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Published: 6 May 2021
Sustainability, Volume 13; doi:10.3390/su13095179

Abstract:
Regenerative sustainability is gaining great attention as an essential concept for a transformative process, a re-designed mindset shifting from the narrowed focus of considering particular aspects such as energy efficiency, renewable materials, or sustainable technology towards the creation of a self-regenerating social and ecological system. Apart from being a vision of the future, regenerative sustainability has already been implemented successfully in individual projects, plans, and extensive strategies. The goals of this research are (1) to set up the conceptual framework for regenerative sustainability principles in the built environment; (2) to investigate and identify the drivers and barriers faced during the implementation of regenerative principles in the built environment; and (3) to identify gaps in the paradigm shift towards regenerative districts and macro-level projects. A multi-stage methodology was implemented. First, an in-depth literature review was conducted aiming to understand regenerative sustainability state of the art and define the key principles. Then, quantitative data analysis was conducted aiming to identify drivers and barriers of regenerative implementation in buildings following by semi-structured interviews with the representatives of regenerative buildings or districts. The step-by-step methodology resulted in the identified drivers of applying the regenerative principles, which are available financial incentives; marketing and sales benefits; improved companies/investors market image and competitive market advantage; reduced building lifecycle costs/effective use of energy and resources; enhancement buildings’ users’ well-being; and receiving building certification. The main barriers identified were lack of knowledge and experience working with regenerative materials and technologies by employees, consultants, and construction companies and usage of the available tools that enable such constructions; overall stakeholders’ culture and their resistance to changing their mindset toward a regenerative approach; inadequacy of national and international standards and legislation to address regenerative policies; and increased construction cost and time and lack of financial incentives. Ultimately, during the broad examination of the case studies, regenerative qualities served as a valuable insight to understand barriers and drivers at neighborhood and macro levels.
, Mario Mardirossian, Luigi Musciacchio, Micol Pacor, Federico Berton, ,
ACS Applied Materials & Interfaces, Volume 13, pp 17255-17267; doi:10.1021/acsami.1c01016

The publisher has not yet granted permission to display this abstract.
Yimeng Li, Leqian Wei, Lizhen Lan, Yaya Gao, Qian Zhang, Hewan Dawit, , Lamei Guo, , Lu Wang
Published: 1 April 2021
Acta Biomaterialia; doi:10.1016/j.actbio.2021.04.018

The publisher has not yet granted permission to display this abstract.
Xiao Chen, , Suihong Liu, Qingxi Hu
Journal of Biomaterials Applications; doi:10.1177/08853282211001006

The publisher has not yet granted permission to display this abstract.
Frontiers in Bioengineering and Biotechnology, Volume 9; doi:10.3389/fbioe.2021.644076

Abstract:
Editorial on the Research Topic Advanced Therapies for Cardiac Regeneration Cardiovascular diseases (CVDs) are the leading cause of death worldwide, accounting for ~18 million deaths annually (WHO data). The term CVD gathers a group of different disorders involving the heart, its constituent structures, and the blood vessels. Among CVDs, coronary heart disease and stroke are responsible for four out of five CVD-related deaths, and one third of these deaths occur prematurely in people aged 70 or younger. The progressive or sudden obstruction of the coronary arteries is responsible for the onset of myocardial infarction which initiates a detrimental cascade of events finally leading to heart failure. More in detail, heart failure results from the continuous remodeling of the scar tissue replacing the beating heart muscle in the infarcted region, and represents a chronic condition in which the heart muscle progressively loses its ability to pump enough blood to fulfill the needs of all the body's compartments. Heart failure thus represents the main cause of morbidity and mortality of myocardial infarcted patients in the long term. Within this context, cardiac tissue engineering/regenerative medicine (TERM) strategies could arise as cutting-edge therapies in the management of myocardial infarcted patients, opening the way to the possibility to replace the damaged heart tissue and recover its functionality. Such an approach could effectively represent a valid alternative to the gold standard heart transplantation, encompassing all issues related to donor shortage and the need for life-long administration of immunosuppressive therapies. Among other common cardiovascular diseases, we also recall valve heart diseases and cardiomyopathies. It must be highlighted the strong associations existing between different cardiovascular diseases, such as coronary heart disease and valvular heart disease, cardiomyopathy and heart failure. This observation indicates that a multiple regenerative medicine approach, which considers different diseases, could be an effective strategy in the management of CVDs. The Research Topic “Advanced Therapies for Cardiac Regeneration” aims at presenting a series of articles summarizing the latest research updates on cardiac TERM approaches which combine cells, biomaterials, hydrogels, tissue engineered scaffolds/patches and physico-chemical stimuli to achieve the ultimate goal of regenerating the injured heart tissue. The issue is comprised of 19 peer-reviewed manuscripts (nine reviews, two perspectives, seven original research articles, and one Brief Research Report) derived from the many fields involved in the topic, namely (bio)materials science and engineering, biology, biotechnology, and biomedical engineering. To better contextualize the Research Topic, the review by Montero et al. presents an in-depth overview of the specific characteristics of the myocardium that determine the needs and requirements cardiac TERM has to meet, with particular emphasis on heart tissue components, architecture and biophysical properties. The authors also briefly revise the key components required to design new cardiac TERM approaches, namely cells, materials, maturation stimuli, and scaffold fabrication techniques. Given the central role of biomaterials in the establishment of cardiac TERM therapies, Bar and Cohen focus their review on the current application of biomaterials in the field of cardiac regeneration, mainly discussing their use as forming materials for nano-carriers and matrices for cardiac regeneration induced by biomolecule release, injectable hydrogels for cell delivery, and cardiac patches. Further and more detailed insight on the use of specific biomaterials in cardiac TERM are provided by Cattelan et al. and Gonzalez De Torre et al., with particular emphasis on their application as hydrogel constituents. Being three-dimensional highly hydrated networks showing mechanical properties similar to soft tissues, hydrogels hold great promise in cardiac TERM. Cattelan et al. elucidate the promising properties of alginate in cardiac regeneration strategies and the outcomes of clinical trials in which this material has been tested to treat myocardial infarcted patients. An additional demonstration of the suitability of this material for cardiac TERM is provided by Bloise et al. who develop alginate hydrogels for the controlled release of immunomodulatory and reparative cytokines (anti-inflammatory interleukins 4/6/13 and colony-stimulating factor) to direct immune cell fate and control the wound healing process in the ischemic heart. The therapeutic ability of the proposed treatment has been proved in rat models by macrophage polarization toward healing and the improved global cardiac functionality. Differently, Gonzalez De Torre et al. discuss on the potential of elastin-based biomaterials as constituents of hydrogel scaffolds, injectable systems, or complex devices (e.g., heart valves, stents) to treat CVD-affected patients. In this regard, Fernàndez-Colino et al. investigate the use of elastin-like recombinamers as forming materials of small caliber compliant vascular grafts. The authors describe material processing into macroporous three-dimensional structures favoring cell homing, extracellular matrix (ECM) deposition and endothelium development, while exhibiting non-thrombogenicity and elastic properties mimicking the native elastin. Graft textile components are finely designed to confer proper suture retention, long-term structural stability, burst strength and compliance. The proper selection of the biomaterials used as constituents of cardiac scaffolds/patches/devices or hydrogels thus represents the first step toward the engineering of successful regenerative strategies for the management of CVD-affected patients. Indeed, biomaterials strongly affect the possibility to provide the resulting devices with proper biological signals and physical...
, Ling Ma, , Ammar H. Elsheikh, Wenjia Li, Qi Yan, Jiachen Wang
Process Safety and Environmental Protection, Volume 147, pp 1209-1228; doi:10.1016/j.psep.2021.01.045

The publisher has not yet granted permission to display this abstract.
Published: 23 February 2021
Sustainability, Volume 13; doi:10.3390/su13042411

Abstract:
The conventional building design and construction have detrimental impact onto the environment. With the current pace of development of the contemporary society, these issues cannot be fully addressed with the concept of sustainable design and construction, which is based on causing less harm to the environment. Thus, the regenerative concept is gaining relevance, as it is changing the construction paradigm toward the delivery of a human-centric environment, which, when coupled with the circular economy, aims to enable the natural environment to evolve. In order to have a more frequent delivery of regenerative buildings, it is necessary to broaden the knowledge on regenerative design, which is the objective of this paper. The aim is to investigate the design process, strategies, and technologies that are applied during the design and construction of a refurbished residential building, which is intended to be the first regenerative building in Spain, and is currently in the process of certification as per the Living Building Challenge (LBC) standard. Therefore, a literature review was performed, followed by a site visit of the case-study building. The research is organized according to the seven categories (petals) of the Living Building Challenge standard, and all 20 imperatives of the LBC are discussed. Additionally, the aspects of costs and project management are investigated. The findings point out the main design features and challenges toward the realization of regenerative refurbishment, in order to fully adhere to the demands of the LBC, and discusses their potential for a broader application in rural as well as urban settings. The analysis of the case-study design and construction can serve as a valuable insight to deliver future regenerative buildings and accelerate their implementation in the construction industry. This article is based upon the work of COST Action RESTORE CA16114, supported by COST (European Cooperation in Science and Technology).
Dorcas A. Ayeni, Victory O. Omeiza
European Journal of Engineering and Technology Research, Volume 6, pp 87-94; doi:10.24018/ejers.2021.6.1.1987

Abstract:
The menace of environmental dilapidation has been an issue of great concern in the built environment since the wake of the industrial revolution. Buildings have been said to be instruments that cut short the natural cycles of resources in both the human and natural ecosystem due to man’s anthropocentric mind-set and activities. Various theories, framework, and models have been proposed to facilitate re-generatively sustainable developments. This paper aims at highlighting strategies that are currently practiced in regenerative development with a view of presenting ideas for the practical application of regenerative sustainability in all its facets and phases. Relevant literature that described the processes of creating a regenerative development and the aspects in which regenerative sustainability principles are implemented were reviewed. The design strategies employed in the studied cases were described as they related to the phases and then grouped into the four facets of regenerative development. The paper, therefore, gives an idea of the various integrative element and practical strategies for the implementation of regenerative design in all its phases and facets. Clarity on the subject of regenerative development is also anticipated as examples of regenerative design element implemented in the cases under study were detailed out. These strategies, when applied with attention to place patterns and potentials in all aspects of the built environment, will help in creating a truly regenerative development in any area.
Jingjing Chen, Yi Shen, Zhisen Shen, Lixin Cheng,
Published: 15 December 2020
by Wiley
Journal of Clinical Laboratory Analysis, Volume 35; doi:10.1002/jcla.23646

Abstract:
Objective Tissue engineering has been a topic of extensive research in recent years and has been applied to the regeneration and restoration of many organs including the larynx. Currently, research investigating tissue engineering of the larynx is either ongoing or in the preclinical trial stage. Methods A literature search was performed on the Advanced search field of PubMed using the keywords: “(laryncheal tissue engineering) AND (cartilage regeneration OR scaffolds OR stem cells OR biomolecules).” After applying the selection criteria, 65 articles were included in the study. Results The present review focuses on the rapidly expanding field of tissue‐engineered larynx, which aims to provide stem cell–based scaffolds combined with biological active factors such as growth factors for larynx reconstruction and regeneration. The trend in recent studies is to use new techniques for scaffold construction, such as 3D printing, are developed. All of these strategies have been instrumental in guiding optimization of the tissue‐engineered larynx, leading to a level of clinical induction beyond the in vivo animal experimental phase. Conclusions This review summarizes the current progress and outlines the necessary basic components of regenerative laryngeal medicine in preclinical fields. Finally, it considers the design of scaffolds, support of growth factors, and cell therapies toward potential clinical application.
, Chen Ling, Xiaolong Li, Renwang Sheng, Haoyang Liu, Aini Zhang, Yujie Jiang, Jialin Chen, Qingqiang Yao
ACS Biomaterials Science & Engineering, Volume 6, pp 6917-6925; doi:10.1021/acsbiomaterials.0c01276

The publisher has not yet granted permission to display this abstract.
Andrea Domingues Goncalves, Wendy Balestri,
Published: 11 November 2020
Biomaterials; doi:10.5772/intechopen.91295

Abstract:
Regenerative therapies aim to develop novel treatments to restore tissue function. Several strategies have been investigated including the use of biomedical implants as three-dimensional artificial matrices to fill the defect side, to replace damaged tissues or for drug delivery. Bioactive implants are used to provide growth environments for tissue formation for a variety of applications including nerve, lung, skin and orthopaedic tissues. Implants can either be biodegradable or non-degradable, should be nontoxic and biocompatible, and should not trigger an immunological response. Implants can be designed to provide suitable surface area-to-volume ratios, ranges of porosities, pore interconnectivities and adequate mechanical strengths. Due to their broad range of properties, numerous biomaterials have been used for implant manufacture. To enhance an implant’s bioactivity, materials can be functionalised in several ways, including surface modification using proteins, incorporation of bioactive drugs, growth factors and/or cells. These strategies have been employed to create local bioactive microenvironments to direct cellular responses and to promote tissue regeneration and controlled drug release. This chapter provides an overview of current bioactive biomedical implants, their fabrication and applications, as well as implant materials used in drug delivery and tissue regeneration. Additionally, cell- and drug-based bioactivity, manufacturing considerations and future trends will be discussed.
Hui Yan, Xin Li, , Daotong Chong, Junjie Yan
Published: 15 September 2020
Energy Conversion and Management, Volume 220; doi:10.1016/j.enconman.2020.113059

The publisher has not yet granted permission to display this abstract.
Tingting Hun, Yaoping Liu, Yechang Guo, Yan Sun, Yubo Fan, Wei Wang
Microsystems & Nanoengineering, Volume 6, pp 1-13; doi:10.1038/s41378-020-00191-5

Abstract:
Interpretation of cell–cell and cell-microenvironment interactions is critical for both advancing knowledge of basic biology and promoting applications of regenerative medicine. Cell patterning has been widely investigated in previous studies. However, the reported methods cannot simultaneously realize precise control of cell alignment and adhesion/spreading with a high efficiency at a high throughput. Here, a novel solid lift-off method with a micropore array as a shadow mask was proposed. Efficient and precise control of cell alignment and adhesion/spreading are simultaneously achieved via an ingeniously designed shadow mask, which contains large micropores (capture pores) in central areas and small micropores (spreading pores) in surrounding areas contributing to capture/alignment and adhesion/spreading control, respectively. The solid lift-off functions as follows: (1) protein micropattern generates through both the capture and spreading pores, (2) cell capture/alignment control is realized through the capture pores, and (3) cell adhesion/spreading is controlled through previously generated protein micropatterns after lift-off of the shadow mask. High-throughput (2.4–3.2 × 104 cells/cm2) cell alignments were achieved with high efficiencies (86.2 ± 3.2%, 56.7 ± 9.4% and 51.1 ± 4.0% for single-cell, double-cell, and triple-cell alignments, respectively). Precise control of cell spreading and applications for regulating cell skeletons and cell–cell junctions were investigated and verified using murine skeletal muscle myoblasts. To the best of our knowledge, this is the first report to demonstrate highly efficient and controllable multicell alignment and adhesion/spreading simultaneously via a simple solid lift-off operation. This study successfully fills a gap in literatures and promotes the effective and reproducible application of cell patterning in the fields of both basic mechanism studies and applied medicine. A solid lift-off method with an ingeniously designed micropore array as a shadow mask enables the efficient and precise control of cell patterning. Cell patterning is an important strategy for both basic biological mechanism studies and applicable technology developments in regenerative medicine, such as tissue engineering. Here, a team led by Prof. Wei Wang from Peking University presents the first report of a simultaneous control of cell alignment and adhesion/spreading via an easy single-step lift-off operation. The key concept is that the micropore array contains the large pores in central areas and small pores in surrounding areas controlling cell capture and alignment, and cell adhesion and spreading, respectively. They demonstrated high-throughput, high-efficiency cell alignment along with a precise control of cell spreading.
Jialiang Liang, Min Wu, Chen Chen, Mingjie Mai, ,
Oxidative Medicine and Cellular Longevity, Volume 2020, pp 1-14; doi:10.1155/2020/2102841

Abstract:
Reactive oxygen species (ROS) have been implicated in mechanisms of heart development and regenerative therapies such as the use of pluripotent stem cells. The roles of ROS mediating cell fate are dependent on the intensity of stimuli, cellular context, and metabolic status. ROS mainly act through several targets (such as kinases and transcription factors) and have diverse roles in different stages of cardiac differentiation, proliferation, and maturation. Therefore, further detailed investigation and characterization of redox signaling will help the understanding of the molecular mechanisms of ROS during different cellular processes and enable the design of targeted strategies to foster cardiac regeneration and functional recovery. In this review, we focus on the roles of ROS in cardiac differentiation as well as transdifferentiation (direct reprogramming). The potential mechanisms are discussed in regard to ROS generation pathways and regulation of downstream targets. Further methodological optimization is required for translational research in order to robustly enhance the generation efficiency of cardiac myocytes through metabolic modulations. Additionally, we highlight the deleterious effect of the host’s ROS on graft (donor) cells in a paracrine manner during stem cell-based implantation. This knowledge is important for the development of antioxidant strategies to enhance cell survival and engraftment of tissue engineering-based technologies. Thus, proper timing and level of ROS generation after a myocardial injury need to be tailored to ensure the maximal efficacy of regenerative therapies and avoid undesired damage.
, Fabian Dawo, Christoph Wieland, Hartmut Spliethoff
Published: 1 August 2020
Energy, Volume 205; doi:10.1016/j.energy.2020.117967

The publisher has not yet granted permission to display this abstract.
, Hussein Mishbak, Glen Cooper, Chris Peach, Ruben F. Pereira, Paulo Bartolo
Biomanufacturing Reviews, Volume 5, pp 1-24; doi:10.1007/s40898-020-00008-y

Abstract:
Articular cartilage and the underlying subchondral bone are crucial in human movement and when damaged through disease or trauma impacts severely on quality of life. Cartilage has a limited regenerative capacity due to its avascular composition and current therapeutic interventions have limited efficacy. With a rapidly ageing population globally, the numbers of patients requiring therapy for osteochondral disorders is rising, leading to increasing pressures on healthcare systems. Research into novel therapies using tissue engineering has become a priority. However, rational design of biomimetic and clinically effective tissue constructs requires basic understanding of osteochondral biological composition, structure, and mechanical properties. Furthermore, consideration of material design, scaffold architecture, and biofabrication strategies, is needed to assist in the development of tissue engineering therapies enabling successful translation into the clinical arena. This review provides a starting point for any researcher investigating tissue engineering for osteochondral applications. An overview of biological properties of osteochondral tissue, current clinical practices, the role of tissue engineering and biofabrication, and key challenges associated with new treatments is provided. Developing precisely engineered tissue constructs with mechanical and phenotypic stability is the goal. Future work should focus on multi-stimulatory environments, long-term studies to determine phenotypic alterations and tissue formation, and the development of novel bioreactor systems that can more accurately resemble the in vivo environment.
Vasco Sampaio-Pinto, Ana C. Silva, Perpétua Pinto-Do-Ó,
Introduction to Antibody Engineering pp 187-211; doi:10.1007/978-3-030-43939-2_10

The publisher has not yet granted permission to display this abstract.
Margherita Zamboni, Jens Magnusson,
Published: 30 June 2020
Stroke Revisited pp 257-269; doi:10.1007/978-981-10-1430-7_18

The publisher has not yet granted permission to display this abstract.
Sunho Park, Hoon Seonwoo, Ki-Taek Lim, Yonghyun Gwon, Daun Kim, Woochan Kim, Sujin Kim, Jong Hoon Chung, Jangho Kim
Soft Matter and Biomaterials on the Nanoscale pp 89-117; doi:10.1142/9789811218026_0003

The publisher has not yet granted permission to display this abstract.
Metha Islameka, Christopher Fernaldy Kusuma,
International Journal of Sustainable Transportation Technology, Volume 3, pp 20-25; doi:10.31427/ijstt.2020.3.1.4

Abstract:
This research aims to investigate the effect of applying braking strategies to the energy consumption of electric trike (e-trike). E-trike is a three-wheeled vehicle that is designed for goods delivery. A simulation is carried out to find the specific electric energy consumption in terms of km/kWh. The simulation is conducted by developing an energy consumption model using Matlab/Simulink software. The input data used in the simulation is obtained from the e-trike specification designed by Institut Teknologi Bandung (ITB) researchers. The output is the battery State of Charge (SOC) and energy required for the Worldwide Harmonized Light Vehicle Test Procedure (WLTP) driving cycle. Four different braking strategies are implemented in the simulation, namely full mechanical braking, serial regenerative braking, parallel regenerative braking, and modified braking strategies. The simulation results show that by applying the modified braking strategy, greater savings of energy can be achieved. Full mechanical braking strategy can achieve energy savings of 19.2 km/kWh whereas the modified braking strategy generates 20 km/kWh. These results indicate that the application of modified braking strategies can significantly increase the e-trike mileage.
Lihong Lei, Yingming Wei, Zhongxiu Wang, Jiayin Han, Jianwei Sun, Yi Chen, Xianyan Yang, Yanmin Wu, ,
ACS Biomaterials Science & Engineering, Volume 6, pp 2376-2387; doi:10.1021/acsbiomaterials.0c00152

The publisher has not yet granted permission to display this abstract.
, Massimo Mari, Giuseppe Scarascia-Mugnozza,
Published: 10 March 2020
Abstract:
<p>The damage and risk to the environment and human health consequent to traditional agricultural practices urged the development of innovative techniques and more environmentally friendly processes and compounds. Nanotechnology can improve the precision in the processes and the coordination of the management strategies of agricultural production. Therefore, innovative and groundbreaking tools have recently been developed employing natural and engineered nanomaterials to deliver agrochemicals to plants for both improving nutrition, stimulate plant growth, improve the quality of the soil and protect plants, while reducing the impact of these compounds on the environment and human health. Electrospinning (ES) is a highly versatile and inexpensive nanotechnology that allows to design and fabricate continuous non-woven polymer fibers with diameters ranging from micrometer to nanometer when a strong electrical field acts on a droplet of a solution with sufficient viscoelasticity. The resulting fibers can assume complex shapes, creating a multitude of structures with a broad spectrum of different properties (porosity, permeability, high fiber interconnectivity, nano-scale interstitial spaces, biomimetism and bioinspiration, etc.).&#160;<br />Since the limitation of iron availability is a crucial condition in plant nutrition, the polymer fabrics here proposed, mimicking the natural strategy adopted by nongraminaceous and graminaceous species (Strategy I and II, respectively), were designed to make available to the plants the insoluble iron (Fe III) widely present in ecosystems by releasing selected iron-chelating molecules. Therefore, we investigated a model system based on ES biodegradable nanofibrous textiles with different shapes capable of releasing natural iron-chelators into soil/water by controlled rates (depending on the membrane morphology). The present study first focused on the production and functionality of a biodegradable nanofibrous polymer (polyhydroxybutyrate-PHB) scaffold, that is naturally produced by microorganisms and algae). &#160;Because of its fragility, PHB was then blended with another biodegradable polymer (polycaprolactone-PCL), and then properly bio-loaded. The resulting polymer blend, due to the physical properties of PCL, resulted softer and mechanically more resistant than the previous one (PHB) and it was poorly affected by sudden changes in temperature. Both polymers are water insoluble and present low environmental impact, and are commonly investigated and used in drug delivery structures. The effectiveness and toxicity of both functional systems mimicking Strategy I and II concepts and dynamics were tested in two different plant hydroponic cultures. Such regenerative and sustainable agricultural practices based on natural sources and waste reduction, inspired by the principles of a circular bio-economy (European Environment Agency, report n. 2/2016), aimed at replacing the use of chemicals and traditional raw materials, improving health and environmental conditions, as required by the original principles of a circular economy, and at facing the increasing risk level for our natural capital.</p>
Timothy Kamaldinov, , Michael Levin, David L. Kaplan,
Published: 1 March 2020
Bioelectricity, Volume 2, pp 21-32; doi:10.1089/bioe.2019.0024

The publisher has not yet granted permission to display this abstract.
Sheng Zhou, Shichao Zhang,
Published: 29 February 2020
Racing for the Surface pp 489-533; doi:10.1007/978-3-030-34471-9_19

The publisher has not yet granted permission to display this abstract.
Pejman Abbasi Pashaki, Fakher Rahim, Mehryar Habibi Roudkenar, Smt Razavi-Toosi, Ammar Ebrahimi
Applied Biochemistry and Biotechnology, Volume 191, pp 1056-1071; doi:10.1007/s12010-020-03229-6

The publisher has not yet granted permission to display this abstract.
Gavin Raddall, Isabel Mello,
Frontiers in Bioengineering and Biotechnology, Volume 7; doi:10.3389/fbioe.2019.00317

Abstract:
Challenges with traditional endodontic treatment for immature permanent teeth exhibiting pulp necrosis have prompted interest in tissue engineering approaches to regenerate the pulp-dentin complex and allow root development to continue. These procedures are known as regenerative endodontic therapies. A fundamental component of the regenerative endodontic process is the presence of a scaffold for stem cells from the apical papilla to adhere to, multiply and differentiate. The aim of this review is to provide an overview of the biomaterial scaffolds that have been investigated to support stem cells from the apical papilla in regenerative endodontic therapy and to identify potential biomaterials for future research. An electronic search was conducted using Pubmed and Novanet databases for published studies on biomaterial scaffolds for regenerative endodontic therapies, as well as promising biomaterial candidates for future research. Using keywords “regenerative endodontics,” “scaffold,” “stem cells” and “apical papilla,” 203 articles were identified after duplicate articles were removed. A second search using “dental pulp stem cells” instead of “apical papilla” yielded 244 articles. Inclusion criteria included the use of stem cells from the apical papilla or dental pulp stem cells in combination with a biomaterial scaffold; articles using other dental stem cells or no scaffolds were excluded. The investigated scaffolds were organized in host-derived, naturally-derived and synthetic material categories. It was found that the biomaterial scaffolds investigated to date possess both desirable characteristics and issues that limit their clinical applications. Future research investigating the scaffolds presented in this article may, ultimately, point to a protocol for a consistent, clinically-successful regenerative endodontic therapy.
, Pierre Perrot, Judith Lorant, Olivier Nerrière, Jean-Michel Nguyen, Soraya Saiagh, Cécile Frenard, Audrey LeDuc, Olivier Malard, Florent Espitalier, et al.
Published: 28 October 2019
Trials, Volume 20, pp 612-10; doi:10.1186/s13063-019-3718-4

Abstract:
Background Wound repair is one of the most complex biological processes of human life. Allogeneic cell-based engineered skin substitutes provide off-the-shelf temporary wound coverage and act as biologically active dressings, releasing growth factors, cytokines and extracellular matrix components essential for proper wound healing. However, they are susceptible to immune rejection and this is their major weakness. Thanks to their low immunogenicity and high effectiveness in regeneration, fetal skin cells represent an attractive alternative to the commonly used autologous and allogeneic skin grafts. Methods/design We developed a new dressing comprising a collagen matrix seeded with a specific ratio of active fetal fibroblasts and keratinocytes. These produce a variety of healing growth factors and cytokines which will increase the speed of wound healing and induce an immunotolerant state, with a slight inflammatory reaction and a reduction in pain. The objective of this study is to demonstrate that the use of this biological dressing for wound healing at the split-thickness skin graft (STSG) donor site, reduces the time to healing, decreases other co-morbidities, such as pain, and improves the appearance of the scar. This investigation will be conducted as part of a randomized study comparing our new biological dressing with a conventional treatment in a single patient, thus avoiding the factors that may influence the healing of a graft donor site. Discussion This clinical trial should enable the development of a new strategy for STSG donor-wound healing based on a regenerative dressing. The pain experienced in the first few days of STSG healing is well known due to the exposure of sensory nerve endings. Reducing this pain will also reduce analgesic drug intake and the duration of sick leave. Our biological dressing will meet the essential need of surgeons to “re-crop” from existing donor sites, e.g., for thermal-burn patients. By accelerating healing, improving the appearance of the scar and reducing pain, we hope to improve the conditions of treatment for skin grafts. Trial registration ClinicalTrials.gov, ID: NCT03334656. Registered on 7 November 2017.
Eric Lambert, Vijay S Gorantla, Jelena M Janjic
Published: 1 October 2019
Nanomedicine, Volume 14, pp 2697-2712; doi:10.2217/nnm-2019-0260

The publisher has not yet granted permission to display this abstract.
Richard L. Youngblood, Joshua P. Sampson, Kimberly R. Lebioda,
Published: 15 September 2019
Acta Biomaterialia, Volume 96, pp 111-122; doi:10.1016/j.actbio.2019.06.032

The publisher has not yet granted permission to display this abstract.
Published: 12 August 2019
Pharmaceutics, Volume 11; doi:10.3390/pharmaceutics11080407

Abstract:
Hyaluronic acid (HA) is a natural, linear, endogenous polysaccharide that plays important physiological and biological roles in the human body. Nowadays, among biopolymers, HA is emerging as an appealing starting material for hydrogels design due to its biocompatibility, native biofunctionality, biodegradability, non-immunogenicity, and versatility. Since HA is not able to form gels alone, chemical modifications, covalent crosslinking, and gelling agents are always needed in order to obtain HA-based hydrogels. Therefore, in the last decade, different strategies for the design of physical and chemical HA hydrogels have been developed, such as click chemistry reactions, enzymatic and disulfide crosslinking, supramolecular assembly via inclusion complexation, and so on. HA-based hydrogels turn out to be versatile platforms, ranging from static to smart and stimuli-responsive systems, and for these reasons, they are widely investigated for biomedical applications like drug delivery, tissue engineering, regenerative medicine, cell therapy, and diagnostics. Furthermore, the overexpression of HA receptors on various tumor cells makes these platforms promising drug delivery systems for targeted cancer therapy. The aim of the present review is to highlight and discuss recent advances made in the last years on the design of chemical and physical HA-based hydrogels and their application for biomedical purposes, in particular, drug delivery. Notable attention is given to HA hydrogel-based drug delivery systems for targeted therapy of cancer and osteoarthritis.
Fu-Jun Zhu, Ya-Lin Tong, ,
Published: 1 August 2019
Acta Biomaterialia, Volume 94, pp 132-144; doi:10.1016/j.actbio.2019.05.038

The publisher has not yet granted permission to display this abstract.
Katharina S. Hellmund,
Published: 27 March 2019
Frontiers in Chemistry, Volume 7; doi:10.3389/fchem.2019.00172

Abstract:
Interest in biologically active materials that can be used as cell culture substrates for medicinal applications has increased dramatically over the last decade. The design and development of biomaterials mimicking the natural environment of different cell types, the so-called extracellular matrix (ECM), is the focus of research in this field. The ECM exists as an ensemble of several adhesion proteins with different functionalities that can be presented to the embedded cells. These functionalities regulate numerous cellular processes. Therefore, different approaches and strategies using peptide- and protein-based biopolymers have been investigated to support the proliferation, differentiation, and self-renewal of stem cells, in the context of regenerative medicine. This minireview summarizes recent developments in this area, with a focus on peptide-based biomaterials used as stem cell culture substrates.
, , K. Chetehouna, A. Ingenito, F. Stella, M. Bouchez, B. Le Naour
Published: 1 March 2019
Fuel, Volume 239, pp 1091-1101; doi:10.1016/j.fuel.2018.11.096

The publisher has not yet granted permission to display this abstract.
, Jiayi Chen, Xueyan Li, Dan Lei
Mechanical Systems and Signal Processing, Volume 116, pp 943-962; doi:10.1016/j.ymssp.2018.07.012

The publisher has not yet granted permission to display this abstract.
Fabian Stamer, Firat Yuce, Matthias Singer, Marc Hiller
IECON 2018 - 44th Annual Conference of the IEEE Industrial Electronics Society pp 1279-1284; doi:10.1109/iecon.2018.8592695

The publisher has not yet granted permission to display this abstract.
Babette Maleiner, Janine Tomasch, , Oliver Spadiut, Dominik Rünzler,
Published: 22 August 2018
Frontiers in Physiology, Volume 9; doi:10.3389/fphys.2018.01130

Abstract:
Classical approaches to engineer skeletal muscle tissue based on current regenerative and surgical procedures still do not meet the desired outcome for patient applications. Besides the evident need to create functional skeletal muscle tissue for the repair of volumetric muscle defects, there is also growing demand for platforms to study muscle-related diseases, such as muscular dystrophies or sarcopenia. Currently, numerous studies exist that have employed a variety of biomaterials, cell types and strategies for maturation of skeletal muscle tissue in 2D and 3D environments. However, researchers are just at the beginning of understanding the impact of different culture settings and their biochemical (growth factors and chemical changes) and biophysical cues (mechanical properties) on myogenesis. With this review we intend to emphasize the need for new in vitro skeletal muscle (disease) models to better recapitulate important structural and functional aspects of muscle development. We highlight the importance of choosing appropriate system components, e.g., cell and biomaterial type, structural and mechanical matrix properties or culture format, and how understanding their interplay will enable researchers to create optimized platforms to investigate myogenesis in healthy and diseased tissue. Thus, we aim to deliver guidelines for experimental designs to allow estimation of the potential influence of the selected skeletal muscle tissue engineering setup on the myogenic outcome prior to their implementation. Moreover, we offer a workflow to facilitate identifying and selecting different analytical tools to demonstrate the successful creation of functional skeletal muscle tissue. Ultimately, a refinement of existing strategies will lead to further progression in understanding important aspects of muscle diseases, muscle aging and muscle regeneration to improve quality of life of patients and enable the establishment of new treatment options.
Harshad Bandal, K. Koteshwara Reddy, Avinash Chaugule,
Published: 1 August 2018
Journal of Power Sources, Volume 395, pp 106-127; doi:10.1016/j.jpowsour.2018.05.047

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Current Organic Chemistry, Volume 22, pp 1193-1204; doi:10.2174/1385272822666180517095551

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Grant M. Liska, Trenton Lippert, Eleonora Russo, Norton Nieves, Cesar V. Borlongan
Published: 1 June 2018
Conditioning medicine, Volume 1, pp 151-166

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George S. Hussey, Jenna L. Dziki,
Nature Reviews Materials, Volume 3, pp 159-173; doi:10.1038/s41578-018-0023-x

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Blockchain Technology and Innovations in Business Processes pp 547-554; doi:10.1007/978-3-319-92099-3_61

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Payam Zarrintaj, Behnaz Bakhshandeh, , Farshid Sefat, Iraj Rezaeian, Mohammad Reza Ganjali, Seeram Ramakrishna,
Published: 1 May 2018
Acta Biomaterialia, Volume 72, pp 16-34; doi:10.1016/j.actbio.2018.03.042

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Huijun Guo, Hongjiang Wang, Suifang Lin
2018 13th IEEE Conference on Industrial Electronics and Applications (ICIEA) pp 486-490; doi:10.1109/iciea.2018.8397766

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Ran Bao, Philip Griggs, James Baxter
Published: 3 April 2018
SAE Technical Paper Series; doi:10.4271/2018-01-0411

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, Nikolay Monarkin, Anna Sizanova, Oleg Derevianko
International Journal of Computational Physics Series, Volume 1, pp 286-286; doi:10.29167/a1i1p286

Abstract:
Investigation of the Arctic region is a crucial task and comprises various geopolitical, economical, technological and ecological activities at a global scale. In the course of intensification of the geopolitical struggle for resources usage, the Arctic region has now brought under new scrutiny. The known development strategies for the Arctic zone of the Russian Federation are based on the usage of advanced technologies. They are aimed at the creation of supply systems for emergency-rescue and other urgent works at specific severe conditions and critically important objects, including oil and gas production, power and communal facilities. These tasks might be accomplished using modern heat-protective devices, which provide effective and sustainable usage of human energy resources. Among the vast variety of individual safety gear for workers, there are some devices which are highly-efficient at extremely low-temperature conditions. These devices are based on thermal energy regeneration process of the exhaled air. Air temperature under the mask is increased driven by the heat of expired air and heating of incoming cold air while passing through the regenerative heat exchange unit. This heat-exchange unit was previously heated during expiration. This paper presents a survey concerning the following themes: a review of scientific researches, concerning tools for human respiratory organs protection at low air temperatures, patent documents and commercially-viable technical devices used for this purpose, as well as mathematical models of regenerative heat exchange. The devices and methods were compared, their advantages and disadvantages were revealed. It was stated that the most effective heat-exchange device is not that made of tissue material, but that is a solid-state composite construction of an irregular shape with internal channels for air transport. The presented thermal mask cap is designed so that vertically oriented channel rows do not connect with each other. The developed mathematical model is based on Newton-Richmann law. This model includes equations with efficiency coefficients for regenerative cap material at accumulation and regeneration heat stages. For various external air temperatures, we have calculated temperature oscillations between regenerative heat exchange unit input and output. These values were plotted together with the experimental temperature values and compared. Mathematical model adequacy and energy efficiency coefficients for thermal masks were determined. An engineering technique for device efficiency determination was proposed. The conducted combined experimental and computational investigations allowed us to carry out the efficiency analysis of the existing heat-protective masks which are based on thermal energy regeneration process of the exhaled air for inhaled air heating. The numerical values for the efficiency coefficients were obtained, and we made some conclusions concerning further device improvements...
Daniela P. Vasconcelos, Madalena Costa, Nuno Neves, José H. Teixeira, Susana G. Santos, , Mário A. Barbosa,
Journal of Biomedical Materials Research Part A, Volume 106, pp 1626-1633; doi:10.1002/jbm.a.36370

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Marietta Landgraf, , Peter Friedl,
Published: 1 March 2018
Trends in Biotechnology, Volume 36, pp 242-251; doi:10.1016/j.tibtech.2017.12.001

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, David Hartzke, Franziska Schmidt, Jan Eucker, , ,
Published: 1 March 2018
Acta Biomaterialia, Volume 69, pp 290-300; doi:10.1016/j.actbio.2018.01.036

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