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(searched for: (Sex and Age Differences in Telomere Length and Susceptibility to COVID-19))
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Manar Ahmed Kamal, Kareem Reda Alamiry, Mahmoud Zaki
Journal of Biomedical Research & Environmental Sciences, Volume 1, pp 303-310; doi:10.37871/jbres1159

Abstract:
Background:
Telomeres
are the ends of a chromosome and play a fundamental role as vanguards contra the chromosomal decay. Due to the inability of DNA polymerase to replicate chromosomal ends, a reduction in
telomeres
length
happens after each cell division. The existence of shorter
telomeres
in older people is related to diminish immune functions. Viral infections able to stimulate remodeling of cells, stress responses, and
telomere
shortening. Moreover,
telomere
shortening can be caused by extrinsic environmental variables which induce oxidative stress under conditions of inflammation. Aim: To identify the correlation between
telomere
shortening and
susceptibility
to Novel Coronavirus Disease 2019 (
COVID
-
19
). In addition to clarifying changes in
telomere
length
according to the viral infection, the effect of
sex
and
age
differences
in
telomere
length
in confirmed positive
COVID
-
19
cases are also reviewed. Conclusion: There is a correlation between
telomere
length
and
COVID
-
19
infection with higher
susceptibly
of elderly patients and males due to shortening in their
telomere
length
. Approximately 53% of (111,428) infected cases (≥ 50) years old are males, and 47% of (111,428) infected cases (≥ 50) years old are females.
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