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(searched for: (10.5155/eurjchem.1.4.297-301.20))
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Alahari Janardhan Rao, Valasani Koteswara Rao, Pasupuleti Visweswara Rao, Chamarthi Naga Raju, Sunil Kumar Ghosh
European Journal of Chemistry, Volume 1; doi:10.5155/eurjchem.1.4.297-301.20

Abstract:
Novel phosphorylated derivatives of stavudine were synthesized by the reaction of bis(2-chloroethyl)phosphoramidic dichloride/4-nitrophenyl phosphorodichloridate with various cyclic amines and amino acid esters in the presence of triethylamine in dry tetrahydrofuran through the corresponding monochloride intermediates 2a-l. Further reaction of the intermediates 2a-l with stavudine in tetrahydrofuran and pyridine in the presence of triethylamine formed the title compounds 4a-l. Their structures were characterized by IR, 1H-, 13C-, 31P-NMR and mass spectral data analyses. They exhibited good antibacterial and antioxidant activities. Their bioactivity was greatly influenced by the different groups present at the phosphorus.
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