applications in a range of fields, such as biochemistry and nanotechnology. This review provides a description of some of the examples of such binding, including the different types of transition metals involved, the binding energies associated and the different structures observed.
Published: 30 October 2022
Journal: Indian Journal of Advanced Chemistry
Indian Journal of Advanced Chemistry, Volume 2, pp 1-11; https://doi.org/10.54105/ijac.d2015.102222
1,3,4-oxadiazole derivatives constitute a group of biologically important compounds that have been used as analgesic, anti-inflammatory, antibacterial, antifungal, antispasmodic, or psychotropic drugs in addition to their role in plant growth regulation and monoamine oxidase inhibition. This study focused on the use of microwaves in the synthesis of oxadiazole derivatives containing thiazolidinediones, which are promising for use as new drugs. For the first time, thiazolidinediones were synthesized by reacting benzaldehyde with cysteine with very good yield using microwave radiation at 340 watt. Subsequently, thiazolidine hydrazide (L3) was synthesized, which was reacted with carboxylic acid or carbon disulfide to be obtained in the presence of a base oxadiazole derivatives L4, L5, L6, L7, L8. The subjectivity of the synthetic compounds was verified by melting point measurement, E. Analy, and analysis using thin layer chromatography (TLC), FT-IR, mass spectrometry (EI-MS), and NMR spectroscopy.
Published: 30 June 2022
International Journal of Advanced Pharmaceutical Sciences and Research, Volume 2, pp 1-15; https://doi.org/10.54105/ijapsr.c4016.062422
This review provides a comprehensive overview of the synthesis, reactivity, and electrochemistry of chemical models of active site structures in [Fe] hydrogenase, an enzyme that catalyzes the reversible reduction of protons to submergence. Related literature on the structure and functions of the [Fe] hydrogenase active site, H cluster, is discussed with an emphasis on the di-iron organosome. In addition, various methods for the preparation and characterization of model complexes are discussed, as well as reactivity studies focusing on the oxidation and reduction of model compounds and their interaction with small molecules such as hydrogen and carbon monoxide. Finally, the electrochemical behavior of the model compounds is discussed in relation to their performance in electrocatalytic applications. This review provides a comprehensive analysis of the chemistry and reactivity of chemical models of the active site of [Fe] hydrogenase, which can be a valuable reference for further research.