(searched for: ("Covid-19") OR ("SARS-CoV-2") OR ("coronavirus") OR ("2019-nCoV"))
A World Out of Reach pp 132-138; doi:10.2307/j.ctv17bt3gt.29
Mexico took swift action and has strictly followed mitigation measures to prevent the spread of coronavirus disease, COVID-19. The present study compared indicators of influenza activity in 2020 before and after public health measures were taken to reduce COVID-19 with the corresponding indicators from three preceding years and the immediate one, and the potential decrease in seasonal influenza cases. Nationwide surveillance data revealed a drastic decline in influenza diagnosis in outpatient clinics and public hospitals, positivity rates of clinical specimens, and confirmed severe cases during the following 10 weeks of 2020 as lockdown activities and control measures were established compared with the same period of 2019, suggesting that the measures taken for COVID-19 were effective in reducing the spread of other viral respiratory diseases in our country.
Background: The recognition, prevention and treatment of venous thromboembolism (VTE) remains a major challenge in the face of the recent SARS-COV-2 pandemic which has been associated with significant cardiovascular, renal, respiratory and hematologic complications related to hypercoagulability. There has been little literature thus far on the utility of screening ultrasound and role of the clinical pharmacist in treating these patients.Methods: We present a prospective pilot program of thirty-one consecutive SARS-CoV-2 patients who were provided four extremity screening ultrasounds for VTE on admission. This was coordinated by a clinical pharmacist as part of a multidisciplinary approach. Quantitative and qualitative data were recorded with the goal of describing the utility of the clinical pharmacist in ultrasound screening. Data collected include: demographics, information on clinical symptoms or signs at presentation, and laboratory and radiologic results during the hospitalization from each individual electronic medical record.Results: Nine of the thirty-one patients presented with venous thrombosis. Of the nine patients, there were twenty-two total clotted vessels, all of which were asymptomatic. The clinical pharmacist, as the coordinator for a multidisciplinary COVID-19 associated coagulopathy management team, drafted a screening and treatment protocol for anticoagulation prophylaxis and therapy of VTE after ultrasound findings.Conclusion: VTE screening of hospitalized SARS-CoV-2 patients reveals a significant number of asymptomatic VTEs and justifies diagnostic, prophylactic, and treatment measures coordinated by a clinical pharmacist.
As of the Fall of 2020, many countries are still fighting the COVID-19 pandemic. After the painful first massive wave in the Spring, more and more of them are facing the new outbreaks of varying impact. Understanding the mortality pattern associated with such subsequent outbreaks would help governments better prepare and save lives. These secondary outbreaks are still quite new to the scientists as the data have not been sufficient to identify robust trends. By now, US is dealing with the second outbreak of large magnitude and statistically significant analyses are finally possible. We have analyzed the weekly mortality death counts for various ages in US for the entire COVID-19 pandemic duration. Three somewhat related features involving age at death have been extracted: a) COVID-19 average age at death, b) fraction of deaths at ages 65+, and c) slope of age gradient regression line on the logarithmic scale. It turns out that during the outbreak the mortality age gradient is undergoing the following changes: a) average age at death at the peak is 4-5 years higher than at the lower point; b) fraction of deaths of 65+ is by approximately 10% higher, and c) the higher slope of the age gradient translates into an extra death risk of 5.8% every year. In other words, risks, to which an elderly population is exposed during all phases of the pandemic, rise sharply during and right after the outbreak peaks.
Sensitive and specific SARS-CoV-2 antibody assays remain critical for community and hospital-based SARS-CoV-2 surveillance. Here, we developed and applied a multiplex microsphere-based immunoassay (MMIA) for COVD-19 antibody studies that incorporates spike protein trimers of SARS-CoV-2, SARS-CoV-1, MERS-CoV, and the seasonal human betacoronaviruses, HCoV-HKU1 and HCoV-OC43, that enables measurement of off-target pre-existing cross-reactive antibodies. The MMIA performances characteristics are: 98% sensitive and 100% specific for human subject samples collected as early as 10 days from symptom onset. The MMIA permitted the simultaneous identification of SARS-CoV-2 seroconversion and the induction of SARS-CoV-2 IgG antibody cross reactions to SARS-CoV-1 and MERS-CoV. Further, synchronous increases of HCoV-OC43 IgG antibody levels was detected with SARS-CoV-2 seroconversion in a subset of subjects for whom early infection sera were available prior to their SARS-CoV-2 seroconversion, suggestive of an HCoV-OC43 memory response triggered by SARS-CoV-2 infection.
The policies for containing the spread of SARS-CoV2 virus include a number of measures aimed at reducing physical contacts. In this paper, we explore the potential impact of such containment measures on social relations of both young adults and elderly in Italy. We propose two ego-centered network definitions accounting for physical distances in light of the recent - and maybe future - COVID-19 containment measures: 1) the easy-to-reach network, that represent a nearby possible source of support in case of new lockdown; 2) accustomed-to-reach network, which include proximity and habit to meet in person. The approach used for constructing personal (ego-centered) networks on data from the most recent release of Families and Social Subject Survey allows to bring in the foreground people exposed to relational vulnerability. The analysis of the most vulnerable No alters individuals by age, gender and place of residence reveal that to be single is often associated with a condition of relational vulnerability not only among elder people, but also for young adults. Results also highlight the role of the place of residence.
Diagnostics, Volume 10; doi:10.3390/diagnostics10120992
Background: Patients with hematological malignancies (HM), including multiple myeloma (MM), frequently suffer from immune deficiency-associated infectious complications because of both the disease and the treatment. Alarming results from China and the UK confirm the vulnerability of HM patients to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-driven coronavirus disease 2019 (COVID-19). Given that the immunoassay interference from the endogenous monoclonal immunoglobulin (M paraprotein) and treatment antibodies continually challenges the MM management, it is critical to evaluate the SARS-CoV-2 serology tests for suspected interference/cross-reactivity. Methods: We compared the degree of interference in three SARS-CoV-2 serology assay platforms in HM patients with and without COVID-19 and on various therapeutic monoclonal antibody (t-mAb) treatments. Further, we confirmed the cross-reactivity in pooled samples from normal and COVID-19 + samples spiked with respective antibodies in vitro. Results: None of the 93 HM patient samples with or without t-MAbs showed cross-reactivity on any of the three serology platforms tested. Conclusions: The tested three serologic assays for SARS-CoV-2 are specific and do not have cross-reactivity with M-components or t-MAbs indicating that they can be used safely in oncology practice and in research exploring the immunologic response to COVID-19 in patients with HM.
Journal of Physics: Conference Series, Volume 1641; doi:10.1088/1742-6596/1641/1/012018
Information about COVID-19 is now very easily accessed on the Internet, even too much. The phenomenon of excessive information obtained can also be linked to psychological illnesses and obtain information retrieval. this article conducts research about information overload about the psychology of information seekers and their protection. The study used the TAM method with SEM tools with 380 respondents. The results of the study show that excessive online information about COVID-19 has a positive influence on the psyche and affects the relationship of information seekers not to continue the search results.
Journal of Physics: Conference Series, Volume 1641; doi:10.1088/1742-6596/1641/1/012032
Nowadays E-Government has a huge impact on supporting and running governments around the world. And a government site is a tool for interacting between the government and its citizens. Recent studies have shown that the quality of the website becomes something that the government mandatory. This research examines the overall quality of the website Covid19 Bogor City. Using the Webqual methodology to assess the quality of the website and to see how the Bogor city government maintains the expectations of its citizens or users. From a three-dimensional variable that has been given by webqual and from 119 respondents as a sample of this research, the author finds that all three variables have significant results for the satisfied citizens or users with certain aspects of the facilities, contents, and menus of the website. Majority respondents who have accessed and using the website of Bogor City Covid19 satisfied with the facilities.
Published: 24 November 2020
L'enseignement à la loupe; doi:10.1787/a8046304-fr
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