Skeletal muscle is an important part of the human body. Most glucose metabolism is accomplished by skeletal muscle through insulin mediation. Skeletal muscle metabolism disorder can affect glucose metabolic homeostasis and insulin sensitivity of the body, and diabetic muscular Hypoplasia is a secondary lesion of muscle tissue caused by diabetes. In recent years, it has been found that in addition to mainstream western medicine and traditional Chinese and Western medicine combined treatment programs, natural products, and nutritional supplements also play an important role in the prevention and treatment of diabetic muscular Hypoplasia. Therefore, this paper will discuss the definition and pathogenesis of diabetic muscular Hypoplasia, as well as the prevention and treatment mechanism of some natural products and nutritional supplements, to provide more theoretical reference for non-drug targeted therapy of diabetic muscular Hypoplasia.

Extrachromosomal circular DNA (eccDNA) is a circular DNA molecule outside of eukaryotic staining, in which DNA forms in the genome or exogenous DNA in the cell. eccDNA is a special class of genetic material that can carry complete genes encoding functional proteins or RNA. Studies have shown that eccDNA can participate in various physiological and pathological processes in a special way, such as aging and the occurrence of tumors. This paper reviews the latest research progress of eccDNA and further expounds on the relationship between eccDNA and tumors.