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Dr. Ashok Kumar, Dr. Britney Yegla, Dr. Thomas C Foster
Antioxidants & Redox Signaling, Volume 28, pp 1724-1745; doi:10.1089/ars.2017.7111

Abstract: SIGNIFICANCE: Oxidative stress increases in the brain with aging and neurodegenerative diseases. Previous work emphasized irreversible oxidative damage in relation to cognitive impairment. This research has evolved to consider a continuum of alterations, from redox signaling to oxidative damage, which provides a basis for understanding the onset and progression of cognitive impairment. This review provides an update on research linking redox signaling to altered function of neural circuits involved in information processing and memory. RECENT ADVANCES: Starting in middle-age, redox signaling triggers changes in nervous system physiology described as senescent physiology. Recent studies indicates N-methyl-D-aspartate and ryanodine receptors, and Ca2+ signaling molecules as molecular substrates of redox-mediated senescent physiology. CRITICAL ISSUES: We review redox homeostasis mechanisms and consider the chemical character of reactive oxygen and nitrogen species, and their role in regulating different transmitter systems. In this regard, senescent physiology may represent the co-opting of pathways normally responsible for feedback regulation of synaptic transmission. FUTURE DIRECTIONS: It will be important to identify the intrinsic mechanisms for the shift in oxidative/reductive processes. Intrinsic mechanism will depend on the transmitter system, the oxidative stressors, and the expression/activity of antioxidant enzymes. In addition, it will be important to identify how intrinsic processes interact with other aging factors including changes in inflammatory or hormonal signals. INNOVATION: Results suggest that physiological rather than pathological mechanisms underlie for the initial diagnosis of cognitive impairment. Because redox signaling is reversible, it provides hope for early identification and treatment of cognitive decline.
Marine Paci, Razan Elkhatib, Guy Longepied, Patrice Bourgeois, Pierre F. Ray, Nicolas Levy, Michael J. Mitchell, Catherine Metzler-Guillemain
Basic and Clinical Andrology, Volume 28; doi:10.1186/s12610-018-0072-4

Hajar Mazahery, Pamela R. von Hurst, Christopher J. D. McKinlay, Barbara E. Cormack, Cathryn A. Conlon
Maternal Health, Neonatology and Perinatology, Volume 4; doi:10.1186/s40748-018-0079-z

Nicholas Genes, Samantha Violante, Christine Cetrangol, Linda Rogers, ERIC E. SCHADT, Yu-feng Yvonne Chan
Published: 20 June 2018
npj Digital Medicine, Volume 1; doi:10.1038/s41746-018-0030-8

Yohanes Buang, Suwari Suwari, David Tambaru, Antonius R. Basa Ola, Department of Chemistry , Faculty of Sciences and Engineering, Nusa Cendana University, Kupang, INDONESIA
Journal of Applied Chemical Science, Volume 5, pp 377-382; doi:10.22341/jacs.on.00501p377

Diana A. Wuri, Department of Public Health Veterinary, Faculty of Veterinary Medicine Nusa Cendana University, Kupang 85361, INDONESIA, Jublin F. Bale-Therik, Gomera Bouk, Department of Animal Science, Post Graduate School, Nusa Cendana University, et al.
Journal of Applied Chemical Science, Volume 5, pp 388-393; doi:10.22341/jacs.on.00501p388

Esti Mumpuni, Esti Mulatsari, Faculty of Pharmacy, University of Pancasila, South of Jakarta, 12640, IINDONESIA
Journal of Applied Chemical Science, Volume 5, pp 409-413; doi:10.22341/jacs.on.00501p409

Christiani Dewi Q. M. Bulin, Department of Chemistry, Faculty of Mathematical and Natural Sciences, Widya Mandira Catholic University Kupang, INDONESIA, Adhitasari Suratman, Roto, Department of Chemistry, Faculty of Mathematical and Natural Sciences, Gadjah Mada University – Yogyakarta, et al.
Journal of Applied Chemical Science, Volume 5, pp 414-417; doi:10.22341/jacs.on.00501p414

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