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(searched for: (title:(Hydrogels: A Novel Drug Delivery System)
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Shailesh Thirumaleshwar, Parthasarthi K. Kulkarni, Devegowda V. Gowda
Current Drug Therapy, Volume 7, pp 212-218; doi:10.2174/157488512803988021

Shabnam Nezami, , Hamidreza Mohajerani
Published: 1 September 2020
Polymer Degradation and Stability, Volume 179; doi:10.1016/j.polymdegradstab.2020.109255

, Jun Yang, Qinghua Li, Ming Huo, Fagang Jiang, Xiaoding Xu, Xianzheng Zhang
Journal of Biomaterials and Nanobiotechnology, Volume 2, pp 622-625; doi:10.4236/jbnb.2011.225074

Abstract:
In the last two decades, 5-fluorouracil (5-FU) is widely used in clinical practice to inhibit the fibroblasts to proliferate and improve the success rate of glaucoma-filtering surgery, but 5-FU has many toxic effects to normal ocular tissues. The self-assembled peptide hydrogels may serve as a new class of biomaterials for applications including tissue engineering and drug delivery. How to deliver 5-FU quickly and precisely to the target sites of ocular tissue by a self-assembled peptide hydrogel remains unexplored. RGD (arginine-glycine-aspartic acid) sequence is cell attachment site in extracellular matrix (ECM). Thus, If the self-assembled peptide hydrogel containing the RGD sequence that act as a specific attachment site for the proliferated fibroblasts adhesion could be designed, after integrated 5-FU, a novel targeting drug delivery system will be put into practice in the future
, Nitin Joshi, Anthony Blikslager, Liara M. Gonzalez, Tiffany Pridgen, Ann Whitlow, Marija Ivanovic, Kai Slaughter, , , et al.
Published: 1 April 2017
Gastroenterology, Volume 152; doi:10.1016/S0016-5085(17)32956-6

R. Mohapatra, D. Ray, A. K. Swain, T. K. Pal,
Published: 5 April 2008
by Wiley
Journal of Applied Polymer Science, Volume 108, pp 380-386; doi:10.1002/app.27089

The publisher has not yet granted permission to display this abstract.
Federica Corrente, , Pietro Matricardi, Beatrice Tita, Federica Vitali,
Published: 1 January 2012
by Wiley
Journal of Pharmaceutical Sciences, Volume 101, pp 256-267; doi:10.1002/jps.22766

The publisher has not yet granted permission to display this abstract.
Laurent Bédouet, Florentina Pascale, Laurence Moine, Michel Wassef, Saïda H. Ghegediban, Van-Nga Nguyen, Michel Bonneau, Denis Labarre, Alexandre Laurent
International Journal of Pharmaceutics, Volume 456, pp 536-544; doi:10.1016/j.ijpharm.2013.08.016

The publisher has not yet granted permission to display this abstract.
Wolfgang A. Ritschel, Mukul A. Agrawal
Ciencia e Investigación, Volume 6, pp 24-29; doi:10.15381/ci.v6i2.3439

Abstract:
Peroral modified drug delivery systems on the market release fue drug by either 0-order, 1º-order, square root oftime or mixed rate. This means that the drugis released mto the gastrointestinallumenin amounts being either constantper unit of time or decreasingwith time. However, physiologically absorption from the GI lumen gets slower and more difficult past the small intestme. A novel drug delivery system is described far 24 horus drug delivery which follows approximate 0-orden release throughout the small intestine, but releases increasing amounts of drug once in the colon ta compensate for increasingly more difficult absorption. Nearly constant steady state drug plasma concentrations are achieved . The novel drug delivery system is a two layered dosage form with an immediate release layer and a modified release layer. The latter ene is a hydrogel piston pump comprised of a drug core layer and a hydrogel swelling layer, embedded into a semipermeable shell by compression coating. The upper site of the shell has a release channel in the center.
, J. Parvathy, Anoop S. Nair
Published: 1 January 2016
Carbohydrate Polymers, Volume 136, pp 1118-1127; doi:10.1016/j.carbpol.2015.10.019

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A. P. Rokhade, P. V. Kulkarni, N. N. Mallikarjuna,
Published: 20 October 2008
Journal of Microencapsulation, Volume 26, pp 27-36; doi:10.1080/02652040802109770

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, Surendra G. Gattani
Published: 31 October 2011
Journal of Microencapsulation, Volume 29, pp 72-82; doi:10.3109/02652048.2011.629789

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R. Dinarvand,
Published: 1 October 1995
Journal of Controlled Release, Volume 36, pp 221-227; doi:10.1016/0168-3659(95)00035-7

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R. Kadri, , A. Tamayol, B. Aliakbarian, H. Y. Zhang, M. Hasan, L. Sánchez-González,
Published: 10 March 2016
RSC Advances, Volume 6, pp 27879-27884; doi:10.1039/C6RA03699F

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MaLing Gou, Xingyi Li, Mei Dai, Changyang Gong, Xianhuo Wang, Yao Xie, Hongxin Deng, Lijuan Chen, Xia Zhao, , et al.
International Journal of Pharmaceutics, Volume 359, pp 228-233; doi:10.1016/j.ijpharm.2008.03.023

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, Naveed Ahmad, Manisha Pandey, Muhammad Mustafa Abeer, Najwa Mohamad
Published: 30 December 2014
Expert Opinion on Drug Delivery, Volume 12, pp 1149-1161; doi:10.1517/17425247.2015.997707

The publisher has not yet granted permission to display this abstract.
Published: 7 December 2020
Pharmaceutics, Volume 12; doi:10.3390/pharmaceutics12121188

Abstract:
Owing to their tunable properties, controllable degradation, and ability to protect labile drugs, hydrogels are increasingly investigated as local drug delivery systems. However, a lack of standardized methodologies used to characterize and evaluate drug release poses significant difficulties when comparing findings from different investigations, preventing an accurate assessment of systems. Here, we review the commonly used analytical techniques for drug detection and quantification from hydrogel delivery systems. The experimental conditions of drug release in saline solutions and their impact are discussed, along with the main mathematical and statistical approaches to characterize drug release profiles. We also review methods to determine drug diffusion coefficients and in vitro and in vivo models used to assess drug release and efficacy with the goal to provide guidelines and harmonized practices when investigating novel hydrogel drug delivery systems.
K. S. Soppimath, T. M. Aminabhavi, A. M. Dave, S. G. Kumbar, W. E. Rudzinski
Drug Development and Industrial Pharmacy, Volume 28, pp 957-974; doi:10.1081/ddc-120006428

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Anish Kumar Gupta
Journal of Drug Delivery and Therapeutics, Volume 2; doi:10.22270/jddt.v2i1.87

Xiaoyan Zhao, Dereje Kebebew Debeli, Guorong Shan
Published: 31 October 2019
by Wiley
Journal of Applied Polymer Science, Volume 137; doi:10.1002/app.48669

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, , Rahila Bhat, Bora Garipcan,
Published: 1 October 2010
Acta Biomaterialia, Volume 6, pp 3890-3898; doi:10.1016/j.actbio.2010.05.009

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, M. Grassi, R. Lapasin, A. Marino, F. Alhaique
Published: 1 July 2003
Biomaterials, Volume 24, pp 2789-2798; doi:10.1016/s0142-9612(03)00087-5

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Shayanne A. Lajud, Danish A. Nagda, Peter Qiao, Nobuaki Tanaka, Alyssa Civantos, Rende Gu, Zhiliang Cheng, Andrew Tsourkas, Bert W. O’Malley,
Otology & Neurotology, Volume 36, pp 341-347; doi:10.1097/mao.0000000000000445

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Lalita Devi, Punam Gaba, Hitesh Chopra
Journal of Drug Delivery and Therapeutics, Volume 9, pp 861-866; doi:10.22270/jddt.v9i4-s.3458

Abstract:
Hydrogels possess three-dimensional polymeric network structure and equipped for retaining extensive measure of water or organic fluids. This quality makes them as exceptional candidate for the simulation of extra cellular matrixes. For this the three dimensional printing (3DP) has evolved as the technique for the formation of the digital models. The 3DP is capable for processing the prescriptions and the therapeutic gadgets. One of the technique known as stereolithographic (SLA) printing has shown promising results in formulating the hydrogel based system for fabrication. The SLA acts by cross connecting the saps to shape the polymer matrices. Due to water captured in the gels it is conceivable to create the pre- wetted, medicate hydrogels and gadgets. The 3DP helps in formation of tailor made drug delivery system as per needs of patients. Many of Bioinks has been tried up for the hydrogel formation such as collagen, gelatin, hyaluronan, silk, alginate, and nanocellulose etc. Keywords: 3D Printing, Hydrogel, Steriolithography
Sang Cheon Lee, Il Keun Kwon,
Published: 1 January 2013
Advanced Drug Delivery Reviews, Volume 65, pp 17-20; doi:10.1016/j.addr.2012.07.015

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Liping Yuan, Meng Pan, Minyi Lei, Xingli Zhou, Danrong Hu, Qingya Liu, Yu Chen, Wei Li,
Published: 1 June 2020
Applied Materials Today, Volume 19; doi:10.1016/j.apmt.2020.100593

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Changhua Liu, Xianxue Gan, Yanqing Chen
Published: 29 March 2011
by Wiley
Starch - Stärke, Volume 63, pp 503-511; doi:10.1002/star.201000120

, Pedram Rafiei, , Soliman Mohammadi-Samani
Published: 1 May 2011
by Wiley
Journal of Pharmaceutical Sciences, Volume 100, pp 1702-1711; doi:10.1002/jps.22395

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, Dhara H. Lakdawala, Anjum A. Shaikh, Ankita R. Desai, Harsh H. Choksi, Rutvi J. Vaidya, Ketan M. Ranch, Akshay R. Koli, Bhavin A. Vyas, Dinesh O. Shah
Published: 1 March 2016
Journal of Controlled Release, Volume 226, pp 47-56; doi:10.1016/j.jconrel.2016.02.012

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Shaoyu Lü, Mingzhu Liu, Boli Ni, Chunmei Gao
Journal of Polymer Science Part B: Polymer Physics, Volume 48, pp 1749-1756; doi:10.1002/polb.22040

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Kuilin Deng, Lirong Dong, Qian Li, Yubo Gou, Pengfei Zhang, Xiaobo Ren, Haibin Zhong
Published: 11 February 2011
by Wiley
Journal of Applied Polymer Science, Volume 120, pp 3297-3303; doi:10.1002/app.33522

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Yuhua Chang, Ling Xiao
Journal of Macromolecular Science, Part A, Volume 47, pp 608-615; doi:10.1080/10601321003742147

The publisher has not yet granted permission to display this abstract.
Published: 1 September 2018
Carbohydrate Polymers, Volume 195, pp 401-412; doi:10.1016/j.carbpol.2018.04.105

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, Peethambaran.L. Divya, Jayachandran Nima
Materials Science and Engineering: C, Volume 55, pp 471-481; doi:10.1016/j.msec.2015.05.068

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Sung-Ching Chen, Yung-Chih Wu, Fwu-Long Mi, Yu-Hsin Lin, Lin-Chien Yu,
Published: 1 April 2004
Journal of Controlled Release, Volume 96, pp 285-300; doi:10.1016/j.jconrel.2004.02.002

The publisher has not yet granted permission to display this abstract.
Published: 28 December 2020
Materials, Volume 14; doi:10.3390/ma14010098

Abstract:
A novel and promising hydrogel drug delivery system (DDS) capable of releasing 5‑fluorouracil (5-FU) in a prolonged and controlled manner was obtained using ε‑caprolactone‑poly(ethylene glycol) (CL-PEG) or rac‑lactide-poly(ethylene glycol) (rac‑LA-PEG) copolymers. Copolymers were synthesized via the ring-opening polymerization (ROP) process of cyclic monomers, ε‑caprolactone (CL) or rac-lactide (rac-LA), in the presence of zirconium(IV) octoate (Zr(Oct)4) and poly(ethylene glycol) 200 (PEG 200) as catalyst and initiator, respectively. Obtained triblock copolymers were characterized by nuclear magnetic resonance (NMR) and gel permeation chromatography (GPC) techniques; the structure and tacticity of the macromolecules were determined. The relationship between the copolymer structure and the reaction conditions was evaluated. The optimal conditions were specified as 140 °C and 24 h. In the next step, CL-PEG and rac-LA-PEG copolymers were chemically crosslinked using hexamethylene diisocyanate (HDI). Selected hydrogels were subjected to in vitro antitumor drug release studies, and the release data were analyzed using zero-order, first-order, and Korsmeyer-Peppas mathematical models. Controlled and prolonged (up to 432 h) 5-FU release profiles were observed for all examined hydrogels with first-order or zero-order kinetics. The drug release mechanism was generally denoted as non-Fickian transport.
Published: 1 July 2001
Journal of Controlled Release, Volume 75, pp 55-67; doi:10.1016/s0168-3659(01)00365-0

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, Laura R. LaBonte, Jakal Amin, Stefan J. Thibodeaux, Cameron C. Lee, O. Andreea Argintaru, Christopher M. Adams
International Journal of Pharmaceutics, Volume 585; doi:10.1016/j.ijpharm.2020.119519

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Mohammad Taghi Nazeri, Siamak Javanbakht, , Marjan Ghorbani
Journal of Drug Delivery Science and Technology, Volume 57; doi:10.1016/j.jddst.2020.101669

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Chao Zhu, Courtney Hard, Caiping Lin,
Journal of Polymer Science Part A: Polymer Chemistry, Volume 43, pp 4017-4029; doi:10.1002/pola.20898

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Orlando J. Ramírez, Simón Alvarez, Pamina Contreras-Kallens, Nelson P. Barrera, Sebastian Aguayo,
Published: 1 January 2020
Drug Delivery, Volume 27, pp 1308-1318; doi:10.1080/10717544.2020.1818880

Abstract:
Throughout the last decade, extracellular vesicles (EVs) have become increasingly popular in several areas of regenerative medicine. Recently, Apis mellifera royal jelly EVs (RJ EVs) were shown to display favorable wound healing properties such as stimulation of mesenchymal stem cell migration and inhibition of staphylococcal biofilms. However, the sustained and effective local delivery of EVs in non-systemic approaches – such as patches for chronic cutaneous wounds – remains an important challenge for the development of novel EV-based wound healing therapies. Therefore, the present study aimed to assess the suitability of type I collagen -a well-established biomaterial for wound healing – as a continuous delivery matrix. RJ EVs were integrated into collagen gels at different concentrations, where gels containing 2 mg/ml collagen were found to display the most stable release kinetics. Functionality of released RJ EVs was confirmed by assessing fibroblast EV uptake and migration in a wound healing assay. We could demonstrate reliable EV uptake into fibroblasts with a sustained pro-migratory effect for up to 7 d. Integrating fibroblasts into the RJ EV-containing collagen gel increased the contractile capacity of these cells, confirming availability of RJ EVs to fibroblasts within the collagen gel. Furthermore, EVs released from collagen gels were found to inhibit Staphylococcus aureus ATCC 29213 biofilm formation. Overall, our results suggest that type I collagen could be utilized as a reliable, reproducible release system to deliver functional RJ EVs for wound healing therapies.
International Journal of Pharmaceutics, Volume 429, pp 31-37; doi:10.1016/j.ijpharm.2012.03.012

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, , Ilka Narita Hatakeyama, Gabriela Marielli Luz, Maria Palmira Daflon Gremião,
Drug Development and Industrial Pharmacy, Volume 39, pp 1750-1757; doi:10.3109/03639045.2012.734510

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Hossein Derakhshankhah, Rana Jahanban‐Esfahlan, Somayeh Vandghanooni, Sattar Akbari‐Nakhjavani, Bakhshali Massoumi, Babak Haghshenas, Aram Rezaei, Amir Farnudiyan‐Habibi, Hadi Samadian,
Published: 10 February 2021
by Wiley
Journal of Applied Polymer Science; doi:10.1002/app.50578

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Jan Romański, , Krystyna Pyrzynska, ,
Journal of Polymer Science Part A: Polymer Chemistry, Volume 50, pp 542-550; doi:10.1002/pola.25063

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, Mar López-González, Isabel Trabado, M. Melia Rodrigo, ,
Published: 1 June 2016
Materials Today Communications, Volume 7, pp 73-80; doi:10.1016/j.mtcomm.2016.04.004

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Zhe Zhang, , Mingxiao Deng, Yunyan Bai, , Xiabin Jing
Journal of Polymer Science Part A: Polymer Chemistry, Volume 49, pp 2941-2951; doi:10.1002/pola.24730

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