Refine Search

New Search

Advanced search

Results: 153

(searched for: Microalbuminuria in Type 2 Diabetes Mellitus and Glycemic Control)
Save to Scifeed
Page of 16
Articles per Page
by
Show export options
  Select all
S. Kh. Mekhdiyev, I. I. Mustafaev, M. N. Mamedov
Cardiovascular Therapy and Prevention, Volume 18; doi:10.15829/1728-8800-2019-3-48-56

Abstract:
Aim. To study the relationship of chronic kidney disease parameters with glycemic control, subclinical and clinical signs of cardiovascular diseases and laboratory parameters.Material and methods. The study included 528 patients with type 2 diabetes mellitus (T2DM) aged 30-69 years. All respondents answered questions from the ARIC questionnaire about T2DM and cardiovascular diseases. We determined the ankle-brachial index, sonographic left ventricular hypertrophy, intima-media thickness and defined hypertensive, diabetic angiopathy and polyneuropathy. The levels of glycemia, lipid spectrum, creatinine, uric acid, glycohemoglobin were evaluted. Glomerular filtration rate (GFR) was calculated using the Cockroft-Gault method, and microalbuminuria (MAU) was determined using Micral tests.Results. Glycohemoglobin did not depend on MAU (p=0,564), a decrease in GFR was accompanied by an improvement in glycemic control (p=0,393). There was a direct association between MAU and the duration of diabetes (p=0,001), in patients with a longer course of the disease GFR was reduced (p=0,001). With increasing of systolic blood pressure, MAU progressed (p=0,016), while GFR decreased (pConclusion. Reduction of GFR and MAU are the major risk factors for cardiovascular diseases in the Azerbaijani population with T2DM. We suppose that periodic monitoring of these parameters for primary and secondary prevention of diabetic nephropathy plays an important role.
Mesbah Uddin Ahmed, Sheuly Ferdousi, Tania Nasreen, Saiful Islam, Quddusur Rahman, Shahjada Selim, Debatosh Paul, Tuhin Sultana
Current Research in Diabetes & Obesity Journal, Volume 10, pp 001-004; doi:10.19080/crdoj.2019.10.555795

Abstract:
Diabetes mellitus is a clinical condition characterized by increased blood glucose level (hyperglycemia) due to insufficient or inefficient (incompetent)insulin [1]. The incidence of diabetes is rising. As a result, Diabetic nephropathy is more common now a days and an important cause of morbidity and mortality in chronic kidney disease and end-stage kidney disease (ESKD) or failure [2]. Improved glycemic control has been demonstrated to reduce micro and macro vascular complications in patients with diabetes. Glycated hemoglobin (HbA1c) is the preferred and widely utilized biomarker of glycemic control in subjects with diabetes with higher concentrations of glucose [3].
Mayssa I. Ali, Lubna A. Fawaz, Eman E. Sedik, Zeinab A. Nour, Radwa M. Elsayed
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, Volume 13, pp 1971-1973; doi:10.1016/j.dsx.2019.04.040

The publisher has not yet granted permission to display this abstract.
Prabin Kumar Karki, Santosh Timalsina, Sanat Chalise, Anita Yadav, Ashish Kumar Bhattarai
Journal of Chitwan Medical College, Volume 9, pp 2-7; doi:10.3126/jcmc.v9i1.23775

Abstract:
Background: Diabetes mellitus has become one of the biggest health problems of this era. The resultant microvascular and macrovascular complications add to significant amount of morbidity and mortality. Urine microalbumin is considered as an early marker for microvascular compli­cations among diabetic patients. The aim of this study was to find out the prevalence of microalbuminuria among type 2 diabetic patients attending Kathmandu Medical College and its relation with glycemic control, age, sex, duration of diabetes. Methods: A total of 208 previously diagnosed type 2 diabetic patients at­tending medical outpatient department of Kathmandu Medical College, Sinamangal were included in the study over a period of 1 year (October 2017 - September 2018). Fasting and 2-hour postprandial venous blood for blood glucose and HbA1c measurement and early morning urine sam­ple (after overnight fast) was collected for detection of microalbuminuria. Statistical analysis was done using SPSS version 23. Results: The prevalence of microalbuminuria among the study population (mean age: 54.22 ± 11.76 years, mean HbA1c: 7.62 ± 1.53 %) was 42.8%. Microalbuminuria had significant correlation with HbA1c and duration of diabetes (p
Moyad Shahwan, Sabrina Ait Gacem, Syed K. Zaidi
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, Volume 13, pp 1491-1496; doi:10.1016/j.dsx.2019.02.017

The publisher has not yet granted permission to display this abstract.
Theodora Stratigou, Natalia G Vallianou, Stavroula Koutroumpi, Barbara Vlassopoulou, Theofanis Apostolou, Stylianos Tsagarakis, George Ioannidis, Julia Riske, Martin Janert, Melanie Kahle-Stephan, et al.
Experimental and Clinical Endocrinology & Diabetes; doi:10.1055/a-0848-8076

The publisher has not yet granted permission to display this abstract.
Diabetology & Metabolic Syndrome, Volume 11; doi:10.1186/s13098-019-0399-9

Abstract:
Polymorphisms in the gene encoding methylenetetrahydrofolate reductase (MTHFR) have been investigated as risk factors for microvascular complications of diabetes; however, simultaneous analysis of these polymorphisms and the methylation pattern of the gene has never been conducted. The objective of the present study was to evaluate the simultaneous relationship between MTHFR methylation and MTHFR C6TT7 and A1298C polymorphisms with metabolic, inflammatory and oxidative stress parameters related to microvascular complications, diabetic retinopathy (DR) and diabetic nephropathy (DN) in diabetic patients. A total of 107 patients who were diagnosed in the previous 5 to 10 years were recruited and divided into groups with complications (DR and/or DN) or without complications. Methylation analysis of the gene promoter was conducted using the MSP technique, and analysis of the A1298C and C677T polymorphisms was conducted using the restriction fragment length polymorphism (RFLP) assay. Microalbuminuria was determined using urine samples, and other analytes of interest were determined in blood samples using commercial kits. The Mann-Whitney and Chi square statistical tests were used with significance considered at p < 0.05. Subjects with a hypermethylated profile and the 1298AA genotype showed the highest levels of blood glucose (p = 0.03), total cholesterol (p = 0.0001) and LDL cholesterol (p = 0.0006). The same profile was associated with higher levels of HbA1c (p = 0.025), glycemia (p = 0.04) and total cholesterol (0.004) in the control group and total cholesterol (p = 0.005) and LDL cholesterol (p = 0.002) in the complications group. Serum creatinine was higher in subjects in the hypermethylated group with the genotype 677CC only in the control group (p = 0.0020). The methylated profile in presence of 677CC + 1298AA and the 677CT/TT +1298AA haplotypes showed higher levels of total cholesterol (p = 0.0024; 0.0031) and LDL cholesterol (p = 0.0060; 0.0125) than 1298AC/CC carriers. The fasting glycemia was higher in hypermethylated profile in the presence of 677CC/1298AA haplotype (p = 0.0077). The hypermethylated methylation profile associated with the 1298AA genotype appeared to be connected to higher values of glycemia, total cholesterol and LDL cholesterol.
Taqwaa Sueud, Najah R. Hadi, Raed Abdulameer, Dina A. Jamil, Hayder A. Al-Aubaidy
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, Volume 13, pp 564-568; doi:10.1016/j.dsx.2018.11.022

The publisher has not yet granted permission to display this abstract.
Ugo Nnenna Chikani, Chinwe Flora Ogugua, Maryann Ugochi Ibekwe, Thomas Ngwieri, Holley Allen
Published: 1 January 2019
Annals of African Medicine, Volume 18, pp 200-205; doi:10.4103/aam.aam_5_19

Abstract:
Background: Clinically evident microvascular complications are rarely seen among children and adolescents with type 1 diabetes mellitus (T1DM), although early signs develop during childhood and accelerate during puberty. Aim: The aim of this study was to determine the prevalence of early signs of microvascular complications in children and adolescents aged 9–19 years with a short duration of T1DM by screening for retinopathy and nephropathy. Methods: A cross-sectional study and participants were consecutively enrolled from the Endocrinology Clinic at Federal Teaching Hospital, Abakaliki. Physical examination and mydriatic ophthalmoscopy were conducted. Three early morning spot urine specimens for albumin/creatinine ratio were estimated 3 months apart. Serum creatinine levels were estimated, and the glomerular filtration rate was calculated. Glycosylated hemoglobin (HbA1c) was determined. Results: Twenty-four individuals participated, 15 (62.5%) were male and the mean age at diagnosis was 12.4 ± 2.3 years. The mean duration of diabetes was 23.8 ± 20.6 months. The mean HbA1c was 11.4%. Retinopathy was seen in 16.7%, whereas 33.3% had microalbuminuria. Blood pressure range was within the 50th–90th percentile for all the participants. Conclusion: The study outcome demonstrated a high prevalence of early signs of microvascular complications such as retinopathy and nephropathy among youths with short duration of T1DM. Poor glycemic control, if not halted, is associated with early signs of microvascular complications which may become clinically evident; contrary to the belief that they are rare in childhood. RésuméObjectif: abstrait Déterminer la prévalence des signes précoces de complications microvasculaires chez les adolescents âgés de 9 à 19 ans ayant une courte durée de T1DM par dépistage de la rétinopathie et de la néphropathie. Méthodes: Une étude transversale et des sujets ont été inscrits consécutivement de la clinique d'endocrinologie à l'hôpital fédéral d'enseignement Abakaliki.L'examen physique et l'ophtalmose mydriatique ont été menés. Trois spécimens d'urine de tache tôt le matin pour le rapport d'albumine/créatinine ont été estimés 3 mois d'intervalle.Des niveaux de créatinine de sérum ont été estimés et le taux glomerular de filtration calculé.L'hémoglobine glycosylated (HbA1c) a été déterminée. Résultats: 24 sujets ont participé, Quinze (62,5%) étaient des mâles et l'âge moyen au diagnostic était de 12,4 à 2,3 ans.La durée moyenne du diabète était de 23,8 à 20,6 mois. Leur HbA1c moyen était de 11,4%.La rétinopathie a été vue dans 16.7% tandis que 33.3% a eu le microalbuminuria. La tension artérielle se situe entre le 50e et le 90e percentile pour tous les participants. Conclusion: Les signes de complication microvasculaire se manifestent tôt chez les enfants et les adolescents atteints de TIDM dans le sud-est du Nigeria.Contrairement à la croyance que les complications microvasculaires cliniquement évidentes sont rarement vues parmi des enfants avec T1DM.Un mauvais contrôle glycémique et la puberté sont des facteurs de risque importants.
Pragati Garg, Smriti Mishra, Ritika Mullick
International Journal of Ophthalmic Research, Volume 5, pp 308-313; doi:10.17554/j.issn.2409-5680.2019.05.87

Abstract:
AIM: The present study was carried out with an aim to study the concordance and correlation of microalbuminuria, dyslipidemia with the severity of Diabetic Retinopathy in type II diabetes mellitus patient and to provide a possible basis for explanation of mechanisms governing this relationship.MATERIAL AND METHOD: The study was conducted in a tertiary care hospital in North India.The patients underwent thorough history and ocular evaluation.The patients included in the study were advised to undergo biochemical investigations for Blood sugar, Urinary albumin to creatinine ratio in a random spot collection of urine and Lipid profile. Patients with acute or chronic renal failure, Opaque/hazy ocular media preventing fundus visualization, Co-existing ocular disorders likely to mask the findings of diabetic retinopathy, Patients with presence of any of the confounding factors, like fever, active systemic infections, exercise, high protein intake, accelerated hypertension, congestive heart failure, patients not willing to participate in the study were excluded from the study.RESULTS: 444 subjects of either gender were included in our study, out of which 236 patients were females and the rest were males. Majority of the patients lied in the age group of 41-60 years (54.73%) followed by 61-80 years (29.28%) and 20-40 years (15.09%), while only 4(0.90%) patients were aged >80 years. A statistically significant association with severity of retinopathy and the age of the patients was observed. Proportion of Group I (No retinopathy) was higher in younger patients i.e. 20- 40 (74.6%) and 41-60 (54.3%) as compared to elderly cases i.e. 61-80 (46.2%) and this difference was found to be statistically significant (p
Page of 16
Articles per Page
by
Show export options
  Select all
Back to Top Top