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(searched for: An Overview of Helicobacter Pylori and Diagnostic Methods)
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Daniel Pohl, Peter M Keller, Valentine Bordier, Sciprofile linkKaroline Wagner
World Journal of Gastroenterology, Volume 25, pp 4629-4660; doi:10.3748/wjg.v25.i32.4629

Abstract:
Helicobacter
pylori
(H.
pylori
) infection is highly prevalent in the human population and may lead to severe gastrointestinal pathology including gastric and duodenal ulcers, mucosa associated tissue lymphoma and gastric adenocarcinoma. In recent years,
an
alarming increase in antimicrobial resistance and subsequently failing empiric H.
pylori
eradication therapies have been noted worldwide, also in many European countries. Therefore, rapid and accurate determination
of
H.
pylori
's antibiotic susceptibility prior to the administration
of
eradication regimens becomes ever more important. Traditionally, detection
of
H.
pylori
and its antimicrobial resistance is done by culture and phenotypic drug susceptibility testing that are cumbersome with a long turn-around-time. Recent advances in
diagnostics
provide new tools, like real-time polymerase chain reaction (PCR) and line probe assays, to diagnose H.
pylori
infection and antimicrobial resistance to certain antibiotics, directly from clinical specimens. Moreover, high-throughput whole genome sequencing technologies allow the rapid analysis
of
the pathogen's genome, thereby allowing identification
of
resistance mutations and associated antibiotic resistance. In the first part
of
this review, we will give
an
overview
on currently available
diagnostic
methods
for detection
of
H.
pylori
and its drug resistance and their implementation in H.
pylori
management. The second part
of
the review focusses on the use
of
next generation sequencing technology in H.
pylori
research. To this end, we conducted a literature search for original research articles in English using the terms "
Helicobacter
", "transcriptomic", "transcriptome", "next generation sequencing" and "whole genome sequencing". This review is aimed to bridge the gap between current
diagnostic
practice (histology, rapid urease test, H.
pylori
culture, PCR and line probe assays) and new sequencing technologies and their potential implementation in
diagnostic
laboratory settings in order to complement the currently recommended H.
pylori
management guidelines and subsequently improve public health.
Parisa Sabbagh, Mostafa Javanian, Veerendra Koppolu, VeneelaKrishna Rekha Vasigala, Sciprofile linkSoheil Ebrahimpour
European Journal of Clinical Microbiology & Infectious Diseases, Volume 38, pp 1035-1045; doi:10.1007/s10096-019-03502-5

The publisher has not yet granted permission to display this abstract.
Endoscopy International Open, Volume 3; doi:10.1055/s-0034-1393091

Abstract: Our newest issue comprises 16 original manuscripts (with one attached editorial) plus 2 case reports and 2 review articles and covers different topics from endoscope reprocessing to more advanced procedures, e.g. the following:
Overview
and analysis
of
the publications on infectious diseases linked to cross-contamination
of
flexible endoscopes, with subsequent recommendations on training, auditing, microbiological testing especially concerning the automatic endoscope reprocessors; Outcomes
of
endoscopic resection for superficial pharyngeal carcinoma (59 % R0 resection and 100 % disease-specific survival at 5 year in a first study with 115 de novo lesions, curative salvage resection in 13 out
of
16 patients previously treated by radiotherapy in a second study); Respective accuracies
of
Narrow Band Imaging (70 %) and probed-based confocal laser endomicroscopy (89 %) to characterize Lugol’s voiding lesions as superficial esophageal squamous cell carcinomas in patients with a history
of
head and neck carcinoma; Specificity
of
anesthesia management during POEM (endotracheal intubation, positive pressure ventilation, prevention
of
aspiration, etc.); Removal
of
embedded esophageal metal stents by the stent-in-stent technique (5 new cases plus a review
of
the literature representing a total
of
46 patients); Advantages
of
esophageal EUS on endobronchial EUS for mediastinal analysis in terms
of
time saving and need for sedation (155 procedures), with
an
attached editorial concerning the respective roles
of
EUS and EBUS for mediastinal diseases; No discontinuation
of
warfarin and low dose aspirin during ESD for a patient at risk (metallic mitral valve and coronary artery stent) and with
an
early gastric carcinoma; Close relationship between endoscopic classification and histological classification
of
gastric atrophy and intestinal metaplasia, demonstrated prior and after
Helicobacter
pylori
eradication on a total
of
230 patients; First demonstration
of
an
increased accumulation in gastric superficial carcinomas
of
minute lipids droplets from ingested food opening the door to a novel functional diagnosis endoscopy; Addition
of
fluid cytology on post-brushing biliary lavage to increase the sensitivity
of
standard sampling
methods
performed on biliary strictures (126 patients); Role
of
side port on 22 G needle to increase the diagnosis yield
of
EUS-guided FNA in pancreatic masses (prospective randomized cross-over study on 30 patients, no difference with and without side-port) ; Better
diagnostic
yield
of
small bowel capsule endoscopy when performed within 2 days after the last overt obscure gastrointestinal bleeding (66.7 vs 40.6 %); Diagnosis
of
Dieulafoy lesions
of
the small bowel by single-balloon enteroscopy (8 cases); Adequacy
of
use (77.3%) and safety (adverse effects < 1 %)
of
sodium phosphate tablets for colon cleansing before colonoscopy in routine practice on 996 patients; Percentage
of
sessile serrated adenoma/polyps in colorectal polyps with hyperplastic features detected by chromoendoscopy with indigo carmine (2.7 % overall, 10.9 % in the proximal colon versus 0.9 % distally); High quality endoscopic and histological pictures
of
a sigmoid adenocarcinoma with a dome-type phenotype; Ability
of
EUS to predict the presence and degree
of
tissue fibrosis prior to colorectal ESD (sensitivity: 77.8 %, specificity: 57.1 %); Combination
of
viscous solutions and high-pressure injection to ease human ESD even with the endoscope in retroflexed position (45 resections, R0 resection rate: 91.1 %); Review
of
the technical advances and published results (9 series)
of
EUS-guided fiducial placement for the radiotherapy
of
pancreatic cancer (Need for dedicated multifiducial delivery system is underlined). Enjoy reading! Thierry Ponchon, MD Editor-in-Chief, Endoscopy International Open
Sciprofile linkJacek Budzyński, Marek Kozinski, Sciprofile linkMaria Klopocka, Julia Maria Kubica, Sciprofile linkJacek Kubica
Clinical Research in Cardiology, Volume 103, pp 855-886; doi:10.1007/s00392-014-0720-4

The publisher has not yet granted permission to display this abstract.
György Miklós Buzás
Published: 1 September 2012
Orvosi Hetilap, Volume 153, pp 1407-1418; doi:10.1556/oh.2012.29443

The publisher has not yet granted permission to display this abstract.
Francis Mégraud
European Journal of Gastroenterology & Hepatology, Volume 9; doi:10.1097/00042737-201204001-00004

The publisher has not yet granted permission to display this abstract.
Sciprofile linkBarbara Braden, B. Lembcke, Sciprofile linkWilhelm Küker, W.F. Caspary
Published: 1 September 2007
Digestive and Liver Disease, Volume 39, pp 795-805; doi:10.1016/j.dld.2007.06.012

The publisher has not yet granted permission to display this abstract.
B. Buszewski, Sciprofile linkEwa Kłodzińska, H. Dahm, H. Rózycki, J. Szeliga, M. Jackowski
Published: 1 February 2007
by Wiley
Biomedical Chromatography, Volume 21, pp 116-122; doi:10.1002/bmc.733

The publisher has not yet granted permission to display this abstract.
Sciprofile linkM Kopácová, J Bures, V Vorísek
Published: 1 June 2000
Vnitrni lekarstvi, Volume 46

The publisher has not yet granted permission to display this abstract.
F Mégraud
European Journal of Gastroenterology & Hepatology, Volume 9

The publisher has not yet granted permission to display this abstract.
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