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(searched for: (10.5155/eurjchem.2.2.243-250.257))
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Hassan Mostafa Faidallah, Khalid Ali Khan, Abdullah Mohammad Asiri
European Journal of Chemistry, Volume 2; doi:10.5155/eurjchem.2.2.243-250.257

Abstract:
Arylhydrazines reacted with dehydroacetic acid (1) to give the corresponding 2H-pyran-2-one hydrazones (2), which on treatment with hydrazine hydrate afforded the corresponding 1-amino-2H-pyridin-2-ones (3). Reaction of 3 with nitrous acid, aromatic aldehyde and substituted benzenesulfonyl chlorides yielded the corresponding 2H-pyridine-2-one derivatives. A series of urea and thiourea derivatives were also prepared. Some of these compounds have shown significant antibacterial and mild to moderate antimycobacterial and antifungal activities.
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