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Ru-Rong Tang, Yan Wang, Chao-Nan Liang, Wei Li, Ling Pei, Jian Kang, Gang Hou
Published: 20 February 2019
OncoTargets and Therapy, Volume 12, pp 1433-1437; doi:10.2147/ott.s190362

Abstract: Multiple extramedullary plasmacytomas of the trachea and pharyngeal tissue: a case report and literature review
Hava Golander
Israel Journal of Health Policy Research, Volume 8; doi:10.1186/s13584-018-0273-5

Abstract: Several models have been proposed to connect academia and practice in order to improve long-term care. In this paper we propose and describe the “Mini-Research Group” as an alternative model of such collaboration. The formation of mini-research groups was the unplanned by-product of a longitudinal action research project headed by the late Prof. Rebecca Bergman, a prominent nursing leader from the Department of Nursing at Tel-Aviv University. It involved a two-stage project aimed at developing, and later implementing, a specific tool to evaluate the quality of care provided in geropsychiatric units and to design a nursing intervention which entailed an improved model for care in specialized geropsychiatric units for persons with dementia. Initially, this article describes the projects that led to the development of mini-research groups, and then continues to describe several mini-research projects, focusing on the research questions which emerged from practice as well as the variety of methodologies used. Finally, we discuss the ways in which mini- research groups contributed to the quality of care for persons with dementia, benefited their families, professional staff, faculty participants, and advanced policy development. We argue that in light of the present array of ethical and legal restrictions which inhibit the recruitment of participants, using mini-research groups combined of practitioners and researchers, can provide a pragmatic solution, not only to overcome these barriers, but to improve the quality of care, stimulate clinical dementia research, and promote new insights into the lives of persons with dementia.
Kelola Sendang Zsl
Published: 20 February 2019
Abstract: Nypa fruiticans, yang dikenal sebagai Nipah, adalah spesies asli pohon palem yang tumbuh di pesisir pantai dan muara di Samudera Hindia dan Pasifik. Luasan Nipah meliputi 700,000 hektar di Indonesia, sedangkan di Sumatera Selatan, Nipah merupakan komponen hutan bakau dan meliputi area besar di sepanjang pantai, muara dan riparian dari sungai. Setengah dari ekosistem alami nipah di Sumatera Selatan telah terganggu oleh kegiatan manusia dan membutuhkan upaya restorasi. Nipah dapat digunakan sebagai salah satu sumber penghasil gula. Hutan alami nipah memiliki potensi untuk menghasilkan penghidupan masyarakat yang berkelanjutan khususnya bagi yang tinggal di kawasan dataran rendah. Saat ini, nipah telah teridentifikasi sebagai sumber potensi dari energi terbarukan. Getah Nipah yang kaya akan gula dapat digunakan untuk memproduksi etanol sebagai biofuel. Potensi ini mendorong Proyek KELOLA Sendang untuk melakukan eksplorasi dari potensi nipah untuk restorasi ekosistem, mitigasi erubahan iklim, penghidupan masyarakat yang berkelanjutan dan energi terbarukan.
Carolyn Ma, Helen Wong Smith, Cherie Chu, Deborah Taira Juarez
Integrated Pharmacy Research and Practice, Volume 8, pp 13-14; doi:10.2147/iprp.s204832

Abstract: Big data in pharmacy practice: current use, challenges, and the future [Corrigendum] Ma C, Smith H, Chu C, Juarez D. Integr Pharm Res Pract. 2015;4:91–99.Page 96, left-hand column, the reference citations for the following text “The US Hawaii Health InformationExchange (HHIE) is a 501 (C) (3) nonprofit, state-wide organization established in 2006. By facilitating assessmentand implementing targeted health initiatives, HHIE strives to enhance care coordination, to improve the health outcomes of Hawai‘i’s patients, and to reduce the cost of care for both patients and health care providers.39” and “A project called Pharm2Pharm, funded for $14.3 million USD by an innovation grant from CMS, uses information provided by HHIE to facilitate all written communication between hospitals and outpatient health care teams.40” were incorrect. The citation numbers 39 and 40 in this section should be replaced by number 55.Page 96, left-hand column, the reference citations for the following text “HHIE Community Health Record, a tool thatpharmacists can use to access patient lab values and other clinical information. This complete record of medications,labs, and other clinical information can then be utilized to support additional health care strategies specificallydesigned for each patient.39,40” were incorrect. The citation numbers 39 and 40 in this section should be replaced by number 55.Page 99, the following reference should be added to the reference list as reference number 55 “Pellegrin KL. The Daniel K. Inouye College of Pharmacy Scripts: Pharm2Pharm: Leveraging Medication Expertise Across the Continuum of Care. Hawaii J Med Public Health. 2015;74(7):248–252.”Read the original article
Safaa Hassan Omer, Tarig Osman Khider, Osman Taha Elzaki, Salaheldin Dafalla Mohieldin, Suhair Kamal Shomeina
Published: 20 February 2019
BMC Chemical Engineering, Volume 1; doi:10.1186/s42480-019-0005-9

Abstract: Abelmoschus esculentus okra as whole stalks was examined for its suitability for pulp and paper production. It’s, fiber dimensions, morphological and chemical characteristics were reported. The pulping trials with soda- Anthraquinone (AQ,) at different chemical charges. Application of 21% as NaOH with 0.1% AQ gave good results in degree of delignification, mechanical properties. Utilization of okra pulps and blender is recommended due to good pulp properties. Evaluation of general characteristics of okra stalks in terms of fiber dimensions morphological indices, chemical components, Soda-AQ cooking and to study their suitability for paper production. Okra Fiber dimension evaluation done after maceration with a mixture of 30% hydrogen peroxide and acetic acid (1:1) for core and bark parts separately and was carried out under microscope staining with aqueous safranin. The Soda-AQ cooks at different active alkali levels were calculated as NaOH on oven dry raw material. The fibers from okra stalks studied (core and bark) were in the range of hardwood fibers, with short fiber length, especially the core with more or less moderate walls, narrow lumen and fiber width. The fiber width of bark was medium –narrow with medium wall thickness. The ash content was rather high whereas the silica content was comparatively high The hot water extractives from okra stalks was (4.1%), cold water (0.4) ethanol/ cyclohexane (1.1), ethanol extractives (1.2%) and 1% NaOH (27.6%) were rather high. The cellulose (Kurschner-Hoffer) was (48.5%) The lignin content was (15.3%) which was relatively moderate. The use of 0.1% AQ enhanced the delignification in the three trials applied. The screened yield increase with increase of chemical dose applied while the rejects decrease. When 21% NaOH was applied, the screened yield was 32.2% with negligible amount of rejects, however with lower alkali charge 18% the screened yield was decreased to 28% with very low rejects 1.5%. on the other hand rejects were increased to 7% when 15% NaOH was applied with very low screened yield 19%.The pulps produced from okra soda-AQ are suitable for production of printing and writing papers and it is advisable to use them in blending due to good papermaking properties.
Uri Zilberman, Jumanna Hassan, Shirley Leiboviz-Haviv
World Journal of Stomatology, Volume 7, pp 20-27; doi:10.5321/wjs.v7.i2.20

Abstract: The aim of this study is to report the diagnostic features, prevalence, mineral content, clinical significance and treatment options of molar incisor hypomineralization (MIH) and pre-eruptive intracoronal lesions (PEIR), in order to minimize miss-treatment of primary and permanent teeth in young children. MIH was defined as the occurrence of hypomineralization of one up to four permanent first molars from a systemic origin and frequently associated with affected incisors. PEIR are lesions that are located in the occlusal portion of the crown of unerupted permanent or primary teeth. The prevalence of MIH was reported between 2.5%-40% in the permanent first molars and 0%-21.8% in primary second molars. PEIR was observed in 2%-8% of children, mainly in mandibular second premolars and second and third permanent molars. A number of possible causes for MIH were mentioned, including environmental changes, diet and genetics in prenatal and postnatal periods, but all are questionable. In PEIR, the resorption of the intracoronal dentine begins only after crown development is complete and is caused by giant cells resembling osteoclast observed histologically on the dentine surface close to the pulp. The mineral content in MIH is reduced in comparison to normal enamel and dependent on the severity of the lesion. In PEIR the resorbed surface of enamel showed less mineral content. The hypomineralized enamel in MIH is not suitable for restorations with amalgam or composite materials, and the best material should be based on remineralization material like glass-ionomers. Similar, the resorbed dentin surface in PEIR should be covered by the biocompatible and re-mineralizing glass-ionomer cement.
Johannes Schneider, Gianluca Iori, Donatien Ramiandrisoa, Maroua Hammami, Melanie Gräsel, Christine Chappard, Reinhard Barkmann, Pascal Laugier, Quentin Grimal, Jean-Gabriel Minonzio, et al.
Published: 20 February 2019
Archives of Osteoporosis, Volume 14; doi:10.1007/s11657-019-0578-1

Abstract: The estimation of cortical thickness (Ct.Th) and porosity (Ct.Po) at the tibia using axial transmission ultrasound was successfully validated ex vivo against site-matched micro-computed tomography. The assessment of cortical parameters based on full-spectrum guided-wave analysis might improve the prediction of bone fractures in a cost-effective and radiation-free manner. Cortical thickness (Ct.Th) and porosity (Ct.Po) are key parameters for the identification of patients with fragile bones. The main objective of this ex vivo study was to validate the measurement of Ct.Po and Ct.Th at the tibia using a non-ionizing, low-cost, and portable 500-kHz ultrasound axial transmission system. Additional ultrasonic velocities and site-matched reference parameters were included in the study to broaden the analysis. Guided waves were successfully measured ex vivo in 17 human tibiae using a novel 500-kHz bi-directional axial transmission probe. Theoretical dispersion curves of a transverse isotropic free plate model with invariant matrix stiffness were fitted to the experimental dispersion curves in order to estimate Ct.Th and Ct.Po. In addition, the velocities of the first arriving signal (υFAS) and A0 mode (υA0) were measured. Reference Ct.Po, Ct.Th, and vBMD were obtained from site-matched micro-computed tomography. Scanning acoustic microscopy (SAM) provided the acoustic impedance of the axial cortical bone matrix. The best predictions of Ct.Po (R2 = 0.83, RMSE = 2.2%) and Ct.Th (R2 = 0.92, RMSE = 0.2 mm, one outlier excluded) were obtained from the plate model. The second best predictors of Ct.Po and Ct.Th were vBMD (R2 = 0.77, RMSE = 2.6%) and υA0 (R2 = 0.28, RMSE = 0.67 mm), respectively. Ct.Th and Ct.Po were accurately predicted at the human tibia ex vivo using a transverse isotropic free plate model with invariant matrix stiffness. The model-based predictions were not further enhanced when we accounted for variations in axial tissue stiffness as reflected by the acoustic impedance from SAM.
Michael J. G. Milevskiy, Udai Gujral, Carolina Del Lama Marques, Andrew Stone, Korinne Northwood, Lez J. Burke, Julia M. W. Gee, Kenneth Nephew, Susan Clark, Melissa A. Brown
Published: 20 February 2019
British Journal of Cancer; doi:10.1038/s41416-019-0395-8

Abstract: MicroRNAs are potent post-transcriptional regulators involved in all hallmarks of cancer. Mir-196a is transcribed from two loci and has been implicated in a wide range of developmental and pathogenic processes, with targets including Hox, Fox, Cdk inhibitors and annexins. Genetic variants and altered expression of MIR196A are associated with risk and progression of multiple cancers including breast cancer, however little is known about the regulation of the genes encoding this miRNA, nor the impact of variants therein. Genomic data and chromatin interaction analysis were used to discover functional promoter and enhancer elements for MIR196A. Expression data were used to associate MIR196A with mechanisms of resistance, breast cancer subtypes and prognosis. Here we demonstrate that MIR196A displays complex and dynamic expression patterns, in part controlled by long-range transcriptional regulation between promoter and enhancer elements bound by ERα. Expression of this miRNA is significantly increased in drug-resistant models of hormone-receptor positive disease. The expression of MIR196A also proves to be a robust prognostic factor for patients with advanced and post-menopausal ER+ disease. This work sheds light on the normal and abnormal regulation of MIR196A and provides a novel stratification method for therapeutically resistant breast cancer.
Fan Zhong, Yan Jiang
Published: 20 February 2019
Frontiers in Endocrinology, Volume 10; doi:10.3389/fendo.2019.00101

Abstract: Endogenous pancreatic β cell regeneration is a potential strategy for β cell expansion or neogenesis to treat diabetes. Regeneration can occur through stimulation of existing β cell replication or conversion of other pancreatic cells into β cells. Recently, various strategies and approaches for stimulation of endogenous β cell regeneration have been evaluated, but they were not suitable for clinical application. In this paper, we comprehensively review these strategies, and further discuss various factors involved in regulation of β cell regeneration under physiological or pathological conditions, such as mediators, transcription factors, signaling pathways, and potential pharmaceutical drugs. Furthermore, we discuss possible reasons for the failure of regenerative medicines in clinical trials, and possible strategies for improving β cell regeneration. As β cell heterogeneity and plasticity determines their function and environmental adaptability, we focus on β cell subtype markers and discuss the importance of research evaluating the characteristics of new β cells. In addition, based on the autoimmunologic features of type 1 diabetes, NOD/Lt-SCID-IL2rgnull (NSG) mice grafted with human immune cells and β cells are recommended for use in evaluation of antidiabetic regenerative medicines. This review will further understand current advances in endogenous β cell regeneration, and provide potential new strategies for the treatment of diabetes focused on cell therapy.
Alexios-Fotios A. Mentis, Efthimios Dardiotis
Published: 20 February 2019
Frontiers in Oncology, Volume 9; doi:10.3389/fonc.2019.00090

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