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(searched for: Oral Lipoma: A Case Report)
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K Kaya, A J Drabkowski
Published: 1 January 1967
The Journal of the Michigan State Dental Association, Volume 49, pp 11-3

Vidyalakshmi S, Umamaheswari G, A. Santha Devy, Satheesh Kumar. K
Journal of Scientific Dentistry, Volume 7, pp 37-41; https://doi.org/10.5005/jsd-7-1-37

, A L Folpe, V S Grieco, R L Garcia
Published: 24 February 2001
The publisher has not yet granted permission to display this abstract.
A Shathur, A Rashid, V Patel, L Ffolkes, R Jayaram
Published: 1 September 2021
British journal of surgery, Volume 108; https://doi.org/10.1093/bjs/znab259.304

Abstract:
Background Lipomas are commonly identified tumours of the body however they are rarely found in the oral cavity. Rarer still is it to report a case of a lipoma in the tongue as they are more commonly located in the buccal mucosa. Objectives To diagnose and explore the pathogenesis of a soft-tissue swelling of unknown origin Method A thorough patient history and clinical examination was undertaken followed by magnetic resonance imaging (MRI) which revealed an alarming report at first glance. An incisional biopsy of the lesion was then carried out to aid in diagnosing the lesion. Results The swelling caused the patient no pain however the mere size of the lesion affected the patient’s tongue movement and function which therefore affected the patient’s quality of life. The imaging and the biopsy of the lesion led to a diagnosis of a large lipoma on the lateral border of the tongue. Conclusions To the authors’ best knowledge, we present a rare case of a patient whom we diagnosed with a large lipoma on the lateral border of the tongue. This case report discusses the stages of patient management from initial presenting complaint, up to the maintenance of the patient following the diagnosis of this lesion.
R. H. B. Allard, P. Blok, W. A. M van der Kwast, I. van der Waal
Published: 1 January 1982
Journal of Oral Pathology & Medicine, Volume 11, pp 18-25; https://doi.org/10.1111/j.1600-0714.1982.tb00139.x

The publisher has not yet granted permission to display this abstract.
Published: 20 March 2008
General dentistry, Volume 56

Abstract:
Oral lipomas are benign lesions that are seen infrequently in the dental practice. This article details the clinical and histopathologic findings of three cases of intraoral lipomas. All of the lesions exhibited a yellow color. Two of the tumors were located on the buccal mucosa, while the other mass arose on the mandibular buccal/labial vestibule, was considerably larger in size, produced extraoral swelling, and necessitated a preoperative MRI due to close approximation to the mental nerve. None of the patients elicited any history of attendant symptomatology. Excisional biopsies in each case revealed well-circumscribed masses surrounded by a thin fibrous capsule and composed of sheets of mature adipocytes arranged in a "chicken wire" configuration. The tumor adipocytes were similar to normal adult fat cells and contained a small, uniformly eccentric nucleus with a single, clear cytoplasmic vacuole. Surgical excision is the modality of treatment and malignant transformation or recurrence is rare.
, Meena Vora, Rakesh Sorathia, Swapnil Shinde
Published: 1 January 2015
Indian Journal of Dentistry, Volume 6, pp 207-210; https://doi.org/10.4103/0975-962x.168520

Abstract:
Lipoma is the most common tumor of the human body, but their presences in the oral cavity are very rare. Reported cases of lipoma of tongue in English literature are very few. Here, we report a case of lipoma of tongue in 63-year-old male patient, with its clinical presentation, the histological picture, classification, and brief review of the literature.
, Netta Sion-Vardy, Peter A. Brennan,
Published: 1 January 2013
Journal: Surgical Science
Surgical Science, Volume 04, pp 196-201; https://doi.org/10.4236/ss.2013.43037

Abstract:
Spindle-cell lipoma (SCL) is a variant of lipoma, usually presenting in the neck or trunk. SCL of the oral cavity is rare. Some cases of oral SCL have been reported; however, the clinico-pathologic characteristics of oral SCL are still unknown. Here we report on 2 cases and review 33 cases of oral SCL published in the literature. The patients were 23 men and 12 women, with a mean age of 55 years (range 23 - 88 years); there were no children. Tumor sites included: tongue (n = 13), cheek/buccal mucosa (n = 11), floor of mouth (n = 5), lip (n = 2), hard palate (n = 2), alveolar ridge (n = 1), and maxilla (n = 1). The mean tumor size was 20.87 mm (range 3 - 50 mm), smaller than extra-oral lesions. Thirty-three patients (94%) presented with a single lesion that was circumscribed and composed of mature adipocytes admixed with bland spindle cells. The spindle cells were strongly immunoreactive for CD34, whereas the adipocytes were negative. The main differential diagnosis is atypical lipoma/well-differentiated liposarcoma. All lesions underwent local excision and recurrences are rare. Oral SCL do not seem to differ from their extra-oral counterpart, which are much more common and larger in size. SCL should be included in the differential diagnosis of oral cavity mesenchymal tumors.
, Risa Chaisuparat, Bernard A Levy, Nikolaos G Nikitakis
Published: 28 December 2012
The Open Dentistry Journal, Volume 6, pp 208-211; https://doi.org/10.2174/1874210601206010208

Abstract:
Sialolipoma is a relatively rare and fairly recently described as a variant of lipoma with salivary elements. Any site within the oral and maxillofacial region may be involved with the parotid gland being the most common location. Herein, we present a case of silaolipoma in lower lip. The clinical and histological features and differential diagnosis are discussed.
G Chiliou, A Mavros, Z Nicolaou
Oral surgery, oral medicine, oral pathology and oral radiology, Volume 132; https://doi.org/10.1016/j.oooo.2021.03.065

The publisher has not yet granted permission to display this abstract.
Audrey F. L. Rocha, Larissa N. Miotto, , Heitor A. Silveira, , , Cláudia M. Navarro,
Published: 24 May 2019
Journal of Cutaneous Pathology, Volume 46, pp 778-783; https://doi.org/10.1111/cup.13512

Abstract:
The low-fat and fat-free spindle cell lipomas (SCLs) are rare and often mistaken for other benign and malignant morphological mimics, because of the fact that the diagnosis relies on its non-lipogenic component analysis. Here, we report the clinicopathological features of two oral SCLs (low-fat and fat-free variants). Both lesions presented clinically as an asymptomatic nodule, which initially yielded diagnostic difficulties on the morphological analysis alone. One case was diagnosed as low-fat SCL on the lower lip in a 29-year-old man, and the other as fat-free SCL on the buccal mucosa in a 46-year-old man. In both cases, immunohistochemistry showed strong positivity for CD34 and, remarkably, retinoblastoma (Rb) protein was deficient. Mast cell (MC) tryptase and toluidine blue stain highlighted numerous MCs distributed throughout all tumor stroma. Alpha-SMA and desmin were negative. S100 evidenced scarce adipocytes only in the low-fat SCL case. Conservative surgical treatment was performed and no recurrence was noticed in about 2-year of follow-up in both cases. Because of the potential pitfalls, careful morphological analysis of the tumor stroma in the low-fat/fat-free SCL diagnosis, supported by immunohistochemistry (especially CD34, Rb and MC tryptase), is strongly recommended. To the best of our knowledge, these are the first and second cases reported of fat-free and low-fat SCL in the oral cavity.
A.B. Bataineh, M.J. Mansour, A. Abalkhail
Published: 31 December 1996
British Journal of Oral and Maxillofacial Surgery, Volume 34, pp 520-523; https://doi.org/10.1016/s0266-4356(96)90249-1

Abstract:
Infiltrating lipomas are unusual benign tumours of mesodermal origin which infiltrate adjacent skeletal muscle and tend to recur after excision. We report three previously unrecorded cases that developed about the mouth, and describe the clinical characteristics of these lesions, together with those of the seven previously reported cases. We have identified a number of differences from oral lipomas that could be of diagnostic value.
Jan G.A.M. de Visscher
Published: 1 January 1982
Journal of maxillofacial surgery, Volume 10, pp 177-181; https://doi.org/10.1016/s0301-0503(82)80036-2

Abstract:
The clinical and histological characteristics of 19 lipomas and fibrolipomas of the oral cavity are presented. Data on age, sex, location, clinical appearance, duration, recurrence and histological diagnosis are reviewed. The data gave a slightly higher incidence of oral lipomas in comparison with lipomas of the whole body (2.2%), and with benign tumours of the oral cavity (2.4%) than reported in the literature. As with many tumours the aetiology of lipomas remains obscure. It is though that repeated mild trauma may trigger the proliferation of fatty tissue and finally causes a lipoma. In 1971 Hatziotis reviewed the literature from 1945 to 1967 and found 145 cases of intraoral lipomas. The literature up to 1981 has been surveyed and 80 additional cases were found. These 225 oral lipomas and fibrolipomas were reviewed. Sixty-six per cent of the tumours occurred in patients in the fifth to the seventh decade. The male-female ratio for lipomas was 1.5:1, and for fibrolipomas 1:1,3. In most cases the only symptom was a painless, palpable tumour. The time between the initial discovery and removal was on average 4 years and 9 months. The cheek was the most favoured site, followed by the tongue, floor of mouth and buccal sulcus and vestibule equally, lip, palate, gingiva and retromolar area. Surgical excision is the treatment of choice and, as far as is known, recurrence has only once been noticed.
A Winnifred Christy, Anitha Bojan, Babu Mathew, S Shanmugam Mds
Journal of Indian Academy of Oral Medicine and Radiology, Volume 22; https://doi.org/10.5005/jp-journals-10011-1070

Abstract:
Lipoma is the benign tumor of adipose tissue. It constitutes about 1 to 2% of all benign neoplasms of the oral cavity. Intraorally, it occurs predominantly in the buccal mucosa followed by tongue, floor of the mouth, buccal vestibule and rarely in the palate and gingiva. A 72-year-old lady reported with a swelling in the hard plate for the past three years. Clinically the swelling was pale pink in color and had a broad peduncle. The swelling was soft to fine in consistency and mobile. A provisional diagnosis of a benign minor salivary gland neoplasm was made. The tumor was excised and histopathological examination showed it to be a fibrolipoma. Lipoma occurring in the palate is rare with only six cases reported in the literature so far. This case of oral lipoma occurring in the hard plate is reported for its rarity and can be considered as a rare possibility in the differential diagnosis of various swellings of the palate
L. K. Surej Kumar, Nikhil Mathew Kurien, Varun B. Raghavan, P. Varun Menon, Sherin A. Khalam
Published: 30 January 2014
Case Reports in Medicine, Volume 2014, pp 1-4; https://doi.org/10.1155/2014/480130

Abstract:
Lipomas are rare in oral and maxillofacial regions although they are the most common tumours of mesenchymal origin in human body. The etiology remains unclear. Various different theories explain the pathogenesis of this adipose tissue tumour and also different histological variants of oral lipoma have been given in literature. A case of intraoral lipoma occurring in mental region in a 77-year-old male is reported along with review of the literature. Wide surgical excision was performed and two-year followup showed excellent healing without any recurrence. Lipomas are benign soft tissue neoplasm of mature adipose tissue seen as a common entity in the head and neck region. Intraoral lipomas are a rare entity which may be noticed only during routine dental examinations. Most of them rarely cause pain, resulting in delay to seek treatment. It is mandatory for a clinician to diagnose intraoral lipomas using latest diagnostic methods and conservatively treat them without causing much discomfort.
Published: 11 September 2022
Journal: Cureus
Abstract:
Lipoma is a common benign soft tissue lesion that can virtually develop anywhere in the body. However, the retropharyngeal space is an extremely rare location for lipoma. We report the case of a 48-year-old man who presented with progressive dysphagia of 3 months duration. It was associated with a weight loss of 6 kg. There was no history of cough, regurgitation, or heartburn. He was a heavy smoker, but he denied consuming alcohol. On examination, the patient was noted to have a hoarse voice. Examination of the oral cavity revealed a bulge in the posterior pharyngeal wall with intact and smooth overlying mucosa. Examination of the neurological system revealed normal findings. The patient was referred to undergo a computed tomography of the neck, which demonstrated a well-defined homogeneous lesion with fat density in the retropharyngeal space. Subsequently, magnetic resonance imaging revealed a well-encapsulated midline retropharyngeal mass, measuring 4.6 x 10.2 x 13.8 cm, filling the retropharyngeal space and extending from the C2 vertebra superiorly to the inferior border of C7 inferiorly. The mass has a high signal intensity on T1- and T2-weighted images with complete suppression of the signal on the fat-saturated sequences, likely representing a retropharyngeal lipoma. The patient underwent surgical resection of the tumor by the lateral cervical approach. Histopathological examination showed lobules of mature adipose tissue, representing a lipoma. Retropharyngeal space is a very rare location of lipoma. The case highlights the importance of considering retropharyngeal lesions when encountering a patient with progressive dysphagia.
P. Christopoulos, O. Nicolatou, A. Patrikiou
International journal of oral and maxillofacial surgery, Volume 18, pp 208-209; https://doi.org/10.1016/s0901-5027(89)80054-2

Abstract:
A case of a spindle cell lipoma of the hard palate of a 58-year-old male is reported. The histologic diagnosis is discussed. Conservative surgical removal is the treatment of choice.
I F Redelinghuys, L A Du Preez
Published: 1 May 1998
South African Dental Journal, Volume 53

Abstract:
Although lipomas are common, benign tumours found in any part of the body, their occurrence in the oral cavity is relatively rare. An unusual case of a large lipoma appearing on the floor of the mouth in a 77-year-old male, is presented in this paper. The unusual appearance in this case suggests that this tumour should be included as a rare possibility in the differential diagnosis of swellings in the floor of the mouth.
Dale A. Miles, Bruce A. Wright
Published: 1 August 1986
Journal of Oral and Maxillofacial Surgery, Volume 44, pp 666-668; https://doi.org/10.1016/s0278-2391(86)80082-9

Abstract:
Two cases with similar initial oral manifestations, i.e., solitary, unilateral soft tissue palatal swellings, were presented. These two cases represented separate and distinct conditions, multiple lipomas and neurofibromatosis. These conditions were reviewed briefly, together with tuberous sclerosis, as conditions in which both oral and multiple cutaneous nodules may be present.
E Kanno, A Takita, S Morikawa, T Saito
Published: 1 November 1989
Ou Daigaku shigakushi, Volume 16

Abstract:
Lipoma, well-circumscribed tumors of mature adipose tissue, are one of the commonest encountered benign neoplasms. In the oral cavity, lipomas almost always occur in the cheek, tongue, and floor, but rarely in the lips. In this paper a 73-year old woman with lipoma in the right lower lip and cases of lipoma in the oral regions that have been reported in Japan are discussed. Her past history was diabetes mellitus and the others had no abnormalities. The specimen was a spherical, encapsulated, soft, bright-yellowish mass measuring 1.5 x 1.0cm. Microscopically, the tumor consisted of matured adipose tissue histological diagnosis of the tumor was simple lipoma. Six months postoperatively there is no sign of recurrence.
, Alessandro Guttadauro, P.A. Mascioli
Published: 31 August 2010
Journal: Oral Surgery
Oral Surgery, Volume 3, pp 140-142; https://doi.org/10.1111/j.1752-248x.2010.01092.x

The publisher has not yet granted permission to display this abstract.
, Y. Papp, M. J. Shelley,
Published: 31 July 2013
Oral and Maxillofacial Surgery, Volume 18, pp 219-222; https://doi.org/10.1007/s10006-013-0426-1

Abstract:
Chondroid lipoma affecting the oral cavity is rare and usually presents as a polyp of benign clinical appearance which is easily excised. However, the histopathological features of chondroid lipoma resemble liposarcoma due to the presence of lipoblasts and lack of mature cartilage. The clinicopathological features of two cases of chondroid lipoma of the dorsum of the tongue, one in a 66-year-old woman and the other in a 43-year-old man, are described. Once the diagnosis had been established, no treatment other than surgical excision was necessary and in neither case has there been recurrence in two years of follow-up.
R C Mahabir, J A Mohammad,
Published: 1 September 2000
The Cleft Palate-Craniofacial Journal, Volume 37, pp 503-505; https://doi.org/10.1597/1545-1569(2000)037<0503:lotcsp>2.0.co;2

Abstract:
Congenital tumors of the oral cavity are extremely uncommon. The teratoid tumors (epiganthi, dermoid, and hairy polyps) account for almost all of the reported cases and are not infrequently associated with cleft of the soft palate. Of the remaining tumors in the pediatric cleft palate population, infantile lipoma of the oral cavity is exceedingly rare. A case of a congenital lipoma associated with a cleft of the soft palate is presented. The review of the literature, the description of the lesion, the diagnosis, and the management of this finding are outlined.
Raman C. Mahabir, Jamal A. Mohammad, Douglas J. Courtemanche
Published: 1 September 2000
The Cleft Palate-Craniofacial Journal, Volume 37, pp 503-505; https://doi.org/10.1597/1545-1569_2000_037_0503_lotcsp_2.0.co_2

Abstract:
Congenital tumors of the oral cavity are extremely uncommon. The teratoid tumors (epiganthi, dermoid, and hairy polyps) account for almost all of the reported cases and are not infrequently associated with cleft of the soft palate. Of the remaining tumors in the pediatric cleft palate population, infantile lipoma of the oral cavity is exceedingly rare. A case of a congenital lipoma associated with a cleft of the soft palate is presented. The review of the literature, the description of the lesion, the diagnosis, and the management of this finding are outlined.
, Mery A. Hristamyan-Cilev, Nikolay D. Kanazirski
Journal of Biomedical and Clinical Research, Volume 14, pp 91-93; https://doi.org/10.2478/jbcr-2021-0010

Abstract:
Summary This report presents clinical case with a histopathologically established lipoma of the sublingual space. Lipomas are benign mesenchymal neoplasms produced by adipocytes. Our search in the literature demonstrated that the development of lipomas in the sublingual space is extremely rare. In the oral cavity, it is seen in less than 5% of patients. In this paper, we describe clinical features, imaging diagnostic and histopathological features. Lipomas are characterized by slow growth and could be asymptomic, therefore diagnosis could be delayed. This report describes and discusses the case of a 64 years-old-man with a formation, located below the left tongue, for a period of 4 years. The patient had repeatedly consulted with Ear-Nose-Throat (ENT) specialists and dentists who recommended surgical treatment. During the last month of the monitoring, the formation had grown significantly and the chewing and speech function had gradually worsened.
Rishabh Sethia, Kasey W. Rawlins, Abdullah Aljasser, Stephen Nogan, ,
International journal of pediatric otorhinolaryngology, Volume 125, pp 103-106; https://doi.org/10.1016/j.ijporl.2019.06.024

Abstract:
A 3-year-old female presented for evaluation of progressive snoring since birth. MRI revealed a fatty-appearing mass measuring 2.4 cm x 1.5 cm x 3.0 cm arising from the predental space of C1 and extending anteriorly through the prevertebral space into the retropharyngeal space. The patient underwent endoscopic trans-oral excision of the mass using electrocautery and blunt dissection, and pathological analysis yielded a diagnosis of fibrolipoma. CT imaging twelve months post-surgery showed no recurrence, and the patient remains symptom free two years later. Very few reported cases of nasopharyngeal fibrolipomas exist, and this is the first report of 2-year clinical follow-up.
L.A.M. Santos, V.M. Santos, D.N. Pitol, D.F. Duailibi
Anales del sistema sanitario de Navarra, Volume 35, pp 317-322; https://doi.org/10.4321/s1137-66272012000200014

Abstract:
Corticosteroid-induced lipomatosis is not a rare condition, but lipoma in the central veins has scarcely been described. According to the databases consulted, this is the first report of a lipoma within the central veins coexistent with long-term use of corticosteroid. It involved a 47-year-old male under treatment for pulmonary sarcoidosis with prednisone. Computerized tomography of the thorax was performed and incidentally the images showed a mass within the central veins with the characteristics of lipoma. He was asymptomatic and refused surgical procedures. The intraluminal lipoma originated in the right brachiocephalic and subclavian veins. Control tomography showed a slow development of this lipoma, without obstructive effects or malignant features. Oral prednisone was changed for methotrexate. The patient is asymptomatic and under longstanding out-patient surveillance. Corticosteroid treatments for sarcoidosis can play a role in the development of intravascular lipoma, but this association is not well defined. Case reports could contribute to clarifying whether this relationship is causal or merely casual.
Mary A. Furlong, Julie C. Fanburg-Smith,
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, Volume 98, pp 441-450; https://doi.org/10.1016/j.tripleo.2004.02.071

Abstract:
Results Of 125 lipomas, 91 tumors occurred in males, 33 in female patients, and 1 of unknown gender. The mean age was 51.9 years, range 9-92 years. Four tumors occurred in pediatric patients (age <18 years). Specific anatomic sites within the oral and maxillofacial region included the parotid region (n = 30); buccal mucosa (n = 29); lip (n = 21); submandibular region (n = 17); tongue (n = 15); palate (n = 6); floor of mouth (n = 5); and vestibule (n = 2). The mean size of tumors was 2.2 centimeters, range 0.5 to 8.0 centimeters. The mean duration of the tumors prior to excision was 3.2 years, range 6 weeks to 15 years. Most patients presented with an asymptomatic, circumscribed mass. Grossly, most tumors were described as pink and smooth, occasionally mucoid. Histologically, the tumors were subclassified as classic lipomas (n = 62); spindle cell/pleomorphic lipomas (n = 59); fibrolipoma (n = 2), and chondroid lipoma (n = 2). Fourteen tumors exhibited secondary changes, such as fat necrosis, atrophy, and prominent hyalinization; 23 tumors were histologically confirmed to be intramuscular. Conclusions Lipomas of the oral and maxillofacial region occur most commonly in adult males in the parotid region, followed closely by the buccal mucosa. These tumors are uncommon in children. Interestingly, spindle cell lipomas are common in this region and comprise the majority of our parotid and lip tumors. Angiolipomas were absent in this anatomic region in this study. Secondary changes and atrophy should not be confused with the malignant histologic features of a liposarcoma. Lipomas are common benign soft tissue neoplasms of mature adipose tissue; however, they are relatively uncommon in the oral and maxillofacial region. Their overall incidence in the oral cavity is thought to be between 1% and 4.4% of all benign oral lesions 1,2 and reportedly higher in one small series. 3 Oral lipomas can occur in various anatomic sites including the major salivary glands, buccal mucosa, lip, tongue, palate, vestibule, and floor of mouth. Numerous case reports have described lipomas and lipoma variants in several locations, predominantly the tongue. 4-21 Fregnani et al 1 have recently reviewed 46 cases of lipomas of the oral cavity, not including the parotid gland. In this study, we review 125 benign lipomas located in the oral and maxillofacial region, including the major salivary glands and correlate site with subclassification. 1 Material and methods The records from the Oral and Maxillofacial Pathology Registry of the Armed Forces Institute of Pathology in Washington, DC, from 1970 to the present were reviewed for cases coded as “lipomas.” The 125 cases included in this study were based on specific anatomic location within the oral and maxillofacial region, benign histology, and available clinical information. No tumor involving the skin, subcutaneous tissues, or arising in bone was included. Lesions noted during third molar extraction were excluded. One tumor with marked cytologic atypia and lipoblasts was reclassified as a well-differentiated liposarcoma and was not included in this study. All available slides and pertinent clinical information were reviewed. 2 Results Of 125 lipomas, 91 tumors occurred in male patients and 33 in female patients. In 1 case, the gender was unknown. In all specific sites, tumors occurred predominantly in males. The overall average age was 51.9 years, range 9-92 years. Four tumors occurred in pediatric patients (age <18 years). The age distribution is presented in Fig 1 . Specific anatomic locations within the oral and maxillofacial region included the parotid region (n = 30), buccal mucosa (n = 29), lip (n = 21), submandibular region (n = 17), tongue (n = 15), palate (n = 6), floor of mouth (n = 5), and vestibule (n = 2). The mean tumor duration prior to excision was 3.2 years (38.3 months), range 6 weeks to 15 years. Most patients were asymptomatic, noting only increased swelling ( Fig 2 ). Three patients with tumors located in the lip (n = 2) and buccal mucosa (n = 1) noted prior trauma and 1 patient with a spindle cell lipoma of the buccal mucosa had a previous tooth extraction. Another patient with a spindle cell lipoma in the parotid also had a concomitant Warthin's tumor. The mean tumor size was 2.2 centimeters, the largest being 8.0 centimeters in the buccal mucosa. Grossly, the tumors were described as circumscribed, encapsulated, and firm to rubbery with a tan, yellow greasy cut surface. Occasionally, there were cyst-like or mucoid areas. Histologically, classic lipomas were composed of encapsulated, mature adipose tissue with variably sized adipocytes (n = 62) ( Fig 3 ). No cytologic atypia was identified. Two such classic lipomas contained areas of metaplastic cartilage ( Fig 4 ). Several other histologic variants were noted, including spindle cell lipoma (n = 59), fibrolipoma (n = 2), and chondroid lipoma (n = 2). Spindle cell lipomas contained the characteristic components of mature fat, bland spindle cells, myxoid change, bundles of ropey collagen, and scattered mast cells ( Fig 5 ). Additionally, spindle cell lipomas with floret-like, multinucleated cells were classified as pleomorphic lipoma ( Fig 6 ). Fibrolipomas were characterized by neoplastic fat cells embedded within dense collagen. Mature fat cells, nests of vacuolated lipoblast-like cells and a chondroid matrix constituted the chondroid lipoma ( Fig 7 ). Further histologic findings included fat necrosis, identified in 2 classic lipomas, sinusoidal changes present in 2 spindle cell lipomas, and hemangiopericytoma-like areas found in 1 spindle cell lipoma of the buccal mucosa. Widened septa characterized 2 otherwise classic lipomas. Four tumors were predominantly hyalinized, nearly obscuring the lipomatous origin. Several tumors (n = 8) exhibited areas of fat atrophy, with smaller, univacuolated cells arranged in lobules. Twenty-three tumors were histologically proven to be...
, S Dall'oca, A Greco Lucchina, R R Palumbo, A Longobardi, A Romeo, ,
Published: 1 March 2009
Minerva Dental and Oral Science, Volume 58

Abstract:
Lipomas are soft tissue mesenchymal neoplasms that rarely occur in the oral and maxillofacial region. Their incidence in the floor of the mouth is very low. The authors present the case of a lipoma of the floor of the mouth, the diagnosis of this lesion was challenging as many clinical signs mimicked the appearance of a common ranula. Also the ultrasound imaging findings were not decisive and only during the operation the yellowish, solid and lobulated aspect of the lesion directed the surgeon to the correct treatment: a block resection of the mass was performed under local anesthesia with no complications. The patient remained asymptomatic with no evidence of recurrences in the postoperative follow-up period of 24 months. Histopathologically, the lesion was classified as a lipoma, a diagnosis based on the presence of mature adipose tissue with no cytologic atypia, subdivided by rare and thin septa of fibrous tissue with the presence of few blood vessels. The case reported highlights the difficulties in diagnosing lesions in the floor of the mouth and the necessity of including rare conditions like lipoma in the differential diagnosis.
Abdulwahid M. Salih, Ari M. Abdullah, Mariwan L. Fatah, Berwn A. Abdulla, Shvan H. Mohammed,
Published: 30 October 2021
Annals of Medicine and Surgery, Volume 72; https://doi.org/10.1016/j.amsu.2021.102985

The publisher has not yet granted permission to display this abstract.
L Silvagni, A Eibenstein, S Chiti-Batelli, S Hueck,
Published: 1 September 2001
The publisher has not yet granted permission to display this abstract.
, Nandesh Shetty, U B Shabari, N A Jaydeep
Published: 1 January 2015
Indian Journal of Dentistry, Volume 6, pp 49-52; https://doi.org/10.4103/0975-962x.151711

Abstract:
Lipomas are the most common subcutaneous soft-tissue tumors. These are benign tumors originating from the adipocytes. They may be located in any part of the body and can be confused clinically with other soft tissue masses. They infrequently occur in the head and neck region. We present a case of solitary lipoma arising in the neck region that was reported to our division of oral and maxillofacial surgery.
Anuradha Navaneetham, Arati Rao, Amul Gandhi, C. A. Jeevan
Published: 1 January 2011
Annals of maxillofacial surgery, Volume 1, pp 93-4; https://doi.org/10.4103/2231-0746.83147

Abstract:
The lipoma is a common tumor of mesenchymal origin, usually seen on the trunk and lower limbs. In the head and neck region, it is usually seen in the posterior neck. It is rarely seen in the anterior neck, infratemporal fossa, oral cavity, pharynx, larynx and parotid gland. It may present in a variety of ways. We report a rare case of a lipoma involving the masticator space.
Published: 18 December 2021
Journal: Cureus
Abstract:
Small intestinal obstruction is a common surgical emergency that has a wide range of underlying etiologies. The most frequent causes of small intestinal obstruction include adhesions, hernias, and malignancies. The diagnosis of small intestinal obstruction is primarily dependent on the clinical findings, but imaging investigations are crucial to confirm the diagnosis and evaluate the complications. We report the case of a middle-aged woman with a complaint of abdominal pain for one week that was associated with abdominal distension and decreased bowel motion. Examination of the abdomen showed a distended abdomen. There was generalized tenderness, but no guarding or rigidity was noted. Initial laboratory investigation showed no derangement in the basic hematological and biochemical parameters. Abdominal CT was performed, which showed a segment of jejunojejunal intussusception causing a small intestinal obstruction. There was a well-defined, oval-shaped fat-attenuation mass lesion acting as a lead-point. Such radiological findings conferred the diagnosis of jejunojejunal intussusception due to jejunal lipoma. The patient underwent laparotomy, which confirmed the radiological finding. The intussusception was reduced, but a gangrenous intestine was observed. Resection of the affected intestine was performed, followed by a primary anastomosis. The patient recovered with no complications. Following the operation, oral feeding was started gradually according to the patient’s tolerance. She was discharged after 10 days of hospitalization. At the follow-up visit after three months, the patient had no active symptoms. This case illustrated a rare etiology of small intestinal obstruction due to gastrointestinal lipoma. A computed tomography scan is strongly advised to reach the diagnosis and identify the lead points.
, Kaniz Hasina, Mohammad A. Chowdhury, Kamrul Hassan
Published: 30 March 2010
Pediatric surgery international, Volume 26, pp 851-853; https://doi.org/10.1007/s00383-010-2593-6

The publisher has not yet granted permission to display this abstract.
Nayyar Abhishek Singh, Patil Namrata N., Gandhi Sweta, Gandhi Rahul A.
International Journal of Clinical Case Reports, Volume 5; https://doi.org/10.5376/ijccr.2015.05.0035

A C Perri De Carvalho, C Martinelli, M G Sanches
Published: 1 November 1987
Quintessence International, Volume 18

N Demetrios, A Theodosios
Hellenika stomatologika chronika. Hellenic stomatological annals, Volume 16

A Nascimento
Published: 1 April 2002
Annals of diagnostic pathology, Volume 6, pp 83-93; https://doi.org/10.1053/adpa.2002.32375

Abstract:
Liposarcomas in the oral cavity have rarely been described, with less than 50 reported cases to date and a purported predominance of the myxoid type. We reviewed our experience with 23 atypical lipomatous tumors/liposarcomas of the oral cavity. Twelve patients were men, 10 were women, and gender was not stated in one case. Age at presentation ranged from 28 to 83 years (median, 49.5 years). The most commonly affected site was the tongue and most cases presented as a slowly growing, painless mass. The clinical impression was lipoma or fibroma in the majority of cases. Tumor size ranged from 0.6 to 8.0 cm (median, 1.5 cm). Five cases were well circumscribed, 5 cases were focally infiltrative, and 13 cases had markedly infiltrative margins. Twenty-one cases were classified as atypical lipomatous tumors (of which 10 showed spindle cell features), one as dedifferentiated liposarcoma, and one as myxoid liposarcoma. Follow-up data was available in 13 of the 23 cases. Five others were lost to follow-up after a short period. Eleven patients remained free of disease without local recurrence or metastasis during the period of follow-up that ranged from 10 months to 9 years (median, 24 months). Two patients had multiple local recurrences. Our study shows that atypical lipomatous tumor is the most common type of malignant fatty tumor to arise in the oral cavity with an apparently low risk of recurrence if widely excised, although follow-up is relatively limited thus far.
A Fehér, L Tiszlavicz
Published: 1 January 1992
Journal: Fogorvosi szemle
Fogorvosi szemle, Volume 85

M Saddik, D J Oldring, W A Mourad
Published: 1 March 1996
Archives of Pathology & Laboratory Medicine, Volume 120

Abstract:
Liposarcomas of the head and neck are exceedingly rare, and fewer than 90 cases have been reported in the literature. Liposarcoma of the oral cavity is an even less common entity, and to our knowledge only nine cases have been reported to date. We report the clinical and pathologic findings of a case of well-differentiated liposarcoma of the base of tongue and tonsillar fossa. The patient is a 76-year-old white man with a long-standing history of a mass in the oral cavity and hypopharynx. The mass had been resected several times over the span of 23 years, and diagnoses of lipoma, neurofibroma, mesenchymoma, and angiofibrolipoma have been rendered on different occasions. At the last admission, a polypoid mass of the left tonsillar fossa and base of tongue was resected. The tumor was multinodular and measured 2.5 cm in greatest diameter. Histologically the tumor was ill-defined with infiltrating borders and was composed predominantly of mature adipose tissue with occasional lipoblasts. A small proportion of the tumor consisted of clusters of spindle cells and pleomorphic lipoblasts. Mitotic activity was not seen. The pleomorphic cells were positive for S100 protein and negative for muscle-specific markers. Ultrastructural analysis confirmed the nature of the lipoblasts. Our case depicts the typical natural history and histologic features of liposarcoma of the oral cavity. This tumor is usually well differentiated and has a high recurrence rate and almost no tendency for metastasis. Based on our case and review of the literature, it appears that well-differentiated liposarcoma of the oral cavity can occasionally be underdiagnosed because of the low mitotic activity and long latent period between the original diagnosis and first recurrence.
T Paragis Sanchez, C Bannwart, D Murilo Araújo, D Dos Santos Pinto Júnior, A C Thomé Capuano
Published: 12 September 2008
Minerva Dental and Oral Science, Volume 57

Abstract:
Liposarcoma of the oral cavity is very rare. The difficulty in clinical and histopatologic differentiation of these oral lipomatous lesions have been recognized by several authors. The aim of this article is to present a case report of a well-differentiated lipoma-like liposarcoma of the tongue, in a 36-year-old woman, and to review the existing literature.
Kavita A Amale, Narendra T Chaudhari, Sweety S Bafna, Hemant R Umarji
Journal of Indian Academy of Oral Medicine and Radiology, Volume 27; https://doi.org/10.4103/0972-1363.188769

Abstract:
Lipomas are benign soft tissue neoplasms of mature adipose tissue usually seen in the head and neck region. Intraoral lipomas are rare lesions, which may be discovered during routine dental examinations since they present as a slow-growing, painless, and asymptomatic yellowish mass. Fibrolipoma is one of the rare variants of the lipoma, and very few cases have been reported in the oral cavity. These lesions infrequently cause pain, but may grow to large size causing difficulty in speech and mastication. Surgical excision is the treatment of choice, and the prognosis is generally good as recurrence rate is very less. Here, we present two cases of fibrolipoma and a brief review of literature.
, Bara’ H. Al-Qutiesh, Khaled H. Badran, Heba H. Al-Mallah, Jesus E. Medina
Published: 24 March 2022
Ear, Nose & Throat Journal; https://doi.org/10.1177/01455613221086036

Abstract:
Lipoma is the most common soft tissue benign tumor in the body. It can occur in the head and neck area as well. Fibrolipoma is a variant of lipoma that contains fibrous tissue. Fibrolipomas of the head and neck are relatively rare, and their presentation depends largely on their size and location; some slowly growing tumors might go unnoticed until they reach significant size and become symptomatic. Here, we report a case of 64-year-old male who presented with large pedunculated oropharyngeal fibrolipoma that originated from the posterior oropharyngeal wall and extended downward into the postcricoid area and cervical esophagus. It was excised transorally using rigid endoscope, and ACE Harmonic scalpel was utilized to excise this 16.7 cm long mass. The postoperative pain was minimal, the surgical site showed complete healing, and oral diet was resumed easily in 5 days.
A. Rousseau, , R.C.K. Jordan
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, Volume 88, pp 581-585; https://doi.org/10.1016/s1079-2104(99)70089-2

The publisher has not yet granted permission to display this abstract.
Published: 1 October 2002
Journal: Modern Pathology
Modern Pathology, Volume 15, pp 1020-1031; https://doi.org/10.1097/01.mp.0000027625.79334.f5

Abstract:
Liposarcoma is rare in the oral and salivary gland region (OSG), previously described in only case reports and two small series. Clinicopathologic features of a large series of these tumors were studied. Cases coded as “liposarcoma or lipoma” from 1970 to 2000 were searched for in our files. Inclusion required an OSG location and diagnosis by established soft tissue criteria. Dermal, other soft tissue, and intraosseous liposarcomas were excluded. Clinical and pathologic material was reviewed and follow-up obtained. Eighteen liposarcomas were included: 10 from males and 8 from females. The median patient age was 51 years (range, 30–70 years). Specific anatomic locations included buccal mucosa (n = 7), tongue (n = 4), parotid gland (n = 3), soft tissue overlying the mandible (n = 2), and one each of palate and submandibular gland. The average tumor size was 4.2 cm (range, 1.5 to 6.0 cm). Histologically, most tumors were well differentiated, including one atypical lipoma (n = 10), followed by myxoid (n = 5) and dedifferentiated (n = 3). OSG liposarcomas of all subtypes had increased numbers of lipoblasts. All patients were treated with surgical excision alone. Follow-up on 15 patients (83%) over a mean of 16.5 years (range, 2 to 53 years) revealed that three patients had between one and six local recurrences over periods of 18 months to 6 years. Twelve patients were without recurrence, with a mean follow-up of 12.8 years (range, 2–23 years). No patients, including those with dedifferentiated liposarcoma, had metastases or died of disease. OSG liposarcomas are rare tumors of adults, occurring most commonly in the buccal mucosa, tongue, and then parotid gland. There were no pleomorphic liposarcomas in this series; well-differentiated liposarcoma was the most common subtype, which can locally recur but, even with high-grade dedifferentiation, does not necessarily predict poor outcome. Therefore, OSG liposarcomas have better prognosis than liposarcoma in other soft-tissue locations, perhaps based on smaller size at presentation. Complete local excision and careful patient follow-up, without adjuvant therapy, appears to be the best treatment for OSG liposarcoma.
A N Makhson, I V Bulycheva, I V Kuz'min, A K Denisov, I A Groshev
Published: 7 June 2006
Journal: Arkhiv patologii
Arkhiv patologii, Volume 68, pp 41-4

Abstract:
Ossifying fibromyxoid tumor (OFMT) is a rare tumor of unknown histogenesis. It consists of chains and trabecules of ovoid cells in the fibromyxoid stroma (ICD code 8842/0). Tumor is frequently surrounded in part by a capsule of laminar bone. It is more frequent in males 14-79 years of age, mean 44 years. Soft tissues of extremities is a preferable location, but body, neck, oral cavity, mediastinum and retroperitoneal tissue can also be the site of OFMT. More than 100 OFMT cases are reported abroad. It is frequently masked by other tumors of soft tissues. We describe 3 cases in our country: 2 in 65 and 66 year old females and in a 44 year old male. Lipoma and soft tissue sarcoma were suspected clinically. Fibroblasts were found cytologically before operation in one case. Diagnosis was established after total biopsy of the tumor. One of the females is under observation after the operation without recurrence during more than two years. Preoperative diagnosis is sometimes possible when characteristic osteoblastic foci are observed.
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