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(searched for: Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION))
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Andrew B. Paxton, Panos G. Christakis, Sciprofile linkJonathan A. Micieli
RETINAL Cases & Brief Reports; doi:10.1097/icb.0000000000001053

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Sciprofile linkPengde Guo, Pengbo Zhao, Han Lv, Yan Su, Ming Liu, Yunxiang Chen, Yan Wang, Haiqin Hua, Shaohong Kang
Published: 9 September 2020
Neural Plasticity, Volume 2020, pp 1-9; doi:10.1155/2020/8826787

Abstract:
Objective. To explore altered regional neuronal activity in patients with nonarteritic anterior ischemic optic neuropathy (NAION) and its correlation with clinical performances using the regional homogeneity (ReHo) method, which is based on resting-state functional magnetic resonance imaging (fMRI). Method. Thirty-one patients with NAION (20 males, 11 females) and 31 age- and sex-matched normal controls (NCs) (20 males, 11 females) were enrolled in the study. All patients underwent ophthalmic examination, including eyesight, intraocular pressure measurement, optimal coherence tomography (OCT), visual field analysis, and fMRI scans. After ReHo was calculated, we investigated group differences in results between the patients and NCs. We analyzed the relationship between ReHo values for different brain regions in patients with NAION and intraocular pressure, visual field analysis, and OCT. A receiver operating characteristic (ROC) curve was used to assess the diagnostic ability of the ReHo method. Results. Compared with NCs, patients with NAION exhibited higher ReHo values in the left middle frontal gyrus, left middle cingulate gyrus, left superior temporal gyrus, and left inferior parietal lobule. Additionally, they exhibited lower ReHo values in the right lingual gyrus, left putamen/lentiform nucleus, and left superior parietal lobule. ReHo values in the left superior parietal lobule were negatively correlated with right retinal nerve fiber layer values (r=−0.462, P=0.01). The area under the ROC curve for each brain region indicated that the ReHo method is a credible means of diagnosing patient with NAION. Conclusion. NAION was primarily associated with dysfunction in the default mode network, which may reflect its underlying neural mechanisms.
Melanie Truong-Le, Sciprofile linkRobert M. Mallery
Current Treatment Options in Cardiovascular Medicine, Volume 22, pp 1-17; doi:10.1007/s11936-020-00829-7

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Samir Nazarali, Henry Liu, Maleeha Syed, Terry Wood, Samuel Asanad, Alfredo A. Sadun, Rustum Karanjia
Aerospace Medicine and Human Performance, Volume 91, pp 715-719; doi:10.3357/amhp.5498.2020

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Dongli Li
Current Stem Cell Research & Therapy, Volume 15, pp 1-3; doi:10.2174/1574888x15666200814121849

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Jeong-Ah Kim, Eun Ji Lee, Tae-Woo Kim, Hyunjoong Kim, Michaël J A. Girard, Jean Martial Mari, Hee Kyung Yang, Jeong-Min Hwang
Published: 15 July 2020
Abstract:
To compare lamina cribrosa (LC) morphology between eyes with nonarteritic anterior ischemic optic neuropathy (NAION) and eyes with normal tension glaucoma (NTG) in the Korean population. This retrospective study included 48 eyes with NAION, 48 eyes with NTG, and 48 healthy control eyes matched by age, intraocular pressure, axial length, and optic disc area. Eyes with NAION and NTG were also matched by retinal nerve fiber layer (RNFL) thickness in the affected sector. Optic nerve heads were scanned using enhanced depth imaging spectral-domain optical coherence tomography. LC depth (LCD) and the LC curvature index (LCCI) were measured at seven locations spaced equidistantly across the vertical optic disc diameter. LCD and the LCCI were compared in the three groups. RNFL thicknesses of the matched affected sectors did not differ between the NAION and NTG groups (P = 0.347). LCD and the LCCI were significantly larger in the NTG group than in the NAION and healthy control groups at all seven planes (P < 0.001 each), but were comparable in the NAION and healthy control groups. The LCCI was larger in the affected than in the unaffected sector of NTG eyes (P = 0.010) but did not differ in NAION eyes (P = 1.000). LCD did not differ between affected and unaffected sectors in either NAION (P = 0.600) or NTG (P = 0.098) eyes. LC morphology differed in eyes with NAION and NTG, despite a similar degree of RNFL damage. Evaluation of LC morphology may help to understand the distinctive pathophysiology of NAION and to differentiate NAION from NTG eyes.
Masoud Aghsaei Fard, Hossein Ghahvechian, Prem S. Subramanian
Journal of Neuro-Ophthalmology; doi:10.1097/wno.0000000000000997

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Lixia Lin, Wenhui Zhu, Nan Ma, Sciprofile linkXiaofeng Lin, Sciprofile linkHui Yang
BMC Ophthalmology, Volume 20, pp 1-7; doi:10.1186/s12886-020-01509-7

Abstract:
To explore the effects of enhanced external counterpulsation (EECP) and its underlying influencing factors in nonarteritic anterior ischemic optic neuropathy (NAION) patients. Patients at Zhongshan Ophthalmic Center with recent-onset (< 8 weeks) NAION were retrospectively recruited. The patients had decided whether or not they would undergo EECP treatment, and the patients who declined were included in the control group. The effectiveness of EECP was evaluated by comparing the visual function and fellow eye involvement in patients with and without EECP treatment. In total, 61 patients (76 eyes) were included. Twenty-nine patients (37 eyes) underwent EECP treatment, while 32 patients (39 eyes) were included in the control group. Mean time from NAION onset to EECP initiation was 27.59 ± 16.70 days. In the EECP group, the mean EECP duration was 31.57 ± 18.45 days. EECP was well tolerated by all patients. However, there was no significant difference in visual function between the EECP and control groups. Furthermore, there was no evidence of the effectiveness of EECP in the subgroup analysis of patients with different systemic health conditions. Among the 42 patients with monocular NAION, the sequential attack rate was comparable between the EECP (27.78%) and control (25.00%) groups. This study is the first nonrandomized controlled study to evaluate the effectiveness of EECP in NAION patients. Unfortunately, we failed to demonstrate the effectiveness of EECP in NAION at the 6-month follow-up. Any further application of EECP in NAION patients should be cautious.
Homayoun Nikkhah, Mahya Golalipour, Azadeh Doozandeh, Mohammad Pakravan, Mehdi Yaseri, Sciprofile linkHamed Esfandiari
European Journal of Applied Physiology pp 1-7; doi:10.1007/s00417-020-04781-x

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Hsiu-Mei Huang, Pei-Chang Wu, Hsi-Kung Kuo, Yung-Jen Chen, Sciprofile linkLinda Yi-Chieh Poon
International Ophthalmology, Volume 40, pp 2667-2676; doi:10.1007/s10792-020-01448-8

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