A series of isolated/fused of pyrazole, isoxazolo, pyrimidine, pyrimidine thione, spiro thiazolodine and spiro β-lactam derivatives incorporating to 4-acetyl-5-imino-3-methyl-1-phenyl-2-pyrazoline have been synthesized by different methods. The structure of chemical reactions based on chemical and spectroscopic evidence. The detailed synthesis and spectroscopic data were reported.