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(searched for: Anti-GnRH Neutralizing Antibodies Produce Testosterone Ablation and Tumor Shrinkage in Prostate Cancer Models)
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Jesús A. Junco, Franklin Fuentes, Lesvia Calzada, Eddy Bover, Eulogio Pimentel, Yovisleidis López, Roberto Basulto, Hilda Garay, Osvaldo Reyes, Angel Cid-Arregui, et al.
Journal of Cancer Science and Clinical Therapeutics, Volume 4, pp 333-348; doi:10.26502/jcsct.5079076

Abstract:
Background: Vaccines based on modified GnRH peptide variants can be an alternative treatment for advanced prostate cancer. However, the efficacy of the GnRH-based vaccine variants has been limited by their insufficient immunogenicity. Methods: The current vaccine based on the modified peptide GnRHm1-TT peptide has been formulated in the different oil adjuvants; Montanide ISA 51 and Montanide ISA 51VG. Results: Experiments carried out in healthy animal models demonstrated to produce significant anti-GnRH antibody levels (p
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