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(searched for: Understanding-Ameloblastomas-Through-Tooth-Development)
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Amer Sehic, Sciprofile linkQalb-E-Saleem Khan, Department of Medical Biology, Faculty of Health Sciences, University of Tromso, Norway
Journal of Dentistry and Oral Care, Volume 1; doi:10.15436/2379-1705.15.023

Dk Shruthi, Mc Shivakumar, Anand S Tegginamani, B Karthik, Bi Chetan
Journal of Oral and Maxillofacial Pathology, Volume 18, pp 365-371; doi:10.4103/0973-029X.151330

Abstract: Odontogenic cysts and tumors arise from the structures and remnants associated with
tooth
development
. Cysts and tumors derived from the odontogenic tissues constitute an unusually diverse group of lesions. This diversity reflects the complex
development
of the dental structures, since all these lesions originate
through
some alteration from the normal pattern of odontogenesis. Cytokeratin (CK) 14 is the typical intermediary filament of odontogenic epithelium, CK 18 is the major components of the intermediate filaments of simple or single layered epithelial tissue; it is not expressed in stratified squamous epithelium. The present study was undertaken to
understand
the expression pattern of these cytokeratins in dentigerous cyst, dental follicular tissue, adenomatoid odontogenic tumor (AOT) and unicystic
ameloblastoma
. The present study consists of 60 specimens consisting of 20 samples of Dentigerous cyst, 20 samples of Reduced enamel epithelium/dental follicles, 10 samples of Follicular type of AOT, 10 samples of unicystic
ameloblastoma
. The sections of these specimens were stained for CK 14 and CK 18. The number of cells positive for CK 14 and CK 18 was counted per 100 cells. The cells were counted in four randomly selected high-power fields and the mean was calculated. Scoring of cytokeratin 14 expressions was done using Remmele score. The highest expression of cytokeratin 14 was noted in AOT, least was seen in dental follicle/Reduced enamel epithelium (REE). CK18 was negative in all the cases included in the present study. In the present study, the expression of CK14 was noted in AOT, Dentigerous cyst (DC), Unicystic
Ameloblastoma
(UCA) and Dental follicle/REE. The expressions between these lesions were compared. These expression pattern may provide an insight to the histogenesis of AOT.
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