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(searched for: doi:10.1039/c8an00772a)
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, Fatma M. Abdelnaeem, Sayed M. Derayea, Mohamed Oraby, Dalia M. Nagy
JPC – Journal of Planar Chromatography – Modern TLC pp 1-9; https://doi.org/10.1007/s00764-022-00209-w

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Lijuan Huang, Yanjiao Zhang, Liang Zhao, QingYou Chen,
Published: 31 January 2022
Neurocritical Care, Volume 36, pp 942-954; https://doi.org/10.1007/s12028-021-01401-2

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, S. Evrim Kepekci Tekkeli, Angela Tartaglia, Ceylin Aslan, Marcello Locatelli,
Published: 5 December 2021
Journal of Chromatography B, Volume 1188; https://doi.org/10.1016/j.jchromb.2021.123070

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Yasaman Sanaei, , Seyed Saied Homami, Amirhossein Monzavi, Zahra Khodadadi
Published: 6 September 2021
Journal: RSC Advances
RSC Advances, Volume 11, pp 30361-30372; https://doi.org/10.1039/d1ra04670e

Abstract:
A sustainable hybrid material based on carbonized cotton cloth/zeolite imidazolate framework-71/Fe3O4/polythionine (CC/ZIF-71/Fe3O4/PTh) was synthesized and applied in ultrasound-assisted dispersive magnetic solid-phase extraction (USA-DMSPE) followed with high performance liquid chromatography-ultraviolet detection (HPLC-UV) for simultaneous quantitation of diclofenac (DIC) and febuxostat (FEB) in human plasma. The surface of CC was modified with nanoarrays of zeolite imidazolate framework-71/Fe3O4/Polythionine. At first, an in situ synthesis of ZIF-71 in the presence of CC was carried out, and followed with magnetization process and oxidative polymerization of thionine. The nano-modifier agents improved the merits of the sorbent involving stability, porosity, mast transfer, π–π interactions and selectivity of CC. Characterizations of the hybrid sorbent were examined with different instrumental techniques. The limits of detection (LODs, S/N = 3) were recognized 2.1 ng mL−1 for DIC and 3.7 ng mL−1 for FEB. Acceptable linearity (0.992 ≤ r2 ≤0.996) and relatively broad dynamic ranges of 10.0–1800.0 ng mL−1 and 15.0–2500.0 ng mL−1 were achieved for DIC and FEB, respectively. Reasonable intra-assay (≤7.2%, n = 9) and inter-assay (≤7.5%, n = 9) precisions as well as appropriate accuracies (≤8.0%) were provided illustrating applicability of the current approach for analytical purposes. Eventually, CC/ZIF-71/Fe3O4/PTh was employed as four-part sorbent for the assessment of DIC and FEB in human plasma at trace levels and subsequently main pharmacokinetic data such as T1/2, Tmax,Cmax, and AUC0–24 of these drugs were comprehensively investigated.
, Fathalla Belal, Ahmed M. Abdel-Megied, Ahmed F. Abdel Hakiem
Published: 26 May 2021
Royal Society Open Science, Volume 8; https://doi.org/10.1098/rsos.210354

Abstract:
Two green, simple and sensitive synchronous spectrofluorimetric methods were developed for the first time for the simultaneous estimation of febuxostat (FEB) and ibuprofen (IBU). Method I is constant-wavelength synchronous spectrofluorimetry where FEB and IBU were recorded at 329 and 258 nm, respectively, using Δ λ of 40 nm. Method II is constant-energy synchronous spectrofluorimetry using a wavenumber interval of −4000 cm −1 . All measurements were carried out in a borate buffer of pH 7 and distilled water for dilution which increased the methods' greenness. The two methods were rectilinear over concentration ranges of 30.0–700.0 ng ml −1 and 0.5–9.0 µg ml −1 in the first method and 20.0–500.0 ng ml −1 and 0.1–8.0 µg ml −1 in the second method for FEB and IBU, respectively. High sensitivity was attained for the two drugs with limits of quantitations (LODs) down to 0.41 and 5.51 ng ml −1 in the first method and 0.25 and 3.32 ng ml −1 in the second method for FEB and IBU, respectively. Recovery percentages were in the range of 97.3–101.9% after extraction from spiked human plasma samples, demonstrating high bioanalytical applicability. The two methods were further applied to tablet dosage forms with good recovery results. The methods' greenness was assessed according to the analytical Eco-Scale and Green Analytical Procedure Index guidelines.
Published: 9 December 2020
Royal Society Open Science, Volume 7; https://doi.org/10.1098/rsos.201156

Abstract:
Sensitive, simple and green analytical methodology for simultaneous estimation of bambuterol and montelukast as a combined medication based on their native fluorescence character was developed. The method relies on synchronous spectrofluorimetry to solve the problem of the overlapping emission spectra of the studied drugs. Using second derivative synchronous spectra enabled the simultaneous quantitation of bambuterol and montelukast without interference. The peak amplitudes of the aqueous solutions at Δ λ = 20 nm were estimated at 284 and 304 nm for bambuterol and at 374 and 384 nm for montelukast. A linear relationship was achieved over the concentration range of 0.2–1.00 µg ml –1 for bambuterol and 0.4–2.00 µg ml −1 for montelukast. All factors and parameters were carefully studied to obtain the highest sensitivity and good precision of the proposed method. Additionally, the validation criteria were assessed in accordance with International Council of Harmonization (ICH) guidelines. The method was used for the estimation of both drugs in their raw materials, synthetic mixtures as well their combined tablets with good agreement between its results and those from the comparison method.
Galal Magdy, Fathalla F. Belal, Ahmed M. Abdel-Megied, Ahmed F. Abdel Hakiem
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Volume 248; https://doi.org/10.1016/j.saa.2020.119239

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, Esraa A. Ahmed, Marwa F. Ali
Published: 6 August 2019
Drug Development Research, Volume 80, pp 1000-1009; https://doi.org/10.1002/ddr.21581

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Jagpreet Singh Sidhu, Shilpa Sharma, Ashutosh Singh, , ,
Published: 19 July 2019
Analytical Methods, Volume 11, pp 4190-4196; https://doi.org/10.1039/c9ay01464k

Abstract:
Fluorescence emission of the receptor enhanced upon its binding with uric acid due to the cancellation of the PET phenomenon.
, Noha N. Atia, Samia M. El-Gizawy
Published: 22 May 2019
Microchemical Journal, Volume 149; https://doi.org/10.1016/j.microc.2019.05.055

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, Katherine Huddersman, Samia M. El-Gizawy, Noha N. Atia
Published: 28 March 2019
Microchemical Journal, Volume 147, pp 717-728; https://doi.org/10.1016/j.microc.2019.03.080

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