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Yukihiro Hirata, Yuto Matsui, Ikuo Wada,
Molecular Biology of the Cell; https://doi.org/10.1091/mbc.e21-07-0372

Abstract:
Collagen is the major protein component of the extracellular matrix. Synthesis of procollagens starts in the endoplasmic reticulum (ER), and three ⍺ chains form a rigid triple helix 300–400 nm in length. It remains unclear how such a large cargo is transported from the ER to the Golgi apparatus. In this study, to elucidate the intracellular transport of fibril-forming collagens, we fused cysteine-free GFP to the N-telopeptide region of procollagen III (GFP-COL3A1) and analyzed transport by live-cell imaging. We found that the maturation dynamics of procollagen III were largely different from those of network-forming procollagen IV (Matsui et al. 2020). Proline hydroxylation of procollagen III uniquely triggered the formation of intralumenal droplet-like structures similar to events caused by liquid–liquid phase separation, and ER exit sites surrounded large droplets containing chaperones. Procollagen III was transported to the Golgi apparatus via vesicular and tubular carriers containing ERGIC53 and RAB1B; this process required TANGO1 and CUL3, which we previously reported were dispensable for procollagen IV. GFP-COL3A1 and mCherry-⍺1AT were co-transported in the same vesicle. Based on these findings, we propose that shortly after ER exit, enlarged carriers containing procollagen III fuse to ERGIC for transport to the Golgi apparatus by conventional cargo carriers. Movie S1: Live-cell imaging of COS7 cells transiently expressing GFP-COL3A1 (green) and Golgi-BFP (blue) after addition of ascorbic acid (Figure 1D). Time-lapse images were acquired every 30 min using fluorescence microscopy (Leica). The arrow indicates the Golgi apparatus. Scale bar, 10 μm. Download Original Video (2.3 MB) https://ascb-prod-streaming.literatumonline.com/journals/content/mboc/0/mboc.ahead-of-print/mbc.e21-07-0372/20220104/media/mc-e21-07-0372-s02.,1200,960,900,768,652,642,.mp4.m3u8?b92b4ad1b4f274c7087751841cabb28b19a3e23570e4794628d00a388fabd4f47061f4b4b81c11dac4c336cd5be6a2a6a495e5def8479aeedf32e6f4ec8f325c8354b92f9a15e63bba6a844857b79b5251ea2f2c474db882c931237fd69b3bd99f9c1261a70275b889ff2377a28b4394592b4b8b9dba9521c9ff2694bc9692c8e1ede08685e57c1a49b323518a78dc4e7f9773f94f53fe7e96de7a00108e742275c59c6715abe6ec396a57845fadfdfba76b Movie S2: Live-cell imaging of RD cells transiently expressing GFP-COL3A1 (green) and PDI-mCherry (red) (Figure 2A). Time-lapse images were obtained every 5 sec using a confocal microscope (Leica SP8) ∼ 1 h after addition of ascorbic acid. The arrow indicates a GFP-COL3A1-containing vesicle trafficking from the ER to the Golgi. Scale bar, 2 μm. Download Original Video (1.0 MB) https://ascb-prod-streaming.literatumonline.com/journals/content/mboc/0/mboc.ahead-of-print/mbc.e21-07-0372/20220104/media/mc-e21-07-0372-s03.,768,652,642,.mp4.m3u8?b92b4ad1b4f274c70877518511abb28bed2c6f7421a565d9f7a5b3e3f5a40bc644191f5cacfb3cc9bc55304dc1c46558ab6522739decd45c6dec6a8654b8369cdf994bf5e08d6d62d0c63d92507c384a30613cc9136b305abcd987bb852e48c3bfa2f16ca4ee4aad0ae92a7d2e5f8643b4e08c9679052ba0208530d29f87ba2b6b53a6539009a288e1aae21665e46dca1812f27e914991221124ce60b25e82b76aea503b25 Movie S3: Living-cell imaging of RD cells transiently expressing GFP-α1AT (green) by confocal microscopy (Figure S4). Time-lapse images were obtained every 4 sec. The arrow indicates a GFP-α1AT-containing vesicle trafficking from the ER to the Golgi. Scale bar, 3 μm. Download Original Video (1.8 MB) https://ascb-prod-streaming.literatumonline.com/journals/content/mboc/0/mboc.ahead-of-print/mbc.e21-07-0372/20220104/media/mc-e21-07-0372-s04.,768,652,642,.mp4.m3u8?b92b4ad1b4f274c70877518511abb28bed2c6f7421a565d9f7a5b3e3f5a40bc644191f5cacfb3cc9bc55304dc1c46558ab6522739decd45c6dec6a8654b8369cdf994bf5e08d6d62d0c63d92507c384a30613cc9136b305abcd987bb852e48c3bfa2f16ca4ee4aad0ae92a7d2e5f8643b4e08c9679052ba0278530d29f87ba2b403120024db18364711f7f0d5f243498270c08a1490b024d43c15f3dadd5c08feffa23061c Movie S4: Time-lapse imaging of RD cells transiently expressing GFP-α1AT (green) and mScarlet-RAB1B (red) acquired by confocal microscopy at 24 h after transfection (Figure S5A). Time-lapse images were acquired every 0.5 sec. The arrow indicates a vesicle containing both GFP-α1AT and mScarlet-RAB1B. Scale bar, 2 μm. Download Original Video (5.1 MB) https://ascb-prod-streaming.literatumonline.com/journals/content/mboc/0/mboc.ahead-of-print/mbc.e21-07-0372/20220104/media/mc-e21-07-0372-s05.,1920,1200,960,900,768,652,642,.mp4.m3u8?b92b4ad1b4f274c70877518b17abb28b8c6166875a97f369b6d543b680497f5bca01d1632f390ebb6e08bd2a2725a70a05738b03ddc7251bffb1206bcd384e738aacf0abe9b4502e102dfa92763a3db1ea5002610ecd6cf45afbe7326f9a386c1d36f0006d1d81b9b5373201812c79db53fcc660bf6b78f30e5c80e5fb44772a3d8f0a70a1ca849de9a5cadbec9762789278d8990160e0dbd92d6961c22181787b18f34a08f23dc11b2f22ff9733aa7d46839ec4a40290 Movie S5: Live-cell imaging of RD cells transiently expressing GFP-COL3A1 (green) and mScarlet-RAB1B (red) by confocal microscopy (Figure 3A). Time-lapse images were acquired every 4 sec starting ∼1 h after addition of ascorbic acid. The arrow indicates a vesicle containing both GFP-COL3A1 and mScarlet-RAB1B. Scale bar, 2 μm. Download Original Video (2.1 MB) https://ascb-prod-streaming.literatumonline.com/journals/content/mboc/0/mboc.ahead-of-print/mbc.e21-07-0372/20220104/media/mc-e21-07-0372-s06.,960,900,768,652,642,.mp4.m3u8?b92b4ad1b4f274c70877518417abb28b5655d276a5eae1bfc19592cc1f1a12ac8d96d0769beebf64b7a7aef1609cbd3a33d54a00c50ff29123db1c37b9b21c021889513e583236cdaa7986fef64374cd452b321552333924b207bc9dc72b7b034093b6c0b7a34856c763afc5b0f3aba405c314d59e2567811fc5b04f3b22a58bd50d6aea80cebbf595289656fc9da755ac39325233a1d95baf6f49f7789ed94903935113bc7c2c427253987c06 Movie S6: Live-cell imaging of RD cells transiently expressing GFP-COL3A1 (green) and mScarlet-RAB1A (red) by confocal...
, Nicholas O'Regan
Published: 19 January 2022
Strategic Change, Volume 31, pp 161-177; https://doi.org/10.1002/jsc.2485

The publisher has not yet granted permission to display this abstract.
Xie Zi-Yun, Zhang Ruo-Lin, Xia Yue-Wei, Bo Tao
Published: 18 January 2022
Frontiers in Pharmacology, Volume 12; https://doi.org/10.3389/fphar.2021.696417

Abstract:
Objective: To systematically review the efficacy and safety of oral Acetaminophen for premature infants with patent ductus arteriosus (PDA).Methods: Databases including Ovid, EMbase, Pubmed, The Cochrane Library, Cumulative Index to Nursing and Allied Health Literature (CINHAL), China National Knowledge Infrastructure (CNKI), Chinese Biomedical Database (CBM), WanFang Data, China Science and Technology Journal Database were searched to collect the randomized controlled trials (RCTs) about Acetaminophen for premature infants with PDA from inception to January 1, 2021. Quality assessment was performed through bias risk evaluation according to the Cochrane Handbook 5.1.0, and then the homogeneous studies were analyzed using Revman 5.4 software.Results: A total of 16 RCTs were included, which were divided into for four subgroups: subgroup I (oral acetaminophen vs. oral ibuprofen, 13 RCTs), subgroup II (oral acetaminophen vs. intravenous indomethacin, 1 RCT), subgroup III (oral acetaminophen vs intravenous ibuprofen, 1 RCT), and subgroup IV (oral acetaminophen vs intravenous placebo, 1 RCT). In subgroup I, There was no significant difference in the ductal closure rate after the first course of drug administration [typical relative risk (RR) 0.97, 95% confidence interval (CI) 0.90 to 1.05], the accumulated ductal closure rate after two course of treatment (RR 0.96, 95% CI 0.91–1.02), and mortality (RR 1.06, 95% CI 0.75–1.49) between treatment with oral acetaminophen versus oral ibuprofen (p &gt; 0.05); compared with oral ibuprofen, oral acetaminophen was associated with a significant reduction in the incidence of gastrointestinal bleeding/stool occult blood positive (RR 0.51, 95% CI 0.32 to 0.82)and oliguria (RR 0.62, 95% CI 0.42–0.91) (p < 0.05).Conclusion: The meta analysis approves the facts that there is no significant difference in the efficacity in premature infants with PDA between oral acetaminophen and buprofen or indometacin, but compared to ibuprofen, oral acetaminophen may decrease the incidence of oliguria and gastrointestinal bleeding. More reliable conclusions should be made through large-size, multi-center, well-designed RCTs.
, Alexey V. Lopatin
Journal of Systematic Palaeontology pp 1-32; https://doi.org/10.1080/14772019.2021.2013965

Abstract:
Parvicursor remotus Karhu & Rautian, 1996 Karhu, A. A. & Rautian, A. S. 1996. A new family of Maniraptora (Dinosauria: Saurischia) from the Late Cretaceous of Mongolia. Paleontological Journal, 30, 583–592. [Google Scholar] , based on a fragmentary skeleton from the Campanian Barungoyot Formation at Khulsan, in the Gobi Desert of Mongolia, is re-described in detail. Contrary to the original description, we find no evidence that the last dorsal vertebra is opisthocoelous. A biconvex last dorsal vertebra could be present in Parvicursor as in other parvicursorines. The transversely compressed sacral centrum with a sharp ventral keel is the last sacral, not the first sacral as originally alleged. The pelvic bones are not fused at the acetabulum. The holotype of P. remotus, the smallest known alvarezsaurid specimen, is a juvenile individual far from skeletal maturity. New morphological details of Parvicursor that are revealed include a ventral ridge on the posterior dorsal vertebrae; a horizontal supraacetabular crest of the ilium whose anterior end is placed anterior to the most ventrally projecting part of the pubic peduncle; the possible presence of a pubic obturator foramen; an entocondylar tuber on the femur; internal flexor flanges on metatarsals II and IV; a lateral flexor ridge on metatarsal IV; and a proximoventral notch on pedal phalanx IV-1. The Tugriken Shireh alvarezsaurid is not referable to Parvicursor because of its much larger ungual phalanx on the second pedal digit. Kol ghuva is excluded from Alzarezsauridae. The two successive sister taxa for Parvicursor are Ceratonykus and Linhenykus. Ceratonykus differs little from Parvicursor and might be a synonym of the latter. Linhenykus is very similar to Parvicursor in all overlapping skeletal elements. The Parvicursorinae includes all Asian Late Cretaceous alvarezsaurids except Qiupanykus and Nemegtonykus.
, Stavroula Rodopoulou, Maria-Ioanna Gavala
Published: 18 January 2022
Aesthetic Plastic Surgery pp 1-10; https://doi.org/10.1007/s00266-021-02739-w

Abstract:
Background: This study presents a classification system and treatment method to correct Rectus diastasis (RD) during abdominoplasty. Materials and methods: One hundred and sixty seven patients undergoing abdominoplasty were enrolled between April 2014 and January 2018. Forty-three patients did not present with RD and were excluded from the analysis. Mean age was 40.32 years, mean BMI was 23.84, and minimum follow-up was 24 months. A four-type (A: mild 2–3cm, B: moderate 3–5cm, C: severe 5–7cm, and D: very severe 7–9cm) classification system is described. A different treatment method is performed in each category using continuous and interrupted absorbable sutures. Postoperatively patients filled up a questionnaire that involved the level of pain, the postoperative day they performed specific indoor/outdoor activities, and the evaluation of the aesthetic result. Results: No statistically significant differences were observed between the four RD types regarding pain, complications, and return to specific activities. All types of RD had the same low rate complication profile. The seroma rate was 0.81%. The infection rate was 0.81%, and the thromboembolism and the pneumonic embolism rate was 0%. After 2–6 years of follow-up no clinical recurrence of rectus diastasis was observed. All reoperations (14.52%) were performed due to scar deformities. Mean pain score levels were very low (<1.5) and within a week most patients returned to specific indoor and outdoor activities. Most patients were extremely satisfied with the results. Conclusions: In this article, we present an updated classification system and treatment protocol to provide surgeons a safe and standardized method that produces high-quality aesthetic results. Level of evidence IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
C Harrison, ,
Published: 18 January 2022
Abstract:
STUDY QUESTION: What are patients’ and fertility staff views of talking about possible IVF/ICSI failure and need for multiple cycles in treatment planning? SUMMARY ANSWER: Healthcare professionals (HCPs) typically plan treatment on a cycle-by-cycle basis but HCPs and patients see benefits in talking about possible IVF/ICSI failure and the consequent need for multiple cycles to better prepare patients for this possibility, to support them through treatment challenges and to foster a sense of collaboration with the clinic in achieving the shared goal of treatment success. WHAT IS KNOWN ALREADY: Many patients need more than one round of IVF/ICSI stimulation to achieve their parenthood goals. About 60% of patients are willing to plan for multiple cycles of treatment in advance of treatment engagement. However, it is not clear how patients are informed about the high possibility of failure and the subsequent need for multiple cycles during their treatment planning consultations, and how approaches could be optimized. STUDY DESIGN, SIZE, DURATION: Qualitative focus groups with HCPs working at fertility clinics, patient advocates employed by patient charities (April 2020) and patients (July and August 2020). Patients were eligible if they had had a consultation to start a first/repeat stimulated IVF/ICSI cycle in the 8 weeks prior to participation, were aged 18 or older (upper age limit of 42 years for women), in heterosexual relationships and fluent in English. Eligible HCPs and patient advocates were those employed at a fertility clinic or charity, respectively. PARTICIPANTS/MATERIALS, SETTINGS, METHOD: Focus group topic guides progressed from general questions about fertility consultations to if and how the possibility of treatment failure and need for multiple cycles was introduced and discussed in (attended/own) clinics. After, preferences regarding planning IVF/ICSI on a multi-cycle or cycle-by-cycle basis were explored. Focus groups were recorded, and recordings transcribed and analysed using framework analysis to identify shared, unique and incongruent themes across participant groups. MAIN RESULTS AND THE ROLE OF CHANCE: Twelve HCPs, 2 patient advocates and 10 patients participated in six semi-structured online focus group discussions. All patients were childless and had been trying to conceive for ∼3 years. Framework analysis generated four themes and one meta-theme across participant groups. The meta-theme showed planning IVF on a cycle-by-cycle basis is the norm at clinics and that this affects how treatment is planned and the acceptability of a shift towards planning for multiple cycles, which was perceived as beneficial despite some apprehension. The four themes were: (i) heterogeneity in information provision during treatment planning; (ii) the need for improved HCP-patient collaboration; (iii) the need to temper optimism about treatment success; and (iv) apprehension, benefits and preferences regarding multi-cycle planning. LIMITATIONS, REASONS FOR CAUTION: Most patients were women from private fertility clinics with no previous treatment experience recruited from social media websites, mainly associated with patient support groups. Similarly, most HCPs were women from private fertility clinics. WIDER IMPLICATIONS OF THE FINDINGS: The findings suggest that shifting from cycle-by-cycle to multi-cycle approaches in IVF planning is possible. Achieving this shift, like other shifts in IVF (e.g. single embryo transfer), is likely to require collaboration among all stakeholders (e.g. users, staff, policymakers, regulators) to ensure that costs and benefits are balanced through using appropriate benchmarks, avoiding deflating optimism, fostering a sense of collaboration and supporting patients through challenges of multi-cycle IVF. STUDY FUNDING/COMPETING INTEREST(S): This research is funded by an Investigator-Sponsor Noninterventional Study from Merck Serono Ltd (MS200059_0010), an affiliate of Merck KGaA, Darmstadt, Germany. ‘Merck KGaA, Darmstadt, Germany reviewed the manuscript for medical accuracy only before journal submission. The Authors are fully responsible for the content of this manuscript, and the views and opinions described in the publication reflect solely those of the authors’. Prof. J.B. reports personal fees from Merck KGaA, Darmstadt, Germany, Merck AB an affiliate of Merck KGaA, Darmstadt Germany, Theramex, Ferring Pharmaceuticals A/S, grant from Merck Serono Ltd, outside the submitted work and that she is co-developer of Fertility Quality of Life (FertiQoL) and MediEmo app. Dr S.G. reports consultancy fees from Ferring Pharmaceuticals A/S, Access Fertility and SONA-Pharm LLC, and grants from Merck Serono Ltd, an affiliate of Merck KGaA, Darmstadt, Germany. Dr C.H. declares no conflicts of interest. TRIAL REGISTRATION NUMBER: N/A.
Published: 18 January 2022
by MDPI
Processes, Volume 10; https://doi.org/10.3390/pr10020184

Abstract:
The financial evaluation of renewable energy sources (RES) projects is well explored in the literature, but many different methods have been followed by different authors. Then, it is important to understand if and how these methods have been changing and what factors may have driven new approaches. Therefore, this article aims to explore the publications on the financial evaluation of RES projects from 2011 to 2020 and to present a critical analysis of the reviewed literature. The methods for evaluating RES projects were grouped into four categories: (i) traditional metrics based on net present value, internal rate of return, and payback period; (ii) levelized cost of electricity; (iii) return on investment approach; and (iv) real options analysis. A quantitative analysis was carried out considering aspects related to the relevance of the authors, productivity by country, and the most relevant journals for each of these groups. Then, a qualitative analysis of the main characteristics of the five most cited articles in each group was conducted. The results show that the more traditional methods are still widely used for the financial evaluation of RES projects. However, approaches based on the levelized cost and real options have been growing in importance to tackle the complex features of financial evaluation and comparison of RES projects.
Jamilla A Hussain, Ian R White, Miriam J Johnson, Anthony Byrne, , Andy Haines, Kathy Seddon, Tim J Peters
Published: 17 January 2022
Abstract:
Background: Missing data can introduce bias and reduce the power, precision and generalisability of study findings. Guidelines on how to address missing data are limited in scope and detail, and poorly implemented. Aim: To develop guidelines on how best to (i) reduce, (ii) handle and (iii) report missing data in palliative care clinical trials. Design: Modified nominal group technique. Setting/participants: Patient and public research partners, palliative care clinicians, trialists, methodologists and statisticians attended a 1-day workshop, following which a multi-stakeholder development group drafted the guidelines. Results: Seven main recommendations for reducing missing data, nine for handling missing data and twelve for reporting missing data were developed. The top five recommendations were: (i) train all research staff on missing data, (ii) prepare for missing data at the trial design stage, (iii) address missing data in the statistical analysis plan, (iv) collect the reasons for missing data and (v) report descriptive statistics comparing the baseline characteristics of those with missing and observed data. Reducing missing data, preparing for missing data and understanding the reasons for missing data were greater priorities for stakeholders than how to deal with missing data once they had occurred. Conclusion: Comprehensive guidelines on how to address missing data were developed by stakeholders involved in palliative care trials. Implementation of the guidelines will require endorsement of research funders and research journals.
Published: 11 January 2022
by MDPI
Energies, Volume 15; https://doi.org/10.3390/en15020486

Abstract:
A synthetic review of the application of multi-objective optimization models to the design of climate-responsive buildings and neighbourhoods is carried out. The review focused on the software utilized during both simulation and optimization stages, as well as on the objective functions and the design variables. The hereby work aims at identifying knowledge gaps and future trends in the research field of automation in the design of buildings. Around 140 scientific journal articles, published between 2014 and 2021, were selected from Scopus and Web of Science databases. A three-step selection process was applied to refine the search terms and to discard works investigating mechanical, structural, and seismic topics. Meta-analysis of the results highlighted that multi-objective optimization models are widely exploited for (i) enhancing building’s energy efficiency, (ii) improving thermal and (iii) visual comfort, minimizing (iv) life-cycle costs, and (v) emissions. Reviewed workflows demonstrated to be suitable for exploring different design alternatives for building envelope, systems layout, and occupancy patterns. Nonetheless, there are still some aspects that need to be further enhanced to fully enable their potential such as the ability to operate at multiple temporal and spatial scales and the possibility of exploring strategies based on sector coupling to improve a building’s energy efficiency.
Hussein Ahmad, Meryem Guvenir, Emrah Guler, Ayse Arikan, Kaya Suer
Bangladesh Journal of Medical Science, Volume 21, pp 101-104; https://doi.org/10.3329/bjms.v21i1.56334

Abstract:
Background: Over the past 20 years, studies have indicated that the increasing spread of methicillinresistant Staphylococcus aureus (MRSA) demonstrates the need for adequate information about their epidemiology. This study was conducted in order to investigate the resistance rate of MRSA which were isolated from the Near East University (NEU) Hospital, North Cyprus. Methods: MRSA was isolated and identified by using selective media and the Phoenix BD 100 system (software version 6.01A) was used for antimicrobial susceptibility testing and identification. The antimicrobial susceptibility results were determined according to the Clinical and Laboratory Standarts Institute (CLSI) and the resistance rates of MRSA isolates to antibiotics were examined retrospectively. Results: The highest number of samples were from the departments of chest disease (24%) followed by dermatology (21.3%) and cardiology (18.7%). Out of 75 MRSA strains,; 29.7% from blood, 25.3% from wound, 14.7% from nasal swabs, 10.7% from aspiration fluids, 9.3% from sputum, 6.7% were from urine, 4.0% from IV catheters culture samples. All strains of MRSA were 94.7% sensitive to vancomycin and teicoplanin.Conclusions: The obtained results revealed that preventative measures should be implemented in order to minimize the bacterial resistance to antibiotics. Bangladesh Journal of Medical Science Vol. 21(1) 2022 Page : 101-104
Nagalakshmi Cs, Shaheen B Shaikh, Santhosh Nu
Bangladesh Journal of Medical Science, Volume 21, pp 19-23; https://doi.org/10.3329/bjms.v21i1.56323

Abstract:
Background: COVID-19 is a rapidly spreading communicable disease worldwide. It varies widely in its spectrum of manifestations, from being mild self-limiting disease, to fulminant disease, often leading to complications and death. Diabetes is an important co-morbidity linked to severity of infection by SARSCoV- 2, which predisposes them to severe pneumonia. Poor glycaemic control is associated with worse outcomes. The disease burden of COVID-19 is continuously increasing, and with a high prevalence of diabetes, it is all the more important to understand the vital aspects of COVID-19 infection in diabetic population. Hence, we try to provide close insights into its pathophysiology, clinical characteristics, recommendations on management and prevention and possible avenues for improving disease outcomes. Methods: PubMed database and Google Scholar were searched using the key terms ‘COVID-19’, ‘SARS CoV- 2’, ‘Corona’ and ‘diabetes’. Full texts of the retrieved articles were accessed and referred. Three main mechanisms which influence COVID-19 disease manifestation in diabetics include: (a) Entry of virus via ACE-2 receptors (b) Action through Dipeptidyl-peptidase-4, and (c) Elevation of glucose concentration in airways by elevated blood glucose.ACE-2 is expressed in alveolar epithelial cells, heart, renal-tubular and intestinal epithelia and pancreas. S-Glycoprotein on the surface of SARS-CoV-2 binds to this ACE-2 and undergoes a conformational change. This allows its’ proteolytic digestion by host cell proteases TMPRSS2 and Furin, leading to internalization of virus. Viral entry into cells triggers an inflammatory response by T-helper-cells and at times, a ‘cytokine storm’, resulting in organ damage. Apart from diminishing neutrophil chemotaxis and reducing phagocytosis, by which diabetes predisposes individuals to infections, there are several specific factors with respect to SARS-CoV2: (i) Increased ACE-2 expression (ii) Raised Furin (iii) Diminished T-cell functioning, and (iv) Increased IL-6 levels. Movement restrictions, increased stress due to social isolation and lack of physical activity further complicates the issue. It is therefore, much essential to raise awareness among front-line workers. Finally, the current situation emphasizes the need for more clinical investigation and define best practices for optimum outcomes. Bangladesh Journal of Medical Science Vol. 21(1) 2022 Page : 19-23
Creating an Undergraduate Literary Journal; https://doi.org/10.5040/9781350160736.ch-002

Abstract:
ExtractA literary journal is a labor of love, as they do not tend to make money. The value is there, no doubt about it: they influence literary agents and small publishers who are looking for the newest writers and artists, the exciting trends. Still, in general, when money comes into play the stoutest and most determined editors (student or professional) take pause. You have to pay the bills. And while a lot can be done with a little, much can be wasted as well. I’ve seen undergraduate literary magazines exist on less than a thousand dollars a year. (Not too long, though; if you keep that up you probably have other means of support that are not evident in the same way as cash. ) At the other end of the spectrum are magazines supported by massive endowments, like Poetry. On average, the more established and successful university literary journals...
P M Irving, M Abreu, J Axler, X Gao, J Torres, E Neimark, A Song, K Wallace, K Kligys, S Berg, et al.
Journal of Crohn's and Colitis, Volume 16; https://doi.org/10.1093/ecco-jcc/jjab232.123

Abstract:
Data from Phase 3 studies in Crohn’s disease (CD) demonstrated significant improvements in endoscopic outcomes with risankizumab (RZB) versus placebo (PBO) following 12-weeks (wks) induction therapy. Continued maintenance therapy with 360mg RZB SC led to significantly higher rates of endoscopic response and remission at Wk52 compared to withdrawal/placebo. This post-hoc analysis examined the durability of SC RZB maintenance therapy for endoscopic outcomes among patients achieving these endpoints at the end of induction Patients achieving clinical response with 12-wks IV RZB induction therapy in ADVANCE or MOTIVATE entered the maintenance study, FORTIFY, and received either RZB SC or had RZB withdrawn and received placebo for 52 wks. For this analysis, endoscopic outcomes in the RZB 360 mg SC (N=141) and withdrawal/placebo (N=164) arms are reported. Maintenance of endoscopic response, endoscopic remission, and/or an SES-CD score of 0–2 were assessed at Wk52 in patients who achieved these endpoints at Wk0 of maintenance (Wk12 of induction). Safety was assessed throughout the study. Following 12-wks of IV RZB induction therapy (FORTIFY Wk0), 141 patients were randomized to RZB 360 mg (patients achieving endoscopic response, 55/141; endoscopic remission, 39/141; SES-CD score of 0–2, 29/141) and 164 were randomized to withdrawal (PBO SC) (patients achieving endoscopic response, 73/164; endoscopic remission, 46/164; SES-CD 0–2, 32/164). Maintenance of endoscopic response at Wk52 was demonstrated in 70.2% (39/55) of patients receiving RZB 360 mg SC versus 38.4% (28/73) of patients in the withdrawal (PBO SC) arm (P<0.001). Maintenance of endoscopic remission at Wk52 was demonstrated in 74.4% (29/39) of patients receiving RZB 360 mg versus 23.9% (11/46) of patients in the withdrawal (PBO SC) arm (P<0.001). Maintenance of an SES-CD score from 0–2 at Wk52 was demonstrated in 65.5% (19/29) of patients receiving RZB 360 mg versus 21.9% (7/32) of patients in the withdrawal (PBO SC) arm (P<0.001).RZB maintenance treatment was well-tolerated and no new safety signals were observed. The safety profile of RZB has been reported previously.1–5 RZB IV induction followed by SC maintenance therapy led to sustained improvements in endoscopic outcomes, demonstrating the durability of efficacy with continued RZB treatment in patients with moderate to severe CD. 1. Feagan, B. G. et al. Lancet 389, 1699–1709 (2017) 2 Feagan, B. G. et al. Lancet Gastroenterol Hepatol 3, 671–680 (2018) 3 Ferrante, M. et al. Journal of Crohn’s and Colitis jjab093 (2021) 4 Ferrante, M. et al. in UEGW 2021 5 D’Haens, G. et al. in DDW 2021
Nguyen Minh Sang
International Journal of ADVANCED AND APPLIED SCIENCES, Volume 9, pp 84-90; https://doi.org/10.21833/ijaas.2022.01.010

Abstract:
The purpose of the article is to use biometric methods to perform a high-level analysis of research trend analysis on supply chain finance through 305 studies in the field of Business-Economics and Social Sciences published on the Scopus database for the period 2006-2021. The findings provide an overview of worldwide publication trends on the topic of supply chain finance, specifically: (i) the most cited studies; (ii) the most cited authors; (iii) the most influential journals; (iv) the main research keywords among which the network links; (v) leading research institutions and (vi) research collaboration trends among countries on supply chain finance. The study provides more scientific evidence about the current big picture of publication trends in the world, thereby suggesting and recommending future research directions on supply chain finance.
, , Rachel Marcus, , , Clara Saldarriaga, Álvaro Sosa Liprandi, Adrián Baranchuk, On Behalf Of The Neglected Tropical Diseases And Other Infectious Diseases Affecting The Heart (Net-Heart) Project
PLOS Neglected Tropical Diseases, Volume 15; https://doi.org/10.1371/journal.pntd.0009954

Abstract:
Background: Chagas disease (CD) is endemic in Latin America; however, its spread to nontropical areas has raised global interest in this condition. Barriers in access to early diagnosis and treatment of both acute and chronic infection and their complications have led to an increasing disease burden outside of Latin America. Our goal was to identify those barriers and to perform an additional analysis of them based on the Inter American Society of Cardiology (SIAC) and the World Heart Federation (WHF) Chagas Roadmap, at a country level in Argentina, Colombia, Spain, and the United States, which serve as representatives of endemic and nonendemic countries. Methodology and principal findings: This is a nonsystematic review of articles published in indexed journals from 1955 to 2021 and of gray literature (local health organizations guidelines, local policies, blogs, and media). We classified barriers to access care as (i) existing difficulties limiting healthcare access; (ii) lack of awareness about CD and its complications; (iii) poor transmission control (vectorial and nonvectorial); (iv) scarce availability of antitrypanosomal drugs; and (v) cultural beliefs and stigma. Region-specific barriers may limit the implementation of roadmaps and require the application of tailored strategies to improve access to appropriate care. Conclusions: Multiple barriers negatively impact the prognosis of CD. Identification of these roadblocks both nationally and globally is important to guide development of appropriate policies and public health programs to reduce the global burden of this disease.
Published: 30 December 2021
by MDPI
Journalism and Media, Volume 3, pp 13-26; https://doi.org/10.3390/journalmedia3010002

Abstract:
In recent years, news media has been greatly disrupted by the potential of technologically driven approaches in the creation, production, and distribution of news products and services. Artificial intelligence (AI) has emerged from the realm of science fiction and has become a very real tool that can aid society in addressing many issues, including the challenges faced by the news industry. The ubiquity of computing has become apparent and has demonstrated the different approaches that can be achieved using AI. We analyzed the news industry’s AI adoption based on the seven subfields of AI: (i) machine learning; (ii) computer vision (CV); (iii) speech recognition; (iv) natural language processing (NLP); (v) planning, scheduling, and optimization; (vi) expert systems; and (vii) robotics. Our findings suggest that three subfields are being developed more in the news media: machine learning, computer vision, and planning, scheduling, and optimization. Other areas have not been fully deployed in the journalistic field. Most AI news projects rely on funds from tech companies such as Google. This limits AI’s potential to a small number of players in the news industry. We made conclusions by providing examples of how these subfields are being developed in journalism and presented an agenda for future research.
Ilhami Daniş
FSM İlmî Araştırmalar İnsan ve Toplum Bilimleri Dergisi pp 33-90; https://doi.org/10.16947/fsmia.1050264

Abstract:
Menzil (halting place) refers to the settlements or the geographical regions used by the postal organization, the army, pilgrims and travelers for accommodation on the way. The Ottoman Empire established menzils serving different purposes on the road network connecting to Istanbul, the capital. Among these, the menzils established on the route followed by the army during campaigns are very important. These places, where the army rest after traveling a certain distance and met its needs, were established close to the waterways and determined according the route of each campaign. Menzils on the campaign routes have been the subject of many works in the context of issues such as their names, geographical locations, physical and architectural features, distances to each other and the condition of the roads connecting them. Thus a literature of Ottoman campaign menzilnâmes emerged. During the reign of Suleiman the Magnificent, the Ottoman army embarked on the Vienna Campaign in 1529. One hundred and fifty-four years after this campaign, in 1683, it reached the gates of Vienna again during the reign of Mehmed IV. The route followed by the army during the first campaign is described in Feridun Bey’s Münşeâtü’s-Selâtîn. The route followed during the second campaign was covered in detail in the Vekâyi-i Beç and Zeyl-i Fezleke (Silâhdâr Tarihi) of Silâhdâr Mehmed Ağa. The part of the Second Campaign for Vienna menzils from Edirne to Belgrade is included as a separate menzilnâme in a journal in the Süleymaniye Manuscripts Library. (Fezâil-i Cihâd Mecmuası) In this study, this menzilnâme, which includes the names, distances and details of the menzils, has been evaluated. Based on the separate menzilnâme in the journal the menzils on the route followed by the army in the Second Campaign for Vienna are discussed in a comparative way with Silahdâr Tarihi. Answers were sought to the questions of how many days the Ottoman army reached Vienna from Istanbul, at what distances it advanced, the dates of arrival at the destinations and the geographical conditions of the destinations on the route. In addition, in the study, the halting places from Belgrade to Vienna were taken from the Vekâyi-i Beç and Silahdâr Tarihi and a framework was presented to the readers and researchers about all the menzils. At the end of the Menzilnâme, there are numerical data about the Ottoman army that participated in the Vienna Campaign. These data were also included in the study. Menzil; posta teşkilatının, ordunun, hacıların ve seyyâhların yol üzerinde konaklama için kullandıkları yerleşim yerlerini veya yerleşim yerleri dışında kurulan coğrafi alanları ifade eder. Osmanlı İmparatorluğu, payitaht İstanbul’a bağlanan yol ağı üzerinde faklı amaçlara hizmet eden menziller kurmuştur. Bunların içinde sefer esnasında ordunun takip ettiği güzergâh üzerinde kurulan menziller oldukça önemlidir. Sefere giden ordunun belli mesafe kat ettikten sonra istirahat ettiği, iaşe ihtiyaçlarını karşıladığı bu menziller su yollarına yakın kurulur ve her seferin güzergâhına göre belirlenirdi. Sefer güzergâhları üzerindeki bu menziller; isimleri, coğrafi konumları, fiziki ve mimari özellikleri, birbirlerine olan mesafeleri ve menzilleri birbirine bağlayan yolların durumu gibi hususlar bağlamında çok sayıda eserlere konu olmuş ve bir Osmanlı sefer menzilnâmeleri literatürü ortaya çıkmıştır. Kanuni Sultan Süleyman döneminde 1529 yılındaki Viyana Seferi’ne çıkan Osmanlı ordusu bu seferden yüz elli dört yıl sonra 1683’te IV. Mehmed döneminde tekrar Viyana kapılarına dayanmıştır. İlk sefer esnasında ordunun takip ettiği güzergâh Feridun Bey’in Münşeâtü’s-Selâtîn eserinde, ikinci sefer esnasında takip edilen güzergâh ise Teşrifatçıbaşı'nın Vekâyi-i Beç eserinde ve Silâhdâr Mehmed Ağa’nın Zeyl-i Fezleke’sinde (Silâhdâr Târihi) detaylı olayları ile ele alınmıştır. II. Viyana Seferi menzillerinin Edirne’den Belgrad’a kadar olan kısmı ise Süleymaniye Yazma Eserler Kütüphanesi’ndeki bir mecmuada (Fezâil-i Cihâd Mecmuası) müstakil bir menzilnâme olarak yer almaktadır. Menzillerin isimleri, mesafeleri ve tafsilatlarının yer aldığı bu menzilnâme kapsamında kaleme alınan bu çalışmada mecmuadaki müstakil menzilnâmeden yola çıkarak II. Viyana Seferi’nde ordunun takip ettiği güzergâh üzerindeki menziller Silâhdar Târihi ile mukayeseli bir şekilde ele alınmış olup Osmanlı ordusunun İstanbul’dan Viyana’ya kaç günde eriştiği, hangi menzillerde konaklayarak ilerlediği, menzillere varış tarihleri ve güzergâhtaki menzillerin hangi coğrafi şartları taşıdığı hususlarına cevaplar aranmıştır. Ayrıca çalışmada Belgrad’dan Viyana’ya olan menziller Vekâyi-i Beç ve Silâhdâr Târihi’nden alınarak...
, Ruben Heradio, Ernesto Aranda-Escolastico, Ángel Sánchez, José F. Vélez
Published: 28 December 2021
Pattern Recognition, Volume 125; https://doi.org/10.1016/j.patcog.2021.108513

Abstract:
Providing computers with the ability to process handwriting is both important and challenging, since many difficulties (e.g., different writing styles, alphabets, languages, etc.) need to be overcome for addressing a variety of problems (text recognition, signature verification, writer identification, word spotting, etc.). This paper reviews the growing literature on off-line handwritten document analysis over the last thirty years. A sample of 5,389 articles is examined using bibliometric techniques. Using bibliometric techniques, this paper identifies (i) the most influential articles in the area, (ii) the most productive authors and their collaboration networks, (iii) the countries and institutions that have led research on the topic, (iv) the journals and conferences that have published most papers, and (v) the most relevant research topics (and their related tasks and methodologies) and their evolution over the years.
Corrigendum
Chengjun Sun, Biao Lu, Yu Liu, Yaqin Zhang, Haiyan Wei, Xu Hu, Pei Hu, Qian Zhao, Yanling Liu, Kan Ye, et al.
Published: 28 December 2021
Frontiers in Endocrinology, Volume 12; https://doi.org/10.3389/fendo.2021.830469

Abstract:
A Corrigendum on:Reduced Effectiveness and Comparable Safety in Biweekly vs. Weekly PEGylated Recombinant Human Growth Hormone for Children With Growth Hormone Deficiency: A Phase IV Non-Inferiority Threshold Targeted Trialby Sun, C., Lu, B., Liu, Y., Zhang, Y., Wei, H., Hu, X., Hu, P., Zhao, Q., Liu, Y., Ye, K., Wang, K., Gu, Z., Liu, Z., Ye, J., Zhang, H., Zhu, H., Jiang, Z., Liu, Y., Wan, N., Yan, C., Yin, J., Ying, L., Huang, F., Yin, Q., Xi, L., Luo, F. and Cheng, R. (2021) Front. Endocrinol. 12:779365. doi: 10.3389/fendo.2021.779365 The second and third authors, Biao Lu and Yu Liu, were not listed as co-first-authors in the article as published originally. The Author Contributions statement, published originally read “FL and RC conceived the study design, managed the study, conducted the data analysis, and wrote the manuscript. CS helped with the data analysis and editing of the manuscript. LX, BL, YL, YZ, HW, XH, PH, QZ, YLL, KY, KW, ZG, ZL, JY, HXZ, HZ, ZJ, YJL, NW, CY, JYY, LY, FH, and QY are site investigators and conducted the study in each participating center. All authors contributed to the article and approved the submitted version”. The corrected Author Contributions statement is as follows: “FL and RC conceived the study design, managed the study, conducted the data analysis, and wrote the manuscript. CS helped with the data analysis and editing of the manuscript. BL and YL contributed to the design of the study protocol, training of trial investigators. LX, BL, YL, YZ, HW, XH, PH, QZ, YLL, KY, KW, ZG, ZL, JY, HXZ, HZ, ZJ, YJL, NW, CY, JYY, LY, FH, and QY are site investigators and conducted the study in each participating center. All authors contributed to the article and approved the submitted version.” The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Keywords: growth hormone deficiency, PEGylated recombinant human growth hormone, PEG-rhGH, IGF-2, children Citation: Sun C, Lu B, Liu Y, Zhang Y, Wei H, Hu X, Hu P, Zhao Q, Liu Y, Ye K, Wang K, Gu Z, Liu Z, Ye J, Zhang H, Zhu H, Jiang Z, Liu Y, Wan N, Yan C, Yin J, Ying L, Huang F, Yin Q, Xi L, Luo F and Cheng R (2021) Corrigendum: Reduced Effectiveness and Comparable Safety in Biweekly vs. Weekly PEGylated Recombinant Human Growth Hormone for Children With Growth Hormone Deficiency: A Phase IV Non-Inferiority Threshold Targeted Trial. Front. Endocrinol. 12:830469. doi: 10.3389/fendo.2021.830469 Received: 07 December 2021; Accepted: 09 December 2021; Published: 28 December 2021. Approved by: Copyright © 2021 Sun, Lu, Liu, Zhang, Wei, Hu, Hu, Zhao, Liu, Ye, Wang, Gu, Liu, Ye, Zhang, Zhu, Jiang, Liu, Wan, Yan, Yin, Ying, Huang, Yin, Xi, Luo and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. *Correspondence: Feihong Luo, [email protected]; Ruoqian Cheng, [email protected] These authors have contributed equally to this work and share first authorship
Yuliia Osypova
Theory and Practice of Intellectual Property pp 94-103; https://doi.org/10.33731/62021.249093

Abstract:
Ключові слова:розподіл майнових прав інтелектуальної власності; майнові права інтелектуальної власності; об’єкт, створений за замовленням; заклади вищої освіти; інте- лектуальна власність закладів вищої освіти; об’єкти права інтелектуальної власності; договір про створення за замовленням та використання об’єктів права інтелектуальної власності Статтю присвячено питанню розподілу майнових прав інтелектуальної власності на ОПІВ, створені у ЗВО України за договором замовлення. У ході проведеного досліджен- ня визначено загальні вимоги чинного законодавства до порядку розподілу майнової частини права інтелектуальної власності на «об’єкт, створений за замовленням». Встановлено, що вирішення цього питання наразі залежить від виду ОПІВ, що ство- рюється за замовленням, а також, у певних випадках, від мети його створення. Описано можливі варіанти розподілу означених вище прав між ЗВО-замовником і творцем-вико- навцем за договором про створення ОПІВ за замовленням. Виявлено прогалини та невід- повідності між нормами чинного законодавства у цій сфері, запропоновано відповідні законодавчі зміни. Список використаних джерел / List of references 1. Чередник Н. В. Права інтелектуальної власності дослідницьких університетів : дис. … канд. юрид. наук : 12.00.03. Київ, 2019. 212 с. 2. Гужва А. М. Особливості договору про створення за замовленням і використання твору у ВНЗ. Актуальні проблеми права інтелектуальної власності : збірник матеріалів I Всеукраїнської науково-практичної конференції, присвяченої 10-й річниці святкування Міжнародного дня інтелектуальної власності, 16 червня 2010 року, м. Одеса. Одеса : 2010. С. 175−178. 3. Про стимулювання розвитку цифрової економіки в Україні : Закон України від 15.07.2021 р. (набув чинності 14.08.2021р.) № 1667-IX. URL: https://zakon.rada.gov.ua/laws/show/1667-20/conv#Text (дата звернення: 1 листопада 2021). 4. Цивільний кодекс України : Закон України від 16.01.2003 р. № 435-IV URL: https://zakon.rada.gov.ua/laws/show/435-15#Text (дата звернення: 01.11.2021 р.). 5. Про авторське право і суміжні права : Закон України від 23.12.1993 р. № 3792-XII. URL: https://zakon.rada.gov.ua/laws/show/3792-12#Text (дата звернення: 01.11.2021 р.). 6. Про охорону прав на сорти рослин : Закон України від 21.04.1993 р. URL: https://zakon.rada.gov.ua/laws/show/3116-12#Text (дата звернення: 01.11.2021 р.). 7. Про охорону прав на винаходи і корисні моделі : Закон України від 15.12.1993 р. № 3687-XII. URL: https://zakon.rada.gov.ua/laws/show/3687-12#top (дата звернення: 01.11.2021 р.). 8. Про охорону прав на промислові зразки : Закон України від 15.12.1993 р. № 3688-XII. URL: https://zakon.rada.gov.ua/laws/show/3688-12/ed20201014#Text (дата звернення: 01.11.2021 р.). 9. Про охорону прав на компонування напівпровідникових виробів : Закон України від 05.11.1997 р. № 621/97-ВР URL: https://zakon.rada.gov.ua/laws/show/621/97-вр/ed20201014#Text (дата звернення: 01.11.2021 р.). 10. Про охорону прав на знаки для товарів і послуг : Закон України від 15.12.1993 р. № 3689-XII. URL: https://zakon.rada.gov.ua/laws/show/3689-12#Text (дата звернення: 01.11.2021 р.). 11. Про правову охорону географічних зазначень : Закон України від 16.06.1999 р. URL: https://zakon.rada.gov.ua/laws/show/752-14#Text (дата звернення: 01.11.2021 р.). 12. Соловйова В. В. Договірне врегулювання створення за замовленням обʼєктів права інтелектуальної власності. Актуальні питання цивільного та господарського права. 2008. № 6. URL: www.journal.yurpayintel.com.ua/2008/6/article03/. 13. Право інтелектуальної власності: науково-практичний коментар до Цивільного кодексу України / за заг. ред. М. В. Паладія, Н. М. Мироненко, В. О. Жарова. Київ : Парламентське вид-во, 2006. 432 с....
Published: 27 December 2021
Oriente Moderno, Volume 101, pp 221-252; https://doi.org/10.1163/22138617-12340263

Abstract:
This article reviews some key concepts of the Arab(ic) Nahḍah with the aim of highlighting the usefulness of a more genuinely linguistic, i.e., grammar- and etymology-oriented approach for a deeper understanding of some basic features of the foundational period of Arab modernity. My contention and starting-point is that the Nahḍah was, among other things, an era in which the Arab subject came to sense its own agency. This is reflected not only in the many phenomena we are used to associate with the Nahḍah — the emergence of the intellectual, of critical journalism, of historicism, sentimentalism, new literary genres, etc. — but also in the morpho-semantics of key Nahḍah terminology. I argue (a) that the self-referential t-morpheme that features in many words signifying important Nahḍah concepts, such as taraqqī, taqaddum, or tamaddun, can and should be seen in the same light, i.e., as an indicator of a new emphasis on the self. Moreover, I argue that both the grammatical form of the new vocabulary (e.g., the -iyyah suffix for abstracts, verbal nouns, the causative patterns of form II and IV) and its “original”, “basic” (root) meanings underline (b) secularisation and the concomitant centrality of the human being, as well as (c) proactivity, energetic verve, and creativity, i.e., the subject’s being a cause of change in time (hence history). Thus, each new conceptual term is a little ‘Nahḍah in a nutshell,’ containing the very essence of Nahḍawi thought and the actual experience of feeling “modern”.
, Ester Adelia Mianing, Retno Sari, Esti Hendradi
Published: 24 December 2021
Frontiers in Pharmacology, Volume 12; https://doi.org/10.3389/fphar.2021.787226

Abstract:
Ursolic acid is a natural pentacyclic triterpenoid that exerts a potent anticancer effect. Furthermore, it is classified as a BCS class IV compound possessing low permeability and water solubility, consequently demonstrating limited bioavailability in addition to low therapeutic effectiveness. Nanoparticles are developed to modify the physical characteristics of drug and can often be produced in the range of 30–200 nm, providing highly effective cancer therapy due to the Enhanced Permeation and Retention (EPR) Effect. This study aims to provide a review of the efficacy and safety of various types of Ursolic Acid-loading nanoparticles within the setting of preclinical and clinical anticancer studies. This literature study used scoping review method, where the extracted data must comply with the journal inclusion criteria of within years of 2010–2020. The identification stage produced 237 suitable articles. Duplicate screening was then conducted followed by the initial selection of 18 articles that had been reviewed and extracted for data analysis. Based on this review, the use of nanoparticles can be seen to increase the anticancer efficacy of Ursolic Acid in terms of several parameters including pharmacokinetic data, survival rates and inhibition rates, as well as the absence of serious toxicity in preclinical and clinical trials in terms of several parameters including body weight, blood clinical chemistry, and organ histipathology. Based on this review, the use of nanoparticles has been able to increase the anticancer efficacy of Ursolic Acid, as well as show the absence of serious toxicity in preclinical and clinical trials. Evenmore, the liposome carrier provides development data that has reached the clinical trial phase I. The use of nanoparticle provides high potential for Ursolic Acid delivery in cancer therapy.
Published: 21 December 2021
by MDPI
Abstract:
In recent years, news media has been greatly disrupted by the potential of technologically driven approaches in the creation, production, and distribution of news products and services. Artificial intelligence (AI) has emerged from the realm of science fiction and has become a very real tool that can aid society in addressing many issues, including the challenges faced by the news industry. The ubiquity of computing has become apparent and has demonstrated the different approaches that can be achieved using AI. We analyzed the news industry’s AI adoption based on the seven subfields of AI: (i) machine learning; (ii) computer vision (CV); (iii) speech recognition; (iv) natural language processing (NLP); (v) planning, scheduling, and optimization; (vi) expert systems; and (vii) robotics. Our findings suggest that three subfields are being developed more in the news media: machine learning, computer vision, as well as planning, scheduling, and optimization. Other areas have not been fully deployed in the journalistic field. Most AI news projects rely on funds from tech companies such as Google. This limits AI’s potential to a small number of players in the news industry. We make conclusions by providing examples of how these subfields are being developed in journalism and present an agenda for future research.
He Wen, , Tanjin Amin, Syeda Z. Halim
Published: 20 December 2021
Computers & Chemical Engineering; https://doi.org/10.1016/j.compchemeng.2021.107639

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Lucas Paulo Silva Borges, Ana Carolina Oliveira Vilhena, Chris Simone dos Santos Nepomuceno, Edina Raquel Meneses Silva
Research, Society and Development, Volume 10; https://doi.org/10.33448/rsd-v10i17.24246

Abstract:
The pharmacist is responsible for monitoring the patient with tuberculosis to assess the use of drugs and possible misuses, their effect iveness and possible adverse effect son the body. Thus, the study sought to carry out na integrative review on the role of the pharmacist in the care of patient swith tuberculosis and asking: "What does the literature show about the role of the pharmacist in the care of patient swith tuberculosis?" The search for articles was performed in the following databases: LILACS (Latin American and Caribbe na Literature in Health Sciences), MEDLINE (Medical Literature Analysis), IBECS (Spanish Bibliographic Index in Health Sciences), BDENF (Database in Nursing), Scientific Electronic Library Online (SCIELO) and CAPES Journal Portal (PPC). Using the descriptors in Health Sciences (DeCS): Multiple Drug-Resistant Tuberculosis and the irrespective synonyms; Pharmaceutical care; Quality of Health Care; Antituberculosis; Mycobacterium tuberculosis; Pulmonary Tuberculosis; tuberculosis; Multiple Bacterial Drug Resistance. A total of 1112 publications were collected for screening, of which 5 were included in the integrative review. The studies carried out, they addressed pharmaceutical care in the care of patients with tuberculosis, investigated the knowledge of pharmacists about tuberculosis and evaluated the pharmaceutical services provided in Primary Health Care. The pharmacist needs to know about the disease, its therapeutics chemes, drug interactions and adverse reactions, however, the lack of publications related to the topic was pointed out and this highlights the need for the pharmacist's engagement to contributed to eradication of this disease.
Yongkang Yuan,
Published: 16 December 2021
Frontiers in Psychology, Volume 12; https://doi.org/10.3389/fpsyg.2021.804304

Abstract:
The third edition of Teaching and Researching Motivation offers newly-updated and extended coverage of motivation research and pedagogical practice. As in the 2001 and 2011 editions, the text provides comprehensive insights into motivation research and teaching. However, the current edition, as in the authors' words, is “not so much a revised version as a newly written book that has the same authors, the same title and the same structure as the previous one” (Dörnyei and Ushioda, 2021, p. x). It reflects the dramatic changes in the field of motivation research and examines how theoretical insights can be used in everyday teaching practice. The monograph comprises four parts. Part I, “What is Motivation?”, consists of four chapters. The first chapter pertains to the complex meaning of the term “motivation” and summarizes the key challenges of theorizing motivation. Appealing to us in this chapter is that the authors put a stronger emphasis on understanding motivation in relation to learning LOTEs (languages other than English) and in relation to individual multilingualism. It is altogether fitting and proper for them to hold this belief since the world is becoming more diversified in terms of multilingualism. Chapter 2 offers a historical overview of the most influential cognitive motivation theories. In the new edition, social cultural factors impacting students' motivation are elaborated in more detail. Chapter 3 presents a historical overview of theories of L2 motivation. Drawing on insights from L2 research and psychology, Dörnyei and Ushioda articulate nine interrelated conditions for the motivating capacity of future L2 self-image. With a focus on the L2 Motivation Self System theory, Chapter 4 also critically examines other new theoretical approaches emerged in the field of L2 motivation over the past decade. Finally, it highlights two new perspectives: a focus on L2 learner engagement and “small lens” approaches. Part II, “Motivation and Language Teaching,” includes three chapters on issues related to the relation between motivation and language teaching. Chapter 5 explores the extent to which theoretical and research insights can lead to practical recommendations for motivating the students in and outside of the language classroom. Based on this principle, it presents instructive approaches to motivating language learners. It also eloquently holds that motivational self-regulation and learner autonomy are two potent energizers which will have a lasing impact beyond the classroom. Chapter 6, “Motivation in Context,” deals with the “dark side” of motivation, “demotivation.” It argues that focused interventions can have significant positive outcomes and help counteract demotivation and facilitate remotivation within second language acquisition (SLA). The last chapter in this part is of special interest as it explores the relationship between language teacher and learner motivation, highlighting possible self theory (exploring conceptual change in language teachers). As a Chinese idiom goes, teaching benefits teachers and students alike. The same is true of language teacher motivation. It argues that teachers' passion and enthusiasm facilitate their teaching and enhance students' learning; and vice versa. Important and of significance is how to do research so that it can facilitate teaching. Part III, “Researching Motivation,” includes two chapters on issues related to primary, data-based motivation research. Chapter 8 covers the unique characteristics, challenges and research strategies that are specific to the empirical study of language learning motivation. An outstanding contribution of this chapter is that four insightful principles of designing L2 motivation studies are proposed. Followed up on an overview of the most useful methods in this field in the past, Chapter 9 examines two new research initiatives: adopting a complex dynamic system approach and researching unconscious motivation, which will hold particular promise for the future. Part IV, “Resources and Further Information” is informative and inspiring. In Chapter 10, the authors judiciously remark that particular aspects and context of L2 learning as well as multilingual communication should be focused in the future after further elaborating the interdisciplinary nature and challenge of L2 motivation research. The last chapter contains lists of key sources and resources on motivation such as relevant journals and latest valuable collections, database, discussion groups, and networks. What is of particular value is key scholars of L2 language motivation research, as well as useful tools and measures for researching motivation. This monograph is a thought-provoking book. Firstly, this new edition reflects the latest research advancement, providing the language teachers and researchers with insights into cultivating motivation. In terms of theoretical paradigm, the L2 Motivation Self System (L2MSS) introduces a holistic approach exploring the combined and interactive operation of a number of different factors in relation to L2 motivation rather than the traditional cause-effect relation between isolated variables. Two recent motivational paradigms originate in L2MSS: directed motivational currents and long-term motivation, focusing on not only what generates language learning motivation but also on what can sustain motivation long enough. In terms of research method, integration of quantitative and qualitative method (e.g., questionnaire + interview) has almost become a new trend in the L2 motivation field. Secondly, Dörnyei and Ushioda provide ideas for theoretical and empirical research by reviewing studies made by them and other researchers. Although a great deal of knowledge has been accumulated, Dörnyei and Ushioda particularly point out...
, Srdjan Saso, Nicolas Galazis, , Timothy Bracewell-Milnes, Mehar Chawla, Yousra Ahmed-Salim, Jara Ben Nagi
Published: 14 December 2021
Abstract:
This review explores the impact of polyunsaturated fatty acid (PUFA) supplementation in women undergoing assisted reproductive technology (ART) on reproductive outcomes. A systematic search of English peer-reviewed journals was carried out using MEDLINE, EMBASE, and the Cochrane Library to identify articles published from January 1978 to 2021. The primary outcomes assessed included pregnancy and live birth rates. Secondary outcome measures included: (i) implantation rate; (ii) fertilisation rate; (iii) number of oocytes retrieved; (iv) number of metaphase II (MII) oocytes; (v) blastocyst conversion; and (vi) embryo quality. A total of 4 randomised control trials (RCTs) met the inclusion criteria. There is a lack of high-quality research to support widespread dietary supplementation with PUFAs in women undergoing ART. Prior to its clinical recommendation, there is a need for well-designed RCTs to facilitate an in-depth understanding of PUFA supplementation in women undergoing ART.
Jiacheng Liu, Yiting Lei, Junyi Liao, Xi Liang, Ning Hu,
Published: 14 December 2021
by BMJ
Abstract:
Introduction: Hip fracture surgery is often associated with substantial blood loss and a high allogeneic blood transfusion (ABT) rate. Preoperative hidden blood loss (HBL) has been observed clinically but there is little evidence for the efficacy of tranexamic acid (TXA) in controlling preoperative HBL. We designed a randomised controlled trial to evaluate the efficacy of preemptive antifibrinolysis with multidose intravenous TXA (IV-TXA) in reducing preoperative HBL in elderly patients with hip fractures.Methods and analysis: This is a prospective, randomised, placebo-controlled clinical trial. Patients older than 65 years diagnosed with primary unilateral femoral neck fracture or intertrochanteric fracture will be randomly assigned to group A (receiving 100 mL of intravenous normal saline every 12 hours preoperatively and 1.5 g of IV-TXA every 12 hours postoperatively for 3 days) or group B (receiving 1.5 g of IV-TXA every 12 hours preoperatively and 1.5 g of IV-TXA every 12 hours postoperatively for 3 days). The primary outcomes will be the hidden blood loss, haemoglobin decrease and ABT rate. The secondary outcomes include the levels of inflammatory factors (such as C reactive protein) and coagulation and fibrinolysis parameters (such as D-dimer). Other outcomes such as injury time, length of stay and hospitalisation expenses will also be compared between groups.Ethics and dissemination: This study has been approved by the Ethics Committee of the First Affiliated Hospital of Chongqing Medical University. The findings of the study will be disseminated through peer-reviewed journals and conference presentations.Trial registration number: ChiCTR2100045960.
Journal of Nuclear Engineering and Radiation Science, Volume 8; https://doi.org/10.1115/1.4052641

Abstract:
This Special Issue of the ASME Journal of Nuclear Engineering and Radiation Science includes 2 editorials and 25 technical papers presenting main achievements of the Horizon-2020 European Union ESFR-SMART project (European Sodium Fast Reactor Safety Measures Assessment and Research Tools) supported by the EURATOM grant and launched in September 2017. ESFR-SMART gathers a consortium of 19 organizations (see Figure 1): Research centres, industries, universities, Technical and Scientific Support Organizations as well as Small to Medium Enterprise aiming at enhancing further the safety of Generation-IV Sodium Fast Reactors (SFRs) and, in particular, of the commercial-size European Sodium Fast Reactor (ESFR) in accordance with the European Sustainable Nuclear Industrial Initiative (ESNII) roadmap.
Ulrik H. U. Holm, Christian H. S. Andersen, Christian K. Hansen, Katrine Tanggaard, ,
Acta Anaesthesiologica Scandinavica; https://doi.org/10.1111/aas.14018

The publisher has not yet granted permission to display this abstract.
A Bello, Hh Wamakko
Insights in Veterinary Science, Volume 5, pp 026-031; https://doi.org/10.29328/journal.ivs.1001033

Abstract:
This research was conducted over period of 3 months with the aim of studying Age related changes of selected bones of forelimb (Scapula, Humerus, Radius and Ulna) in Local Mongrelian Dog (Canis lupus familiaris). The study entails biometrical and gross observations on the bones. The sample bones were acquired from the experimental animals of comparative anatomy in the department. The bones were categorized into various age groups for the research. The length, width, diameter and circumference of the samples (scapula, humerus, radius and ulna bones) were determined for all the groups. The shape, size, color, location, position and relation of each segment of the samples at various stages of development were determined. The differences across the age groups of different samples were observed and recorded. Based on the research result, it was concluded that, the biometric and morphometry data was found to be increasing with advancement of age. A baseline data was established with the view to enhance learning.
Junguo Shi, Xuhua Hu, Shanshan Dou, David Alemzero, Elvis Elvis Alhassan
Published: 10 December 2021
Abstract:
This study analyses the drivers that impact innovation on offshore wind energy for a select group of countries, applying the quantile and GMM approaches for a period between 2010-2019. The OLS results from the quantile analysis say the log of trademark, Carbon emissions, offshore wind capacity, and electricity from renewable energy are significant and impact on innovation regarding offshore wind energy. Generally, the Breusch-Pagan / Cook-Weisberg test for heteroskedasticity test reveals the variables have a constant variance, confirming the robustness of the findings. The quantile regression depicts that at 25th and 75th quantiles levels, the log of trademark, the log of trade flows, the log of scientific and technical journals quantile coefficients is significantly different from zero and exhibit varied effects on the explained variable patent.Similarly, the analysis applied the IV-GMM estimation in ivreg2 to identify the over restrictions, the Hansen J statistic, and give the robust moment of conditions analysis. The findings are consistent with prior analysis with the log of trademark, the log of offshore wind capacity, the log of carbon emissions, Scientific and technology journals, the log of patent, electricity from renewables to be significant and impact on innovation.The robustness was done on the GMM models, by applying the Huber-White-Sandwich estimator of the variance of the GMM linear models approximators. The ivreg2 robust analysis revealed that the estimates are efficient for homoskedasticity and Statistics robust to heteroskedasticity.Ultimately, the interaction term ‘’cross’’ came out significant in the analysis. Signifying the importance of the interaction variables in scaling innovation.This study will sever as a reference document for policy formulators regarding scaling up innovation for offshore wind energy.
, Sharon J. Williams
Published: 9 December 2021
Frontiers in Public Health, Volume 9; https://doi.org/10.3389/fpubh.2021.765501

Abstract:
Introduction: During the ongoing COVID-19 pandemic there have been much publicised shortages in Personal Protective Equipment for frontline health care workers, from masks to gowns. Recent previous airborne pandemics provide an opportunity to learn how to effectively lead and manage supply chains during crisis situations. Identifying and plotting this learning against time will reveal what has been learnt, when and, significantly, what can be learnt for the future.Aims: (i) To identify the temporal trajectory of leadership and management learning in health supply chain management through pandemics and (ii) to identify leadership and management lessons to enable the resilient supply of key items such as PPE in future pandemics.Methods: We undertook a scoping review in line with PRISMA (scoping review extension) searching Business Source Premier, Health Business Elite, Medline, ProQuest Business Collection and PubMed. Search terms were focused on recent airborne pandemics (SARS; Ebola; Zika virus; H1N1 swine flu, COVID-19), supply chain management, PPE, leadership, learning, inhibitors and facilitators and resilience e.g., SARS AND supply chain* AND (“personal protective equipment” OR PPE) (leaders* OR manage*) Titles and abstracts were downloaded to Endnote and duplicates removed. Two authors independently screened all of the titles and abstracts. Inclusion criteria focused on leadership and management in health supply chains during pandemics, peer reviewed or grey literature (either from business journals or reports): exclusion criteria included not in English and not focused on a named pandemic. Once interrater reliability was assured, authors completed a title and abstract screening independently. Ten percent of the resultant full text articles were screened by both authors, once agreement was reached the full text articles were screened independently noting reasons for exclusion. A data extraction tool was designed to capture findings from the final articles included in the review.Results/Discussion: We found 92 articles and, after screening, included 30 full text articles. The majority were focused on COVID-19 (N = 27) and most were from the USA (N = 13). We identified four themes related to leadership and management of pandemic PPE supply chains, (i) Leadership and management learning for pandemic PPE supply chain management, (ii) Inhibitors of PPE supply chain resilience during a pandemic, (iii) Facilitators employed to manage the immediate impacts of PPE supply chain demands during a pandemic,and (iv) Facilitators proposed to ensure longer term resilience of PPE supply chains during pandemics Our study suggests there has been limited leadership and management learning for PPE supply chains from previous pandemics, however there has been extensive learning through the COVID-19 pandemic. Lessons included the importance of planning, the significance of collaboration and relationship building. Resilience of PPE supply chains was reported to be dependent on multiple levels from individuals to organisation level and also interdependent on (i) sustainability, (ii) the practise of PPE and (iii) long term environmental impact of PPE suggesting the need, long term, to move to a circular economy approach.
Zane Schnurman, Gustavo Chagoya, , Mark R Harrigan
Published: 8 December 2021
by BMJ
Trauma Surgery & Acute Care Open, Volume 6; https://doi.org/10.1136/tsaco-2021-000741

Abstract:
Background: Blunt cerebrovascular injuries (BCVI) remain a significant source of disability and mortality among trauma patients. The purpose of the present study was to determine whether knowledge silos exist in the overall BCVI literature.Methods: An object-oriented programmatic script written in Python programming language was used to extract and categorize articles and references on the topic of BCVI. Additionally, each BCVI article was searched for by digital object identifier in the other BCVI references to build a network analysis and visualize topic reference patterns. Analyses were performed using Stata V.14.2 (StataCorp).Results: A total of 306 articles with 10 282 references were included for analysis. Of these, 24% (74) were published in neurosurgery journals, 45% (137) were published in trauma journals, and 31% (95) were published in a journal of another specialty. Similar proportions were found when categorized by author departmental affiliation. Trauma surgery authors disproportionately referenced articles in the trauma literature, compared with neurosurgeons (73.5% vs. 48.0%, p<0.0001), and other authors. The biggest factor influencing reference proportions was the specialty of the publishing journal. Finally, a network analysis revealed that there are more trauma BCVI articles, and there are more frequently cited trauma BCVI articles by all specialties.Conclusions: This study revealed the existence of a one-way knowledge silo in the BCVI literature. However, a robust preference by both trauma and neurosurgery to cite trauma references when publishing in trauma journals may indicate a possible conscious curating of citations by authors to increase the likelihood of publication. These observations highlight the need for an active role by journal editors, peer reviewers, and authors to actively foster diversity of citations and cross-specialty collaboration to improve dissemination of information between these specialties.Level of evidence: Level IV. Observational study.
Rebecca Miller, Sheina Macadam, Daniel Demsey
Published: 8 December 2021
Abstract:
Introduction and Purpose: Breast reconstruction is an active area of plastic surgery research. Citation analysis allows for quantitative analysis of publications, with more citations presumed to indicate greater influence. We performed citation analysis to evaluate the most cited papers on breast reconstruction between 2000 to 2010 to identify contemporary research trends. Methods: The SCI-EXPANDED database was used to identify the 50 most cited papers. Data points included authorship, publication year, publication journal, study design, level of evidence, number of surgeons/institutions, center of surgery, primary outcome assessed, implant/flap/acellular dermal matrix/fat graft, acellular dermal matrix brand and use with implants/flaps, fat graft use with implants/flaps, unilateral/bilateral, one-/two-stage, immediate/delayed, number of patients/procedures, complications. Descriptive analysis of trends was performed based on results. Results: 20% of papers were published in 2006, 16% in 2007 and 12% in both 2004/2009. 66% were published in Plastic and Reconstructive Surgery. The majority were retrospective or case series, and of Level III or IV evidence. The one Level I study was a prospective multicenter trial. 21 and 7 papers discussed procedures by single/multiple surgeons, respectively. Results from single/multiple centers were discussed in 18 and 6 papers, respectively. 30 papers discussed implant-based reconstruction, 22 papers flap-based (19 microsurgical), 15 papers acellular dermal matrix, and five papers fat grafting. The primary focus in the majority was complications or outcomes. Conclusion: Our analysis demonstrates continually evolving techniques in breast reconstruction. However, there is notable lack of high quality evidence to guide surgical decision-making in the face of increasing surgical options.
Uwe Bieri, Juliette Slieker, Lukas John Hefermehl, Sebastian Soppe, Gerfried Teufelberger, Regula Tedaldi, Nicole Graf, Marco Bieri,
Published: 7 December 2021
by BMJ
Abstract:
Introduction: Postoperative urinary retention (POUR) is a common complication after inguinal hernia repair with a reported incidence up to 34%. It can be described as the inability to initiate urination or insufficient bladder emptying following surgery. It usually requires the use of catheterisation to empty the bladder in order to prevent further injury to the bladder or kidneys and to relief from pain. Tamsulosin is a medication that is commonly used in men with urinary symptoms related to an enlarged prostate. There is some evidence to suggest that it may also potentially be beneficial for preventing POUR.Methods and analysis: This is a multicentre, blinded, prospective, phase IV randomised controlled trial with parallel allocation. Six hundred and thirty-four patients scheduled for elective endoscopic inguinal hernia repair surgery will be recruited. There will be effective (concealed) randomisation of the subjects to the intervention/control groups. Group assignment will be performed using a covariate-adaptive allocation procedure to provide a balance for selected covariates. The interventional group receives 0.4 mg tamsulosin hydrochloride and the control-group receives one placebo capsule matching the active study drug, both daily, starting from 5 days prior to the day of surgery, at the day of surgery and for 1 day following surgery. The primary outcome is any need for urinary catheterisation postoperatively as a binary outcome. Secondary outcome measures include postoperative pain, change in International Prostate Symptom Score from baseline prior to surgery to after surgery and hospital stay.Ethics and dissemination: The study has been approved by the Northwestern and Central Switzerland Ethics Committee (2020–00569) and it is being conducted in accordance with the Declaration of Helsinki and Good Clinical Practice. Study results will be disseminated through peer-reviewed journals and national and international scientific conferences.Trial registration numbers: SNCTP000003904. NCT04491526.
Pamela J. Fink
Published: 6 December 2021
Annual Review of Immunology, Volume 40; https://doi.org/10.1146/annurev-immunol-101220-014126

Abstract:
I've had serious misgivings about writing this article, because from living the experience day by day, it's hard to believe my accomplishments merit the attention. To skirt this roadblock, I forced myself to pretend I was in a conversation with my trainees, trying to distill the central driving forces of my career in science. The below chronicles my evolution from would-be astronaut/ballerina to budding developmental biologist to devoted T cell immunologist. It traces my work from a focus on intrathymic events that mold developing T cells into self–major histocompatibility complex (MHC)-restricted lymphocytes to extrathymic events that fine-tune the T cell receptor (TCR) repertoire and impose the finishing touches on T cell maturation. It is a story of a few personal attributes multiplied by generous mentors, good luck, hard work, perseverance, and knowing when to step down. Expected final online publication date for the Annual Review of Immunology, Volume 40 is April 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
Adzra Taqiyyah,
Jurnal Ekonomi Syariah Teori dan Terapan, Volume 8, pp 714-726; https://doi.org/10.20473/vol8iss20216pp714-726

Abstract:
ABSTRAKPenelitian bertujuan untuk mengetahui bagaimana pengaruh dari variabel pangkat dan golongan, jenis kelamin, jumlah tanggungan keluarga, lama pendidikan, frekuensi pengajian, serta pendapatan lain selain gaji sebagai determinan terhadap pembayaran zakat profesi di kalangan Pegawai Negeri Sipil (PNS) di Kota Banjarmasin. Penelitian ini menggunakan pendekatan kuantitatif dengan teknik analisis regresi logistik untuk menganalisis data. Penelitian ini melibatkan data primer atas 126 responden yang diambil menggunakan teknik convenience sampling dengan kriteria PNS Golongan III dan IV di mana golongan tersebut memiliki gaji yang telah memenuhi nisab zakat profesi. Diperoleh hasil bahwa variabel pangkat dan golongan, jenis kelamin, dan pendapatan lain selain gaji masing-masing berpengaruh negatif signifikan terhadap pembayaran zakat profesi sedangkan variabel jumlah tanggungan keluarga, lama pendidikan, dan frekuensi pengajian masing-masing ditemukan memiliki pengaruh positif signifikan terhadap pembayaran zakat profesi.Kata Kunci: pembayaran zakat profesi, pangkat dan golongan, jenis kelamin, jumlah tanggungan keluarga, lama pendidikan, frekuensi pengajian, pendapatan lain selain gaji ABSTRACTThis study aims to determine how the influence from titles and ranks, gender, number of family dependents, education history, frequency of communal Qur’an reading, and other forms of income apart from the actual salary itself as a determinant of professional zakat payments paid by State Civil Servants (PNS) in Banjarmasin City. This study uses a quantitative approach with logistic regression analysis techniques to analyze data. This study involved primary data on 126 respondents who were taken using a convenience sampling technique with the criteria of PNS Group III and IV where the group had a salary that met the professional zakat nisab. The results show that the variables of titles and ranks, gender, and other forms of income have a significant negative effect on the payment of zakat on profession, while the variables of the number of family dependents, education history, and the frequency of communal Qur’an reading are found to have a significant positive effect on zakat on profession payments.Keywords: zakat on profession, titles and ranks, gender, numbers of family dependents, education history, the frequency of communal Qur’an reading, other forms of income apart from the actual salary itself. DAFTAR PUSTAKAAbdullah, M., & Sapiei, N. S. (2018). Do religiosity, gender and educational background influence zakat compliance? The case of Malaysia. International Journal of Social Economics, 45(8), 1250–1264. https://doi.org/10.1108/IJSE-03-2017-0091Ahmad, S., Nor, N. G. M., & Daud, Z. (2011). Tax-based modeling of zakat compliance. Jurnal Ekonomi Malaysia, 45, 101-108.Al Qardhawi, Y. (2011). Fiqh Al Zakah. Beirut: Muassasah al-RisalahAndam, A. C., & Osman, A. Z. (2019). Determinants of intention to give zakat on employment income: Experience from Marawi City, Philippines. Journal of Islamic Accounting and Business Research, 10(4), 528–545. https://doi.org/10.1108/JIABR-08-2016-0097Anshori, M., & Iswati, S. (2009). Metodologi penelitian kuantitatif. Surabaya: Airlangga University Press (AUP).Arsyianti, L. D., Kassim, S., & Adewale, A. (2017). Socio-demographic and economic factors affecting regular charity-giving: A case of low-income households in Indonesia. International Journal of Zakat, 2(1), 21-29. https://doi.org/https://doi.org/10.37706/ijaz.v2i1.12Azen, R., & Walker, C.M. (2010). Categorical data analysis for the behavioral and social sciences. London: Routledge. https://doi.org/10.4324/9780203843611Azman, F. M. N., & Bidin, Z. (2015). Zakat compliance intention behavior on saving. International Journal of Business and Social Research, 5(1), 118–128.Badan Kepegawaian Daerah Provinsi Kalimantan Selatan. (2020). Jumlah PNS berdasarkan jenis kelamin. Diakses dari https://data.kalselprov.go.id/?r=JmlPns/index BAZNAS. (2021). Laporan kinerja badan amil zakat nasional tahun 2020. Jakarta: BAZNAS.BAZNAS Kota Banjarmasin. (2020). Infografik penerimaan BAZNAS Kota Banjarmasin 2019. Diakses dari https://baznas.banjarmasinkota.go.id/detailpost/infografik-penerimaan-baznas-kota-banjarmasin-2019Direktorat Jenderal Pajak. (2020). Penghasilan Tidak Kena Pajak. Diakes dari https://www.pajak.go.id/id/penghasilan-tidak-kena-pajakDinas Komunikasi dan Informatika Provinsi Kalimantan Selatan. (2020). Produktivitas Perkebunan Karet Menurun. Diakses dari https://diskominfomc.kalselprov.go.id/2020/06/09/produktivitas-perkebunan-karet-menurunDSN MUI. (2003). Fatwa MUI nomor 3 tahun 2003 tentang zakat penghasilan. Jakarta: DSN MUI.Eagly, A.H. (2013). Sex differences in social behavior: A social-role interpretation. New York: Psychology Press. https://doi.org/10.4324/9780203781906Hilbe, J.M. (2015). Practical guide to logistic regression. New York: Chapman and Hall/CRC. https://doi.org/10.1201/b18678Top of FormHosmer, D. W., Lemeshow, S., & Sturdivant, R. X. (2013). Applied logistic regression. Hoboken (N.J.): Wiley.Kastlunger, B., Dressler, S. G., Kirchler, E., Mittone, L., & Voracek, M. (2010). Sex differences in tax compliance: Differentiating between demographic sex, gender-role orientation, and prenatal masculinization (2D:4D). Journal of Economic Psychology, 31 (4), 542-552. https://doi.org/10.1016/j.joep.2010.03.015Bottom of FormLaLumia, S. (2008). The effects of joint taxation of married couples on labor supply and non-wage income. Journal of Public Economics, 92(7), 1698–1719. https://doi.org/10.1016/j.jpubeco.2008.01.009Lind, D. A., Marchal, W. G., & Wathen, S. A. (2011). Statistical techniques in business & economics. Boston: McGraw-Hill/Irwin.Medias, F. (2018). Ekonomi mikro Islam. Magelang: UNIMMA Press.Pemerintah RI. (2017). Peraturan Pemerintah nomor 11 tahun 2017 tentang manajemen pegawai negeri sipil.Pusat Kajian Strategis Badan Amil Zakat Nasional....
, Ciara O'Brien, Nathan Giles, Sally Fenton, Sue Neilson, Joan L Duda
Published: 3 December 2021
by BMJ
Abstract:
Introduction: Non-ambulant children and young people with physical disabilities are at high risk of experiencing negative health outcomes associated with sedentary time. A previous scoping review summarising evidence relating to sedentary behaviours of children with physical disabilities identified the need for validated methods of measuring physical activity of children who use wheelchairs and evaluation of interventions to reduce sedentary time. The scoping review did not assess the quality of evidence relating to this topic, therefore its validity remains unclear. No reviews focussing on non-ambulant children and young people up to the age of 25 years have been undertaken.The objectives of this systematic search and review are to: Identify all peer-reviewed articles relating to sedentary behaviour of non-ambulant children and young people. Categorise the articles according to study design and four subquestions relating to (i) measurement, (ii) patterns, (iii) associated risks and (iv) interventions to reduce sedentary time or behaviour. Critically appraise quality of the articles using established critical appraisal tools. Summarise the evidence for each subquestion. Describe its cumulative strength and identify knowledge gaps. Methods and analysis: This protocol was developed using the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) checklist. The research questions, inclusion/exclusion criteria and search terms have been developed a priori using the ‘Population, Concept and Context’ framework. Online databases will be systematically searched to identify peer-reviewed articles published between 1996 and 2021. Two reviewers will screen, categorise and critically appraise the articles. Data extraction and analysis will be verified by the second reviewer.Results will be reported as a best evidence synthesis, with reference to the PRISMA checklist.Ethics and dissemination: Ethical approval is not required. The review will be submitted to an appropriate peer-reviewed journal.Registration: The review is registered on the Open Science Framework database. DOI: https://doi.org/10.17605/OSF.IO/SQXJB. Any protocol amendments will be recorded in the Open Science Framework database.
Nohade Nasrallah, Osama F. Atayah, Rim El Khoury, , Shaher Obaid
Journal of Information & Knowledge Management; https://doi.org/10.1142/s0219649222500010

The publisher has not yet granted permission to display this abstract.
Developments in the Built Environment, Volume 9; https://doi.org/10.1016/j.dibe.2021.100064

Abstract:
The study presents and analyzes innovation metrics in construction and civil engineering, domains which are found to lag behind other fields of science and technology in terms of innovation output. A specific line of focus is put on research and development (R&D) both in academia and industry. Scientific production is analyzed by treating eighteen of the oldest peer-reviewed journals in the field with over a hundred thousand articles published over the past fifty years. The aim is to capture and interpret trends with respect to four field verticals: (i) new materials and systems (hardware), (ii) digitalization, (iii) environmental impact and (iv) novelty/efficiency. The analysis reveals distinctive rates of innovation for each vertical, with some slowing down, as innovation becomes standardized and mainstream, and others peaking up, stemming from developments in other fields of science. Results are treated with respect to the S-curve technology maturity framework which accounts for effort and time towards development and the widely adopted scale of technology readiness levels. Further, corporate innovation is analyzed through patent search covering twelve key inventors and various technology focuses. While no straightforward approach exists to present innovation metrics without considering the broader socio-political and economic context, the present work seeks to provide a comprehensive monitoring of the progress in the field which reflects capital, time and effort put together, towards advancing propositions for future research.
Andrey A. Paramonov, Northern Research Institute of Forestry, Sergey V. Tretyakov, , Aleksandr P. Bogdanov, Ilia V. Tsvetkov
Lesnoy Zhurnal (Forestry Journal) pp 69-78; https://doi.org/10.37482/0536-1036-2021-6-69-78

Abstract:
In order to improve the accuracy of forest inventory works, tables of stem volume by height classes of willow trees in the northern taiga region of the European part of the Russian Federation were created. Forest inventory standards have not previously been developed for this species in the northern taiga region. The analytical technique proposed by I.I. Gusev in 1971 for spruce forests of the European North was used in compiling the height class volume tables. It was later adopted for the description of other tree species as well. Diameters and heights of trees were measured at 41 sample plots laid out in the Verkhnyaya Toyma and Arkhangelsk forestries of the Arkhangelsk region; 105 model trees were sampled. In most cases, sample plots were laid out in mixed plantations with the predominance of willow. The data obtained on the sample plots served to determine the parameters of the height class scale. The information source for stem volume of willow trees used to be the stem volume tables for aspen trees. A comparative analysis of the tables compiled for willow trees stems with the tables for aspen taken from the Forest Valuation Handbook for the Northeast of the European part of the Russian Federation was carried out. The analysis shows significant discrepancy in the scales for willow and aspen. The use of aspen height class volume tables for willow leads to a systematic overestimation of wood volumes. Tables of stem volumes by height classes of willow trees are used to determine stand stock with the enumeration data by 4-centimeter diameter classes. The developed tables meet the forest practice requirements. The volume tables by height classes are used to calculate timber reserves when laying out sample plots; to determine the damage level in case of stand damage; and for other practical purposes. For citation: Paramonov A.A., Tretyakov S.V., Koptev S.V., Bogdanov A.P., Tsvetkov I.V. Stem Volume Tables by Height Classes of Willow Trees in the Northern Taiga Region of the European Part of the Russian Federation. Lesnoy Zhurnal [Russian Forestry Journal], 2021, no. 6, pp. 69–78. DOI: 10.37482/0536-1036-2021-6-69-78
, Susan S. Eagle
Journal of Cardiothoracic and Vascular Anesthesia, Volume 35, pp 3675-3676; https://doi.org/10.1053/j.jvca.2021.07.051

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Arthroscopy: The Journal of Arthroscopic & Related Surgery, Volume 37; https://doi.org/10.1016/s0749-8063(21)00944-0

The publisher has not yet granted permission to display this abstract.
Sergey E. Rudov, Military Academy Of Communications Named After Marshal Of The Soviet Union S.M. Budyonny, , Olga I. Grigoreva, Igor V. Grigorev, Olga A. Kunitskaya, Sаint-Petersburg State Forest Technical University named after S.M. Kirov, Arctic State Agrotechnological University
Lesnoy Zhurnal (Forestry Journal) pp 121-134; https://doi.org/10.37482/0536-1036-2021-6-121-134

Abstract:
The urgency of the task of effective development of cutting areas on the slopes of mountains, hills, and hilly-ridge reliefs is primarily due to the depletion of available, special, lowland operational forests in Siberia and the Far East, which were once, not quite correctly, called forest-surplus regions of the Russian Federation. The operational woodlands that are convenient for development in Siberia and the Far East are largely depleted. To develop new ones, large-scale road construction is necessary, which requires significant financial expenses and reduces the already low profitability of logging production. It is also declining due to the ever-increasing volume of export of harvested timber, even if the cost of construction and maintenance of a new network of logging roads is not considered. Forest ecosystems located on slopes are among the most vulnerable. When working on the slopes with traditional systems of logging machines, it becomes necessary to cut a serpentine of skid trails, which later become concentrators of water and wind erosion. Currently, leading manufacturers of machinery and equipment for the forest industry, such as Ponsse, John Deer, Komatsu, and others, have developed technical solutions that significantly facilitate the operation of forest machine systems. Such solutions, first of all, include winches integrated into the transmissions of machines. Another solution is to use separate self-propelled winches remotely controlled by the operator of a forest machine, for example, T-winch. In this case, the machine does not receive additional weight from the winch integrated into it; however, the negative impact of forest machines on soils does not disappear, but has its own significant specifics. The article shows that when performing logging operations on slopes, primarily steep ones with slope angles exceeding 20–25°, it is necessary to make adjustments to the assessment of the destruction nature of the soil array and the patterns of the track depth formation under the influence of the skidding system. For citation: Rudov S.E., Shapiro V.Ya., Grigorev I.V., Kunitskaya O.A., Grigoreva O.I. Modeling the Interaction of Forest Machines with Soil when Working on Slopes. Lesnoy Zhurnal [Russian Forestry Journal], 2021, no. 6, pp. 121–134. DOI: 10.37482/0536-1036-2021-6-121-134
Joseph M. Pimbley
The Journal of Derivatives, Volume 29, pp 1-3; https://doi.org/10.3905/jod.2021.29.2.001

Abstract:
As I’ve written and reminded for past two quarters, Frank Fabozzi, editor of The Journal of Portfolio Management, and I are collaborating to create a special issue for The Journal of Derivatives (JOD) with a scheduled publication in May 2022. The issue’s focus will be derivatives in the asset management world. Our authors will be practitioners and the mission will be educational.
Published: 30 November 2021
by MDPI
Abstract:
Background: We have conducted a systematic review focusing on the advancements in preclinical molecular imaging to study the delivery and therapeutic efficacy of miRNAs in mouse models of breast cancer. Methods: A systematic review of English articles published in peer-reviewed journals using PubMed, EMBASE, BIOSIS™ and Scopus was performed. Search terms included breast cancer, mouse, mice, microRNA(s) and miRNA(s). Results: From a total of 2073 records, our final data extraction was from 114 manuscripts. The most frequently used murine genetic background was Balb/C (46.7%). The most frequently used model was the IV metastatic model (46.8%), which was obtained via intravenous injection (68.9%) in the tail vein. Bioluminescence was the most used frequently used tool (64%), and was used as a surrogate for tumor growth for efficacy treatment or for the evaluation of tumorigenicity in miRNA-transfected cells (29.9%); for tracking, evaluation of engraftment and for response to therapy in metastatic models (50.6%). Conclusions: This review provides a systematic and focused analysis of all the information available and related to the imaging protocols with which to test miRNA therapy in an in vivo mice model of breast cancer, and has the purpose of providing an important tool to suggest the best preclinical imaging protocol based on available evidence.
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