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(searched for: doi:10.1288/*)
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The Laryngoscope; doi:10.1288/00005537-200704000-00039

The Laryngoscope; doi:10.1288/00005537-200702000-00042

The Laryngoscope; doi:10.1288/00005537-200612000-00028

The Laryngoscope; doi:10.1288/00005537-200607000-00051

The Laryngoscope, Volume 116; doi:10.1288/00005537-200606000-00001

Steven J. Millen, V. M. Haughton, Z. Yetkin
The Laryngoscope, Volume 105, pp 1305-1310; doi:10.1288/00005537-199512000-00008

The publisher has not yet granted permission to display this abstract.
Christopher H. Kassekh, Jonas T. Johnson, Eugene N. Myers
The Laryngoscope, Volume 105, pp 1334-1336; doi:10.1288/00005537-199512000-00013

Abstract: Management of the neck in squamous cell carcinoma of the upper aerodigestive tract continues to be a topic of great debate. One major problem is that incorrect clinical staging is expected in approximately 20% of necks. This is true of both clinical stage N0 and N+ necks, even when imaging studies are used. This prospective study of 108 necks in 79 patients examined the role of intraoperative palpation and inspection in improving the surgeon's ability to predict nodal stage. Of 62 patients with N0 necks clinically on both sides, 26 were staged N+ by intraoperative node examination. Nineteen of the 26 were histologically negative (73% false‐positive). Of the 36 patients staged intraoperatively as N0, 10 were histologically positive (28% false‐negative). Of 108 necks judged clinically to be N0, 25 (23%) had occult metastases and 11 (10%) had extracapsular spread. Forty‐one of 108 clinical N0 necks were believed to have positive nodes at the time of neck dissection. Of these 41 necks, 30 (73%) were found to be histologically N0 (false‐positive). Of the 67 clinical N0 necks that were also believed to be N0 intraoperatively, occult metastases were found in 14 (21% false‐negative). Therefore, intraoperative staging did not significantly improve the false‐negative rate. Frozen‐section biopsy obtained in the operating room was reliable in 24 (92.3%) of 26 patients. Although frozen‐section biopsy was not performed in all patients, these data suggest that upstaging the neck without frozen‐section biopsy is much less reliable. This study supports the use of frozen‐section biopsy before converting the selective dissection to a radical or modified neck dissection in most instances.
Stefan Gottschlich, Peter B. Billings, Elizabeth M. Keithley, Michael H. Weisman, Jeffrey P. Harris
The Laryngoscope, Volume 105, pp 1347-1352; doi:10.1288/00005537-199512000-00016

Abstract: The immunoreactivity of sera from patients with rapidly progressive sensorineural hearing loss (SNHL) or Meniere's disease with bovine inner ear material was determined using the Western blot technique. Patients with other otologic conditions, autoimmune disorders, or arthritic disorders and age‐matched randomly chosen patients with no hearing complaints served as controls. Twenty‐two percent of the patients with bilateral rapidly progressive SNHL and 30% of the patients with Meniere's disease had antibodies that reacted with a 68 kd antigen in the inner ear material. In the control groups, the incidence of reactivity was 5.0% (P<.001). When the results of this study were compiled with data collected previously, it was found that of 279 patients with bilateral rapidly progressive SNHL, 90 (32%) were positive with the 68 kd protein. Thus, the anti‐68 kd antibody may provide a good marker for an immune etiology of these patients' hearing loss.
The Laryngoscope, Volume 105, pp 24-30; doi:10.1288/00005537-199512000-00034

Dimitry Rabkin, David C. Chhieng, Mitchell B. Miller, Timothy Jennings, Paul Feustel, Josenh Steinisrer, Steven M. Parnes
The Laryngoscope, Volume 105, pp 1294-1299; doi:10.1288/00005537-199512000-00006

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