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(searched for: Peak Exercise Cardiac Output but Not Oxygen Uptake Increases in All Heart Failure Patients After Successful Resynchronization Therapy)
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Gaia Cattadori, Carlo Vignati, Alice Bonomi, Massimo Mapelli, Susanna Sciomer, Mauro Pepi, Claudio Tondo, Giuseppe Ambrosio, Silvia Di Marco, Massimo Baravelli, et al.
Cardiology and Cardiovascular Medicine, Volume 4, pp 386-395; doi:10.26502/fccm.92920135

Abstract:
Objectives and Background: Hemodynamic changes at rest and during exercise in heart failure (HF) after cardiac resynchronization therapy (CRT) are still undefined. Methods: In 93 HF patients, before and 8 ± 3 months after CRT, we assessed clinical conditions, ECG and standard echocardiography and we performed a maximal cardiopulmonary exercise test with non-invasive measurement of cardiac output (CO) by inert gas rebreathing method. Results: At rest, CRT shortened QRS and improved NYHA class and left ventricular ejection fraction (LVEF), but not CO and stroke volume (SV). On average, at peak exercise, a significant improvement of oxygen uptake (VO2) (from 13.8 ± 3.8 ml/min/kg to 14.9 ± 4.6, p
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