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Steven Imburgio, Anmol Johal, Ndausung Udongwo, Anton Mararenko, Anas Alrefaee, Joseph Heaton
Journal of Integrative Cardiology Open Access, Volume 2022, pp 1-4; https://doi.org/10.31487/j.jicoa.2022.03.05

Abstract:
BRASH syndrome is a newly coined diagnosis consisting of the clinical pentad of bradycardia, renal failure, atrioventricular (AV) nodal blockade, shock, and hyperkalemia. It is a rare syndrome with just under 50 reported cases. This case report and literature review present a case of BRASH syndrome, refractory to pharmaceutical measures, and subsequent literature review to assess treatment decisions and overall outcomes. The consensus from the literature supports the use of advanced interventions in most cases, including transcutaneous or transvenous pacing, hemodialysis, and adrenergic support. The early recognition and initiation of treatment in this patient demographic are paramount to reducing possible multi-system organ damage and mortality. This case report and literature review aim to improve patient outcomes and help further elucidate a protocol for treating BRASH syndrome.
Jorge Mario Molina Díaz, Luis Guillermo Martínez Domínguez, Karla Eugenia Hernández Trejo
Published: 1 October 2022
Clinical Oncology and Research, Volume 2022, pp 1-4; https://doi.org/10.31487/j.cor.2022.04.01

Abstract:
Introduction: DSD are congenital alterations in which either sexual chromosomes, gonadal or anatomical development are atypical. It is estimated that about 1 in every 4500 live births has some type of DSD, ovotesticular DSD representing around 3-10% of the cases. Given the rarity of DSD, it is an underexplored area, and little is known of ovotesticular DSD. Materials and Methods: A retrospective study on patients diagnosed with Ovotesticular DSD in a tertiary medical center from 2009 to 2018. The clinical presentation, phenotype, gonadal features, gender assignment and medical management were evaluated. Results: A total of 184 cases matched the initial search criteria. Only 9 patients with confirmed histopathological diagnosis were selected. Eight out of the nine cases evaluated presented ambiguous genitalia at birth, and only one was detected until pubertal age with presence of bilateral gynecomastia. A female 46 XX karyotype was reported in six patients, whereas the remaining three patients had mosaicism. Four patients were at pubertal age at the time of the study, and three of them required induction of puberty due to lack of sexual steroid production due to loss of gonadal organs. Discussion: Ovotesticular DSD is a rare finding with a heterogeneous spectrum concerning its genetic etiology, clinical presentation, and surgical findings. Most patients are diagnosed during infancy or childhood; few are diagnosed at pubertal age. Conclusion: Actual management and decision on gender assigning and treatment is challenging and debatable; therefore, a scrupulous clinical examination, as well as hormonal, imaging, genetic and molecular investigation is needed for a correct diagnosis. Further investigation is required to fully understand the disease.
Hirotaka Kato, Masaaki Deguchi, Yoshifumi Sakata
Published: 27 September 2022
Surgery Case Reports, Volume 2022, pp 1-3; https://doi.org/10.31487/j.jscr.2022.02.03

Abstract:
Introduction: Urachal remnants, such as the vesicourachal diverticulum, or urachal cysts are rarely involved in calculus or calcification. There are currently no case reports of urachal remnants with calculus just below the umbilicus. Case Presentation: A healthy 28-year-old man presented with umbilical drainage. Abdominal computed tomography showed inflammation just below the umbilicus with calculus. The patient was diagnosed with ombilitis with a urachal remnant and underwent laparoscopic resection for the urachal remnant after the attenuation of ombilitis. Surgical findings showed that the omentum adhered to the abdominal wall along with the urachal duct. The urachal duct with calculus was resected at the top of the bladder. The main component of calculus was silicic acid. Pathological findings were compatible with a urachal remnant and there was no evidence of a malignant tumor. Discussion: The main component of calculus is derived from necrotic material caused by inflammation because silicic acid was detected, indicating a different etiology from that of urinary calculus. Conclusion: We encountered a rare case of a urachal remnant with calculus below the umbilicus.
Émille Dalbem Paim, Felipe De Oliveira Goulart, Vera Beatris Martins, Fernanda Tormen Korspalski, Fabrício Edler Macagnan
Published: 29 September 2022
Abstract:
Photobiomodulation (PBM) as a therapeutic technology is justified by the biochemical changes caused in the intracellular environment, such as increased production of adenosine triphosphate and activation of antioxidant enzymes, allowing early recovery and maintenance of the homeostasis and proper functioning. This case report aimed to describe the effect of orofacial myofunctional therapy associated or not with photobiomodulation in the rehabilitation of radio-induced trismus in 6 patients. Two intervention modalities were performed, with three patients undergoing OMT isolated and the other two subjects undergoing oral myofunctional therapy associated with photobiomodulation therapy (OMT+PBM). All participants completed the radiotherapy between 3 and 15 months before starting the trismus rehabilitation. The mouth opening was 21.00mm for the patients who underwent exclusive OMT and reached 30.25mm at the end of the rehabilitation (difference of 9.25mm), but for the other three patients submitted to OMT+PBM, it went from 8.4mm to 31.5mm (difference of 23,1mm). It was observed that patients who performed PBM+OMT had greater tolerance to the protocol exercises and less pain report. OMT+PBM was a good combination for trismus rehabilitation and could be considered in further randomized clinical trials.
Murat Bektaş, Mustafa Ay, Muhammed Hamdi Uyar, Muhammed Ikbal Kılıç, Nevzat Koca, Burak Ince
Published: 28 September 2022
Abstract:
Background: Severe COVID-19 course is associated with higher inflammatory state (cytokine storm) due to the excessive release of pro-inflammatory cytokines. Some preliminary results showed higher disease severity as well as mortality in patients with COVID-19 accompanying cancer. In this study, we aimed to evaluate the high dose intravenous anakinra treatment response and outcome in patients with severe and critically ill COVID-19 accompanying cancer. Method: This observational retrospective study was carried out at a tertiary referral center between 01.09.2021 and 01.02.2022 in Turkey. The study population consisted of two groups as follows; the patients receiving high dose intravenous anakinra (anakinra group) and the patients treated with standard of care (SoC, control group). Anakinra was started in patients who did not respond to steroid therapy at least two days or concomitantly with steroids in patients with higher risk and/or critical illness at admission. Results: Data of 146 patients in anakinra and 114 patients in control group were analyzed. Median±interquartile range (IQR) patient age was 71 (25) years, duration of hospitalization were 11 (12) days in anakinra group and 65.5 (23) years and 9 (7.3) days in control group, respectively. Fifty-seven (39 %) and 68 (59.6 %) patients had severe, 89 (61 %) and 46 (40.4 %) had critical disease in anakinra and control group, respectively. Overall, ICU admission was in 58 (39.7 %) and 25 (22 %), intubation was in 52 (35.6 %) and 13 (11.4 %) patients, 54 (37 %) and 27 (23.7 %) patients died in anakinra and control group, respectively. Malignancy frequency was 11 % (n=16) in anakinra group and 7 % (n=8) in the control group. In survival analysis, significantly lower survival rate was observed in patients with malignancy than those without in control group (Log-Rank: p=0.002) and patients with malignancy in control group compared to anakinra group (Log-Rank: p=0.013); but did not differ between patients with and without malignancy in anakinra group (Log-Rank: p=0.9). Conclusion: In our study, mortality was higher in patients with malignancy compared to those without control but not in anakinra group and also higher in patients receiving anakinra compared to SoC. Our study indicates that intravenous high dose anakinra treatment is safe and effective in patients with COVID-19 associated cytokine storm accompanying cancer.
Raja Wakim, Adham Alkadri, Souad Ghattas, Kamal Abi Mousleh, Ribal Abi Hadeer, Youssef Mahfouz, Georges Sakhat, Marwan Haddad
Published: 24 September 2022
American Journal of Surgical Case Reports, Volume 2022, pp 1-6; https://doi.org/10.31487/j.ajscr.2022.03.02

Abstract:
Conventionally, patients with recurrent cholangiocarcinoma have been treated palliatively, most often with supportive care only. Since intrahepatic cholangiocarcinoma (I-CCA) is an uncommon malignancy, treatment guidelines for I-CCA therapy have a low level of support, and guidelines for the treatment of recurrence are particularly challenging to establish. While a surgical approach is not clearly recommended for recurrent I-CCA in current guidelines, this approach has been reported as reasonable in a particular patient demographic and should be considered [1-3]. Herein we present to you a case of a 56-year-old female patient who presented with local recurrence 1.5 years post resection and was treated surgically.
Kevin J Ferrick, Alex Conant, Jay J Chudow, Syona S Shetty, Rahul Grover, John D Fisher, Andrew Krumerman
Journal of Integrative Cardiology Open Access, Volume 2022, pp 1-4; https://doi.org/10.31487/j.jicoa.2022.03.04

Abstract:
Fast and accurate identification of cardiac devices can facilitate device programming and interrogation in various medical settings. We have previously demonstrated the accuracy of the PacemakerID machine learning algorithm for mobile phone cardiac device identification. However, the questions of the reproducibility of this algorithm and whether a single trial sufficiently maximizes accuracy have yet to be answered. Here, we examine 502 chest x-rays performed at a single institution on patients with implantable cardioverter-defibrillators and permanent pacemakers. The PacemakerID mobile phone application was used for five sequential trials on each image and the accuracy of one, three, and five trials were compared. A single trial resulted in a 79% accuracy and 82% positive predictive value with no significant difference (p=0.69) as compared to five trials at identifying device manufacturers. Across all devices, the results of a single trial were not significantly different from those of five trials. Our data demonstrate that a single trial is sufficient to maximize diagnostic accuracy with the PacemakerID mobile phone application, facilitating rapid identification for prompt programming and interrogation of cardiac devices.
Aynur Aktas, Declan Walsh, Wael Lasheen, Bernadette Brady, Michelle Barrett, Bassam Estfan
Published: 23 September 2022
Abstract:
Objective: We examined whether cardiovascular vital signs (VS) were prognostic for overall survival (OS) in newly diagnosed adult cancer outpatients. Methods: Electronic medical records data for patients with a solid tumor diagnosis and ≥2 consecutive weight measurements were analysed. BP (mmHg) and RHR (beats/minute) were identified at diagnosis (T1) and final visit (T2; >=7 days after T1). Systolic blood pressure (SBP) categories: <120; 120-129; 130-139; 140-149; ≥150. RHR categories: <60; 60-69; 70-79; 80-89; 90-100; 101-109; ≥110. Proportional Hazards Models examined potential prognostic factors for OS. Kaplan-Meier analysis estimated OS using lower (<80), normal (80-119), higher (≥120) SBP, and RHR of normal (60-100), bradycardia (100) categories. Results: N=5819; 59% men; mean age 61 (±12) years; 77% Caucasians; 9% African Americans. The most common tumor sites: prostate (19%), lung (15%), breast (14%). 18% had metastatic disease. Median OS after diagnosis was 27 months (range 25-28). Tachycardia had 2 to 3-fold increase in mortality. Survival time decreased by 8-10 months with lower SBP. RHR and SBP remained independently prognostic after adjusting clinically relevant characteristics at both timepoints. Conclusion: Elevated RHR and lower SBP independently predicted greater mortality in newly diagnosed cancer outpatients. These associations remained statistically significant longitudinally, and the differences observed were clinically important.
Ravneet Kaur Gill, Ashwani Mudgal
Published: 20 September 2022
Surgical Case Reports, Volume 2022, pp 1-3; https://doi.org/10.31487/j.scr.2022.09.03

Abstract:
Right bundle branch block (RBBB) and left bundle branch block (LBBB) are commonly seen in geriatric cases posted for surgeries. LBBB usually results from conduction system degeneration or myocardial pathology. LBBB is often associated with hypertension, myocarditis, coronary heart disease, aortic valve disease, cardiomyopathy etc. We report a case of diagnosed LBBB preoperatively posted for emergency spinal decompression. After induction of anaesthesia, the heart rate settled below 77 beats per minute (bpm) and led to reversion of LBBB to normal sinus rhythm. LBBB is a red flag diagnosis to the anaesthesiologist. But the knowledge of critical heart rate is important; below which the rhythm may revert back to normal sinus rhythm. The knowledge to differentiate between myocardial ischaemia and LBBB is the need of the hour.
Christopher K. Mehta, Sandeep N. Bharadwaj, Stephen F. Chiu
Published: 12 September 2022
Surgery Case Reports, Volume 2022, pp 1-4; https://doi.org/10.31487/j.jscr.2022.02.01

Abstract:
Background: A 49-year-old male presented with a delayed diagnosis of infective endocarditis leading to extensive intracardiac destruction. Such cases present technical challenges to operative debridement as crucial anchoring points for replacement conduits are compromised. Case Presentation: Our patient presented at age 49 with nausea, lethargy, and diarrhea 2 weeks after recent travel. His prior history included bioprosthetic valve replacement for a bicuspid aortic valve. The patient was first given a trial of antimicrobials for a suspected UTI. Subsequently, he was admitted briefly to an outside hospital for a “cardiac work-up,” which returned negative. The patient sought care for the third time, during which he developed unstable supraventricular tachycardia, prompting echocardiography 16 days following the onset of symptoms. Echocardiography demonstrated a 6 cm abscess cavity invading the interventricular septum with a fistula into the left ventricular outflow tract, multiple ventricular septal defects (VSD), and suspected fistulae into the right ventricular outflow tract. The patient was treated with valve explant and extensive debridement. A valved-conduit for the aorta could not be sewn to the aortic annulus in the usual fashion due to destruction and debridement of the annulus, so a neo-annulus was created using the anterior leaflet of the mitral valve and the left ventricular outflow tract of the heart below the level of the VSDs. A mechanical-valved conduit was implanted onto the neo-annulus. A pacemaker was subsequently implanted. Conclusion: In patients with extensive intracardiac destruction with the compromise of the aortic annulus due to infective endocarditis, a low-seated, mechanical-valved conduit implanted directly to the aorto-mitral curtain and left ventricular outflow tract should be considered a novel, durable reconstructive option that allows complete debridement of infected tissues.
Mathey Marina, Pennella Carla, Zubizarreta Pedro
Published: 12 September 2022
Surgical Case Reports, Volume 2022, pp 1-6; https://doi.org/10.31487/j.scr.2022.09.01

Abstract:
Colorectal carcinoma (CRC) is extremely rare among pediatrics, particularly before puberty. It usually begins with nonspecific signs and symptoms, so the index of suspicion is low, consequently, the diagnosis may be delayed. Reports in the literature indicate that poor prognostic factors are more common in children than in adults, resulting in a worse outcome. Our objective is to report clinical profile, treatment and prognosis of CRC in children and adolescents admitted in our institution, and to perform a systematic review of reports in the bibliography.
Artur Zanellato, Rory Thompson, Ruairidh Crawford, Tina Rashid, Andrea Frilling
Published: 30 September 2021
Abstract:
Postpartum gangrenous cystitis is a rare condition with only a few reported cases in the literature. We report a case of a 26-year-old lady who developed gangrenous cystitis and perforation 48 hours after a prolonged labour when she presented in urinary retention and sepsis. Computerised Tomography (CT) scans revealed ascites. With clinical signs of peritonitis, emergency diagnostic laparoscopy was performed, identifying the bladder perforation. The procedure was converted to laparotomy and necrotic bladder tissue was excised and bladder was repaired. We highlight the important learning points from the case and review the current literature on aetiology, diagnostic challenges and management of this rare complication.
Dheeraj Nagore, Shridhar Pandya, Chetan Savaliya, Kamlesh Thummar
International Journal of Regenerative Medicine, Volume 2022, pp 1-6; https://doi.org/10.31487/j.rgm.2022.02.01

Abstract:
Type I or Type II diabetes, once recognized as juvenile diabetes or insulin-dependent diabetes, is a chronic illness in which the pancreas produces slight or no insulin. Insulin-dependent diabetes is a syndrome of glucose homeostasis considered by autoimmune destruction of the insulin-producing pancreatic Beta-cell that gradually leads to insulin deficiency. As there is no perfect treatment for management, Gplife has thought of and developed a product that is found to be effective in the management of insulin-dependent diabetes. After 60 days of evaluation of cases, it is observed that fasting blood glucose was reduced by 62.25%, postprandial glucose levels were reduced by 62.37%, HBA1C levels were reduced by 39.57%, C Peptide levels were increased by 26.67%, also the external insulin injection requirement of the patient’s decreased by 88.57%. This case study gives an overview of the current understanding of the disease and the efficacy of advance diabetic support products in insulin-dependent diabetes. It is evident that the said product further helps to reduce insulin and OHA doses for the management of insulin-dependent diabetes. It is suggested that the advance diabetes support product should be further extensively used as a monotherapy or adjunctive therapy for the regulation, or management or control of insulin-dependent diabetes.
Gustavo Moncada, Gabriela Díaz Mujica, Constanza Valdés
Dental Oral Biology and Craniofacial Research, Volume 2022, pp 1-10; https://doi.org/10.31487/j.dobcr.2022.03.01

Abstract:
Objective: Evaluate the evidence of the clinical correlation between vitamin D and symptomatic degenerative joint disease. Methods: A systematic search and meta-analysis was conducted of randomized controlled studies (RCTs) published in between January 1st, 2010, and March 30th, 2020 on five different databases. The study population consisted of adult patients with symptomatic knee osteoarthritis; the intervention was vitamin D; the comparison was placebo, and the outcomes included the Western Ontario and McMaster Universities Arthritis Index (WOMAC) (pain, function, stiffness), tibial cartilage volume, synovial tissue volume (STV), subchondral bone marrow lesion (BML) volume, effusion-synovitis, serum vitamin D3 levels, serological inflammatory and metabolic biomarkers levels and adverse events. Results: Nine RCTs involving 2,168 patients were included in this study. Pooled estimates suggested that vitamin D supplementation was associated with reduction in WOMAC pain (Std. Mean=1.08(0.90, 1.25); I2=99%; p=0.00001), function (Mean=1.1(0.92, 1.27); I2=99%; p=0.00001), stiffness (Std. mean= 0.72(0.54, 0.90); I2=98%; p=0.00001) and synovial effusion in the suprapatellar pouch numbers. There was no significant difference in tibial cartilage volume incidence (Std. Mean=0.26(0.44, 0.80); I2=99%; p=0.00001), STV, BML volume, inflammatory biomarkers and adverse events between the vitamin D and the placebo groups. Conclusion: Vitamin D supplementation was effective in improving WOMAC pain and function in patients with knee OA and also improved serological vitamin D levels. However, it had no beneficial effect on structural cartilage change or inflammatory biomarker reduction. Therefore, there is currently a lack of evidence on vitamin D regimen dosage and length to obtain benefits in preventing knee disease progression.
Mathey Marina, Peruzzo Luisina Belen, López Marti Jessica, Innocenti Sergio, Ramos Pacheco Maria Luz, Cacciavillano Walter, Felizzia Guido, Viso Marianela, Zubizarreta Pedro, Rose Aadriana
Published: 14 September 2022
Surgical Case Reports, Volume 2022, pp 1-8; https://doi.org/10.31487/j.scr.2022.09.02

Abstract:
Infantile fibrosarcoma (IFS) is the most common non-rhabdomyosarcoma soft-tissue sarcoma in children under 1 year of age, with local aggressiveness, but a high cure rate with conservative treatment. We report our experience with 15 patients with histological diagnosis of IFS treated at our Institution from January-2003 to December-2020. The median age was 6.72 months (range: 0-36); 66% were males. The extremities were the most common tumor site (66.7%). The tumor size was > 5 cm in 10 patients. Only one patient had metastatic disease (lung). Molecular studies were performed in 14 patients and were positive in ten: nine ETV6/NTRK3 and one RAF1. Initial non-mutilating surgery was performed in six patients. A delayed surgery could be performed in 4/8 patients after neoadjuvant chemotherapy with Vincristine - Actinomycin-D, and in one patient a watch-and-wait strategy was adopted. With a median follow-up of 58.67 months, all patients are alive except for the patient with metastatic disease. The 5-year overall and event-free survival were 93.5% and 86.5% respectively. Although IFS is locally aggressive, it has a high rate of overall survival due to its good response to chemotherapy and non-mutilating surgery even with involved margins. Advances in molecular genetics have improved diagnosis and refined classification.
Neha A. Panse, Nikhil Bhoi, Aparajita Pandey, Priyanka Dhananjay Tikait
Published: 14 September 2022
Anesthesia and Clinical Research, Volume 2022, pp 1-4; https://doi.org/10.31487/j.acr.2022.03.02

Abstract:
Background: With the increasing trend of IONM in neurosurgery the role of total intravenous anaesthesia has gained upper hand in the practice of neuro anaesthesia. Propofol based TIVA techniques facilitates rapid recovery of consciousness and psychomotor function with lower incidence of post-operative nausea and vomiting. It also facilitates satisfactory IONM monitoring while maintaining the adequate depth of anaesthesia. Available literature focuses on the surgical aspects with IONM. Few studies are available, which compare TIVA with general anaesthesia that too without IONM. Earlier TIVA for IONM has been studied in patients undergoing kyphoscoliosis correction surgery. This study was conducted to evaluate the efficacy of TIVA in facilitating IONM in resection of intracranial masses and to study its effects on hemodynamics and post op recovery. Methods: In our retrospective study of 23 cases, patients undergoing intracranial tumor mass excision surgeries requiring IONM were given standardized general anaesthesia using intubating dose of short acting muscle relaxant and further maintenance of anaesthesia was done using infusion of propofol and dexmeditomidine with the minimal inhalational agents. IONM was recorded successfully. Results: 18 patients were haemodyanamically stable. 3 patients had intermittent episodes of bradycardia, and 2 patients had hypotension. Three patients elicited dampened response requiring reduction in anaesthetic dose. Six patients exhibited delayed recovery. Conclusion: TIVA with propofol and dexmeditomidine is a good anaesthetic modality to facilitate IONM in resection of intracranial masses.
Woojin Chong
Published: 9 September 2022
American Journal of Surgical Case Reports, Volume 2022, pp 1-5; https://doi.org/10.31487/j.ajscr.2022.03.01

Abstract:
A thorough knowledge of both normal and variant abdominopelvic anatomy is important to the surgeon treating patients with pelvic organ prolapse and pathology in the pelvis. Knowledge of the location of the kidney and ureters is mandatory in treating women with pelvic organ prolapse and a pelvic kidney. This case report describes surgical management for a woman with the right pelvic kidney and symptomatic pelvic organ prolapse.
George Uchenna Eleje, Chidiebele Malachy Ezeude, Celestine Ogonna Oguejiofor, Charlotte Blanche Oguejiofor, Iffiyeosuo Dennis Ake, Patrick Maxwell Uche, Ifeoma Clara Ajuba, Chinyelu Uchenna Ufoaroh, Ekene Agatha Emeka, Arinze Anthony Onwuegbuna, et al.
Published: 9 September 2022
Surgical Case Reports, Volume 2022, pp 1-4; https://doi.org/10.31487/j.scr.2022.09.04

Abstract:
Background: Despite the prevalence and quality of life impact of diabetic foot ulcer (DFU), novel topical and oral therapy standard-of-care remain an important research priority. To date, the lack of available data has made it difficult to assess the efficacy of topical and capsular RM diabetes wound cure for DFUs. Case Presentation: We report the case of a 59-year-old Nigerian woman P2+0 with 2 living children, a known diabetes mellitus patient since 2006 and has been compliant with her antidiabetic medications, who presented with complaint of right foot ulcer. We also report the case of a 69-year-old Nigerian man that presented with DFU. The latter is a known diabetic and hypertensive diagnosed 15 years prior to presentation. For the first case, both topical and capsular RM wound cure were applied twice daily over an area of the ulcer for 8 weeks. For the second case, only RM diabetes wound cure capsule applied twice daily was received for 8 weeks. Efficacy was analysed by lesion measurements and photographs to determine overall response rate (ORR), and complete response (CR). All doses were well tolerated, and potentially efficacious. At 8 weeks across all dose levels, subjects achieved 100.0% ORR and 50.0% CR. Conclusion: Application of topical and ingestion of the oral capsule of RM diabetes wound cure appear safe and well tolerated with some reduction in lesion pain. Some greater levels of lesion stabilization was observed in the subjects, and this demonstrated great clinical benefit in foot ulcers. A randomized, placebo-controlled trial to confirm these findings is recommended.
Marco De Monti, Alessandro Torre, Laura De Pellegrin, Marta Teglas
Published: 7 September 2022
American Journal of Surgical Case Reports, Volume 2022, pp 1-5; https://doi.org/10.31487/j.ajscr.2022.02.03

Abstract:
Background: Spontaneous pathologic fractures of the calcaneum in diabetic patients are rarely described in the literature. The pathologic fractures following osteomyelitis represent a possibly limb-threatening condition and if associated with a concomitant calcaneal ulcer, they present defiance for the surgeon and furthermore an outstandingly challenging condition to handle. Methods: A 61-year-old diabetic female patient on insulin therapy has been treated for a penetrating foot ulcer. In sequence the following procedures were carried out: Negative pressure wound therapy with instillation and dwell time (NPWTi-d), Negative Pressure Wound Therapy (NPWT), arterial percutaneous angioplasty (PTA), calcanectomy and temporary arthrodesis, application of Dermal Regeneration Template (DRT) and transplantation of microfractured autologous adipose graft (LIPOGEMS®), treatment of residual dehiscence with physical cold plasma (kINPen®MED). Results: The patient completely healed within 20 months and was able to walk without further aids. Conclusion: The authors point to the promptness within the treatment of pathologic calcaneal fractures, whether throughout the usage of technical devices targeting the reduction of the bacterial load and stimulation of healthy tissue, like in NPWTi-d and kINPen®MED. The use of a dermal regeneration template followed by skin grafting enriched with autologous microfractured adipose tissue (LIPOGEMS®), therefore represents today the most advanced regenerative surgical procedures.
Nada Al-Sakini, Daniela Bispo, Shreya Ohri, Wasyla Ibrahim, Cathy West, Michael Gatzoulis, Wei Li
International Journal of Surgical Case Reports, Volume 2022, pp 1-6; https://doi.org/10.31487/j.ijscr.2022.01.05

Abstract:
We present the case of a patient with transposition of the great arteries (TGA) post atrial switch repair (Mustard) with a failing sub-pulmonary left ventricle. Our case highlights the importance of early identification of a failing sub-pulmonary LV and the significance of utilising multi-modality imaging in diagnosing and monitoring these patients. Similarly, it emphasizes the importance of a holistic approach in managing patients with complex physical and psychological needs in relation to timely transplantation referral.
Nada Al-Sakini, Shreya Ohri, Mohammad Khurram Nadeem, Sam Seitler, Wasyla Ibrahim, Mohamed Zuhair, Isma Rafiq, Alexander Kempny, Michael Gatzoulis
International Journal of Surgical Case Reports, Volume 2022, pp 1-4; https://doi.org/10.31487/j.ijscr.2022.01.04

Abstract:
A middle aged male with history of Fallot type Double outlet right ventricle and coarctation of aorta who underwent multiple surgeries since childhood. With RV to pulmonary artery conduit and end to end coarctation repair initially, followed by aortic valve, pulmonary valve and RV-PA conduit replacements later. He subsequently developed significant flow through a fistula between a previously coiled aortic pseudoaneurysm and LVOT. This was percutaneously closed with a vascular plug and additionally a PFO, detected, was closed with a device. Patient returned to the clinic with decompensated heart failure. Updated imaging demonstrated that the plug had migrated and together with the coil, which was impinging on the AVR, resulting in severe supra-valvar AS and continuous significant persistent residual flow across the Aorta- LVOT fistula via false aneurysm. Our case highlights the importance of using multimodality imaging for complex congenital heart diseases. In view of high surgical risks associated with previous multiple sternotomies and patient’s preference, percutaneous approaches were adopted initially: however, it was unfortunate to see the migration of vascular plug. After successful deployment of AVP, migration or recanalization is rare, but should not be completely discounted.
Neha A. Panse, Jyoti P. Deshpande
Published: 30 August 2022
Anesthesia and Clinical Research, Volume 2022, pp 1-4; https://doi.org/10.31487/j.acr.2022.03.01

Abstract:
Clavicle fractures are commonly encountered in orthopedic outpatient department but are often managed conservatively. Yet some clavicle fractures need surgical intervention which in turn demand adequate anaesthesia and analgesia. Due to complex sensory innervation there is no sole regional anaesthesia technique which could provide adequate analgesia for clavicle fractures. With the advent of ultra-sonography (USG) and the description of clavipectoral fascia plane block (CPB) by Dr. Valde a lot was simplified. Administration of CPB provides intra as well as postoperative analgesia, maintains hemodynamics, reduces opioid consumption and improvises postoperative recovery of the patients undergoing clavicle surgeries.
Giuseppe Colloca, A. Bellieni, D. Fusco, F. Benvenuto, S. Bracci, E. Villani, B. Di Capua, F. Marazzi, L. Tagliaferri, L. Balducci, et al.
Published: 30 August 2022
Annals of Clinical Oncology, Volume 2021, pp 1-4; https://doi.org/10.31487/j.aco.2021.01.01

Abstract:
The SARS-CoV-2 pandemic has led us to imagine the current scenario as something terrible, disastrous, but temporary. However, history teaches us that an event of this magnitude can only evolve towards “new” normality, a new equilibrium, but it will only be reached through a transition that will last over the years. In this scenario, the term “frailty”, which is known to few, has become common. The need for healthcare that, alongside high specialization, focuses on the complexity of the individual is increasingly intense. Geriatric oncology probably represents the clearest example of how much the current scenario has impacted the health and social fields, as it involves frail adults with cancer. How to draw the future?
Melissa Johnson, Mohammed Teleb
Published: 24 August 2022
Neurology and Neurobiology, Volume 2022, pp 1-4; https://doi.org/10.31487/j.nnb.2022.03.01

Abstract:
Introduction: This review article outlines the clinical symptoms associated with isolated occlusions in the major branches of the anterior, middle, and posterior cerebral arteries. Methods: Review article Conclusion: A comprehensive understanding of isolated branch infarcts will deepen clinical acumen, aid in precise infarct localization, and optimize diagnostic management.
Raghda Rizk, Amel M. Ali, Hoda Abdellatif, Karin Mohamed Lotfi Dowidar
Published: 23 August 2022
Abstract:
Objective: To evaluate virtual reality glasses versus premedication with oral midazolam, and their effect on separation anxiety and postoperative behavioural changes in children experiencing dental rehabilitation under general anaesthesia. Introduction: Several children suffer anxiety when experiencing dental rehabilitation under general anaesthesia, which may be caused by separation from parents, and negative anticipation of surgical procedures. Midazolam (MDZ) is a generation of Benzodiazepines that have been widely used as a premedication. Whereas distraction is a common technique used to reduce pain and anxiety during short invasive procedures. Methodology: This was a randomized clinical trial; children aged 4-6 years who were healthy, uncooperative, and planned to be treated using general anaesthesia were randomly distributed between two groups (Group I), using the Virtual glasses and (Group II), given oral midazolam. The baseline heart rate (HR) was recorded twice. Ease of separation was assessed for all the participants using the Parental Separation Anxiety Scale (PSAS). The Postoperative behavioural changes were scored using (PHBQ) Questionnaire after 24 hours and 14 days after the operation. Results: Regression analysis showed that the type of intervention was non-significantly associated with the acceptability of separation. Males showed significantly less acceptable separation than females. There was a statistically significant increase in the heart rate readings in both groups when compared before and after separation. The parent-reported child morbidity following the surgery showed no significant difference except when regarding the children “who were upset at mentioning doctors, dentists or hospitals” where (P=0.000). Conclusion: VR and premedication with oral midazolam were both effective strategies for controlling preoperative anxiety in children during parental separation, with lots of advantages when using the VR distraction approach.
Robert J. Macielak, Katerina Green, Seid Temam, Joshua P. Wiedermann
Published: 19 August 2022
Abstract:
Animal-induced trauma can lead to severe injury and death, especially in medically isolated settings. Few reports of hyena attacks on humans have been reported in the literature. The goal of this report is to describe such an attack and the heroic efforts required to preserve life and function in a resource-limited environment. We present a case of a 55-year-old female who was attacked by a hyena in a rural region of Ethiopia. Despite delays in medical care, she was able to survive this attack and was successfully discharged after prolonged treatment efforts. Animal-induced trauma is a potential source of substantial and disfiguring injury – especially in resource-limited environments. Early transfer to tertiary care centers and creative solutions are needed to optimize outcomes in such environments.
Soheila Asgari, Hassan Hashemi, Rama Pourmatin
Published: 24 August 2022
Surgical Case Reports, Volume 2022, pp 1-3; https://doi.org/10.31487/j.scr.2022.08.06

Abstract:
Introduction: Conventional phacoemulsification and intraocular lens (IOL) implantation for patients who already have a phakic IOL (PIOL) in situ can present challenges in IOL power calculation and the surgical procedure. Here we report a case of phacoemulsification with IOL implantation without removing the anterior toric PIOL. Patient and Clinical Findings: This 45-year-old male was referred to our clinic with mature cataract in the right eye, and a history of multiple corneal surgical procedures including radial keratotomy, LASIK, corneal cross-linking, and Artiflex toric PIOL implantation. Uncorrected (UDVA) and corrected (CDVA) distance visual acuity were 20/2000. Diagnosis, Intervention, and Outcomes: Since CDVA was 20/25 after toric PIOL implantation and prior to the development of cataract, and the cornea was compromised, the toric PIOL was not removed. Using femtosecond laser assisted cataract surgery (FLACS) through the toric PIOL, capsulotomy and lens fragmentation were completed without modifying the device setting, and an IOL was inserted in the bag. At one year after surgery, right eye UDVA, CDVA, and refraction were 20/32, 20/25, and +1.25/-1.00*120ᵒ. Conclusion: In this case, FLACS was a successful technique for preserving the toric PIOL, and results were stable during the one year of postoperative follow up.
Shahar Kol, Peter Humaidan
Clinical and Experimental Investigations, Volume 2022, pp 1-5; https://doi.org/10.31487/j.cei.2022.01.01

Abstract:
The current commentary paper follows the historical introduction of gonadotropins and gonadotropin releasing hormone (GnRH) analogues to the in-vitro fertilization (IVF) market. We maintain that business decisions significantly influenced research and development; however, pharma decisions did not always align with physiology and clinical interests. Specifically, the never-ending debate on the issue of luteinizing hormone (LH) supplementation during ovarian stimulation was repeatedly studied using population-based randomized controlled trials. However, LH activity supplementation is an endocrine issue and therefore, specific endocrine inclusion/exclusion criteria should be used when assessing the needs or not for LH in our “every-day” patients. We propose that the approach until now has defocused the research question and thus, also the debate and that there is a need to revisit physiology and clinical thinking if the LH supplementation issue is to be unravelled.
Dheeraj Nagore, Shridhar Pandya, Chetan Savaliya, Kamlesh Thummar, Vaishali Undale
International Journal of Regenerative Medicine, Volume 2022, pp 1-8; https://doi.org/10.31487/j.rgm.2022.01.03

Abstract:
Aim: Diabetes support product (ADSP) with phytocompounds was proposed to improve insulin secretion, avoid pancreatic beta cell apoptosis, and moderate beta cell differentiation and proliferation. In this research work, beta cell regenerative potential of ADSP was evaluated with STZ induced diabetes in rodents. Method: Single dose of Streptozotocin (STZ) (70mpk; i.p.) was used to induce diabetes in the Wistar rats. The treatment of vehicle or test or GLB was continued for the next 28 days to assess sub-acute anti-diabetic potential. Fasting blood glucose levels (BGL) was monitored weekly once throughout the experiment. Bodyweight, Feed-water consumption was calculated on every day till end of the experiment. Interleukin-6, Interleukin-1β and Interferon-γ was also analysis from blood serum after 28 days of treatment in rats. Further, animal was humanely sacrifice and organs such as liver, kidney(s) and pancreas were isolated for histopathology analysis. Result: Research showed that Insulin is Increased by 3 times in comparison with the diabetic group by ADSP after 28 days. After 28 days treatment of ADSP to rodents, Interleukin-6 decreased by 52%, Interleukin-1β decreased by 73% and Interferon-γ decreased by 28% in comparison with the diabetic control group. It is also observed in histopathology studies that there was a rise in the quantity of islets after 28 days treatment of ADSP in Streptozotocin carried diabetic rats. Conclusion: Hence in conclusion, advance diabetes support product supposed to be appreciated as synergistic product of encouraging the β-cell regeneration in vivo.
Alexander Kervyn De Volkaersbeke, Lenny Rostomian, Behnum Habibi
Published: 18 August 2022
Surgical Case Reports, Volume 2022, pp 1-1; https://doi.org/10.31487/j.scr.2022.08.02

Abstract:
A 50-year-old male with a past medical history of borderline hyperlipidemia developed COVID-19 in Fall 2020 and recovered without complication. Approximately 5 months later, he sought care for a prolonged episode of right-sided weakness that self-resolved. He was diagnosed with a Transient Ischaemic Attack (TIA) and discharged the same day. The following day, he developed persistent right-sided hemiplegia and was diagnosed with an acute left basal ganglia stroke.
Alexander Kervyn De Volkaersbeke, Angela Taylor, Behnum Habibi
Published: 19 August 2022
Surgical Case Reports, Volume 2022, pp 1-2; https://doi.org/10.31487/j.scr.2022.08.03

Abstract:
A 50-year-old female patient presented with several weeks of right-sided neck, posterior shoulder, and arm pain suggestive of cervical radiculopathy. Her diagnostic workup included cervical spine x-rays and a cervical spine MRI which showed degenerative changes and mild cervical spinal stenosis. She was evaluated by a spine surgeon and a pain medicine specialist. Multiple treatments were administered without success, including courses of celecoxib and gabapentin. Several rounds of epidural steroid injections were also administered, with only transient relief. Upon developing acute right upper quadrant abdominal pain and undergoing a laparoscopic cholecystectomy for biliary colic, the patient reported resolution of her chronic right neck, posterior shoulder, and arm pain.
Andrew Larner
Published: 19 August 2022
Neurology and Neurobiology, Volume 2022, pp 1-4; https://doi.org/10.31487/j.nnb.2022.03.02

Abstract:
Functional amnesia, also known as dissociative amnesia, psychogenic amnesia, or mnestic block syndrome, is a rare disorder which, although clinically heterogeneous, is most often characterised by dense retrograde amnesia mainly affecting the episodic-autobiographical domain but with relative preservation of anterograde memory function, a pattern dissimilar to that seen in other amnesic disorders. The pathogenesis of functional amnesia remains unknown. Here, appeal is made to the study of artificial neural networks in the hope that, as in other mnestic disorders, this might give insight into the mechanisms underpinning functional amnesia. Specifically, the observation of catastrophic forgetting or catastrophic interference occurring in artificial neural networks, that is the abrupt and complete loss of previously learned information when learning new information, is extended to the human nervous system to develop a novel hypothesis: the Catastrophic Forgetting Hypothesis of functional amnesia.
Nadine Magy-Bertrand, Andréa Pastissier, Jérôme Razanamahery, Sébastien Humbert, Thibaud Soumagne, Etienne Daguindau, Catherine Chirouze, Gaël Piton
Published: 12 August 2022
Clinical Oncology and Research, Volume 2022, pp 1-4; https://doi.org/10.31487/j.cor.2022.03.04

Abstract:
Hemophagocytic lymphohistiocytosis (HLH) may be secondary to cancer or other conditions in adults. We aimed to compare characteristics and outcomes of secondary HLH depending on cancer status among adults. Weight loss over 10 %, headache and enlarged lymph nodes were more frequent in malignant- HLH (M-HLH). Higher phosphatase alkaline level and CRP level were present in M-HLH. Mortality rate tended to be higher in M-HLH group in the first month and during the two years follow-up. Some clinical features and biological abnormalities are associated with an increased probability of malignancy in secondary HLH among adults.
Abdullah Saud Arafat, Rawan AlMalki, Mohammed Asiri, Amirah Almutairi, Mohammad Jihad Al Mahdi
Published: 11 August 2022
Surgical Case Reports, Volume 2022, pp 1-4; https://doi.org/10.31487/j.scr.2022.08.05

Abstract:
Encephalocele is less common than other neural tube defects. This report details a bilateral frontal meningoencephalocele that presented at a later than usual age with tonic-clonic seizure and cerebral spinal fluid (CSF) rhinorrhea of a 65-year-old female, a known case of hypertension, and controlled epilepsy.
Christos Siafarikas, Stavros Liatis, Christos Kapelios, Marina Skouloudi, Maria Bonou, John Barbetseas
Journal of Integrative Cardiology Open Access pp 1-5; https://doi.org/10.31487/j.jicoa.2022.03.02

Abstract:
Objectives: Optimal regulation of modifiable risk factors, has been proposed as the standard of care, both for primary and secondary prevention of cardiovascular disease (CVD). The aim of this study was to investigate at what extent individuals who experienced an acute coronary syndrome (ACS) had previously been receiving adequate preventive measures against classical risk factors for CVD. Methods: Data were analysed for all 185 hospitalized patients with a diagnosis of ACS in the Cardiology department of our hospital during an annual period (1/7/2019 until 30/6/2020). The study population was divided into two groups, primary and secondary prevention subgroups, according to the previous medical history of CAD. Results: The mean age of the participants was 65.5 ±12.2 years and most patients were male (81.6%). Fifty-seven patients (30.8%) had a history of diabetes mellitus (DM) and 97 (52.4%) had a history of dyslipidemia. Hypertension was present in 101 (54.6%) patients and coronary artery disease (CAD) in 51 (27.9%). In the secondary prevention group, the LDL-C was on target in only one-third, while one out of 5 patients did not use statins. The use of antiplatelet/anticoagulant agents was 94.5%. Among patients with diabetes, only one out of five patients had been using a GLP-1 receptor agonist or/and an SGLT-2 inhibitor, while the HbA1c was on target in half of them. One-quarter of the patients were active smokers. In the primary prevention group, the use of statins was overall low (25.8%) but more frequent in patients with diabetes and those without diabetes at very high-risk (47.1% and 32.1%, respectively). Overall, the LDL-C was on target in less than one-quarter of patients. The use of antiplatelet/anticoagulant agents was low (20.1%), but higher in those with diabetes (52.9%). In the diabetic group, HbA1c was on target at 61.8%. Active smoking was practiced by more than one-third of the patients. Conclusion: Our data show that in a substantial proportion of patients presenting with ACS, previous CVD prevention, both primary and secondary, fails to meet the current recommendations provided by scientific societies.
Emily Austin, Smith Megan, Barbara Wexelman
Published: 9 August 2022
Surgical Case Reports, Volume 2022, pp 1-3; https://doi.org/10.31487/j.scr.2022.08.04

Abstract:
Fibromatosis of the breast represents <0.02% of all breast tumors. Typically, fibromatosis is non-metastasizing but locally aggressive and is treated with surgical excision. We report a case of a nonagenarian requiring mastectomy for an epidermal inclusion cyst that diagnostically mimicked fibromatosis of the breast. She underwent diagnostic breast imaging for a period of almost two years to monitor the size of her breast tumor. However, in a six-month timeframe, her mass dramatically increased in size and was becoming symptomatic to the patient. The rapidly growing tumor was concerning for occult breast malignancy.
Dong Y Han, Michael W. Williams, Justin E. Karr, Alyssa M. Day, Amanda C. Glueck, Siddharth Kapoor
Published: 8 August 2022
Neurology and Neurobiology, Volume 2022, pp 1-7; https://doi.org/10.31487/j.nnb.2022.02.04

Abstract:
This study examined the relationships between post-traumatic headache (PTH) and mental health symptoms after concussions to inform adolescent concussion management. Headache is the most common complaint following adolescent concussion. In this sample of 123 adolescents with concussion, there was a 5-fold increase in odds of clinically elevated anxiety, as well as increased mental health symptoms (anxiety, depression, anger, and disruptive behaviours), among adolescents with PTH relative to those without PTH. Adolescents with headache following concussions are vulnerable to worse mental health outcomes, particularly anxiety, and may benefit from routine monitoring of mental health symptoms for early detection and intervention.
Zoe Baker, Andrew Cowan, Arthi Hannallah, Thalia Bajakian, Christopher Gayer, Shengmei Zhou, Andy Chang, Yuding Wang, Paul Kokorowski
Published: 4 August 2022
Surgical Case Reports, Volume 2022, pp 1-3; https://doi.org/10.31487/j.scr.2022.08.01

Abstract:
A 20-month-old female presented with a palpable abdominal mass. Imaging revealed bilateral renal masses and pulmonary nodules. The genetic evaluation identified a de novo 540kb X-chromosome deletion involving GPC3, PHF6, and HPRT1, and highly skewed X-inactivation (100:0). This clinical picture was suggestive of Wilms’ tumor in the setting of Simpson-Golabi-Behmel Syndrome.
Dong Y Han, Madeline Aulisio, Sandro Pasagic, Amanda C. Glueck, Timothy J. Ainger
Published: 5 August 2022
Neurology and Neurobiology, Volume 2022, pp 1-3; https://doi.org/10.31487/j.nnb.2022.02.03

Abstract:
A 53-year-old male with history of traumatic brain injury (TBI) presented with localized dissociative amnesia following a second head injury. While memory loss due to TBI is present in the literature, presentations of this type are very rare. Although fully independent in activities of daily living, this patient demonstrated severe deficits in visual memory and processing speed upon neurocognitive evaluation. Effort testing was unremarkable. Increased awareness and study of memory loss following TBI can contribute to enhanced understanding and improved care for patients experiencing these deficits. The authors present this unique case’s profile, clinical history, and discuss their findings.
Catherine Roy, Minault Quentin, Philippe Barthelemy, Marie Mielcarek, Pierre Leyendecker, Mickael Ohana
Published: 5 August 2022
Clinical Oncology and Research, Volume 2022, pp 1-8; https://doi.org/10.31487/j.cor.2022.03.03

Abstract:
Objective: Assessment of a volumetric method versus gold standard unidimensional measurement based on RECIST 1.1 in advanced renal clear cell carcinoma (RCC) treated by immunotherapy. Materials and Methods: We retrospectively recorded the CT data of 14 adult patients treated with immunotherapy for metastatic RCC from February 2016 to January 2018. Follow-up CT scanners were independently reviewed by two radiologists. Unidimensional RECIST 1.1 and volumetric measurements were compared at each time point, with a total of 810 measurements performed for statistical analysis. The main criterion was the inter-observer agreement for each method. The secondary criterion was the tumoral response assessment based on three different items: RECIST 1.1, spherical volumetric method, ellipsoidal volumetric method. Results: Intraclass coefficient correlation in volumetric method (0.986 [95% CI: 0.980, 0.990]) was higher than in RECIST (0.903 [95% CI: 0.861, 0.928]). Relative measurement differences with Bland and Altman plot were lower in the volumetric method with shorter limits of agreement (0.8%; upper LOA95%: 36.5; lower LOA95%: −35), versus those in RECIST (-5.1 % (upper LOA95%: 46; lower LOA95%: −57). The volumetric method (especially the ellipsoidal one) assesses the progression disease earlier than RECIST for 57% of patients, but there is no formal difference for partial response assessment. Conclusion: Volumetric assessment for tumoral response in metastatic RCC compared to unidimensional measurements had a higher inter-observer agreement and might predict disease progression earlier.
Lynn Nl Verrelst, Thomas Jardinet, Martin Ruppert, Paul Van Schil, Annemiek Snoeckx, Guy Hubens, Michiel Fg de Maat
American Journal of Surgical Case Reports pp 1-5; https://doi.org/10.31487/j.ajscr.2022.02.02

Abstract:
Post-esophagectomy chylothorax is a therapeutic dilemma. Understanding anatomy and leakage site is essential, although imaging techniques for thoracic lymphatics are challenging and not always available. We describe a patient with chylothorax post-esophagectomy from a left-sided thoracic duct traversing to the right chest. We applied intranodal Lipiodol® lymphangiography, computed tomographic lymphangiography, and performed fluorescence-guided thoracic duct ligation at the level of the aortic arch. These techniques are not only useful in a postoperative setting but may be used as preventive strategies to reduce morbidity and mortality from chylothorax after any thoracic surgical procedure where the thoracic duct is at risk.
Kassi Anicet Adoubi, Esaie Kossa Soya, Florent Kouakou Diby, Thierry Niamkey, Pinnin Ouattara, Chrisophe Konin
Journal of Integrative Cardiology Open Access, Volume 2022, pp 1-8; https://doi.org/10.31487/j.jicoa.2022.03.01

Abstract:
Background: New classification of heart failure according to ejection fraction calls for exploring in black Africans. Objectives: To determine our patient's characteristics and prognosis of the subtypes of heart failure. Methods: We analysed data from consecutive black African patients hospitalised for heart failure at Heart Institute of Abidjan in 2018 and followed up for one year. Results: Were considered 251 heart failure patients (age: 55.5 ± 16.3 years, 63.7% of males) with preserved (HFpEF) (18.7%), mid-range (HFmrEF) (17.6%), and reduced ejection fraction (HFrEF) (63.7%). HFpEF patients were older (p <0.0001) and had more frequently. acute pulmonary oedema. From an echocardiographic point of view, HFpEF patients had, on average, a smaller left ventricle than the other patients (p <0.001), but a larger left atrium (p <0.05). Clinically, these patients were admitted more often with acute pulmonary oedema (p = 0.01) and had more often comorbidities (p=0.00)4. However, survival was better with HFpEF patients than HFrEF patients (log-rank = 4.61; p = 0.032). HFmrEF patients have an intermediate profile. Conclusion: In our context, although they have the same expression, HFrEF and HFPEF appear very different. We need further studies for a better understanding of HFmrEF.
Simon Forstmeier, Shapour Fereydouni, Samira Fereidouny Doshmanzeiary
Published: 29 July 2022
Psychological Disorders and Research, Volume 2022, pp 1-7; https://doi.org/10.31487/j.pdr.2022.01.02

Abstract:
A considerable proportion of young adults studying at universities have a mental disorder. Previous research has shown a negative relationship between various religiosity and psychopathology measures, with different strengths of this correlation depending on the religiosity measure. The aim of the present study is to investigate the strength of association between religious attitude and depression, anxiety and stress in Iranian university students. Thirty-three students from two Iranian universities filled in the Religious Attitude Scale for University Students (RASUS), the Beck Depression Inventory-II (BDI-II), and the Depression, Anxiety and Stress Scale (DASS-42). Religious attitude correlates negatively with all psychopathological variables with a moderate effect size (e.g., with BDI-II: r = -.47; p = .006). When dividing the sample in low vs. high religious people, there were significantly more students without depression symptoms in the high religious attitude group than in the low group.
, Yu-Wei Lin, Chiang-Yun Chen
Published: 29 July 2022
Anesthesia and Clinical Research, Volume 2022, pp 1-5; https://doi.org/10.31487/j.acr.2022.02.04

Abstract:
Infrared laser as a heat source could induce gene expression by activating heat promoter genes in Caenorhabditis elegans, as previously reported. In this study, we innovatively used a 266-nm laser to irradiate C. elegans for only one second and observed a significant inhibition of the overall number of eggs laid (P < 0.0001) and the first day egg laying (P=0.005). This is the first study to establish how light with a wavelength of 266-nm can influence a life activity such as laying eggs in C. elegans.
Oyinem Odumah, Jose Isaac Reyes, Jesam Usani, Jaime Yun, Tareq AlQasas
Published: 29 July 2022
Surgical Case Reports, Volume 2022, pp 1-3; https://doi.org/10.31487/j.scr.2022.06.02

Abstract:
Pulmonary sequestration is a rare congenital malformation whereby abnormal lung tissue forms that do not communicate with the tracheobronchial tree. Pulmonary sequestration receives its blood supply via single or multiple vessels, typically arising from the systemic circulation. Symptoms can include a chronic or recurrent cough, respiratory distress, hemoptysis, or pneumonia. Management typically involves treatment of symptoms, sometimes requiring surgery. This case reviews the clinical presentation, work-up, and management of pulmonary sequestration presenting in an adult patient.
, Yu Wei Lin, Chiang Yun Chen
Published: 29 July 2022
Abstract:
Infrared laser as a heat source could induce gene expression by activating heat promoter genes in Caenorhabditis elegans, as previously reported. In this study, we innovatively used a 266-nm laser to irradiate C. elegans for only one second and observed a significant inhibition of the overall number of eggs laid (P < 0.0001) and the first day egg laying (P=0.005). This is the first study to establish how light with a wavelength of 266-nm can influence a life activity such as laying eggs in C. elegans.
Vasilopoulou Angeliki, Georgas A, Hristoforou E
Journal of Integrative Cardiology Open Access, Volume 2022, pp 1-7; https://doi.org/10.31487/j.jicoa.2022.02.02

Abstract:
Nowadays, problems in healthcare sector seem to be more crucial than ever. Among these, cardiovascular diseases (CVDs) play an important role, being for years a major threat to human health. In a bid to reduce the number of deaths due to heart diseases by taking precautions, science has turned to the development of devices able to offer early diagnosis of a heart failure. Recently, many biosensors have been developed based on cardiac biomarkers that can be detected in blood and predict the risk of heart failure. Of these, cardiac troponin is the best known, while C-reactive protein and myoglobin have also been used. Troponin is a complex of proteins found in the thin filaments of striated muscles and consists of three protein subunits, I, C and T. In case of myocardial malfunction, troponin is released into the blood. Consequently, the detection of elevated troponin levels at an early stage in human serum, is an indication of high risk of cardiovascular event enabling early medical intervention and treatment. In the present work, after the analysis of heart diseases, medical tests, troponin and its role in controlling myocardial health, there is an overview of the available biosensor platforms for cardiac biomarkers detection.
Oyinem Odumah, Jessica Pagé, Mohammad Gilani, Gary Kronfeld, Mina Iskaros, Leaque Ahmed
Published: 28 July 2022
Surgical Case Reports, Volume 2022, pp 1-3; https://doi.org/10.31487/j.scr.2022.06.03

Abstract:
Pancreatic cancer carries one of the worst prognoses in the United States. It is the fourth leading cause of cancer-related death in the United States and second after colorectal cancer in digestive system cancer-related death. Early detection is the key to improving its prognosis. Surgical resection is the only curative treatment, but even after margin-negative resection, the 5-year survival rate is still 30%. The following case presents a fascinating diagnosis of pancreatic cancer. Despite an initial diagnosis of pancreatitis, negative cytology, tumor markers, and imaging suggestive of intraductal papillary mucinous neoplasm (IPMN), this patient underwent surgical resection that later revealed pancreatic adenocarcinoma of the tail. This article highlights certain imaging modalities and characteristics that are essential in the diagnosis of pancreatic adenocarcinoma, in an effort to guide management of similar cases, with hope it leads to better outcomes.
Emery M. Cuellar, Lisa Kenney, Marybeth Hughes
Published: 27 July 2022
Abstract:
Glomus tumors (GTs) are mesenchymal tumors derived from modified smooth muscle cells of the glomus body. These tumors account for less than 2% of all soft tissue tumors, and of those less than 1% are malignant. A 35-year-old African American female presented with symptomatic iron deficiency anemia. On esophagogastroduodenoscopy, a 5 cm mass was seen partially obstructing the antrum and tissue biopsy was obtained. The biopsy showed low-grade epithelial mesenchymal neoplasm with features of a glomus tumor. A follow up computed tomography (CT) chest/abdomen/pelvis revealed a 5 cm relatively homogeneous solid mass in the gastric antrum, which appeared most similar to a gastrointestinal stromal tumor. During the planned distal gastrectomy with reconstruction, one hepatic metastasis was identified via intraoperative ultrasound and was confirmed by frozen section consultation to be the same histologic type as the antral mass. Pathologic and immunohistochemical findings were consistent with a malignant gastric glomus tumor with liver metastasis. Most GTs have a benign clinical course making the diagnosis and treatment of malignant GTs an ongoing challenge. The data on glomus tumors of the viscera is limited by the rarity of these tumors, with most of the known presentation and treatment gathered from case reports.
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