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, , Arnar S. Ágústsson, , Edward Rumba, Bs Daníel A. Pálsson, Indriði E. Reynisson, Ms Brynja R. Guðmundsdóttir, , Md Einar S. Björnsson
Annals of Internal Medicine; https://doi.org/10.7326/m21-1474

, , , MD George M. Abraham, Md Janet A. Jokela, Matthew C. Miller, Mary Ann Forciea, Md Linda L. Humphrey, Scientific Medical Policy Committee of the American College of Physicians*
Annals of Internal Medicine; https://doi.org/10.7326/l21-0607

Anjum S. Kaka, MS Roderick MacDonald, Bs Eric J. Linskens, Md Timothy J. Wilt
Annals of Internal Medicine; https://doi.org/10.7326/l21-0600

Bsj Ryan Crowley, Omar Atiq, Md David Hilden, Thomas G. Cooney, Health and Public Policy Committee of the American College of Physicians*
Annals of Internal Medicine; https://doi.org/10.7326/m21-2392

Safia Kuriakose, Md Kanal Singh, Alice K. Pau, Eric Daar, Rajesh Gandhi
Annals of Internal Medicine, Volume 174; https://doi.org/10.7326/l21-0537

Med Sylvia S. Villarreal
Annals of Internal Medicine, Volume 174; https://doi.org/10.7326/m20-6399

Daniel G. Deschler
Annals of Internal Medicine, Volume 174, pp 1474-1475; https://doi.org/10.7326/m21-3162

, Saad B. Omer, Peng Yan, Obaid S. Shaikh,
Annals of Internal Medicine, Volume 174, pp 1404-1408; https://doi.org/10.7326/m21-1577

Abstract:
With the emergency use authorization of multiple vaccines against SARS-CoV-2 infection, data are urgently needed to determine their effectiveness in a real-world setting. To evaluate the short-term effectiveness of vaccines in preventing SARS-CoV-2 infection. Test-negative case-control study using conditional logistic regression. U.S. Department of Veterans Affairs health care system. All veterans who had testing for SARS-CoV-2 infection between 15 December 2020 and 4 March 2021 and no confirmed infection before 15 December 2020. SARS-CoV-2 vaccination with either the BNT-162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna) vaccine as part of routine clinical care. Effectiveness of vaccination against confirmed SARS-CoV-2 infection. Among 54 360 persons who tested positive and 54 360 propensity score-matched control participants, the median age was 61 years, 83.6% were male, and 62% were White. Median body mass index was 31 kg/m2 among those who tested positive and 30 kg/m2 among those who tested negative. Among those who tested positive, 9800 (18.0%) had been vaccinated; among those who tested negative, 17 825 (32.8%) had been vaccinated. Overall vaccine effectiveness 7 or more days after the second dose was 97.1% (95% CI, 96.6% to 97.5%). Effectiveness was 96.2% (CI, 95.5% to 96.9%) for the Pfizer-BioNTech BNT-162b2 vaccine and 98.2% (CI, 97.5% to 98.6%) for the Moderna mRNA-1273 vaccine. Effectiveness remained above 95% regardless of age group, sex, race, or presence of comorbidities. Predominantly male population; lack of data on disease severity, mortality, and effectiveness by SARS-CoV-2 variants of concern; and short-term follow-up. Currently used vaccines against SARS-CoV-2 infection are highly effective in preventing confirmed infection in a high-risk population in a real-world setting. None.
Md Shikha Garg, Mph Kadam Patel, Mph Huong Pham, Mph Michael Whitaker, Alissa O’Halloran, , Mph Onika Anglin, Mph Pam D. Kirley, Arthur Reingold, Mph Breanna Kawasaki, et al.
Annals of Internal Medicine, Volume 174, pp 1409-1419; https://doi.org/10.7326/m21-1991

Urvi Bihani, Keerthi Muthukumar, Aya Khasati, Ayesha Ali, Raja Ohri, Yusuf Sheikh, Alan Hasanic
Annals of Internal Medicine, Volume 174; https://doi.org/10.7326/g21-0050

, , Miriam Kimpton, , Md Clive Kearon, Jeffrey I. Weitz, Md Harry R. Büller, Gary E. Raskob, Walter Ageno, , et al.
Annals of Internal Medicine, Volume 174, pp 1420-1429; https://doi.org/10.7326/m21-1094

Jonathan C. Yeh
Annals of Internal Medicine, Volume 174; https://doi.org/10.7326/m20-7506

Md Megan Mack, Md Matthew Luzum, David H. Wesorick
Annals of Internal Medicine, Volume 174; https://doi.org/10.7326/awho202110190

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