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(searched for: Effects of Cold Saline Solution Infusion on Cooling Performance with Endovascular Therapeutic Hypothermia)
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Luis Augusto Palma Dallan, Michael Dae, Natali Schiavo Giannetti, Tathiane Facholi Polastri, Carlos Eduardo Rochitte, Ludhmila Abrahao Hajjar, Claudia Yanet Bernoche San Martin, Felipe Gallego Lima, Jose Carlos Nicolau, Mucio Tavares De Oliveira Jr, et al.
Cardiology and Cardiovascular Medicine, Volume 4, pp 334-345; doi:10.26502/fccm.92920131

Abstract:
Background: Therapeutic hypothermia (TH) reduces the damage by ischemia/reperfusion cell syndrome in cardiac arrests, however, the role of cold saline as an adjuvant therapy to endovascular cooling in STEMI remains controversial. The aim was the evaluation of cold saline infusion versus no cold saline concomitant to endovascular cooling in the development of a TH protocol in STEMIs. Methods: Patients within the 6h onset of chest pain, presenting anterior or inferior STEMIs. TH induced through the Proteus® Endovascular System implant, by cooling for 18 minutes before coronary recanalization at the target temperature of 33±1.0°C before PCI. Patients were randomized to the administration of 1L cold saline solution at 1-4°C (CSS) versus no cold saline solution (NCSS). The primary endpoint was lower temperature by the opening of the vessel through primary PCI. Results: TH was successfully induced in 10 patients – 5 in the CSS group and 5 in the NCSS group. After 18 minutes of TH, all patients (100%) had already achieved core temperature
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