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Duon Nguyen Thi Thuy, Phuong Le Thi Hoai
Journal of Medicine and Pharmacy, Volume 11, pp 44-51; https://doi.org/10.34071/jmp.2021.1.6

Abstract:
Background: In order to treat cervical lesion of teeth, class V cavity is prepared and filled with restored materials. However, class V restoration is a common challenge to clinicians: low retention capacity, marginal defect and secondary caries due to microleakages. The aim of this study was to compare microleakage of class V cavities restored by glass ionomer cement and composite restoration with or without protective coating material. Materials and Methods: 60 extracted premolars were randomly divided into 6 groups (n=10/ group). Each group were prepared and restored with one of three materials: conventional glass ionomer (CGIC), resin-modified glass ionomer (RMGIC) and composite, with or without G-Coat Plus. All samples were thermocycled, immersed in 0.5% Fuschin solution and evaluated microleakage by dye penetration. Results: Gingival margin showed higher microleakage than occlusal margin in Composite group and CGIC groups with G-Coat Plus (p < 0.05). RMGIC showed lower microleakage than CGIC and Composite when assessed on gingival margin (p < 0.05). G-Coat Plus reduced the microleakage in the RMGIC and Composite groups when compared with the uncoated group (p < 0.05). Conclusions: Microleakage depends on evaluated site and restored materials. Protective coating material reduces microleakage, especially on RMGIC and Composite restorations. Key words: microleakage, class V cavity, glass ionomer cement, composite, provetive coating
Quynh Vo Nhu, Thao Nguyen Thanh
Journal of Medicine and Pharmacy pp 7-15; https://doi.org/10.34071/jmp.2021.1.1

Abstract:
Carpal tunnel syndrome is the most common condition of peripheral nerve compression. Most carpal tunnel syndrome is primary, also known as idiopathic carpal tunnel syndrome. Modern imaging techniques play an important role in the diagnosis of carpal tunnel syndrome as well as in assessing and predicting surgery outcome. Ultrasound and magnetic resonance imaging are becoming important diagnostic techniques and should be widely indicated for patients with clinically suspected carpal tunnel syndrome. Key words: Carpal tunnel syndrome
Giang Truong Thi Linh
Journal of Medicine and Pharmacy pp 16-23; https://doi.org/10.34071/jmp.2021.1.2

Abstract:
Twin-twin transfusion syndrome (TTTS) and twin anemia polycythemia sequence (TAPS) are serious complications of monochorionic (MC) twin gestations. Only MC twins have these complications because, in contrast to dichorionic twins, the circulatory systems of almost all MC twins have arteriovenous (AV) anastomoses in the placenta, thus forming a vascular connection between them. TTTS - TTTS is characterized by relative hypovolemia of one twin and hypervolemia of the other as a result of many or large AV anastomoses deep in the placenta. The cardinal prenatal finding is MC placentation with discordant amniotic fluid volumes (maximum vertical pocket < 2 cm in one amniotic sac and > 8 cm in the other amniotic sac). TAPS - TAPS are an atypical chronic form of TTTS caused by slow transfusion of red blood cells through a few very small (< 1 mm diameter) placental AV anastomoses, resulting in anemia of one twin and polycythemia of the co-twin. Amniotic fluid volumes are normal. The cardinal prenatal finding is MC placentation with middle cerebral artery-peak systolic velocity greater than 1.5 multiples of median (MoM) in one twin and less than 0.8 MoM in the other twin. These descriptions reflect the characteristics of each disorder in its classic, pure form. However, diagnosis can be challenging because TAPS, TTTS, and a third disorder, selective intrauterine growth restriction (sIUGR), are not necessarily mutually exclusive of each other and can present together in any combination. This topic will review screening, prevalence, pathophysiology, and diagnosis of TTTS and TAPS. Management and outcome of patients with TTTS and TAPS, including neurodevelopmental outcomes, are discussed separately
An Van Thi Minh, Bang Le Van
Journal of Medicine and Pharmacy pp 30-34; https://doi.org/10.34071/jmp.2021.1.4

Abstract:
Background: COPD is one of the leading causes of death. The lack of an accurate prognostic tool that can accurately predict in-hospital mortality and help clinicians triage patients to the appropriate level of care is still challenging. This study aims to: 1/ To evaluate the parameters of DECAF Score, 2/ To assess the prognosis for in-hospital mortality of acute exacerbation of COPD. Materials and methods: 68 male patients with the diagnosis of acute exacerbation of COPD admitted to the hospital. Admission clinical data and inhospital death rates were recorded. The prognostic value of DECAF score were assessed by the area under the receiver operator characteristic (AUROC) curve. Results: DECAF score included 5 factors: eosinopenia (26.5%), consolidation (10.3%), acidemia (14.7%), atrial fibrilation (5.9%), eMRCD 5a (10.3%), eMRCD 5b (2.9%). The DECAF AUROC curve for in-hospital mortality was 0.884 (95%CI: 0.783 - 0.949) with sensitivity 77.8% (95%CI: 40.1 - 96.5) and specificity 93.2% (95%CI: 83.5 - 98.1). Conclusion: DECAF is a simple but powerful predictor of in-hospital mortality for acute exacerbation of COPD. Key words: DECAF score, acute exacerbation of COPD, mortality, prognostic value
Thi Ha Thi Minh, Khanh Huynh Vu Viet, Ngan Nguyen Thi Mai, Huy Tran Van, Thuan Dang Cong
Journal of Medicine and Pharmacy, Volume 11, pp 72-78; https://doi.org/10.34071/jmp.2021.1.10

Abstract:
Background: cagA gene EPIYA motifs of H. pylori play an important role in the pathogenesis of gastroduodenal disease. This study is aimed at (1) Identify patterns of cagA gene EPIYA motifs ofH. pyloristrains from gastric biopsy specimens; (2) Investigate the association between cagA gene EPIYA motifs and gastroduodenal diseases. Patients and methods: Eighty-nine gastroduodenal disease patients infected with cagA-positive H. pylori were enrolled in this study. The patterns of cagA gene EPIYA motifs were determined by PCR. Result: cagA-positive H. pylori strains with East Asian-type EPIYA motif were predominant (89.9%), whereas strains with Western-type EPIYA motif accounted for only 10.1%. There were two strains with rare East Asian-type EPIYA, as -ABDBD and -AABD. In the duodenal ulcer group, the prevalence of East Asian-type and Western-type EPIYA motifs were 80% and 20%, respectively. Meanwhile, East Asian-type and Westerntype EPIYA motifs accounted for 95.8% and 4.2%, respectively in the gastric cancer group. Conclusion: cagA gene EPIYA motifs of cagA-positive H. pylori were quite diverse with the predominance of East Asian-type EPIYA motif. There were two rare motifs as -ABDBD and -AABD. The frequency of strains with East Asian-type EPIYA motif was highest in the gastric cancer group, whereas it was lowest in the duodenal ulcer group. Key words: Helicobacter pylori, cagA gene, EPIYA motif, gastroduodenal diseases
Minh Doan Van, Lien Nguyen Thi Kim, Tam Nguyen Quang, Thao Le Thi Minh, Minh Tran Nhat
Journal of Medicine and Pharmacy, Volume 11, pp 79-86; https://doi.org/10.34071/jmp.2021.1.11

Abstract:
Background: Dysmenorrhea is understood as a woman suffering from menstrual pain. Dysmenorrhea is often manifested with symptoms such as abdominal pain, back pain, vomiting, nausea, diarrhea, dizziness,... it not only causes physical pain for the patient, expensive treatment, but also greatly affects the quality of life. Objective: To stduy characteristics of dysmenorrhea and the need for treatment with traditional medicine of female students of Hue university of medicine and pharmacy. Materials and method: A crosssectional descriptive study was conducted in 409 female students from 8 academic majors at Hue University of Medicine and Pharmacy. Students were instructed and completed a self-administered questionnaire, using the Cox Retrospective Symptom Scale (RSS –Cox) to assess menstrual symptoms, using the VAS pain severity scale to assess the level of pain. Result: The rate of dysmenorrhea among female students of Hue University of Medicine and Pharmacy was 88.8%. Moderate pain (according to VAS) accounts for 51.8%, mild pain 30.3% and severe pain 17.9%. The average RSS-Cox1 score was 16.7 ± 10.6 and the RSS-Cox 2 score was 13.0 ± 9.5. According to traditional medicine, Excess accounts for 65.3%, Deficiency 47.9%, Heat 3.0% and Cold 51.8%. In clinical type, the pattern of stagnation of cold-dampness accounts for 38.3%, stagnation of Qi and blood stasis 30.9%, deficiency of Qi and blood 18.7% deficiency of the liver and kidney 10.5%. The proportion of students who need for treatment with traditional medicine is 14.9%, acupress massage and moxibustion are the two methods with the highest demand for treatment. Conclusion: The rate of dysmenorrhea among female students at Hue University of Medicine and Pharmacy is high, most of them have moderate pain, and menstrual-related symptoms appear more often with quite severe levels. According to traditional medicine, most of them have the manifestations of Excess and Cold, corresponding to stagnation of cold-dampness and stagnation of Qi and blood stasis are higher than the others. Demand for treatment of dysmenorrhea with traditional medicine is relatively low, most of them need treatment with acupress massage and moxibustion methods. Key words: dysmenorrhea, the need for treatment, female students, Hue university of medicine and pharmacy
Tri Nguyen Van, Bao Hoang Bui, Minh Huynh Van
Journal of Medicine and Pharmacy, Volume 11, pp 97-104; https://doi.org/10.34071/jmp.2021.1.13

Abstract:
Survey serum levels of NT-proBNP and cardiovascular risks in patients with preeclampsia. Methods: A descriptive cross-sectional study. A survey of 52 women with preeclampsia in the Department of Gynecology and Obstetrics - Hue Central Hospital, from August 2019 to September 2020. Results: In preeclampsia patients, the rate of grade 3 hypertension was 46.1%, of grade 2 hypertension was 32.7%, of grade 1 hypertension was 21.2%. The average Sokolow-Lyon index in preeclampsia group with and without severe features was respectively 22.25 ± 7.38mm; 20.16 ± 5.54mm, the average Sokolow-Lyon index were not significantly higher in severe features preeclampsia group compared with without severe features preeclampsia group. The average LVMI in patients with and without severe features preeclampsia was respectively 120.68 ± 16.47g/m2; 92.27 ± 14.56g/m2 and the average EF in patients with and without severe features preeclampsia was respectively 56.21 ± 7.12%; 65.11 ± 3.45%. The average LVMI and the average EF were significantly higher in severe features preclampsia group compared with without severe features preclampsia group (p < 0.05). In additon, the average serum levels of NT-proBNP in patients with preeclampsia were 598.22 ± 234.35pg/ml. Serum NT-proBNP levels were significantly higher in the severe features preeclampsia groups than in the without severe features group (p < 0.05). Conclusion: The NT-proBNP level were statiscally significantly increased in the patients with preeclampsia. Preeclampsia patients are at increased risks of cardivacular diseases later in life. The serum NT-proBNP level appears to be useful marker to evaluate long-term cardivascular risks.
Tuyet Nguyen Thi Hiep, Thuy Bui Thanh, Hue Phan Minh, Hang Hoang Ngoc
Journal of Medicine and Pharmacy, Volume 11, pp 105-112; https://doi.org/10.34071/jmp.2021.1.14

Abstract:
Objectives: (1) To describe sperm kinetics in semen samples in infertile couples; (2) Evaluation of the factors related to sperm kinetics. Subjects and methods: Descriptive study cross-sectional 50 semen samples in the husband of the infertile couple. Sperm motility and kinetics were evaluated using computer‐aided sperm analysis Hamilton Thorne IVOS II. Results: The mean values ​​of VCL, VSL, VAP, ALH in the normal morphological group were higher than in the abnormal morphology group (p < 0.05). There were the positive correlations between VCL (r = 0.373, p = 0.008), VSL (r = 0.343, p = 0.015), VAP (r = 0.381, p = 0.006), ALH (r = 0.311, p = 0.028) with normal sperm morphology; and negative correlation between VCL (r = -0.286, p = 0.044) with head abnormality. The normal morphological in the group with drinking alcohol was lower than in the group that did not drink, (p = 0.027). The neck-tail abnormality in the drinking group was higher than in the non-drinking group (p = 0.124); The neck-tail abnormality in the smoker group was higher than in the non-smoker group (p = 0.001). Sperm kinetics parameters (VCL, VSL, VAP, ALH, LIN, STR) recorded lower than in the drinking and smoker group, (p > 0.05). Conclusion: Motility and kinetics are related to sperm morphology. Sperm kinetics combines semen parameters to evaluate male fertility more totally. Key words: sperm, semen parameters, sperm kinetics, computer‐aided sperm analysis
Thao Pham Vo Phuong
Journal of Medicine and Pharmacy pp 24-29; https://doi.org/10.34071/jmp.2021.1.3

Abstract:
Background: Mortality of diarrhea have decreased significantly starting in 2000, from about 1.2 million deaths among children under 5 years old to 526,000 in 2015 - a 57% reduction. Despite this, diarrhea remains the second most common cause of death among children under 5, closely following pneumonia. Objectives: To describe clinical and subclinical characteristics of acute diarrhea in children from 2 months to 5 years of age. Subjects and methods: 148 patients from 2 months to 5 years of age who were diagnosed with acute diarrhea for treatment in General Pediatrics Department 1 - Pediatric Center - Hue Central Hospital from April 2018 to April 2019. Set up a cross-sectional study. Results: The group of 2 - 24 months of age accounted for the highest proportion (83.1%), no dehydration (84.5%), dehydration (15.5%), no severe dehydration. The common electrolyte disturbance is hyponatremia (15.5%) and hypokalemia (32.4%). Conclusion: Acute diarrhea in children usually lasts less than 7 days; The common symptoms are vomiting, fever, inflammation of the upper respiratory tract; Laboratory tests showed that peripheral leukocytes were usually not increased and most of them were caused by Rotavirus. Key words: clinical, subclinical, acute diarrhea
Tri Tran Duc Duy, Minh Nguyen Thanh, Tri Truong Van
Journal of Medicine and Pharmacy pp 35-43; https://doi.org/10.34071/jmp.2021.1.5

Abstract:
Objective: To evaluate radiographic and clinical outcomes following anterior cervical discectomy and fusion with cage and plate in patients with degenerative spondylosis. Methods: A prospective study. Patients were performed this technique between August 2013 and October 2017. Radiographic follow-up included static and flexion/extension radiographs obtained to assess fusion, focal and segmental kyphosis, and change in disc space height. The Odom’s criteria and NDI were used to assess outcomes at most recent follow-up. Results: Twenty-two patients with singlelevel degenerative spondylosis underwent ACDF with cage and plate during the study period. The mean duration of follow-up was 17.6 ± 7.3 months. Radiographic evidence of fusion was present in 21 patients (95.5%). The focal alignment at operated level on postoperative radiographs was slightly changed (mean α2 was 4.30 ± 5.50) and segment alignment was a little increased lordosis with mean Cobb angle β2 was 15.70 ± 12.40. Mean decrease in disc space height was 5.4 ± 2.4%. Six patients (27.3%) had dysphagia. Fifteen patients (68.2%) had excellent results according to Odom’s criteria. The mean post-operation NDI score was 5.1 ± 5.8 (median 2.5 range 1-21). Conclusions: Single-level ACDF with cage and plate for cervical spondylosis is an effective treatment, achieves high rate of fusion and preserves the alignments of cervical spine. Key words: Anterior Cervical Discectomy and Fusion, cervical spondylosis
Le Trinh Thi My, Dung Ho Dang Quy, Huy Tran Van
Journal of Medicine and Pharmacy pp 60-65; https://doi.org/10.34071/jmp.2021.1.8

Abstract:
Background: Pancreatic cancer is a common disease of digestive cancers. The tumor progresses rapidly and malignantly, showed a low 5-year survival rate. However, when diagnosed and treated early, the 5-year survival rate of pancreatic cancer improves significantly. Endoscopic ultrasound (EUS) has the advantage that probe can optimal access to the pancreas and surrounding organs, therefore, diagnose pancreatic tumors can be made even when the tumor is small (< 2 cm). Furthermore, Endoscopic Ultrasound- Guided Fine needle aspiration (EUS-FNA) can determine the exact histology of the tumor. Objectives: 1. Investigate some clinical, biological and endoscopic ultrasound characteristics in patients with pancreatic cancer. 2. Evaluate the relationship between endoscopic ultrasound images with clinical and biological characteristics and compare the results between endoscopic ultrasound with computer tomography. Materials and methods: Descriptive cross-sectional studies in 58 patients with pancreatic cancer had endoscopic ultrasound. Results: In 58 patients with pancreatic cancer, we recorded that patients with a history of smoking accounted for 32.8%, and drinking alcohol 31%. Abdominal pain was 89.7%, 44.8% of patients show anorexia, 37.9% have weight loss. 69% of patients had CA 19-9 > 37 UI/ml. EUS found a patient with pancreatic tumor < 2 cm, but CT scan could not detect. Tumors in pancreatic head accounted for 60.3%; in the body 24.1%, 96.6% of pancreatic cancer have a hypoechoic structure, heterogeneous ultrasound. There was a significant relation between pancreatic head tumor and other part with jaundice (p = 0.013). Compatibility in diagnosis of vascular invasion between EUS and CT scan was average (K = 0.483). Conclusion: Smoking and alcohol consumption accounted for the highest proportion, abdominal pain was the most common clinical symptom. Endoscopic ultrasound can diagnose small pancreatic tumors that CT scan can not detect. Key words: Pancreatic cancer, endoscopic ultrasound, clinical characteristics, bio-marker
Huy Tran Van, Thanh Tran Nguyen Ai
Journal of Medicine and Pharmacy pp 66-71; https://doi.org/10.34071/jmp.2021.1.9

Abstract:
Background: The introduction of a new generation of direct acting antiviral agents (DAAs) is a revolution in the treatment of hepatitis C, opening the prospect of eliminating HCV in the future. In Vietnam, the combination of NS5A/NS5B drugs is officially circulated, which has very few studies assessing the therapeutic efficacy and drug tolerance of these drugs in hepatitis C. On the other hand, there are also fewer data on treatment efficiency of patients with genotype 1.6 in the world. Objective: We survey clinical, biochemical and viral response in patients with hepatitis – C, genotype 1,6 treated with the combination of sofosbuvir and ledipasvir (LDV/SOF). Methods: A prospective descriptive study was performed on 48 diagnosed patients who had chronic hepatitis C and/or compensated cirrhosis genotypes 1 or 6 and they were treated for 12 weeks with the combination of sofosbuvir and ledipasvir (LDV/SOF) at Internal Medicine Department, Thu Duc District Hospital. Results: ALT decreased from 72.3 ± 31.9U/L to 29.4 ± 9.3 U/L, AST decreased from 72.9 ± 40.3U/L down to 35.2 ± 23.5 U/L after 12 months of treatment. Albumin and bilirubin maintained 3.64 ± 0.61 g/dL and 0.69 ± 0.26 g/dL. Platelets increase from 145.0 ± 36.3 to 173.9 ± 36.7 after treatment. Percentage of HCV RNA below threshold at the 4-week period later treatment achieved 93.3% and reached 95.5% achieved by SVR12. The incidence of drug side effects is 18.7%. Most are mild, transient symptoms such as fatigue, nausea, diarrhea or loss of appetite... Conclusion: LDV/SOF is an effective, improved interferonfree treatment, good biochemical and microbiological aspects. LDV/SOF therapy is safe and has little effect serious side effects due to medication. Key words: chronic hepatitis C, ledipasvir, sofosbuvir, viral response
Nga Tran Thi Thanh, Thuy Le Thi Bich, Lan Nguyen Hoang
Journal of Medicine and Pharmacy, Volume 10, pp 50-56; https://doi.org/10.34071/jmp.2020.6.7

Abstract:
Objectives: To assess the health literacy and identify the relationship between the health literacy and health care seeking behavior among the older persons in Hue city. Methods: A cross-sectional study was conducted in Hue city. 400 older persons were interviewed directly using a structured questionnaire. Health literacy was assessed by HLS- Asian- Q. Multivariate logistic regression model was used to identify the relationship between health literacy and health care seeking behavior. Results: 20.0% of the respondents got inadequate health literacy. The proportion of the elderly who achieved health literacy in health care, health prevention and health promotion were 25.7%, 10.0% and 28.0%, respectively. The percentage of the elderly who have sought health care services and health promotion services were 76.7% and 68,0%, respectively. There was a relationship between health literacy and treatment seeking behaviour (OR= 3.71; 95% CI: 1.25-11.01) and health prevention service seeking behaviour among participants (OR=3.30; 95% CI:1.16-9.40). Conclusions: Health literacy of the elderly was still low in Hue city. There is influence of health literacy on health care seeking behavior among them. Enhancing health literacy for the older persons should be a necessary solution to improve their health status. Keywords: Health literacy, health seeking behavior, older persons, Hue city.
Tuan Huynh Long, Thao Nguyen Thanh
Journal of Medicine and Pharmacy, Volume 10, pp 79-83; https://doi.org/10.34071/jmp.2020.6.11

Abstract:
Purpose: To study magnetic resonance imaging characteristics and the added values of x-ray and ultrasonography in diagnosis of rotator cuff lesions. Material and method: 45 patients with clinical suspected rotator cuff lesions were recruited from may 2018 to august 2019 at Hue University of Medicine and Pharmacy Hospital. Patients undergone X-ray, Ultrasonography, and Mri of shoulder joint. The X ray and sonographic features were compared to MRI results to evaluate the added value of X-ray and ultrasonography in diagnosing rotator cuff lesions. Results: Ultrasound detected supraspinatus tear in 86.7%, tendonitiss in 40% and tenosynovitis in 8.9% of cases. X-ray detected suggestive features of supraspinatus tendon injuries in 88.9% of cases. Patients with two or more suggestive features was 46.7% with greater tuberosity sclerosis and calcification at the attachment site of tendon were the most common findings. The relationship between diagnosis of supraspinatus tendon tear, tendonitis and tenosynovitis on ultrasound with the number of suggested features on X-rays was 0.02, 0.564, 0.89. Conclusion: X-ray have supportive value for ultrasound in diagnosis of supraspinatus tendon tear. Keywords: Rotator cuff tear, MRI and Ultrasonography rotator cuff tear, The value of Ultrasonography in Rotator cuff lesions.
An Nguyen Truong, Tu Nguyen Minh, Nguyễn Trường An, Thang Phan Van, Phuong Ha Minh, Anh Vo Phuc, Ha Tran Dang Xuan, Hoa Nguyen Thi Nhat, Loi Tran Thi, My Vo Ngoc Ha, et al.
Journal of Medicine and Pharmacy, Volume 10, pp 84-89; https://doi.org/10.34071/jmp.2020.6.12

Abstract:
Background: The objective multiple-choice test is an assessment method that has been applied widely in universities. The meticulous judgment of complication and differentiation level of objective test questionnaire can beneficially lead to the growth of high quality multiple-choice questionnaire bank and effective examination. Objectives: To evaluate the difficulty level and differentiate level of the objective multiple-choice tests. Materials and method: The multiple-choice theory test (01 Elemental medical exam with 242 students, 01 Clinical medicine exam with 163 students). The difficulty degree of questions was determined by calculating the percentage of students who gave the answers correctly for the given questions in total. The differentiation level was differentiated by the percentage of students who answered correctly in corresponding groups: excellent, good, average, below average, poor. Results: The elemental medical examination comprises 7 hard questions, 58 medium questions, and 35 simple questions; 10 questions have poor degree of difference, 83 questions have good and very good degree of difference. The clinical medicine examination comprises 9 hard questions, 57 medium questions and, 34 simple questions; 23 questions have poor degree of differentiation, 51 questions have good and very good degree of difference. Conclusions: It is crucial to evaluate the difficulty and differentiation standards of the objective multiple-choice examination which enhance the quality of assessment. Thereby, the faculties need to regularly judge these factors while creating the questionnaire and completely evaluating the tests, and the inappropriate questions will be eliminated. Keywords: difficulty level, differentiation level, Objective multiple-choice test.
Linh Hoang Thi My, Tan Nguyen Thi, Hung Nguyen Van
Journal of Medicine and Pharmacy, Volume 10, pp 90-96; https://doi.org/10.34071/jmp.2020.6.13

Abstract:
Backgrounds: Shoulder and neck pain is a common disease in the world as well as in Viet Nam and tends to increasingly rejuvenate, it impacts on patient’s ability to work and quality of life. Surveying the clinical symptoms according to the traditional medicine on purpose of making diverse diagnostic and towards comprehensive treatment. Therefore, in this study we contribute to build standardization of diagnostic symptoms according to traditional medicine. Objectives: To survey the frequency of some clinical symptoms according to traditional medicine and find outseveral factors related with frequency appear clinical groups of shoulder and neck pain. Materials and Methods: Including 87 patients were diagnosed with shoulder and neck pain treatment at the Traditional Medicine Department of Hue Central Hospital and Thua Thien Hue Traditional Medicine Hospital. Research methodology is descriptive cross-sectional. Results: about the tongue body: higher abnormal group is 18.4% pale tongue, 27.6% enlarged tongue. About the tongue fur: 75.9% white fur, 58.6% thin fur, slippery fur (31%) is higher than dry fur (17.2%). Cold symptom are the most common: warm compress relieve pain (62.1%). Heat symptom are the most common: dry thirsty mouth (34.5%). About pain feature, common symptoms such as press relieve pain (64.4%), dull pain (71.3%) and persistent pain (69%). About the pulse: sunken pulse 65.5%, slow pulse (31.1%), moderate pulse (47.1%), weak pulse (55.2%). Conclusion: symptoms have high rate such as pink moist tongue, white fur, dull pain, sunken pulse. Symptoms have low rate such as bluish purple tongue, sticky slimy fur. There were significant relationships between clinical groups and age, gender, disease duration, warm compress relieve pain, body palpation and pulse frequency (p <0.05). Key words: frequency, symptoms, shoulder and neck pain, traditional medicine.
Anh Mai Ba Hoang, Duan Nguyen Duy, Cat Mai Thi Cam, Nga Le Thi Thuy, Phuong Nguyen Thi Thanh, Nguyen Le Thi Cao, My Nguyen Thi Tra, Nam Tran Ngoc Khanh
Journal of Medicine and Pharmacy, Volume 10, pp 25-29; https://doi.org/10.34071/jmp.2020.6.4

Abstract:
Background: Cutaneous wart is a common disease caused by the infection of Human Papillomavirus, this disease has diverse clinical characteristics and many different treatments. We conducted this study to evaluate the clinical features and the efficacy electrosurgery treatment. Methods: A total 75 patients was diagnosed with cutaneous wart and treated by electrosurgery method at Dermatology Clinic of Hue University of Medicine and Pharmacy Hospital. Results: The age has a wide distribution. The female/male ratio was nearly egal. Most patients had a single lesion. Plantar wart was predominate with 63.3%. After the procedure, 90.8% of patients had mild and moderate pain. The rate of post-operative bleeding was high 85.3%. In the first week, the dried wound was 64.2%. The average healing time was about 4 weeks. The infection rate was 11%. Conclusion: The most common clinical form was plantar wart; electrosurgery had many advantages but some disadvantages in wound healing related to heat damage. Keywords: cutaneous wart, electrosurgery, HPV.
Trang Hoang Xuan Huyen, Duc Ho Viet, Hoai Nguyen Thi
Journal of Medicine and Pharmacy, Volume 10, pp 7-11; https://doi.org/10.34071/jmp.2020.7.1

Abstract:
Background: Hippeastrum reticulatum (L.Hér.) Herb is a species of the Hippeastrum Herb. genus. Screening studies have shown that this species has the ability to inhibit the enzyme acetylcholinesterase. So far, research on this species is still very limited. The purpose of this study is to provide some more informations about the chemical composition and bioactive of isolated compounds from this species. Materials and method: Bulbs of Hippeastrum reticulatum was collected in Thua Thien Hue province in May 2018. The compounds were isolated by using various chromatographic methods and their structures were identified by 1D and 2D-NMR spectroscopic methods in reference to the literature. The acetylcholinesterase inhibitory activity was determined by Ellman’s microplate colorimetric method. Results and conclusions: Two alkaloids including N-methyltiramine (1), narciclasine-4-O-β-D-xylopyranoside (2) was isolated from bulbs of Hippeastrum reticulatum (L’Hér.) Herb. These compounds were isolated from Hippeastrum Herb. genus for the first time. Compound 2 showed moderate acetylcholinesterase inhibitory activity, with IC50 value of 70.06 ± 1.46 µg/mL. Key words: Hippeastrum reticulatum (L’Hér.) Herb., alkaloid, N-methyltiramine, narciclasine-4-O-β-Dxylopyranoside.
Binh Le Trong, Bac Pham Thanh, Chau Tran Minh, Khoan Le Trong
Journal of Medicine and Pharmacy, Volume 10, pp 7-14; https://doi.org/10.34071/jmp.2020.6.1

Abstract:
Magnetic Resonance Urography (MRU) provides a comprehensive assessment of both morphology and function of the urinary system by using various sequences of T1W, T2W, 2D and 3D. T1W and T2W 2D images are optimal to evaluate the morphology of the kidneys and the urinary tract. Fast gradient echo 3D T1W sequence with the use of fat saturation technique (Fatsat or Dixon sequences), gadolinium administration, diuretic maneuver, and maximum intensity projection allows visualization of the urinary tract similar to that of conventional intravenous urography. MRU is also helpful in investigating renal function based on the hemodynamic study of contrast medium. Recent data prove that MRU, except for the study of renal calculi, is not inferior to computed tomographic urography (CTU) in evaluating diseases of the urinary system such as neoplasm, malformation and obstruction. MRU is an alternative to CTU when CTU is contraindicated. This article aims to review the techniques of MRU to optimize visualization of the urinary system and their indications in daily practice. Key words: MRU, MR hydrography, MR dynamic
Nhon Tran Van, Mai Do Van, Hien Ha Minh
Journal of Medicine and Pharmacy, Volume 10, pp 15-24; https://doi.org/10.34071/jmp.2020.6.2

Abstract:
Background: To survey for evaluation the use of antibiotic for diarrhea treatment on pediatric inpatient in compliance with MOH, WHO or treatment regimen. Objectives: (1) To describe the situation of antibiotic use for diarrhea treatment and (2) to determine factors that affected on indication of antibiotic for pediatric inpatient under 15 years at Kien Giang General Hospital in 2019. Subjects and methods: A cross-sectional study on 251 medical records of pediatric inpatients who treated by one of any drug from 01/2019 to 12/2019. Results: one antibiotic was prescribed in 71.7% in comparison with 17.1% on two antibiotics. The antibiotic prescription was based on the results of blood test including examinations of white blood cells (WBC), the percentage of neutrophils (Neu%) and/or C-reactive protein (CRP) (59.4%), stool with white blood cells and/or red blood cells (1.6%), high fever without causes (27.9%), watery stool (86.3%), loose stool with blood (100%), loose stool (97.9%). The most used antibiotics are ceftriaxone (53.4%), ciprofloxacin (12.4%). Duration of antibiotic use is 5 days in median. Conclusion: The rate of antibiotic prescription that met MOH and WHO guidelines was 88.3% in comparison with 11.7% of non-conformance. The compliance prescriptions based on antibiogram were 77.8%, non-compliance were 22.5%. The compliance dosage refered to guideline was 86.4%, non-conpliance was 2.4%. The duration of hospitalization and neutrophil are factors that affected the use of antibiotics (p < 0.05). Keywords: diarrhea, pediatric inpatient, antibiotic, Pediatrics-Kien Giang General Hospital
Anh Mai Ba Hoang, Duy Bui Van, Vy Vo Tuong Thao, Thanh Duong Huu, Nam Tran Ngoc Khanh
Journal of Medicine and Pharmacy, Volume 10, pp 25-29; https://doi.org/10.34071/jmp.2020.6.3

Abstract:
Background: Sexually transmitted diseases are popular, not only affecting the health but also affecting the psychology and social behavior of patients. After being diagnosed, the patients were hospitalized at the Department of Dermatology, Hue Central Hospital. Therefore, we conducted this study to investigate some characteristics of sexually transmitted diseases. Materials and methods: Cross-sectional study on 72 patients having one of sexually transmitted diseases,we investigated some characteristics and clinical forms. Results: The proportion of male and female was the same and the most common age group was 15-25 with 44.4%. Most patients had two or more sexual partners with 62.5% and very few often used condoms. Only three diseases were diagnosed with genital warts, syphilis and urethritis; among them genital warts was the most common 66.7%. Latent syphilis and small papules were the most common clinical forms of syphilis, condylomata acuminata, respectively. Conclusion: Sexually transmitted diseases were relatively common among inpatient diseases and had diverse characteristics. Keywords: sexually transmitted diseases, gonorrhea, syphilis, condylomata acuminata
Dung Phan Dinh Tuan, Hung Dang Ngoc, Loc Le
Journal of Medicine and Pharmacy, Volume 10, pp 97-102; https://doi.org/10.34071/jmp.2020.6.14

Abstract:
Background: Achalasia is a primary motor disorder of the esophagus characterized by insufficient lower esophageal sphincter relaxation and loss of esophageal peristalsis. Diagnosis is confirmed by clinical symptoms, endoscopic, radiographic and manometric. Although pneumatic dilation has a role in the treatment of achalasia, laparoscopic Heller myotomy is considered by many experts as the best treatment modality for most patients with newly diagnosed achalasia. Objective: To evaluate the efficacy and safety of laparoscopic Heller myotomy with Dor antireflux procedure. Patients and Methods: Prospective analyses of the patients of achalasia undergoing laparoscopic Heller myotomy with Dor antireflux procedure from 01/2012 to 06/2020. We evaluated the data according to outcome measures, characteristics and treatment results of achalasia after laparoscopic Heller myotomy with Dor antireflux procedure. Results: We found 11 patients with achalasia were diagnosed and treated by laparoscopic. 100% of the patients have dysphagia, weight loss; 81.8% have chest pain and regurgitation. Mean operative duration was 148 ± 21 minutes. There was no complications had found in our patients. Follow-up after 3 - 6 months by Eckardt score show that 90.9% had a good result, 01 patient with persistent symtomps (Eckardt score > 3) had to undergo a pneumatic dilation. Conclusion: The results of the laparoscopic Heller myotomy with Dor antireflux procedure were safe and effective. Keywwords: Achalasia, laparoscopic Heller myotomy, Dor antireflux procedure
Hung Nguyen Trung, Thuy Nguyen Hai, Quan Nguyen Phuoc Bao
Journal of Medicine and Pharmacy, Volume 10, pp 73-78; https://doi.org/10.34071/jmp.2020.6.10

Abstract:
Objectives: To compare the levels and pathological values of serum Tg and TgAb between the patients with benign and malignant thyroid nodules and evaluate the relationship between serum Tg and TgAb levels with the rim characteristic and elasticity score of the nodule by thyroid elasto-echography. Subjects: 30 patients with thyroid nodules, Serum Tg and TgAb levels and thyroid elasto-echography are examen before operation. Results: The ratio of the positive Tg level of malignant thyroid nodules was higher than the benign thyroid nodules (16.7% vs 8.3%) but the serum Tg level was not significantly different (33.48 ± 38.67 ng/ml vs 27.32 ± 28.44 ng/ml, p > 0.05) and The ratio of positive TgAb level of malignant thyroid nodules was higher than that of benign thyroid nodules (22.2% vs 0%) but serum TgAb level was not different (64.15 ± 14.91 UI/ml vs 16.9 ± 14.48 UI/ml, p > 0.05). The combination of the ratio of positive Tg and positive TgAb level did not show any difference in the ratio of pathological value between benign and malignant thyroid nodules (5.6% vs 0%). Serum Tg levels in patients with irregular rim thyroid nodules were higher than those in patients with regular rim thyroid nodules but the serum Tg level was not different when evaluated with the elastic score. Conclusions: The mean level and ratio of the pathological value of serum Tg and TgAb did not differ between malignant and benign thyroid nodules. There is a relationship between serum Tg level and irregular rim characteristic of thyroid nodule (p < 0.05). Key words: serum thyroglobulin level, serum anti thyroglobulin level, thyroid nodule.
Nhung Phan Thi Hong, Tan Nguyen Thi, Hung Nguyen Van
Journal of Medicine and Pharmacy, Volume 10, pp 65-72; https://doi.org/10.34071/jmp.2020.6.9

Abstract:
Background: Low back pain is a very common disease in daily life and clinical, which affects much to the health. Traditional medical symptoms of low back pain are very diverse and clinically difficult to diagnose. So we conduct this study to contribute to the standardization of symptoms according to traditional medicine and initially contributed to the improvement of diagnosis and treatment of diseases. Objectives: to survey the frequency of clinical symptoms according to traditional medicine in patients with low back pain and find out some factors related to the frequency of clinical types of the disease. Subjects and Methods: Including 92 patients were diagnosed with low back pain and treatment at the Traditional Medicine department of Hue Central Hospital and Thua Thien Hue Traditional Medicine Hospital. Research methodology is descriptive cross-sectional. Results: The symptoms of the tongue: 65.2% pale red tongue, 6.5% bluish purple tongue, 37.0% enlarged tongue, 8.7% thin tongue. About the tongue fur: 68.5% white fur and 31.5% yellow fur, 42.4% moist fur, 4.3% sticky slimy fur, 58.7% thin fur and 41.3% thick fur. The symptoms of the pulse: 17.4% floating pulse, 69.6% sunken pulse, nmoderate pulse 43.5%, powerful pulse 84.8%, weak pulse 15.2%. Among the patients have 33.7% constipation, 45.7% nocturia, 34.8% inability to sleep, 17.4% night sweating 12.0% spontaneous sweating. Conclusion: Symptoms: pale red tongue, white fur, moist fur, thin fur, constipation, nocturia, inability to sleep, sunken pulse, moderate pulse, powerful pulse have high rate; Symptoms have low rate such as bluish purple, the thin tongue, sticky slimy fur. There were significant relationships between clinical types and age, tongue color, tongue fur color, pain properties and pulse frequency (p < 0.05). Key words: Low back pain, symptoms, traditional medicine.
Hang Tran Nhu Minh, Linh Nguyen Quang Ngoc, Han Vo Thi, Anh Le Tran Tuan
Journal of Medicine and Pharmacy, Volume 10, pp 57-64; https://doi.org/10.34071/jmp.2020.6.8

Abstract:
Background: The prevalence of depression is high in patients with type 2 diabetes mellitus (T2DM). Several studies showed that suitable health behavior and treatment adherance could be factors asociated with low prevalence of depression among patients with type 2 diabetes mellitus. Objectives: 1. To investigate the prevalence of depressive disorder using ICD10 clinical criteria among patients with T2DM. 2. To analyze the association between depressive disorder with health behavior, treatment adherence and commorbidities in the participants. Subjects and methods: This is a descriptive cross - sectional study on 210 inpatients with T2DM at the Department of General Internal Medicine, Hue University of Medicine and Pharmacy Hospital and at the Department of Endocrinology - Neurology, Hue Central Hospital. PHQ - 9 with the cutoff of 10 was used to screen depressed patients among participants, then psychiatrists used clinical criteria of ICD 10 to diagnose depression definitively. Patients who were diagnosed with depression according to clinical criteria were analyzed the association between depression with health behavior, treatment adherence and comorbidities by using univariable and multivariable logistic regression. Results: The prevalence of depressive disorder among patients with T2DM assessed by clinical criteria of ICD 10 was 31.4% in which severe (7.6%), moderate (19.5%) and mild depression (4.3%). Health behavior associated with depression in patients with T2DM are light or moderate activities such as practising yoga, walking, riding bicycle ... that help reduce the rate of depression, while working hard or playing heavy sports increases the rate of depression. In addition, patients with 2 or more complications, hypertension and kidney diseases increased the risk of depression in univariate analysis. The multivariate analysis of risk factors for depression were infectious diseases. Conclusion: Depression is found at a high rate among patients with T2DM. Light or moderate physical activity reduces the prevalence of depression. The complications and associated infectious disease are risk factors for depression. . Key words: Depression, type 2 diabetes mellitus, health behavior, comorbidities, treatment adherence
Anh Mai Ba Hoang, Phuong Nguyen Thi Thanh, My Nguyen Thi Tra, Nguyen Le Thi Cao, Nam Tran Ngoc Khanh
Journal of Medicine and Pharmacy, Volume 10, pp 56-61; https://doi.org/10.34071/jmp.2020.5.8

Abstract:
Background: Bacterial skin infections are common due to the bacteral invasion into the skin and cause a variety of clinical manifestation. In order to assess the characteristics of this group, we conducted this study to evaluate the clinical and main subclinical features. Methods: A total of 95 patients were diagnosed with bacterial skin infections at Dermatology Clinic of Hue University of Medicine and Pharmacy Hospital from June 2015 to May 2016, of which 34 patients had some tests and 19 patients had samples for culture. Results: The age group of 16 - 30 years old was the most popular: 50.5%; High rate of patients came for consultation in winter (49.5%), most patients had no fever. For functional symptoms, pain accounted for the highest proportion: 71.6%. The most common skin lesion was nodule: 38.8%, the lower extremities were the most common position: 38.9%. Furuncle had the highest incidence: 45.3%. For main laboratory tests, most patients had a normal number of leucocyte: 71.4%; ESR increased by two times accounting for a rate of 20.6%; culture results showed Staphylococcus aureus being a highest percentage: 57.9%. Conclusion: Most skin infections localized and were less systemic effect, the most common agent was S. aureus. Keywords: infection, bacteria, skin, fever, S. aureus
Duan Nguyen Duy, Khanh Hoang
Journal of Medicine and Pharmacy, Volume 10, pp 50-55; https://doi.org/10.34071/jmp.2020.5.7

Abstract:
Purpose: To investigate Non-Thyroidal Illness Syndrome (NTIS) and the association with National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS) and functional improvement at 3 months in patients with acute ischemic stroke (AIS). Materials and methods: we conducted a longitudinal observational study of 57 patients with AIS in Department of Endocrinology-Neurology of Hue Central Hospital from May 2018 to June 2019. Results: NTIS presenting with low FT3 and normal FT4, TSH accounted for 17.54% patients with AIS. NIHSS in the group with NTIS and without NTIS were 12 (8.75 - 15.75;CI: 95%) and 6 (4.00 - 8.00;CI: 95%), respectively. mRS on admission and at 3 months in the group with NTIS are 1.21 and 2.41 higher than in those without NTIS. mRS on admission was an independent prognostic factor of mRS at 3 months. With the cut-off FT3 > 3.755, it predicts patients are likely to recover with 63.90% sensitivity and 71.40% specificity with the Area Under the Cure of 0.70 (95%CI: 0.55 – 0.85). Conclusion: 17.54% patients with AIS had NTIS. The severity of stroke on admission with NIHSS and 3-months functional recovery with mRS in patients with NTIS are worse than in those without NTIS. Keywords: Non-thyroidal Illness Syndrome, Thyroid function test, acute ischemic stroke prognosis.
Ha Bui Manh, Thanh Le Thai Van
Journal of Medicine and Pharmacy, Volume 10, pp 72-77; https://doi.org/10.34071/jmp.2020.5.10

Abstract:
Aims: To evaluate the efficacy, side effects of laser 532-nm Nd:YAG picosecond in treating solar lentigo and ephelides at HCMC hospital of dermato-venereology. Objectives and Method: Prospective - descriptive study. There were 43 patients dealing with solar lentigo and ephelides treated with laser 532-nm Nd:YAG picosecond. Each patient went through 3 treatments with one month interval, three months follow up for delayed side effects and recurrent. Evaluating the treatment by MI, VLCS, self-patient evaluation with 5 grades scale. Evaluating side effects of the treatment by 5 grade Wong-Baker scale. Collected data were analysed with SPSS.20.0. Results: Based on MI at the end of the study, the effectiveness of the treatment gained 81.4% good, 16.3% average and 2.3% bad. Self-patient evaluation revealed 76.7% good, 20.9% average and 2.3% bad. VLCS of post-treatment reduced 7.44 ± 2.14 unit compares with of pre-treatment. Recently after treatment, 100% patients had erythema and mild pain in 5 grade Wong-Baker scale, 20.9% had mild edema, 2.3% had post imflammatory hyperpigmentation (PIH). Two ephelides cases recurred 3 months after treatment (4.6%). Conclusions: Laser 523-nm Nd:YAG picosecond has high efficacy and less side effects in treating solar lentigo and ephelides. Key words: solar lentigo, ephelides, laser 532-nm Nd:YAG picosecond
Triet Le Phan Minh, Keopaseuth Phoukhong, Nghiem Nguyen Dac Duy, Hoàng Thị Anh Thư, Thu Hoang Thi Anh, Nhu Truong Thi Quynh, Dat Le Quoc
Journal of Medicine and Pharmacy, Volume 10, pp 45-49; https://doi.org/10.34071/jmp.2020.5.6

Abstract:
Background: To evaluate the complete blood count of Laotian students in Hue city. Materials and method: A cross-sectional study on 400 Lao students who were examinated the complete blood count at Department of Hematology, Hue University of Medicine and Pharmacy from September 2019 to May 2020. Results: 400 Lao students (male/female = 1/1.2), the students who came from Salavan province accounted for the highest percentage (22.25%). The mean of age was 24.78 ± 6.44 (17 - 44). The mean of red blood cells (RBC) was 5.13 ± 0.73 T/L and of hemoglobin in the study group was 129.27 ± 18.58 g/L. The percentage of students with anemia was 13.5% and there were 3 students with severe anemia. The mean of mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were respectively 81.27 ± 9.32 fL (49.2 - 103.9) and 25.50 ± 3.56 pg (11.8 - 33.2). The mean of white blood cells (WBC) and platelets (PLT) were respectively 7.42 ± 2.29 G/L and 272.33 ± 83.62 G/L. There was a correlation between anemia and age (p < 0.05), mainly in 26 - 40. There was significant difference about RBC and Hb between anemic group and non-anemic group (p < 0.05). Conclusion: It is essential to check the complete blood count of Laotian students to evaluate anemia and screen hemoglobinopathies. Keywords: Laotian students, red blood cell (RBC), white blood cell (WBC), platelet (PLT), hemoglobin (Hb)
Huong Le Lam, Giang Truong Thi Linh, Lam Vo Hoang, Thao Ngo Thi Minh, Tan Dang Van, Thang Nguyen Minh
Journal of Medicine and Pharmacy, Volume 10, pp 18-23; https://doi.org/10.34071/jmp.2020.5.3

Abstract:
Mục tiêu: Khảo sát một số yếu tố nguy cơ doạ sinh non. Phương pháp: Nghiên cứu mô tả cắt ngang có so sánh. Gồm 73 bệnh nhân được chẩn đoán dọa sinh non được theo dõi và điều trị tại khoa Phụ sản Bệnh viện Trung ương Huế từ tháng 06/2018 đến tháng 08/2019. Kết quả: Đa thai có nguy cơ dọa sinh non cao gấp 8,8 lần so với đơn thai 95%CI (1,2 - 82,7), đa ối nguy cơ dọa sinh non 4,9 lần 95%CI (1,1 - 23,9). Chiều dài CTC < 25 mm nguy cơ dọa sinh non cao hơn 4,2 lần 95% CI (1,3-13,1). Viêm đường sinh dục thấp tăng nguy cơ 2,6 lần ( 1,3 - 13,1) p < 0,05. Tuổi mẹ ≤ 20 hoặc > 35 có nguy cơ cao gấp 9,5 và 3,7 lần 95%CI (1,1 - 80,1) và (1,4 - 7,5). Thai phụ làm việc trên 40 giờ/tuần nguy cơ tăng 4,9 lần 95%CI (1,1 - 23,9), lao động nặng, môi trường làm việc ô nhiễm tăng nguy cơ 11,4 lần (1,4 - 91,7) và 8,8 lần (1,1 - 72,7). Sinh 3 lần dọa sinh non cao gấp 4,1 lần (1,3 - 13,1). BMI < 18,5 nguy cơ hơn 9,8 lần 95%CI (1,1 - 82,5); ≥ 23 tăng nguy cơ 4,4 lần (1,6 - 11,9). Tiền sử thai chết lưu, nạo thai, sẩy thai nguy cơ dọa sinh non tăng 6,9 lần 95%CI (1,5 - 22,4). Tiền sử sinh non, dọa sinh non nguy cơ tăng lên 9,1 lần 95%CI (2,0 - 41,7). Khoảng cách giữa hai lần mang thai < 12 tháng nguy cơ tăng 4,9 (1,0 - 23,9) lần. Kết luận: Phát hiện các yếu tố nguy cơ dọa sinh non để dự phòng sớm và theo dõi thai phụ tránh trình trạng dọa sinh non xảy ra là việc làm rất cần thiết. Từ khóa: Dọa sinh non, phụ nữ mang thai, yếu tố nguy cơ.
Ha Vo Viet, Quan Phan Van Minh
Journal of Medicine and Pharmacy, Volume 10, pp 99-105; https://doi.org/10.34071/jmp.2020.5.14

Abstract:
Ojectives: 1. To describe the clinical and subclinical characteristics of patients with acute respiratory failure requiring invasive ventilation. 2. To evaluate the outcome of acute respiratory failure treatment with invasive ventilation and factors related to treatment failure. Materials and Method: 51 patients diagnosed with acute respiratory failure requiring invasive mechanical ventilation in ICU at Hue University of Medicine and Pharmacy Hospital. The prospective cohort study. Results: The mean age was 69.6 ± 16.4. Tachypnea and agitation were the most common sign (51%). The mean APACHE II score was 20.2 ± 3.3. The mortality rate was 33.3%. The variables associated with treatment failure were age ≥ 70 tuổi (RR = 2.7; p < 0.05), history of chronic kidney disease (RR = 2.9; p < 0.05), sepsis as a cause of mechanical ventilation (RR = 2.5; p < 0.05), ventilator-associated pneumonia (RR = 2.4; p < 0.05) and renal dysfunction during treatment (RR =2.4; p < 0.05). Conclusion: The clinical characteristics of ARF patients requiring IMV were various and the mortality rate remained high. Risk factors for treatment failure included age ≥ 70, history of chronic kidney disease, sepsis as a cause of mechanical ventilation, ventilator-associated pneumonia and renal dysfunction during treatment. Keywords: acute respiratory failure, invasive ventilation, invasive mechanical ventilation
Giang Truong Thi Linh, Quang Mai Van
Journal of Medicine and Pharmacy, Volume 10, pp 78-84; https://doi.org/10.34071/jmp.2020.5.11

Abstract:
Background: Fetal macrosomia has a major influence on maternal, neonatal and pregnancy outcomes.Objective: To describe the clinical and subclinical features and the management of fetal macrosomia on pregnancy outcomes. Subjects and methods: Study subjects including pregnant women and babies born ≥ 3500 g with nulliparous and over 4000 grams with primiparous or multiparous at Departement of Obstetrics and Gynecology in Hue University of Medicine and Pharmacy Hospital. The time of choosing subjects to enter the research group is that after birth, the weight is above 3500/4000 grams, then follow up the pregnancy result and retrospect the clinical and subclinical characteristics. Results: From May 2019 to April 2020, there were 223 pregnant women with the birth weight ≥ 3500 g in this study. The mean neonatal weight for macrosomia was 3869.96 ± 315.72 (g). The birth weight ≥ 4000 g, the rate of cesarean section was 91.5%, vaginal birth was 8.5%. The birth weight 3500 - under 4000 g, the rate of cesarean section was 76%, vaginal birth was 24%. 1.1% maternal complications was perineal tear. Conclusion:Factors related to fetal macrosomia: Maternal age, gender of fetus, parity, a history of fetal macrosomia, maternal height, pregnancy weight gain. Caesarean section is the majority. Key words: Fetal macrosomia, gestational diabetes mellitus, normal labor, caesarean section.
Phuc Le Hong, Son Tran Thiet, Thuy Nguyen Xuan
Journal of Medicine and Pharmacy, Volume 10, pp 85-91; https://doi.org/10.34071/jmp.2020.5.12

Abstract:
Background: In recent years, the composite anterolateral thigh free flap with tensor fasciae latae or vastus lateralis has been a new-applied type of flap that can provide very good reconstruction materials in complex defects of lower leg and foot. The study purpose is to evaluate the systematically complications of donor site, related factors to results of the donor area, in order to apply the result to improve the treatment, which have not been much reported in literature. Materials and Methods: Systematic donor site morbilidy evaluation in a prospective, uncontrolled clinical descriptive study of 33 composite anterolateral thigh free flaps in various forms to reconstruct anatomical structures or to resconstruct deep defects combined with covering the surfaces for complex soft tissue defects in lower extremities for 32 patients due to different causes in lower leg and foot area from 2014-2019 at Hue University of Medicine and Pharmacy. Examining and evaluating aesthetic and functional result of donor-site 3 months and 6 months up to 2 year after surgery; evaluating the correlation between the width and the type of the flaps and donor site closure methods. Result: In 33 composite flaps used, flap width to thigh circumference less than 20% in 27 cases (81.8%), more than 20% in 6 cases (18.20% ); There were 28 cases in which the donor site was directly closed, 5 cases required skin graft; All direct closed cases had flap width/ thigh circumference index below 20%; On the contrary, in cases having this index greater than 20%, the donor site required skin graft with p < 0.01. There are 11/33 (33.33%) of cases reported complications in donor site ; lateral thigh paresthesia is the most complicated complication with 8/33 cases (24.24%), followed by bad scarring 3/33 cases (9.09%). Conclusion: Long term follow up donor site morbility after composite anterior thigh free flap present 11/33 cases (33.33%): mostly complications of the donor site are thigh paresthesia with 8/33 cases (24.24%), and bad scarring 3/33 cases (9,09%), which improve time by time. Keywords: Composite anterior thigh free flap, lower extremities soft tissue defect, donor site morbidity
Phuong Phan Thi Minh, Na Phan Thi Ni
Journal of Medicine and Pharmacy, Volume 10, pp 92-98; https://doi.org/10.34071/jmp.2020.5.13

Abstract:
Introduction: Autoimmune diseases are usually systemic. The autoimmune polyendocrine syndrome was defined as a failure of various endocrine glands caused by an autoimmune mechanism. Autoimmune diabetes (type 1 and LADA) is not exceptional, the long-lasting positivity of anti-GAD may increase the risk of developing thyroid autoimmune diseases. Aims: (1) To determine the concentration and the positivity rate of Thyroglobulin autoantibody (TgAb) and TPO autoantibody (TPOAb) on non-obese diabetic patients. (2) To examine the relationship between thyroglobulin autoantibody (TgAb) and TPO autoantibody (TPOAb) to the negative and positive anti GAD autoantibody status and some other factors. Subjects and methods: 85 serum samples of non-obese diabetic patients (BMI < 23) were used to measure the anti GAD autoantibody, anti Tg and anti TPO autoantibody by enzyme-linked immunoassay and electrochemiluminescence immunoassay, at the Hue university hospital. Results: The mean concentration of the TgAb and TPOAb were 1118.35 ± 1583.45 IU/ml and 85.85 ± 42.22 IU/ml, respectively. The positivity rate of the TgAb was 9.4% and the positive rate of the TPOAb was là 14.1%. There was a statistically significant difference in the positivity of the TPO antibody with the presence or absence of the GAD antibody, between the mean concentration of TPO antibody and diabetes detection time and HbA1C concentration between anti-Tg (+), anti-TPO (+) groups and anti-Tg (-), anti-TPO (-) groups. Conclusions: There was a correlation between anti-TPO positivity with non-obese diabetes patients with positive anti-GAD, between diabetes detection time with anti-TPO concentration. In patients with anti-Tg (+), anti-TPO (+), the HbA1C concentration was found higher than those with anti-Tg(-), anti-TPO(-). Keywords: diabetes, non-obese, GAD autoantibody, Tg autoantibody, TPO autoantibody.
Nguyen Le Thi Cao
Journal of Medicine and Pharmacy, Volume 10, pp 7-10; https://doi.org/10.34071/10.34071/jmp.2020.5.1

Abstract:
Acne scars are common sequelae of adolescent acne and have many negative effects on patients. Scars can affect the aesthetics and psychology of patients, limiting social interaction and affecting success in life. The forms of acne scars are very diverse and complex. Each patient can have many scars associated with different degrees. Although there are many methods treatment, successfully treating acne scars is still challenging. Combinating dermal filler with other scar treatments (dermal subcision, laser fractional CO2, RF needle ...) accurately helping improve treatment effectiveness, minimizes side effects or complications due to treatment. Objective of the review is to classify acne scars and choose effective treatments for each type of scars. The method of applying fillers during scar treatment. Key words: Acne scar treatment, ice pick, box scar, rolling scar, subcision, filler
Thuan Duong Thi Bich, Lan Hoang Thi, Dung Hoang Anh, Hai Nguyen Dong
Journal of Medicine and Pharmacy, Volume 10, pp 24-31; https://doi.org/10.34071/jmp.2020.5.4

Abstract:
High expression of FRA is observed in malignant epithelial ovarian tumors. This study is aimed to determine of serum folate receptor alpha levels in patients of epithelial ovarian carcinoma and to investigate the relationship between serum folate receptor alpha levels and serum CA125 levels and histopathological characteristics in patients of epithelial ovarian carcinoma. Materials and methods: Cross-sectional study was conducted on 26 patients with epithelial ovarian carcinoma and 56 patients with benign ovarian tumors. The subjects’ blood was collected to measure serum folate receptor alpha levels and serum CA125 levels. Information of clinical and subclinical characteristics were collected. Results: Median of serum folate receptor alpha levels in patients of epithelial ovarian carcinoma is higher than those with benign ovarian tumors (1683,0 compared with) 6.1, p < 0.001). With the cut-off point > 209.8 pg/mL, serum folate receptor alpha test has the diagnostic value of epithelial ovarian carcinoma with Se = 84.6%, Sp = 98.2%, PPV = 95, 65%, NPV = 93.22%, AUC = 0.978. Levels of serum alpha folate receptor were highly correlated to levels of serum CA125, tumor grade, and clinical stage of the disease. Conclusions: We suggest that serum alpha folate receptor is a highly promising biomarker for epithelial ovarian carcinoma. Key words: serum folate receptor alpha, epithelial ovarian carcinoma.
Anh Le Thy Phuong
Journal of Medicine and Pharmacy, Volume 10, pp 106-109; https://doi.org/10.34071/jmp.2020.5.15

Abstract:
Childhood sarcoidosis is an uncommon disease and recognition of this disease in children is often delayed because of the lack of awareness and unfamiliarity with its clinical features. With the aim of providing clues for diagnosis and treatment of disease, we reported a a 23-month-old boy hospitalized for multiple pinkish papules and painless cystic swellings in ankles and wrists, diagnosed with sarcoidosis, treated with corticosteroid and well recovered. This case reminds us to include childhood sarcoidosis in the differential diagnosis in pediatric patients who present with multiple papular eruptions along with systemic manifestations. It is characterized by arthritis, uveitis, and cutaneous involvement. The prognosis of early-onset childhood sarcoidosis varies in different studies due to the rarity of the disease. The treatment of choice in systemic involvement of childhood sarcoidosis is corticosteroids. Key words: sarcoidosis in children, childhood sarcoidosis, granulomatous disorder, arthritis, uveitis.
Trang Dao Nguyen Dieu, Huy Nguyen Vu Quoc, Thanh Cao Ngoc, Ngoc Phan Thi Bich
Journal of Medicine and Pharmacy, Volume 10, pp 32-44; https://doi.org/10.34071/jmp.2020.5.5

Abstract:
Objectives: To describe the knowledge, attitudes, practices of reproductive health care among adolescent girls in A Luoi district, Thua Thien Hue province and to identify the related factors to reproductive health care in adolescent girls. To assess the results of intervention solutions of reproductive health care in adolescent girls. Methods: A cross-sectional study design. A study design for community intervention comparision with control group. Results: The percentage of adolescents with not good knowledge, attitudes and practices on reproductive health care has accounted for fairly high as respectively: 85.9%, 73.9%, 72.9%. There is an a relationship between education level, adolescent stage with general knowledge on adolescent reproductive health care (p < 0.05). There is a relationship between ethnicity, education level, adolescent stage with the general attitude on adolescent reproductive health care (p < 0.05). There is a relationship between knowledge, attitude, education level, adolescent stage, economic condition, the condition of the family living at the percentage of general practice on adolescent reproductive health care (p < 0.05). The effective of intervention: Good knowlegde increase from 10% to 24.1%. Good attitude increase from 16.7% to 61.4%. Good practice increase from 27.1% to 42.9%. The effective of intervention: change knowlegde: 21.6%, change attitude: 54.2%, change practice: 34.6%. Conclusion: There is need to enhance the communication and education reproductive health for aldolescent girls and to enhance communication knowlegde and skills for reproductive health staff. Keywords: adolescents, get married early, reproductive health.
Tuan Duong Quang, Anh Le Ho Thi Quynh, Hung Nguyen Nam, Tam Nguyen Minh
Journal of Medicine and Pharmacy, Volume 10, pp 62-71; https://doi.org/10.34071/jmp.2020.5.9

Abstract:
Although health status in Vietnam has been much improved, people living in rural areas have faced several challenges, including a rapid increase of the aging population, inadequate capacity of health system, and problems of inequities in access to the healthcare system. Objectives: This study aimed to explore the common health problems and health care utilization of people living in the rural areas of Thua Thien Hue province. Methods: A cross-sectional study and geography information system application were carried out. A total of 2.631 individuals in 599 households of a lowland area and a mountainous area was interviewed with a structured questionnaire regarding to health status and health care utilization during the last 6 months. Geography information system software was used to visualize these data of household. Results: 32.8% of participants reported at least an episode of illness within 6 months prior to the interviews. Most of illness people lived in mountainous area. Fever, uncomplicated hypertension, cough, and headache were reported as the most common health problems among participants. Most of participants preferred to visit commune health centers and district hospitals. People in different areas have a significant difference trend from another in choosing health facilities. Conclusion: Residents in difficult-to-reach areas had high prevalence of health problems and experienced social and structural barriers of healthcare services access. It is necessary to improve the availability and quality of primary care services to improve the health status and accessibility of disadvantaged people. Keywords: primary care, utilization, rural areas, health care acessibility
Nam Phan Trung, Bich Nguyen Thuy
Journal of Medicine and Pharmacy, Volume 10, pp 11-17; https://doi.org/10.34071/jmp.2020.5.2

Abstract:
Background: Irritable bowel syndrome (IBS) is considered as a common functional bowel disorder. The prevalence of IBS vary in different communities and has been related to multifactorial mechanisms. Objective: To investigate the prevalence and some related factors about irritable bowel syndrome among medical students in Hue University of Medicine and Pharmacy, Vietnam. Methods: A cross-sectional study was carried out among medical students of first to sixth year enrolled in Hue University of Medicine and Pharmacy during the academic year 2018 to 2019. Participants were asked to complete a comprehensive anonymous questionnaire which detailed characteristics on socio-demographic, health-related, lifestyle factors (according to DASS-21, ISS) and Rome IV Diagnostic Questionnaires & Tables for Investigators and Clinicians. Results: 299 medical students completed the survey. The prevalence of IBS was 14.4% (43/299) according to ROME IV criteria, female are higher than male (60.5% vs 39.5%). Among the IBS subjects, IBS-M accounted for 44.2%, IBS-D with 32.6%, IBS-C and IBS-U with the same 11.6%. Live-alone status, exercise habits, depression, anxiety, stress (according to DASS-21) are factors related to IBS. Conclusion: IBS among medical students are with a quite high prevalence. Screening of these IBS students for psychological problems and stress need to consider. Keywords: Irritable bowel syndrome, IBS , Prevalence, Medical students, ROME IV criteria
Anh Nguyen Phan Quynh, Thuan Dang Cong, Tien Nguyen Phuong Thao, Song Nguyen Tran Bao
Journal of Medicine and Pharmacy, Volume 10, pp 23-31; https://doi.org/10.34071/jmp.2020.4.3

Abstract:
Background: Breast cancer is the most frequent cause of cancer-related deaths among women worldwide. Molecular classification and the analysis of gene expression have been playing a pivotal role in deciding treatment therapy. The aim of study was to identify molecular surrogate subtypes of breast cancer by immunohistochemistry and Dual In Situ Hybridization, analysis of BCL11A gene expression was performed in molecular subtypes by RT-PCR and assessed the correlation between molecular subtypes and clinic-pathological characteristics. Materials and methods: Cross-sectional description study, tumor specimens from 138 patients were stained with Hematoxylin and Eosin to diagnosis, histopathological classification, stained with immunohistochemical markers ER, PR, HER2, Ki67 and Dual In Situ Hybridization (DISH) to classify molecular subtypes breast cancer. In which, RNA of 20 samples were extraction and performed by RT-PCR. Results: A significant association between breast carcinoma subtypes with histologic type (p=0.022) and grade (p=0.021). BCL11A was significantly down regulated in all molecular breast cancer subtypes especially in triple negative group. Conclusion: This study may help to understand pathological characteristics and the gene expression of difference breast cancer subtypes, contributing to the successful identification of therapeutic targets for breast cancer, especially triple negative group. Key words: Invasive breast carcinoma, molecular subtypes, histologic grade, Dual In Situ Hybridization (DISH), qRT-PCR
Minh Nguyen Thanh, Tam Vo
Journal of Medicine and Pharmacy, Volume 10, pp 57-62; https://doi.org/10.34071/jmp.2020.4.7

Abstract:
Objectives: To investigate the correlation between the concentration in blood of bone minerals: Phosphorus, calcium, PTH, vitamin D, β2 microglobulin, aluminium with some clinical and subclinical factors in patients with dialysis chronic kidney patients. Materials and Methods: Descriptive cross-sectional study, include 163 patients with dialysis chronic kidney disease, from January 2017 to December 2018 at the Department of Haemodyalysis, District 2 Hospital, Ho Chi Minh City. Results: Serum phosphorus is negatively correlated with age r = - 0.342; positively correlated with albumin: r = 0.156, urea: r = 0.328, creatinine: r = 0.175, calcium x phosphorus index: r = 0.809,PTH: 0.273. Corrected serum calcium is negatively correlated with albumin: r = - 0.917, Hb: r = - 0.369, urea: r = - 0.178, creatinine: r = - 0.188, calcium x phosphorus index: r = 0.492. Plasma PTH positively correlated with dialysis time: r = 0.336, β2 microglobulin: r = 0.247; negatively correlated with Aluminum: r = - 0.161. Serum vitamin D negatively correlated with age: r = - 0.166, β2microglobulin: r = - 0.231. Serum aluminium positively correlated with diastolic blood pressure: r = 0.207 and systolic: r = 0.209. Serum β2 microglobulin positively correlated with dialysis time: r = 0.233, urea: r = 0.168; negatively correlated with Aluminum: r = - 0.224. Conclusion: Some bone mineral in dialysis patients are correlated with age, dialysis time, blood pressure, albumin, urea, creatinine. There is also a intercorrelation between bone minerals. Therefore, it is necessary to screen for bone mineral disorders and correlations as recommended by KDOQI, KDIGO. Key words: End-stage chronic kidney disease, dialysis, correlation, bone mineral disorders
Minh Nguyen Hoang, Thao Trinh Cong
Journal of Medicine and Pharmacy, Volume 10, pp 69-74; https://doi.org/10.34071/jmp.2020.4.9

Abstract:
Saphenous venous insufficency (VI) is more and more common. This disease is diagnosed by clinical symptoms and doppler US. In the last decade, ligation and stripping was main treatment modalities. Recently, there are many alternative methods for this disease such as sclerotherapy, thermal therapies… Laser is one of effective procedure for VI. Objective: To evaluate short-term outcomes of endovenous laser ablation for the treatment of saphenous venous insufficiency. Methods: This retrospective study included 124 patients at C2 stage and above (CEAP classification) who underwent endovenous laser ablation at Hue Central Hospital from 12/2014 to 02/2017. Results: The patients’ average median age was 52 ± 12.18. Patients with great saphenous insufficency were 98.4% (181 limbs) and only 1.6% with small saphenous disease. Most of them were treated with laser wavelength at 1470nm, power at 6-10W. There were 82 patients needed phlebectomy (Muller) and 20 patients associated with sclerotherapy. Most of cases underwent local anesthesia. The initial outcomes of the patient are excelent, there were no major complication related to the procedure. Most of patient were no pain significantly after treatment. The number of patient with mild (no need of antalgics) and severe pain (needed fort antalgics for 5 days) due to laser ablation were 4 cases and 1 case, respectively. Patients could return to daily activities at the day after. A follow – up postoperative ultrasound after 10 days: 100% of cases presented sclerosant veins and no intravenous flow, no deep venous thrombose. There were no recurrence at 3 and 6 month of medical revisit. Conclusion: Endovenous laser treatment was proven as a method of preference for chronic vein insufficiency because of its advandtages such as minimal invasive technique, high successive percentage, least of complication, high aesthetics and early to return daily activities. Key words: Saphenous venous insufficency (VI), laser, endovenous laser ablation
Thuoc Doan Phuoc, Lien Duong Thi Hong, Tu Nguyen Viet, Thao Tran Thi Thanh
Journal of Medicine and Pharmacy, Volume 10, pp 46-56; https://doi.org/10.34071/jmp.2020.4.6

Abstract:
Background: The quality of nursing care plays an important role in overall quality of medical care. Nurses and midwives perform care well, contributing to making patients feel secure, confident, cooperative, and increasing treatment efficiency and patient satisfaction. Objective: To assess the patient’s satisfaction with nursing care provided by clinical departments in Hue University of Medicine and Pharmacy Hospital in 2019. Subject and method: A cross-sectional study on 600 inpatients at Hue University of Medicine and Pharmacy Hospital. Results: The general proportion of patient statisfaction was 71.4%%. Patients were satisfied more with mental health services (77.8%), nursing care skills (75.5%) and the relationship with nurses (70.2%), consulting health education services (73.6%). Patient were less satisfied with hospital hygiene (61.5%). Conclusion: overall, more patient show enthusiasm with the medical care provided by nurse (71.4%). However, the patient’s satisfaction with hospital hygiene stood at only 61.5%. Keywords: Quality of nursingcare, nurse, midwife
Lan Nguyen Hoang, Thong Truong Dinh
Journal of Medicine and Pharmacy, Volume 10, pp 16-22; https://doi.org/10.34071/jmp.2020.4.2

Abstract:
Objectives: To compare quality of life of patients before and one- month after spinal surgery and to identify factors affecting improvement on their quality of life. Materials and Methods: A longitudinal study was conducted in 60 patients who were diagnosed with complicated degenerative lumbar spine and scheduled for surgery of spine at Quang Ngai General Hospital. The SF-36 scale was used to evaluate quality of life of the patients. Results: Findings showed that quality of life after surgery of patients was improved significantly in all components. The better change was found in items of bodily paint and social functioning while the least improvement was reported in physical functioning and role physical. Conclusion: Factors affecting improvement on quality of life of patients after degenerative lumbar surgery were age, BMI and accompanied diseases Key words: degenerative lumbar disease, surgery, quality of life, SF-36, Quang Ngai
Duong Nguyen Thi Thuy, Huong Nguyen Thi Kim
Journal of Medicine and Pharmacy, Volume 10, pp 38-45; https://doi.org/10.34071/jmp.2020.4.5

Abstract:
Background: Composite and Glass ionomer cement (GIC) are common restorative materials of non carious cervical lesions (NCCLs), which effects are controverisial. The aim of the present study was to compare the result of restorations on NCCLs between Composite and GIC. Materials and Methods: follow-up clinical trial with split-mouth design. Thirty-six patients with 96 NCCLs were divided into 2 groups (n=48/group): Group 1 restored by Composite, Group 2 restored by GIC. The restorations were evaluated at baseline, 1 and 3 months for pulpal sensitivity, restoration morphology and overall success grade. Results: GIC restorations gained 100% Good results for all parameters at 3 time points. Composite showed 87.5%, 93.8% and 97.9% Good results at baseline, 1 and 3 months, sequentially. At 3 weeks recall, 1 Composite restorations (2.1%) showed Moderate results of Retention and 2 Composite restorations (4.2%) changed colour. Conclusions: There was no statistically significant difference seen among the three groups for 3 parameters. Key words: non-carious cervical lesion, Composite, Glass ionomer cement
Nhan Ho Hoang, Tuan Nguyen Van Anh, Thu Ho Nguyen Anh, Hao Le Hoang
Journal of Medicine and Pharmacy, Volume 10, pp 99-104; https://doi.org/10.34071/jmp.2020.4.13

Abstract:
Background (including purposes): Periodontitis is a chronic bacterial infection destroying tooth supporting tissues. Although metronidazole exhibits a high effectiveness in the periodontitis treatment, its fast release and the usage frequency of several times per day can become obstacles for the local treatment. Therefore, nanotechnology is necessary to extend the duration of action and reduce the frequency of drug usage per day. The aim of this study was to formulate metronidazole nanoparticles by the nanoprecipitation method and to evaluate their physicochemical properties. Materials and methods: Metronidazole, Eudragit RS100 polymer were used in this study. Nanoparticles containing metronidazole were prepared by the nanoprecipitation method. The factors of the formulation and manufacturing process of nanoparticles containing metronidazole were investigated. The resulting nanoparticles were characterized in terms of the particle size, polydispersed index (PDI), encapsulation efficiency, etc. Results: The nanoparticles containing metronidazole were successfully prepared with the spherical shape, the particle size of 201.9 ± 5.6 nm, PDI of 0.092 ± 0.014, and entrapment efficiency of 46.28 ± 1.18%. These nanoparticles could prolong the drug release (53.45 ± 1.49% at 24 hours). The Korsmeyer-Peppas equation best described the release kinetics of the drug from metronidazole nanoparticles. Key words: Metronidazole, nanoparticle, periodontitis
Linh Nguyen Mai Ha, Van Nguyen Hoang Thanh
Journal of Medicine and Pharmacy, Volume 10, pp 83-88; https://doi.org/10.34071/jmp.2020.4.11

Abstract:
Objectives: To study clinical, subclinical features and to evaluate therapeutic efficacy of Secukinumab in patients with active Ankylosing Spondylitis (AS). Patients and methods: Descriptive, comparative, retrospective and prospective study, combination with treatment intervention in patients diagnosis with AS, following to modified ACR-1984 criteria (New York criteria) who are inpatient or outpatient in the Department of General Internal Medicine - Endocrinology of Hue University of Medicine and Pharmacy and in the Department of Nephrology and Rheumatology of Hue Central Hospital from May 2018 to August 2019. Results: The study recruited of 38 patients, (76.3% males) with mean age of 29.76 ± 9.75 years old. The age of onset was about 23 years old and the percentage of patients who were diagnosed AS under 30 years old was 73.7%. The majority of patients were hospitalized with severe pain (92.1%), in which 86.8% of patients sufferred from spinal pain, 71.1% of patients showed peripheral joint pain, commonly seen in hip joints (44.7%). Other common symptoms were lumbar Schober (about 3 cm), hand to ground distance (about 20 cm), median BASDAI score: 4.15 ± 1.01, median ASDAS-CRP: 3.81 ± 0.94, increasing CRP (81.58%), increasing erythrocyte sedimentation rate (81.6%), the percentage of HLA-B27 (+): 81.25% (for patients who have received this test). For patients treated with Fraizeron, in general, there were changes in patient global assessment, noctural back pain, peripheral swelling, lumbar Schober, hand to ground distance, BASDAI, ASDAS-CRP, erythrocyte sedimentation rate, CRP. These changes were positive with p < 0.05. When we assessed the safety of Secukinumab, we did not record any clinical or subclinical undesirable effects. Conclusion: At week 16, Secukinumab has been effectively shown to improve clinical symptoms as well as subclinical symptoms in patients with AS. It is also considered safe for use in these patients. Key words: Ankylosing Spondylitis, Secukinumab
Phuc Le Hong, Son Tran Thiet, Khoa Tran Dang
Journal of Medicine and Pharmacy, Volume 10, pp 89-98; https://doi.org/10.34071/jmp.2020.4.12

Abstract:
Introduction: The research of the lateral femoral circumflex artery has been studied and applied in many clinical fields. Objectives: To investigate branched anatomical features of the lateral femoral circumflex artery used in the construction of the composite anterolateral thigh (ALT) flap. Patients and research methods: 60 thigh areas of 30 Vietnamese adult cadavers meeting the research standards were conducted cross-sectional descriptive analysis. Result: lateral femoral circumflex artery usually has three branches that are ascending branch, oblique branch and descending branch. Descending branch usually separated independently (11.7%), oblique branch and ascending branch often have common body (83.3%). The majority of ascending branches have origin from lateral femoral circumflex (76.7%). Ascending branche has average of 4.1 branches to supply the anterior thigh muscles. Ascending branches has 2-3 cutaneous perforators were the majority (41.7%). There are 73 descending branch, 75.34% descending branch from the original branch of the lateral femoral circumflex artery, 8.22% lateral femoral circumflex artery from femoral artery and 16.44% descending branch from deep femoral artery. Averaging descending branch has 8.9 ± 0.2 branches to muscles of anteriolateral thigh area and on average had 3.1 ± 0.3 perforators per thigh specimen. The number of branches to lateralis muscles was at most 7.9 ± 0.4 branhes. Conclusion: Anatomical research of the lateral femoral circumflex artery branching as a premise to build a composite ALT flaps with lateralis component or with TFL makes sense in the creation of workhorse materials in clinical application. Key words: lateral femoral circumflex artery
Giang Huynh Huong, Tan Nguyen Thi, Hung Nguyen Van
Journal of Medicine and Pharmacy, Volume 10, pp 105-111; https://doi.org/10.34071/jmp.2020.4.14

Abstract:
Background: Sciatica due to lumbar spondylosis is a common disease syndrome, include pathological signs from lumbar spine and sciatic nerve. It occurs for a long time and affects to working ability and daily life. Currently there are many methods of treatment with modern medicine and traditional medicine. Electroacupuncture combined with acupressure point, massage treatment and “Doc hoat tang ky sinh” remedy is a highly effective method on treating sciatica due to lumbar spondylosis. Objectives: To evaluate the effectives of electroacupuncture combined with acupressure point, massage treatment and “Doc hoat tang ky sinh” remedy on treating sciatica due to lumbar spondylosis. Materials and Method: A total of 43 patients was diagnosed sciatica caused by lumbar spondylosis who treated at Thua Thien Hue Traditional Medicine Hospital. The study was designed by method of prospective study, assessed the results before and after the treatment. Results: Very good: 34.9%; good: 34.9%; average 7%. There was not any unexpected effects observed in this trial. Conclusion: Electroacupuncture combined with acupressure point, massage treatment and “Doc hoat tang ky sinh” remedy is a effective method on treating sciatica caused by lumbar spondylosis. Key words: sciatica, lumbar spondylosis, acupuncture, electroacupuncture, acupressure point, massage treatment
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