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Andrea Zatkova, LakshmiNarayan Ranganath, Sciprofile linkLudevit Kadasi
The Application of Clinical Genetics, Volume 13, pp 37-47; doi:10.2147/tacg.s186773

Abstract: Alkaptonuria: Current Perspectives
Siddharth Mehrotra, Shailendra Lalwani, Sciprofile linkSamiran Nundy
Hepatic Medicine: Evidence and Research, Volume 12, pp 1-13; doi:10.2147/hmer.s223022

Abstract: Management Strategies for Patients with Hilar Cholangiocarcinomas: Challenges and Solutions
Da Sychev, Oa Baturina, Kb Mirzaev, Sciprofile linkE Rytkin, Sciprofile linkDv Ivashchenko, Da Andreev, Ka Ryzhikova, Ea Grishina, Po Bochkov, Rv Shevchenko
Pharmacogenomics and Personalized Medicine, Volume 13, pp 29-37; doi:10.2147/pgpm.s234910

Abstract: CYP2C19*17 May Increase the Risk of Death Among Patients with an Acute Coronary Syndrome and Non-Valvular Atrial Fibrillation Who Receive Clopidogrel and Rivaroxaban
Journal of Multidisciplinary Healthcare, Volume 13, pp 85-97; doi:10.2147/jmdh.s214378

Abstract: Dementia Care Education Targeting Job Strain and Organizational Climate Among Dementia Care Specialists in Swedish Home Care Services Mandana Fallahpour,1,2 Lena Borell,1 Linda Sandberg,1 Anne-Marie Boström3– 5 1Department of Neurobiology, Care Sciences and Society, Division of Occupational Therapy, Karolinska Institutet, Stockholm, Sweden; 2Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden; 3Department of Neurobiology, Care Sciences and Society, Division of Nursing, Karolinska Institutet Stockholm, Solna, Sweden; 4Theme Aging, Karolinska University Hospital, Stockholm, Sweden; 5Department of Nursing, Western Norway University of Applied Science, Haugesund, NorwayCorrespondence: Mandana FallahpourDepartment of Neurobiology, Care Sciences and Society, Division of Occupational Therapy, Karolinska Institutet, Fack 23200, Huddinge SE-141 83, Stockholm, SwedenTel +46 8 524 838 56Fax +46 8 34 50 14Email [email protected]: An increasing number of older persons live at home with various limitations, such as dementia, requiring well-educated and trained home care staff to meet their complex care needs. Dementia care specialists working in home care service have reported high levels of job strain in comparison with home care staff in general.Aim: This pilot study aims to evaluate the effects of a dementia care education model targeting self-reported job strain and organizational climate, among dementia care specialists in home care service.Methods: A quasi-experimental, one-group pretest–posttest design was applied, with 12 months’ follow-up. Participants were dementia care specialists who worked in home care service (n=34 baseline; n=30 follow-up). The data were collected using the Strain in Dementia Care Scale and Creative Climate Questionnaires, administered pre- and post-intervention. The intervention applied an educational model based on previous research in dementia care and a person-centered approach.Results: The educational model was implemented in the context of home care services. Of 34 participants at baseline, only 21 responded to the questionnaires, due to a drop off of 13 participants and recruitment of 9 new participants (follow-up=30). A significantly reduced perceived job strain among the participants was detected, indicating perceiving less difficulty in “Balancing competing needs” when caring for the older persons. No significant difference was found in the self-reported creative organizational climate between the two occasions.Conclusion: The educational model could be integrated into dementia home care and it seemed to reduce job strain among dementia care specialists. Future studies are needed to evaluate the effects of the intervention using a stronger study design and a larger sample.Keywords: creative climate questionnaire, dementia, home care services, interventions, job strain, national guidelines, strain in dementia...
Danlei Yang, Ying Yan, Fen Hu, Tao Wang
International Journal of Chronic Obstructive Pulmonary Disease, Volume 15, pp 167-175; doi:10.2147/copd.s220675

Abstract: CYP1B1, VEGFA, BCL2, and CDKN1A Affect the Development of Chronic Obstructive Pulmonary Disease Danlei Yang,1 Ying Yan,2 Fen Hu,1 Tao Wang1 1Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Ningxia People’s Hospital, Yinchuan 750002, People’s Republic of ChinaCorrespondence: Tao WangDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, People’s Republic of ChinaTel +86-13971477320Email [email protected]: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by poor airflow. The purpose of this study was to explore the mechanisms involved in the development of COPD.Patients and Methods: The mRNA expression profile GSE100281, consisting of 79 COPD and 16 healthy samples, was acquired from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) between COPD samples and healthy samples were analyzed using the limma package. Functional enrichment analysis for the DEGs was carried out using the Database for Annotation, Visualization, and Integrated Discovery (DAVID) tool. Furthermore, DEG-compound pairs were predicted using the Comparative Toxicogenomics Database. The KEGG metabolite IDs corresponding to the compounds were also obtained through the MetaboAnalyst pipeline. Based on the diffusion algorithm, the metabolite network was constructed. Finally, the expression levels of key genes were determined using quantitative PCR (qPCR).Results: There were 594 DEGs identified between the COPD and healthy samples, including 242 upregulated and 352 downregulated genes. A total of 696 DEG-compound pairs, such as BCL2-C00469 (ethanol) and BCL2-C00389 (quercetin) pairs, were predicted. CYP1B1, VEGFA, BCL2, and CDKN1A were included in the top 10 DEG-compound pairs. Additionally, 57 metabolites were obtained. In particular, hsa04750 (inflammatory mediator regulation of TRP channels)-C00469 (ethanol) and hsa04152 (AMPK signaling pathway)-C00389 (quercetin) pairs were found in the metabolite network. The results of qPCR showed that the expression of CYP1B1, VEGFA, BCL2, and CDKN1A was consistent with that predicted using bioinformatic analysis.Conclusion: CYP1B1, VEGFA, BCL2, and CDKN1A may play important functions in the development and progression of COPD.Keywords: chronic obstructive pulmonary disease, differentially expressed genes, enrichment analysis, disease metabolites, metabolite network
Mohammed F Rafey, Conor F Murphy, Razk Abdalgwad, Katriona Kilkelly, Helena Griffin, Niamh Beatty, Paula M O'shea, Sciprofile linkChris Collins, Sciprofile linkRobert McGrath, Mary Hynes, et al.
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Volume 13, pp 197-205; doi:10.2147/dmso.s226327

Abstract: Effects of a Milk-Based Meal Replacement Program on Weight and Metabolic Characteristics in Adults with Severe Obesity
Ayşe Oğuzlar
Öneri Dergisi, Volume 6, pp 315-321; doi:10.14783/maruoneri.678958

International Journal of Chronic Obstructive Pulmonary Disease, Volume 15, pp 177-187; doi:10.2147/copd.s234882

Abstract: Arterial Stiffness Increases Over Time in Relation to Lung Diffusion Capacity: A Longitudinal Observation Study in COPD
Mustafa M. Özkan
Öneri Dergisi, Volume 6, pp 323-355; doi:10.14783/maruoneri.678962

Chen Qin, Xiuli Yan, Hang Jin, Ruyi Zhang, Yaode He, Xin Sun, Yihe Zhang, Zhen-Ni Guo, Yi Yang
Neuropsychiatric Disease and Treatment, Volume 16, pp 283-299; doi:10.2147/ndt.s231944

Abstract: Effects of Remote Ischemic Conditioning on Cerebral Hemodynamics in Ischemic Stroke
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