The most common and aggressive primary malignancy of the central nervous system is Glioblastoma that, as a wide range of malignant solid tumor, is characterized by extensive hypoxic regions. A great number of PET radiopharmaceuticals have been developed for the identification of hypoxia in solid tumors, among these, we find copper-based tracers. The object of the current review paper is to provide an overview of radiocopper compounds applied for preclinical and clinical research in brain tumors and hypoxia imaging or therapy. Copper offers a wide variety of isotopes, useful for nuclear medicine applications, but only 64Cu and 67Cu are under the spotlight of the scientific community since being good candidates for theranostic applications. Between the two, 64Cu availability and production cost have attracted more interest of the scientific community. In order to better understand the application of copper-bis thiosemicarbazones in hypoxia imaging, an overview of the role of hypoxia in cancer, existing non-imaging and imaging techniques for hypoxia identification and promising future avenues regarding hypoxia is necessary. Different proposed uptake mechanisms of [64Cu][Cu(ATSM)] inside the cell will be discussed and other 64Cu-based tracers for brain tumors described. Among radio copper compounds [64Cu][Cu(ATSM)] is the most studied radiopharmaceutical for imaging and treatment of brain tumors. Experimental evidence suggested that [64Cu][Cu(ATSM)] could be more appropriately considered as a marker of over-reduced intracellular state rather than a pure hypoxia agent. Moreover, preliminary clinical data suggested that [64Cu]CuCl2 can be a potentially useful diagnostic agent for malignancies of the central nervous system (CNS).

We developed a Cu/Cu₂O-immobilized filter-type adsorbent for efficient iodide anion removal. A cellulose filter (CF) was used as a support, and its surface was modified using acrylic acid to enhance copper immobilization. The modified filter (CF-AA) exhibited 10x higher copper adsorption than the unmodified filter. Cu/Cu₂O was prepared on CF-AA by using a simple hydrothermal method to obtain CF-AA-Cu, and the prepared Cu/Cu₂O was characterized with scanning electron microscopy/energy-dispersive spectroscopy, x-ray photoelectron spectroscopy, and thermogravimetric analysis. While CF and Cu₂O themselves exhibited limited iodide adsorption performance, CF-AA-Cu exhibited fast adsorption kinetics with a half-life of 60 min as well as a high adsorption capacity of 10.32 mg/g, as obtained using the Langmuir adsorption isotherm model. Moreover, it exhibited high selectivity for iodide when high concentrations of other anions were present. The adsorption mechanism was proved by means of material characterization before and after adsorption. The coexistence of Cu⁰, Cu⁺, and Cu²⁺ in CF-AA-Cu make it effective in broader pH conditions via the redox reaction between Cu⁰ and Cu²⁺. Overall, iodide adsorbents in the form of filters with high adsorption capacity, selectivity, and ability over a wide pH range are potentially useful for removing iodide from water.

Herein, we illustrate a feasible strategy to strengthen the gas sensing of Y-doped CaZrO₃ (Y_xCa_1−xZr_0.7O_3−δ (x = 0.05, 0.06, and 0.07))/0.1Co₃O₄ used as sensing materials.

First-principles calculations were used to explore the effect of various Y-doping levels on the electrical conductivity of SrTiO₃.