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(searched for: Effects of Testosterone Replacement in Hypogonadal Heart Transplanted Men)
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Doris Wagner, Karin Amrein, Julia Mader, Astrid Fahrleitner-Pammer
Archives of Nephrology and Urology, Volume 3, pp 61-76; doi:10.26502/anu.2644-2833022

Abstract:
Context: Hypogonadism is common in cardiac transplant patients and exerts negative effects on bone, but also libido and quality of life. Objective: We investigated whether testosterone replacement therapy (TRT) on top of ibandronate in hypogonadal CTX recipients is beneficial for important clinical outcomes. Design: Observational study (eugonadal and hypogonadal) and non-blinded randomized controlled trial (hypogonadal subgroup). Setting: Academic tertiary care center at the Medical University of Graz, Austria Patients: 52 heart transplanted men (21 eugonadal, 31 hypogonadal) with untreated osteoporosis (median 50 months post transplantation). 8 patients could not enter the study because of pathological urologic examination. Intervention(s): Besides standard therapy with ibandronate 2 mg quarterly iv and oral daily calcium/vitamin D, hypogonadal men were randomly assigned to either testosterone replacement (n=14) or not (n=17). Main Outcome Measures: Bone mineral density (BMD), fracture incidence, sexual function Results: At baseline, hypogonadal compared to eugonadal men had lower Z-score values at the femoral neck (-1.54 vs. 0.15) and total hip (-1.34 vs. 0.01) (all P
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