Refine Search

New Search

Advanced search

Result: 1

(searched for: (10.5155/eurjchem.9.4.322-330.1748))
Save to Scifeed
Page of 1
Articles per Page
by
Show export options
  Select all
Ashok Reddy AnkiReddy, Sciprofile linkRambabu Gundla, Sciprofile linkTuniki Balaraju, Venkanna Banothu, Krishna Prasad Gundla, Uma Addepally, Jithendra Chimakurthy
European Journal of Chemistry, Volume 9; doi:10.5155/eurjchem.9.4.322-330.1748

Abstract:
A series of C-7 substituted-2-morpholino-N-(pyridin-2-ylmethyl)quinazolin-4-amine have been synthesized and biochemical assay was examined against α-glucosidase function inhibition activity. A structure activity and structure property relationship study was experimented to surface the new hit compound. This study led to the identification of C-7substituted quinazolines with minimum inhibitory concentrations (MICs) in the preffered micromolar range in addition with interesting physicochemical properties. Biological evaluation yielded eight analogs which rose with significant α-glucosidase inhibition potency (IC50 values < 2 μM, where reference compound (Acarbose) potency value is IC50 = 0.586 uM) and could be promising candidates for further lead optimization.
Page of 1
Articles per Page
by
Show export options
  Select all
Back to Top Top