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(searched for: Penile Paget ’s Disease: A Case Report and Review of the Literature)
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Flanigan Rc, Dornbier R, Quek Ml, Woods M, Gorbonos A, Gupta G, Harkenrider Mm, Solanki A, Badami A, Henry E, et al.
Archives of Nephrology and Urology, Volume 3, pp 90-96; doi:10.26502/anu.2644-2833025

Abstract:
Extramammary Paget’s Disease (EMPD) is a rare cutaneous, slow growing, intraepithelial adenocarcinoma that can be either primary (intraepithelial arising within the epidermis) or secondary (intraepithelial spread of a visceral carcinoma). Here we present the case of a 63-year-old male with EMPD of the glans penis stemming from underlying urothelial carcinoma. Our treatment decision elected for management with chemotherapy and local treatment with radiation therapy. Subsequent, review of the literature demonstrated a rare disease with a variety of underlying malignancies causing this secondary pathology. Caregivers should be aware of the association of Paget’s disease and urothelial cancer and should have a high index of suspicion that erythematous penile lesions may represent Paget’s disease and that penile biopsies should be performed early in this setting.
Published: 1 January 2013
Gulhane Medical Journal, Volume 55; doi:10.5455/gulhane.17644

Abstract:
Extramammary Paget's disease (EMPD) is a rare, usually non-invasive intraepithelial skin adenocarcinoma which predominantly involves vulvar, perianal, scrotal and penile skin. Management of EMPD is rather complicated due to multifocal involvement, lack of clear tumor boundaries and clinically occult extensions. High recurrence rates following surgery together with the goal of achieving a better cosmetic and functional outcome have prompted the utilization of non-surgical treatment modalities in the management of EMPD. Radiotherapy may either be used as adjunct to surgery after recurrence or may be employed in the treatment of patients with high risk of local failure after surgery. 76-year-old male patient was admitted to Gulhane Military Medical Academy with the complaints of persistent anal itching. He was diagnosed with perianal Pagets disease after consecutive skin biopsies. The patient was deemed unsuitable for surgery due to external anal sphincter involvement which was detected by endoanal ultrasonography and he was treated with curative radiotherapy in our department. We reviewed the pertinent literature, and discussed treatment options and outcomes. In conclusion, we recommend radiotherapy as a treatment option for patients with perianal Pagets disease with curative intent.Key words: Extramammary Paget\'s disease, radiotherapyMeme d Perianal Paget Hastalnda Radyoterapi: Olgu sunumuzetMeme d Paget hastal (EMPD) nadir grlen, arlkl olarak vulvar, perianal, skrotal ve penil blgeyi tutan, sklkla invaziv olmayan intraepidermal cilt adenokarsinomasdr. Multifokal tutulum, tmr snrlarnn belirgin olmamas ve klinik olarak gizli uzanmlar nedeniyle EMPDnin tedavisi komplikedir. Cerrahi sonras yksek rekrrens oranlar ile birlikte daha iyi kozmetik ve fonksiyonel sonu elde etme amac EMPDnin tedavisinde cerrahi d tedavi modalitelerinin kullanlmasna neden olmutur. Radyoterapi cerrahi sonras rekrrensde veya cerrahi sonras lokal baarszlk riski yksek olan hastalarn tedavisinde kullanlabilir. 76 yanda erkek hasta persistan anal kant ikayeti nedeniyle Glhane Askeri Tp Akademisine bavurdu. Mteakip cilt biyopsileri sonrasnda perianal Paget hastal tans konuldu. Endoanal ultrasonografide eksternal anal sfinkter tutulumu olmasndan dolay cerrahi uygun grlmedi ve kliniimizde kratif radyoterapi ile tedavi edildi. Biz ilgili literatr gzden geirdik, tedavi seenekleri ile tedavi sonularn tarttk.. Sonu olarak radyoterapiyi Perianal Paget hastal olan hastalar iin kratif bir tedavi seenei olarak nermekteyiz.Anahtar Kelimeler: Meme d Paget hastal, Radyoterapi
Jr. Antonio Macedo, Jan Fichtner, Rudolf Hohenfellner
Published: 1 January 1997
European Urology, Volume 31, pp 382-384; doi:10.1159/000474489

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Y Hayashibara, S Ikeda
Gan to kagaku ryoho. Cancer & chemotherapy, Volume 15

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