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Bharath Babu Nunna, Debdyuti Mandal, Joo Un Lee, Harsimranjit Singh, Shiqiang Zhuang, Durgamadhab Misra, Md Nasir Uddin Bhuyian, Eon Soo Lee
Published: 17 January 2019
Nano Convergence, Volume 6; doi:10.1186/s40580-019-0173-6

Abstract: Integrating microfluidics with biosensors is of great research interest with the increasing trend of lab-on-the chip and point-of-care devices. Though there have been numerous studies performed relating microfluidics to the biosensing mechanisms, the study of the sensitivity variation due to microfluidic flow is very much limited. In this paper, the sensitivity of interdigitated electrodes was evaluated at the static drop condition and the microfluidic flow condition. In addition, this study demonstrates the use of gold nanoparticles to enhance the sensor signal response and provides experimental results of the capacitance difference during cancer antigen-125 (CA-125) antigen–antibody conjugation at multiple concentrations of CA-125 antigens. The experimental results also provide evidence of disease-specific detection of CA-125 antigen at multiple concentrations with the increase in capacitive signal response proportional to the concentration of the CA-125 antigens. The capacitive signal response of antigen–antibody conjugation on interdigitate electrodes has been enhanced by approximately 2.8 times (from 260.80 to 736.33 pF at 20 kHz frequency) in static drop condition and approximately 2.5 times (from 205.85 to 518.48 pF at 20 kHz frequency) in microfluidic flow condition with gold nanoparticle-coating. The capacitive signal response is observed to decrease at microfluidic flow condition at both plain interdigitated electrodes (from 260.80 to 205.85 pF at 20 kHz frequency) and gold nano particle coated interdigitated electrodes (from 736.33 to 518.48 pF at 20 kHz frequency), due to the strong shear effect compared to static drop condition. However, the microfluidic channel in the biosensor has the potential to increase the signal to noise ratio due to plasma separation from the whole blood and lead to the increase concentration of the biomarkers in the blood volume for sensing.
Peter R. Hansen, Karl Emil Nelveg-Kristensen, Henrik B. Rasmussen, Christian Torp-Pedersen, Lars Køber, Claus Henrik Nielsen, Christian Enevold
Published: 17 January 2019
The Pharmacogenomics Journal; doi:10.1038/s41397-019-0068-2

The publisher has not yet granted permission to display this abstract.
Mattias Hedegaard Kristensen, Sigrún Alba Jóhannesdóttir Schmidt, Line Kibsgaard, Mette Mogensen, Mette Sommerlund, Uffe Koppelhus
Published: 17 January 2019
Clinical Epidemiology, Volume 11, pp 115-124; doi:10.2147/clep.s184742

Abstract: Validity of first-time diagnoses of congenital epidermolysis bullosa in the Danish National Patient Registry and the Danish Pathology Registry
Iyza F Baig, Alexis R Pascoe, Ashwini Kini, Andrew G Lee
Published: 17 January 2019
Eye and Brain, Volume 11, pp 1-12; doi:10.2147/eb.s170388

Abstract: Giant cell arteritis: early diagnosis is key
Revista de la Facultad de Medicina; doi:10.22201/fm.24484865e

Emily A. Seidler, Lauren A. Murphy, Denis A. Vaughan, Denny Sakkas, Gabor Kovacs, Anthony Rutherford, David K. Gardner
How to Prepare the Egg and Embryo to Maximize IVF Success pp 224-231; doi:10.1017/9781316756744.019

David K. Gardner, Denny Sakkas, Gabor Kovacs, Anthony Rutherford
How to Prepare the Egg and Embryo to Maximize IVF Success pp 232-244; doi:10.1017/9781316756744.020

Luís Felipe Skinner, Rosana M. Rocha, Bailey K. Counts
Published: 17 January 2019
Zootaxa, Volume 4545, pp 264-276; doi:10.11646/zootaxa.4545.2.6

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L. Lee Grismer, Evan S. H. Quah
Published: 17 January 2019
Zootaxa, Volume 4545, pp 230-248; doi:10.11646/zootaxa.4545.2.4

The publisher has not yet granted permission to display this abstract.
Matthew J Medeiros, Jessica Kirkpatrick, Christine H Elliott, Andersonn Prestes, Jesse Eiben, Daniel Rubinoff
Published: 17 January 2019
Zootaxa, Volume 4545, pp 277-285; doi:10.11646/zootaxa.4545.2.7

The publisher has not yet granted permission to display this abstract.
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