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(searched for: Prognostic Analysis of Patients with Resectable T4 Colorectal Cancer)
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Erin A. Strong, Sandra H. Park, Cecilia G. Ethun, Bonnie Chow, David King, Meena Bedi, John Charlson, Harveshp Mogal, Susan Tsai, Kathleen Christians, et al.
Published: 1 October 2020
Surgery, Volume 168, pp 760-767; doi:10.1016/j.surg.2020.06.017

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Sciprofile linkSimone Conci, Andrea Ruzzenente, Corrado Pedrazzani, Giulia Isa, Giulia Turri, Tommaso Campagnaro, Alessandro Valdegamberi, Fabio Bagante, Ivan Marchitelli, Alfredo Guglielmi
Published: 25 September 2020
European Journal of Surgical Oncology; doi:10.1016/j.ejso.2020.09.015

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Sciprofile linkMelissa J Conroy, Susan A Kennedy, Suzanne L Doyle, Brian Hayes, Maria Kavanagh, Eric P. Van Der Stok, Katie O’Sullivan, Mary-Clare Cathcart, John V Reynolds, Joanne Lysaght
Published: 17 September 2020
Carcinogenesis; doi:10.1093/carcin/bgaa101

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Sciprofile linkLiming Wang, Yasumitsu Hirano, Gregory Heng, Toshimasa Ishii, Hiroka Kondo, Kiyoka Hara, Nao Obara, Masahiro Asari, Shigeki Yamaguchi
Published: 31 August 2020
In Vivo, Volume 34, pp 2981-2989; doi:10.21873/invivo.12129

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Yi-Feng Zou, Qiu-Ning Wu, Si Qin, Xi Xi Chen, Jia-Wei Cai, Ying-Xin Tan, Jing-Rong Weng, Yu-Ming Rong, Sciprofile linkXutao Lin
Published: 26 August 2020
Abstract:
Background and aimsA certain number of early-stage colorectal cancer (CRC) patients suffer tumor recurrence after initial curative resection. In this context, an effective prognostic biomarker model is constantly in need. Autophagy exhibits a dual role in tumorigenesis. Our study aims to develop an autophagy-related gene (ATG) signature based on high-throughput data analysis for disease-free survival (DFS) prognosis of patients with stage I/II CRC.MethodsGene expression profiles and clinical information of CRC patients extracted from four public datasets were divided into training cohort (GSE39582, n=566), validation cohort (TCGA CRC, n=624), and meta-validation cohort (GSE37892 and GSE14333, n=420). Autophagy genes significantly associated with prognosis were identified.ResultsAmong 655 autophagy-related genes, a 10 gene ATG signature, which was significantly associated with DFS in the training cohort (HR, 2.76[1.56–4.82]; P=2.06×10-4), was constructed. The ATG signature, stratifying patients into high and low autophagy risk groups, was validated in the validation (HR, 2.29[1.15–4.55]; P=1.5×10-2) and the meta-validation cohorts (HR, 2.5[1.03–6.06]; P=3.63×10-2), and proved to be prognostic in a multivariate analysis. Functional analysis revealed enrichment of several immune/ inflammatory processes in the high autophagy risk group, where significantly higher infiltration of T regulatory cells (Tregs) was observed.ConclusionsOur study established a prognostic ATG signature that effectively predicted DFS for early-stage CRC patients. Meanwhile, the study also revealed the possible correlation between autophagy and immune/ inflammatory processes and tumorigenesis.
Sciprofile linkHenrik Petrowsky, Michael Linecker, Dimitri A. Raptis, Christoph Kuemmerli, Ralph Fritsch, Onur E. Kirimker, Deniz Balci, Francesca Ratti, Luca Aldrighetti, Sergey Voskanyan, et al.
Annals of Surgery; doi:10.1097/sla.0000000000004330

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Chung-Yu Chen, Peng-Sheng Lai, Ying-Yin Chen, Long-Wei Lin
Tumor Biology, Volume 80, pp 353-353; doi:10.1158/1538-7445.am2020-353

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Sciprofile linkAlessandro Vanoli, Federica Grillo, Camilla Guerini, Giuseppe Neri, Giovanni Arpa, Catherine Klersy, Gabriella Nesi Md, Paolo Giuffrida, Gianluca Sampietro, Sandro Ardizzone, et al.
Annals of Surgical Oncology pp 1-11; doi:10.1245/s10434-020-08926-4

Abstract:
Small bowel adenocarcinoma is a relatively rare cancer, often diagnosed in an advanced stage. In localized and resectable disease, surgery alone or in combination with adjuvant chemotherapy is the mainstay of treatment. In the recently published National Comprehensive Cancer Network Clinical Practice guidelines, criteria for selecting patients with stage II small bowel adenocarcinoma to receive adjuvant chemotherapy are provided, and they are mainly extrapolated from studies on colorectal cancer. In the present study, we aimed to verify whether mismatch repair deficiency phenotype, high-risk pathologic features (including T4, positive resection margins and a low number of lymph nodes harvested), as well as tumor histologic subtype, were associated with cancer-specific survival in 66 stage II non-ampullary small bowel adenocarcinoma patients, collected through the Small Bowel Cancer Italian Consortium. A central histopathology review was performed. Mismatch repair deficiency was tested by immunohistochemistry for MLH1, MSH2, MSH6 and PMS2, and confirmed by polymerase chain reaction for microsatellite instability. We identified mismatch repair deficiency, glandular/medullary histologic subtype, and celiac disease as significant predictors of favorable cancer-specific survival using univariable analysis with retained significance in bivariable models adjusted for pT stage. Among the high-risk features, only T4 showed a significant association with an increased risk of death; however, its prognostic value was not independent of mismatch repair status. Mismatch repair protein expression, histologic subtype, association with celiac disease, and, in the mismatch repair proficient subset only, T stage, may help identify patients who may benefit from adjuvant chemotherapy.
Yi-Feng Zou, Qiu-Ning Wu, Si Qin, Xi Xi Chen, Jia-Wei Cai, Ying-Xin Tan, Jing-Rong Weng, Yu-Ming Rong, Sciprofile linkXutao Lin
Published: 2 August 2020
Abstract:
Background and aimsA certain number of early-stage colorectal cancer (CRC) patients suffer tumor recurrence after initial curative resection. In this context, an effective prognostic biomarker model is constantly in need. Autophagy exhibits a dual role in tumorigenesis. Our study aims to develop an autophagy-related gene (ATG) signature based on high-throughput data analysis for disease-free survival (DFS) prognosis of patients with stage I/II CRC.MethodsGene expression profiles and clinical information of CRC patients extracted from four public datasets were divided into training cohort (GSE39582, n=566), validation cohort (TCGA CRC, n=624), and meta-validation cohort (GSE37892 and GSE14333, n=420). Autophagy genes significantly associated with prognosis were identified.ResultsAmong 655 autophagy-related genes, a 10 gene ATG signature, which was significantly associated with DFS in the training cohort (HR, 2.76[1.56–4.82]; P=2.06×10-4), was constructed. The ATG signature, stratifying patients into high and low autophagy risk groups, was validated in the validation (HR, 2.29[1.15–4.55]; P=1.5×10-2) and the meta-validation cohorts (HR, 2.5[1.03–6.06]; P=3.63×10-2), and proved to be prognostic in a multivariate analysis. Functional analysis revealed enrichment of several immune/ inflammatory processes in the high autophagy risk group, where significantly higher infiltration of T regulatory cells (Tregs) was observed.ConclusionsOur study established a prognostic ATG signature that effectively predicted DFS for early-stage CRC patients. Meanwhile, the study also revealed the possible correlation between autophagy and immune/ inflammatory processes and tumorigenesis.
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